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Select item 109179111.

Mapping of a hybrid insulin peptide in the inflamed islet β-cells from NOD mice

Janet M. Wenzlau, Orion J. Peterson, Anthony N. Vomund, James E. DiLisio, Anita Hohenstein, Kathryn Haskins, Xiaoxiao Wan

Front Immunol. 2024; 15: 1348131. Published online 2024 Feb 22. doi: 10.3389/fimmu.2024.1348131

PMCID:: PMC10917911

Abstract Article PDF–11M

Select item 99383142.

Islet amyloid polypeptide does not suppress pancreatic cancer

Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere

Mol Metab. 2023 Feb; 68: 101667. Published online 2023 Jan 5. doi: 10.1016/j.molmet.2023.101667

PMCID:: PMC9938314

Abstract Article PDF–2.7M

Select item 93760863.

Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing

Daniel T. Meier, Leila Rachid, Sophia J. Wiedemann, Shuyang Traub, Kelly Trimigliozzi, Marc Stawiski, Loïc Sauteur, Denise V. Winter, Christelle Le Foll, Catherine Brégère, Raphael Guzman, Alex Odermatt, Marianne Böni-Schnetzler, Marc Y. Donath

Nat Commun. 2022; 13: 4761. Published online 2022 Aug 13. doi: 10.1038/s41467-022-32509-4

PMCID:: PMC9376086

Abstract Article PDF–3.6M

Select item 88258114.

Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice

Kansai Fukumitsu, Misato Kaneko, Teppo Maruyama, Chihiro Yoshihara, Arthur J. Huang, Thomas J. McHugh, Shigeyoshi Itohara, Minoru Tanaka, Kumi O. Kuroda

Nat Commun. 2022; 13: 709. Published online 2022 Feb 8. doi: 10.1038/s41467-022-28131-z

PMCID:: PMC8825811

Abstract Article PDF–10M

Select item 75299805.

Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro

Andrew T. Templin, Mahnaz Mellati, Daniel T. Meier, Nathalie Esser, Meghan F. Hogan, Joseph J. Castillo, Rehana Akter, Daniel P. Raleigh, Sakeneh Zraika, Rebecca L. Hull, Steven E. Kahn

Diabetologia. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Diabetologia. 2020 Nov; 63(11): 2385–2395. Published online 2020 Jul 29. doi: 10.1007/s00125-020-05232-2

PMCID:: PMC7529980

Abstract Article PDF–973K

Select item 61177636.

A Study of Short- and Long-term mRNA Levels of the Retn, Iapp, and Drd5 Genes in Obese Mice Induced with High-fat Diet

OZLEM TIMIRCI-KAHRAMAN, UMIT YILMAZ, NESIBE YILMAZ, AYDIN CEVIK, CEM HOROZOGLU, FARUK CELIK, MUHAMMED OGUZ GOKCE, ARZU ERGEN, ABDULLAH MELEKOGLU, UMIT ZEYBEK

In Vivo. 2018 Jul-Aug; 32(4): 813–817. Published online 2018 Jul 3. doi: 10.21873/invivo.112312

PMCID:: PMC6117763

Abstract Article PDF–117K

Select item 61103167.

CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse

Rocky L. Baker, Braxton L. Jamison, Timothy A. Wiles, Robin S. Lindsay, Gene Barbour, Brenda Bradley, Thomas Delong, Rachel S. Friedman, Maki Nakayama, Kathryn Haskins

Diabetes. 2018 Sep; 67(9): 1836–1846. Published online 2018 Jul 5. doi: 10.2337/db18-0200

PMCID:: PMC6110316

Abstract Article PDF–1.2M

Select item 59100008.

Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus

Thomas A. Lutz, Bernd Coester, Lynda Whiting, Ambrose A. Dunn-Meynell, Christina N. Boyle, Sebastien G. Bouret, Barry E. Levin, Christelle Le Foll

Diabetes. 2018 May; 67(5): 805–817. Published online 2018 Feb 21. doi: 10.2337/db17-1347

PMCID:: PMC5910000

Abstract Article PDF–2.3M

Select item 58893179.

Amylin and Diabetic Cardiomyopathy – Amylin-Induced Sarcolemmal Ca²⁺ Leak Is Independent of Diabetic Remodeling of Myocardium

Miao Liu, Amanda Hoskins, Nirmal Verma, Donald M Bers, Sanda Despa, Florin Despa

Biochim Biophys Acta. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Biochim Biophys Acta. 2018 May; 1864(5 Pt B): 1923–1930. Published online 2017 Oct 21. doi: 10.1016/j.bbadis.2017.10.024

PMCID:: PMC5889317

Abstract Article PDF–2.0M

Select item 571539410.

Involvement of Amylin and Leptin in the Development of Projections from the Area Postrema to the Nucleus of the Solitary Tract

Kathrin Abegg, Andreas Hermann, Christina N. Boyle, Sebastien G. Bouret, Thomas A. Lutz, Thomas Riediger

Front Endocrinol (Lausanne) 2017; 8: 324. Published online 2017 Nov 28. doi: 10.3389/fendo.2017.00324

PMCID:: PMC5715394

Abstract Article PDF–1.1M

Select item 558411411.

