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Items: 1 to 20 of 157

1.
Involvement of PAR-2 in the Induction of Cell-Specific Matrix Metalloproteinase-2 by Activated Protein C in Cutaneous Wound Healing
Sohel M. Julovi, Kelly McKelvey, Nikita Minhas, Yee-Ka Agnes Chan, Meilang Xue, Christopher J. Jackson
Int J Mol Sci. 2024 Jan; 25(1): 370. Published online 2023 Dec 27. doi: 10.3390/ijms25010370
PMCID:
PMC10779272
AbstractArticlePDF–4.3M
2.
Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice
Steven P. Grover, Vanthana Bharathi, Jens J. Posma, John H. Griffin, Joseph S. Palumbo, Nigel Mackman, Silvio Antoniak
Blood Adv. 2023 May 23; 7(10): 1945–1953. Published online 2022 Dec 9. doi: 10.1182/bloodadvances.2022008637
PMCID:
PMC10189413
AbstractArticlePDF–983K
3.
The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability
Scott Peng, Megan S. Grace, Arisbel B. Gondin, Jeffri S. Retamal, Larissa Dill, William Darby, Nigel W. Bunnett, Fe C. Abogadie, Simona E. Carbone, Tara Tigani, Thomas P. Davis, Daniel P. Poole, Nicholas A. Veldhuis, Peter McIntyre
Lab Invest. Author manuscript; available in PMC 2023 Apr 7.
Published in final edited form as: Lab Invest. 2020 Aug; 100(8): 1057–1067. Published online 2020 Apr 27. doi: 10.1038/s41374-020-0430-7
PMCID:
PMC10080476
AbstractArticlePDF–2.2M
4.
PARIN5, a Novel Thrombin Receptor Antagonist Modulates a Streptozotocin Mice Model for Diabetic Encephalopathy
Valery Golderman, Zehavit Goldberg, Shany Guly Gofrit, Amir Dori, Nicola Maggio, Joab Chapman, Ifat Sher, Ygal Rotenstreich, Efrat Shavit-Stein
Int J Mol Sci. 2023 Feb; 24(3): 2021. Published online 2023 Jan 19. doi: 10.3390/ijms24032021
PMCID:
PMC9917200
AbstractArticlePDF–1.7M
5.
KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages
Yo Sep Hwang, Hee Jun Cho, Eun Sun Park, Jeewon Lim, Hyang Ran Yoon, Jong-Tae Kim, Suk Ran Yoon, Haiyoung Jung, Yong-Kyung Choe, Yong-Hoon Kim, Chul-Ho Lee, Yong Tae Kwon, Bo Yeon Kim, Hee Gu Lee
Cells. 2022 Dec; 11(24): 4101. Published online 2022 Dec 16. doi: 10.3390/cells11244101
PMCID:
PMC9777288
AbstractArticlePDF–3.6M
6.
EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia
Magdalena L. Bochenek, Rajinikanth Gogiraju, Stefanie Großmann, Janina Krug, Jennifer Orth, Sabine Reyda, George S. Georgiadis, Henri M. Spronk, Stavros Konstantinides, Thomas Münzel, John H. Griffin, Philipp Wild, Christine Espinola-Klein, Wolfram Ruf, Katrin Schäfer
JCI Insight. 2022 Jul 22; 7(14): e157701. Published online 2022 Jul 22. doi: 10.1172/jci.insight.157701
PMCID:
PMC9431695
AbstractArticlePDF–4.9M
7.
Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma
Yuxue Gao, Qingguo Xu, Xinqiang Li, Yuan Guo, Bowen Zhang, Yan Jin, Cunle zhu, Yuntai Shen, Pengxiang Yang, Ying Shi, Rifeng Jin, Daojie Liu, Yabo Ouyang, Xiaoni Liu, Wenjing Wang, Dexi Chen, Tongwang Yang
Cell Death Dis. 2022 Mar; 13(3): 213. Published online 2022 Mar 7. doi: 10.1038/s41419-022-04654-7
PMCID:
PMC8901912
AbstractArticlePDF–7.9M
8.
Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers
Zehavit Goldberg, Ifat Sher, Lamis Qassim, Joab Chapman, Ygal Rotenstreich, Efrat Shavit-Stein
Int J Mol Sci. 2022 Jan; 23(2): 984. Published online 2022 Jan 17. doi: 10.3390/ijms23020984
PMCID:
PMC8778890
AbstractArticlePDF–1.7M
9.
Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2
Meilang Xue, Haiyan Lin, Ruilong Zhao, Callum Fryer, Lyn March, Christopher J. Jackson
Int J Mol Sci. 2022 Jan; 23(1): 516. Published online 2022 Jan 3. doi: 10.3390/ijms23010516
PMCID:
PMC8745259
AbstractArticlePDF–39M
10.
The Thrombin Receptor Modulates Astroglia-Neuron Trophic Coupling and Neural Repair after Spinal Cord Injury
Ha Neui Kim, Erin M. Triplet, Maja Radulovic, Samantha Bouchal, Laurel S. Kleppe, Whitney L. Simon, Hyesook Yoon, Isobel A. Scarisbrick
Glia. Author manuscript; available in PMC 2022 Sep 1.
Published in final edited form as: Glia. 2021 Sep; 69(9): 2111–2132. Published online 2021 Apr 22. doi: 10.1002/glia.24012
PMCID:
PMC8672305
AbstractArticlePDF–1.9M
11.
The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
Hui Chen, Mindy Smith, Jasmin Herz, Tong Li, Rebecca Hasley, Cecile Le Saout, Ziang Zhu, Jie Cheng, Andres Gronda, José A. Martina, Pablo M. Irusta, Tatiana Karpova, Dorian B. McGavern, Marta Catalfamo
iScience. 2021 Nov 19; 24(11): 103387. Published online 2021 Oct 30. doi: 10.1016/j.isci.2021.103387
PMCID:
PMC8605340
AbstractArticlePDF–3.3M
12.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
13.
Cell type-specific roles of PAR1 in Coxsackievirus B3 infection
Michael F. Bode, Clare M. Schmedes, Grant J. Egnatz, Vanthana Bharathi, Yohei M. Hisada, David Martinez, Tomohiro Kawano, Alice Weithauser, Leah Rosenfeldt, Ursula Rauch, Joseph S. Palumbo, Silvio Antoniak, Nigel Mackman
Sci Rep. 2021; 11: 14264. Published online 2021 Jul 12. doi: 10.1038/s41598-021-93759-8
PMCID:
PMC8275627
AbstractArticlePDF–1.6M
14.
Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex
Pauline Antonie Ulmke, M. Sadman Sakib, Peter Ditte, Godwin Sokpor, Cemil Kerimoglu, Linh Pham, Yuanbin Xie, Xiaoyi Mao, Joachim Rosenbusch, Ulrike Teichmann, Huu Phuc Nguyen, Andre Fischer, Gregor Eichele, Jochen F. Staiger, Tran Tuoc
Stem Cell Reports. 2021 Apr 13; 16(4): 968–984. Published online 2021 Apr 1. doi: 10.1016/j.stemcr.2021.03.008
PMCID:
PMC8072132
AbstractArticlePDF–8.1M
15.
PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus
Silvio Antoniak, Kohei Tatsumi, Clare M. Schmedes, Grant J. Egnatz, Alyson C. Auriemma, Vanthana Bharathi, Tracy Stokol, Melinda A. Beck, John H. Griffin, Joseph S. Palumbo, Nigel Mackman
J Thromb Haemost. 2021 Apr; 19(4): 1103–1111. Published online 2021 Feb 19. doi: 10.1111/jth.15221
PMCID:
PMC8048419
AbstractArticlePDF–1.3M
16.
The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury
Erin M. Triplet, Ha Neui Kim, Hyesook Yoon, Maja Radulovic, Laurel Kleppe, Whitney L. Simon, Chan-il Choi, Patrick J. Walsh, James R. Dutton, Isobel A. Scarisbrick
Neurobiol Dis. Author manuscript; available in PMC 2021 May 1.
Published in final edited form as: Neurobiol Dis. 2021 May; 152: 105294. Published online 2021 Feb 5. doi: 10.1016/j.nbd.2021.105294
PMCID:
PMC8021459
AbstractArticlePDF–3.5M
17.
Ischemic stroke in PAR1 KO mice: Decreased brain plasmin and thrombin activity along with decreased infarct volume
Efrat Shavit-Stein, Ekaterina Mindel, Shany Guly Gofrit, Joab Chapman, Nicola Maggio
PLoS One. 2021; 16(3): e0248431. Published online 2021 Mar 15. doi: 10.1371/journal.pone.0248431
PMCID:
PMC7959388
AbstractArticlePDF–1.1M
18.
Thrombin-PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment
Patrick G. Schweickert, Yi Yang, Emily E. White, Gregory M. Cresswell, Bennett D. Elzey, Timothy L. Ratliff, Paritha Arumugam, Silvio Antoniak, Nigel Mackman, Matthew J. Flick, Stephen F. Konieczny
J Thromb Haemost. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: J Thromb Haemost. 2021 Jan; 19(1): 161–172. Published online 2020 Oct 25. doi: 10.1111/jth.15115
PMCID:
PMC7790967
AbstractArticlePDF–1.5M
19.
Factor VIIa induces biased cytoprotective signal in mice through the cleavage of PAR1 at canonical Arg41 site
Vijay Kondreddy, Usha R. Pendurthi, Xiao Xu, John H. Griffin, L. Vijaya Mohan Rao
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2021 May 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 May; 40(5): 1275–1288. Published online 2020 Mar 26. doi: 10.1161/ATVBAHA.120.314244
PMCID:
PMC7405933
AbstractArticlePDF–2.2M
20.
Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation
Darin L. Wiesner, Richard M. Merkhofer, Carole Ober, Gregory C. Kujoth, Mengyao Niu, Nancy P. Keller, James E. Gern, Rebecca A. Brockman-Schneider, Michael D. Evans, Daniel J. Jackson, Thomas Warner, Nizar N. Jarjour, Stephane J. Esnault, Michael B. Feldman, Matthew Freeman, Hongmei Mou, Jatin M. Vyas, Bruce S. Klein
Cell Host Microbe. Author manuscript; available in PMC 2021 Apr 8.
Published in final edited form as: Cell Host Microbe. 2020 Apr 8; 27(4): 614–628.e6. Published online 2020 Mar 3. doi: 10.1016/j.chom.2020.02.006
PMCID:
PMC7305569
AbstractArticlePDF–3.9M

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