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Items: 1 to 20 of 23

1.
Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production
Jin Zhao, Jiaoshan Chen, Congcong Wang, Yajie Liu, Minchao Li, Yanjun Li, Ruiting Li, Zirong Han, Junjian Wang, Ling Chen, Yuelong Shu, Genhong Cheng, Caijun Sun
PLoS Pathog. 2022 Mar; 18(3): e1010366. Published online 2022 Mar 2. doi: 10.1371/journal.ppat.1010366
PMCID:
PMC8920235
AbstractArticlePDF–3.6M
2.
Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation
Randi Lassiter, Todd D. Merchen, Xuexiu Fang, Youli Wang
Front Immunol. 2021; 12: 671025. Published online 2021 Jul 7. doi: 10.3389/fimmu.2021.671025
PMCID:
PMC8293746
AbstractArticlePDF–6.4M
3.
Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington’s disease
Marie Katrin Bondulich, Yilan Fan, Yeojin Song, Flaviano Giorgini, Gillian P. Bates
Sci Rep. 2021; 11: 5484. Published online 2021 Mar 9. doi: 10.1038/s41598-021-84858-7
PMCID:
PMC7943810
AbstractArticlePDF–9.8M
4.
Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice
Rooban B. Nahomi, Mi-Hyun Nam, Johanna Rankenberg, Stefan Rakete, Julie A. Houck, Ginger C. Johnson, Dorota L. Stankowska, Mina B. Pantcheva, Paul S. MacLean, Ram H. Nagaraj
Int J Mol Sci. 2020 Mar; 21(5): 1795. Published online 2020 Mar 5. doi: 10.3390/ijms21051795
PMCID:
PMC7084183
AbstractArticlePDF–3.4M
5.
Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice
Chieko Tashita, Masato Hoshi, Akihiro Hirata, Kentaro Nakamoto, Tatsuya Ando, Takayuki Hattori, Yasuko Yamamoto, Hiroyuki Tezuka, Hiroyuki Tomita, Akira Hara, Kuniaki Saito
World J Gastroenterol. 2020 Mar 7; 26(9): 918–932. Published online 2020 Mar 7. doi: 10.3748/wjg.v26.i9.918
PMCID:
PMC7081011
AbstractArticlePDF–21M
6.
Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury
Xiaozhong Zheng, Ailiang Zhang, Margaret Binnie, Kris McGuire, Scott P. Webster, Jeremy Hughes, Sarah E. M. Howie, Damian J. Mole
Exp Mol Med. 2019 Feb; 51(2): 15. Published online 2019 Feb 13. doi: 10.1038/s12276-019-0210-x
PMCID:
PMC6374422
AbstractArticlePDF–1.7M
7.
Adaptive and Behavioral Changes in Kynurenine 3-monooxygenase Knockout Mice: Relevance to Psychotic Disorders
Sophie Erhardt, Ana Pocivavsek, Mariaelena Repici, Xi-Cong Liu, Sophie Imbeault, Daniel C Maddison, Marian AR Thomas, Joshua L Smalley, Markus K Larsson, Paul J Muchowski, Flaviano Giorgini, Robert Schwarcz
Biol Psychiatry. Author manuscript; available in PMC 2018 Feb 14.
Published in final edited form as: Biol Psychiatry. 2017 Nov 15; 82(10): 756–765. Published online 2016 Dec 16. doi: 10.1016/j.biopsych.2016.12.011
PMCID:
PMC5812460
AbstractArticlePDF–620K
8.
Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain
Geoffroy Laumet, Wenjun Zhou, Robert Dantzer, Jules D. Edralin, XiaoJiao Huo, David P. Budac, Jason C. O’Connor, Anna W. Lee, Cobi J. Heijnen, Annemieke Kavelaars
Brain Behav Immun. Author manuscript; available in PMC 2018 Nov 1.
Published in final edited form as: Brain Behav Immun. 2017 Nov; 66: 94–102. Published online 2017 Jul 11. doi: 10.1016/j.bbi.2017.07.008
PMCID:
PMC5650931
AbstractArticlePDF–1.1M
9.
Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation
J M Parrott, L Redus, D Santana-Coelho, J Morales, X Gao, J C O'Connor
Transl Psychiatry. 2016 Oct; 6(10): e918. Published online 2016 Oct 18. doi: 10.1038/tp.2016.200
PMCID:
PMC5315555
AbstractArticlePDF–1.2M
10.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
11.
Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria
Ron Korstanje, Konstantin Deutsch, Patricia Bolanos-Palmieri, Nils Hanke, Patricia Schroder, Lynne Staggs, Jan H. Bräsen, Ian S.D. Roberts, Susan Sheehan, Holly Savage, Hermann Haller, Mario Schiffer
J Am Soc Nephrol. 2016 Nov; 27(11): 3271–3277. Published online 2016 Mar 28. doi: 10.1681/ASN.2015070835
PMCID:
PMC5084883
AbstractArticle
12.
Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
Damian J Mole, Scott P Webster, Iain Uings, Xiaozhong Zheng, Margaret Binnie, Kris Wilson, Jonathan P Hutchinson, Olivier Mirguet, Ann Walker, Benjamin Beaufils, Nicolas Ancellin, Lionel Trottet, Véronique Bénéton, Christopher G Mowat, Martin Wilkinson, Paul Rowland, Carl Haslam, Andrew McBride, Natalie ZM Homer, James E Baily, Matthew GF Sharp, O James Garden, Jeremy Hughes, Sarah EM Howie, Duncan S Holmes, John Liddle, John P Iredale
Nat Med. Author manuscript; available in PMC 2016 Jul 11.
Published in final edited form as: Nat Med. 2016 Feb; 22(2): 202–209. Published online 2016 Jan 11. doi: 10.1038/nm.4020
PMCID:
PMC4871268
AbstractArticlePDF–1.1M
13.
Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine
C.M. Forrest, K. McNair, M. Pisar, O.S. Khalil, L.G. Darlington, T.W. Stone
Neuroscience. 2015 Dec 3; 310: 91–105. doi: 10.1016/j.neuroscience.2015.09.022
PMCID:
PMC4642643
AbstractArticle
14.
Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory
Jillian M. Heisler, Jason C. O’Connor
Brain Behav Immun. Author manuscript; available in PMC 2016 Nov 1.
Published in final edited form as: Brain Behav Immun. 2015 Nov; 50: 115–124. Published online 2015 Jun 27. doi: 10.1016/j.bbi.2015.06.022
PMCID:
PMC4631688
AbstractArticlePDF–1.5M
15.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
16.
Targeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAIN
Flaviano Giorgini, Shao-Yi Huang, Korrapati V. Sathyasaikumar, Francesca M. Notarangelo, Marian A. R. Thomas, Margarita Tararina, Hui-Qiu Wu, Robert Schwarcz, Paul J. Muchowski
J Biol Chem. 2013 Dec 20; 288(51): 36554–36566. Published online 2013 Nov 4. doi: 10.1074/jbc.M113.503813
PMCID:
PMC3868768
AbstractArticlePDF–2.1M
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K
20.
RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer
Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki
Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600
PMCID:
PMC310992
AbstractArticlePDF–3.4M

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