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Select item 112769051.

Human Neutrophil Elastase: Characterization of Intra- vs. Extracellular Inhibition

Denise Birk, Erika Siepmann, Stefan Simon, Christian P. Sommerhoff

Int J Mol Sci. 2024 Jul; 25(14): 7917. Published online 2024 Jul 19. doi: 10.3390/ijms25147917

PMCID:: PMC11276905

Abstract Article PDF–1.7M

Select item 110888902.

ELANE rs17223045C/T and rs3761007G/A variants: Protective factors against COVID-19

José Manuel Fragoso, Gilberto Vargas-Alarcón, Ángel Emmanuel Martínez-Flores, Isela Montufar-Robles, Rosa Elda Barbosa-Cobos, Gustavo Rojas-Velasco, Julian Ramírez-Bello

Biomol Biomed. 2024 Jun 1; 24(3): 665–672. Published online 2024 Jun 1. doi: 10.17305/bb.2023.9940

PMCID:: PMC11088890

Abstract Article PDF–809K

Select item 110503523.

Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages

Shuo Zheng, Gamze B. Bulut, Apparao B. Kummarapurugu, Jonathan Ma, Judith A. Voynow

Int J Mol Sci. 2024 Apr; 25(8): 4265. Published online 2024 Apr 12. doi: 10.3390/ijms25084265

PMCID:: PMC11050352

Abstract Article PDF–3.7M

Select item 109872874.

Neutrophil elastase remodels mammary tumors to facilitate lung metastasis

Amriti R. Lulla, Said Akli, Cansu Karakas, Joseph A. Caruso, Lucas D. Warma, Natalie W. Fowlkes, Xiayu Rao, Jing Wang, Kelly K. Hunt, Stephanie S. Watowich, Khandan Keyomarsi

Mol Cancer Ther. Author manuscript; available in PMC 2024 Oct 2.

Published in final edited form as: Mol Cancer Ther. 2024 Apr 2; 23(4): 492–506. doi: 10.1158/1535-7163.MCT-23-0414

PMCID:: PMC10987287

Abstract Article PDF–2.7M

Select item 107847045.

Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase–mediated proteolysis of corticosteroid-binding globulin

Anastasia Chernykh, Jodie L. Abrahams, Oliver C. Grant, Lucas Kambanis, Zeynep Sumer-Bayraktar, Julian Ugonotti, Rebeca Kawahara, Leo Corcilius, Richard J. Payne, Robert J. Woods, Morten Thaysen-Andersen

J Biol Chem. 2024 Jan; 300(1): 105519. Published online 2023 Nov 30. doi: 10.1016/j.jbc.2023.105519

PMCID:: PMC10784704

Abstract Article PDF–5.2M

Select item 107596966.

Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes

Lihong Wang, Zhoujunhao Zhou, Xinming Xu, Yue Li, Rui Zhang, Zhiyan Yu, Xinmei Huang, Shufei Zang, Tiange Sun

Reprod Biol Endocrinol. 2024; 22: 2. Published online 2024 Jan 2. doi: 10.1186/s12958-023-01170-x

PMCID:: PMC10759696

Abstract Article PDF–1.5M

Select item 107127367.

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

Chang Cui, Kasturi Chakraborty, Xu Anna Tang, Guolin Zhou, Kelly Q. Schoenfelt, Kristen M. Becker, Alexandria Hoffman, Ya-Fang Chang, Ariane Blank, Catherine A. Reardon, Hilary A. Kenny, Tomas Vaisar, Ernst Lengyel, Geoffrey Greene, Lev Becker

Cell. Author manuscript; available in PMC 2023 Dec 11.

Published in final edited form as: Cell. 2021 Jun 10; 184(12): 3163–3177.e21. Published online 2021 May 7. doi: 10.1016/j.cell.2021.04.016

PMCID:: PMC10712736

Abstract Article PDF–3.3M

Select item 104881728.

Could the Oxidation of α1-Antitrypsin Prevent the Binding of Human Neutrophil Elastase in COVID-19 Patients?

Maura D’Amato, Monica Campagnoli, Paolo Iadarola, Paola Margherita Bignami, Marco Fumagalli, Laurent Roberto Chiarelli, Giovanni Stelitano, Federica Meloni, Pasquale Linciano, Simona Collina, Giampiero Pietrocola, Valentina Vertui, Anna Aliberti, Tommaso Fossali, Simona Viglio

Int J Mol Sci. 2023 Sep; 24(17): 13533. Published online 2023 Aug 31. doi: 10.3390/ijms241713533

PMCID:: PMC10488172

Abstract Article PDF–3.6M

Select item 101819489.

Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomain from the epithelial surface

Apparao B. Kummarapurugu, Adam M. Hawkridge, Jonathan Ma, Stephanie Osei, Rebecca K. Martin, Shuo Zheng, Judith A. Voynow

J Biol Chem. 2023 Jun; 299(6): 104820. Published online 2023 May 13. doi: 10.1016/j.jbc.2023.104820

PMCID:: PMC10181948

Abstract Article PDF–2.0M

Select item 1016456410.

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing

Yingxiao Chen, Yanping Li, Roselyn S Dai, Jonathan C Savage, Ujwal Shinde, John Klimek, Larry L David, Emma A Young, Markus Hafner, Rosalie C Sears, Xiao-Xin Sun, Mu-Shui Dai

Nucleic Acids Res. 2023 May 8; 51(8): 3934–3949. Published online 2023 Mar 13. doi: 10.1093/nar/gkad140

PMCID:: PMC10164564

Abstract Article PDF–3.8M

Select item 1015442511.

Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells

Sara S. Oltra, Sara Colomo, Laura Sin, María Pérez-López, Sara Lázaro, Angela Molina-Crespo, Kyoung-Han Choi, David Ros-Pardo, Lidia Martínez, Saleta Morales, Cristina González-Paramos, Alba Orantes, Mario Soriano, Alberto Hernández, Ana Lluch, Federico Rojo, Joan Albanell, Paulino Gómez-Puertas, Jae-Kyun Ko, David Sarrió, Gema Moreno-Bueno

Cell Death Differ. 2023 May; 30(5): 1366–1381. Published online 2023 Mar 11. doi: 10.1038/s41418-023-01143-y

PMCID:: PMC10154425

Abstract Article PDF–6.6M

Select item 1014222512.

Paediatric autoimmune diseases with ELANE mutations associated with neutropenia

Dan Zhang, Gaixiu Su, Sheng Hao, Jianming Lai, Shunqiao Feng

Pediatr Rheumatol Online J. 2023; 21: 41. Published online 2023 Apr 28. doi: 10.1186/s12969-023-00824-9

PMCID:: PMC10142225

Abstract Article PDF–1.2M

Select item 1009478613.

The Direct Anti-Virulence but Not Bactericidal Activity of Human Neutrophil Elastase against Moraxella catarrhalis

Justyna Roszkowiak, Siobhán McClean, