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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103078522.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 100748103.

A novel calcium channel Cavβ₂ splice variant with unique properties predominates in the retina

Hartwig Seitter, Jana Obkircher, Patricia Grabher, Julia Hartl, Lucia Zanetti, Uwe Thorsten Lux, Georgios Fotakis, Monica L. Fernández-Quintero, Teresa Kaserer, Alexandra Koschak

J Biol Chem. 2023 Apr; 299(4): 102972. Published online 2023 Feb 2. doi: 10.1016/j.jbc.2023.102972

PMCID:: PMC10074810

Abstract Article PDF–5.5M

Select item 99382164.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes

Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x

PMCID:: PMC9938216

Abstract Article PDF–5.3M

Select item 81979975.

Mechanisms and Regulation of Cardiac Ca_V1.2 Trafficking

Maartje Westhoff, Rose E. Dixon

Int J Mol Sci. 2021 Jun; 22(11): 5927. Published online 2021 May 31. doi: 10.3390/ijms22115927

PMCID:: PMC8197997

Abstract Article PDF–2.9M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 58526177.

Caveolae-localized L-type Ca²⁺ channels do not contribute to function or hypertrophic signalling in the mouse heart

Robert N. Correll, Catherine A. Makarewich, Hongyu Zhang, Chen Zhang, Michelle A. Sargent, Allen J. York, Remus M. Berretta, Xiongwen Chen, Steven R. Houser, Jeffery D. Molkentin

Cardiovasc Res. 2017 Jun; 113(7): 749–759. Published online 2017 Apr 11. doi: 10.1093/cvr/cvx046

PMCID:: PMC5852617

Abstract Article PDF–796K

Select item 56450828.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 55097409.

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling

Brent Wilkinson, Jing Li, Marcelo P. Coba

Sci Rep. 2017; 7: 5272. Published online 2017 Jul 13. doi: 10.1038/s41598-017-05588-3

PMCID:: PMC5509740

Abstract Article PDF–4.6M

Select item 513054510.

A novel transgenic mouse model of lysosomal storage disorder

Sonia Ortiz-Miranda, Rui Ji, Agata Jurczyk, Ken-Edwin Aryee, Shunyan Mo, Terry Fletcher, Scott A. Shaffer, Dale L. Greiner, Rita Bortell, Ronald G. Gregg, Alan Cheng, Leah J. Hennings, Ann R. Rittenhouse

Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1; 311(5): G903–G919. Published online 2016 Sep 22. doi: 10.1152/ajpgi.00313.2015

PMCID:: PMC5130545

Abstract Article

Select item 466104611.

The Ca²⁺ Channel Subunit β2 Regulates Ca²⁺ Channel Abundance and Function in Inner Hair Cells and Is Required for Hearing

Jakob Neef, Anna Gehrt, Anna V. Bulankina, Alexander C. Meyer, Dietmar Riedel, Ronald G. Gregg, Nicola Strenzke, Tobias Moser

J Neurosci. 2009 Aug 26; 29(34): 10730–10740. doi: 10.1523/JNEUROSCI.1577-09.2009

PMCID:: PMC4661046

Abstract Article PDF–4.6M

Select item 456482912.

Molecular Basis of the Membrane Interaction of the β2e Subunit of Voltage-Gated Ca²⁺ Channels

Dong-Il Kim, Mooseok Kang, Sangyeol Kim, Juhwan Lee, Yongsoo Park, Iksoo Chang, Byung-Chang Suh

Biophys J. 2015 Sep 1; 109(5): 922–935. Published online 2015 Sep 1. doi: 10.1016/j.bpj.2015.07.040

PMCID:: PMC4564829

Abstract Article PDF–2.5M

Select item 444278613.

Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca²⁺ channels

Dong-Il Kim, Yongsoo Park, Deok-Jin Jang, Byung-Chang Suh

J Gen Physiol. 2015 Jun; 145(6): 529–541. doi: 10.1085/jgp.201411349

PMCID:: PMC4442786

Abstract Article PDF–2.6M

Select item 434039814.

Characterization of Ca_v1.4 Complexes (α₁1.4, β₂, and α₂δ₄) in HEK293T Cells and in the Retina

Amy Lee, Shiyi Wang, Brittany Williams, Jussara Hagen, Todd E. Scheetz, Françoise Haeseleer

J Biol Chem. 2015 Jan 16; 290(3): 1505–1521. Published online 2014 Dec 2. doi: 10.1074/jbc.M114.607465

PMCID:: PMC4340398

Abstract Article PDF–2.3M

Select item 433519915.

Direct Interaction of Ca_Vβ with Actin Up-regulates L-type Calcium Currents in HL-1 Cardiomyocytes

Gabriel Stölting, Regina Campos de Oliveira, Raul E. Guzman, Erick Miranda-Laferte, Rachel Conrad, Nadine Jordan, Silke Schmidt, Johnny Hendriks, Thomas Gensch, Patricia Hidalgo

J Biol Chem. 2015 Feb 20; 290(8): 4561–4572. Published online 2014 Dec 22. doi: 10.1074/jbc.M114.573956

PMCID:: PMC4335199

Abstract Article PDF–3.5M

Select item 396495516.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 395644317.

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels

Laurent Vergnes, Jessica M. Lee, Robert G. Chin, Johan Auwerx, Karen Reue

Cell Metab. Author manuscript; available in PMC 2014 Jun 4.

Published in final edited form as: Cell Metab. 2013 Jun 4; 17(6): 916–928. doi: 10.1016/j.cmet.2013.04.007

PMCID:: PMC3956443

Abstract Article PDF–3.9M

Select item 389830018.

Differential Neuronal Targeting of a New and Two Known Calcium Channel β₄ Subunit Splice Variants Correlates with Their Regulation of Gene Expression

Solmaz Etemad, Gerald J. Obermair, Daniel Bindreither, Ariane Benedetti, Ruslan Stanika, Valentina Di Biase, Verena Burtscher, Alexandra Koschak, Reinhard Kofler, Stephan Geley, Alexandra Wille, Alexandra Lusser, Veit Flockerzi, Bernhard E. Flucher

J Neurosci. 2014 Jan 22; 34(4): 1446–1461. doi: 10.1523/JNEUROSCI.3935-13.2014

PMCID:: PMC3898300

Abstract Article PDF–4.4M

Select item 346420719.

A Mutation in the Srrm4 Gene Causes Alternative Splicing Defects and Deafness in the Bronx Waltzer Mouse

Yoko Nakano, Israt Jahan, Gregory Bonde, Xingshen Sun, Michael S. Hildebrand, John F. Engelhardt, Richard J. H. Smith, Robert A. Cornell, Bernd Fritzsch, Botond Bánfi

PLoS Genet. 2012 Oct; 8(10): e1002966. Published online 2012 Oct 4. doi: 10.1371/journal.pgen.1002966

PMCID:: PMC3464207

Abstract Article PDF–4.1M

Select item 339112820.

Deletion of the C-terminal Phosphorylation Sites in the Cardiac β-Subunit Does Not Affect the Basic β-Adrenergic Response of the Heart and the Ca_v1.2 Channel

Julia Brandmayr, Montatip Poomvanicha, Katrin Domes, Jie Ding, Anne Blaich, Jörg W. Wegener, Sven Moosmang, Franz Hofmann

J Biol Chem. 2012 Jun 29; 287(27): 22584–22592. Published online 2012 May 15. doi: 10.1074/jbc.M112.366484

PMCID:: PMC3391128

Abstract Article PDF–1.5M

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