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

Abhisek Mukherjee, Diego Morales-Scheihing, Natalia Salvadores, Ines Moreno-Gonzalez, Cesar Gonzalez, Kathleen Taylor-Presse, Nicolas Mendez, Mohammad Shahnawaz, A. Osama Gaber, Omaima M. Sabek, Daniel W. Fraga, Claudio Soto

J Exp Med. 2017 Sep 4; 214(9): 2591–2610. doi: 10.1084/jem.20161134

PMCID:: PMC5584114

Abstract Article PDF–2.4M

Select item 502692212.

The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets

Daniel T. Meier, Leon Entrup, Andrew T. Templin, Meghan F. Hogan, Mahnaz Mellati, Sakeneh Zraika, Rebecca L. Hull, Steven E. Kahn

Diabetologia. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Diabetologia. 2016 Oct; 59(10): 2166–2171. Published online 2016 Sep 1. doi: 10.1007/s00125-016-4045-x

PMCID:: PMC5026922

Abstract Article PDF–255K

Select item 486146013.

Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates

Clara Westwell-Roper, Heather C. Denroche, Jan A. Ehses, C. Bruce Verchere

J Biol Chem. 2016 Apr 22; 291(17): 8908–8917. Published online 2016 Jan 19. doi: 10.1074/jbc.M115.712455

PMCID:: PMC4861460

Abstract Article PDF–2.1M

Select item 470899214.

Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8)

Miriam Ejarque, Joan Mir-Coll, Ramon Gomis, Michael S. German, Francis C. Lynn, Rosa Gasa

PLoS One. 2016; 11(1): e0146273. Published online 2016 Jan 11. doi: 10.1371/journal.pone.0146273

PMCID:: PMC4708992

Abstract Article PDF–7.0M

Select item 468326915.

Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity

Daniel T. Meier, Ling-Hsien Tu, Sakeneh Zraika, Meghan F. Hogan, Andrew T. Templin, Rebecca L. Hull, Daniel P. Raleigh, Steven E. Kahn

J Biol Chem. 2015 Dec 18; 290(51): 30475–30485. Published online 2015 Oct 19. doi: 10.1074/jbc.M115.676692

PMCID:: PMC4683269

Abstract Article PDF–1.6M

Select item 431221016.

IAPP driven metabolic reprogramming induces regression of p53 - deficient tumours in vivo

Avinashnarayan Venkatanarayan, Payal Raulji, William Norton, Deepavali Chakravarti, Cristian Coarfa, Xiaohua Su, Santosh K. Sandur, Marc S. Ramirez, Jaehuk Lee, Charles V. Kingsley, Eliot F. Sananikone, Kimal Rajapakshe, Katherine Naff, Jan Parker-Thornburg, James A. Bankson, Kenneth Y. Tsai, Preethi H. Gunaratne, Elsa R. Flores

Nature. Author manuscript; available in PMC 2015 Jul 29.

Published in final edited form as: Nature. 2015 Jan 29; 517(7536): 626–630. Published online 2014 Nov 17. doi: 10.1038/nature13910

PMCID:: PMC4312210

Article PDF–4.5M

Select item 402073117.

Expression of wild‐type and mutant S20G hIAPP in physiologic knock‐in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

Henry J Hiddinga, Setsuya Sakagashira, Masayuki Ishigame, Pranathi Madde, Tokio Sanke, Kishio Nanjo, Yogish C Kudva, James J Lee, Jan van Deursen, Norman L Eberhardt

J Diabetes Investig. 2012 Mar 28; 3(2): 138–147. Published online 2011 Oct 11. doi: 10.1111/j.2040-1124.2011.00166.x

PMCID:: PMC4020731

Abstract Article PDF–682K

Select item 400208818.

Thioredoxin-interacting Protein Promotes Islet Amyloid Polypeptide Expression through miR-124a and FoxA2

Gu Jing, Clara Westwell-Roper, Junqin Chen, Guanlan Xu, C. Bruce Verchere, Anath Shalev

J Biol Chem. 2014 Apr 25; 289(17): 11807–11815. Published online 2014 Mar 13. doi: 10.1074/jbc.M113.525022

PMCID:: PMC4002088

Abstract Article PDF–1.9M

Select item 381567619.

CD4 T cells reactive to an IAPP peptide accumulate in the pancreas and contribute to disease pathogenesis in NOD mice

Rocky L. Baker, Thomas Delong, Gene Barbour, Brenda Bradley, Maki Nakayama, Kathryn Haskins

J Immunol. Author manuscript; available in PMC 2014 Oct 15.

Published in final edited form as: J Immunol. 2013 Oct 15; 191(8): 10.4049/jimmunol.1301480. Published online 2013 Sep 16. doi: 10.4049/jimmunol.1301480

PMCID:: PMC3815676

Abstract Article PDF–647K

Select item 378040620.

Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C₂C₁₂ muscle and AML12 liver cell lines

H.-S. Moon, J. P. Chamberland, C. S. Mantzoros

Diabetologia. Author manuscript; available in PMC 2013 Sep 23.

Published in final edited form as: Diabetologia. 2012 Jan; 55(1): 215–225. Published online 2011 Oct 14. doi: 10.1007/s00125-011-2332-0

PMCID:: PMC3780406

Abstract Article PDF–721K

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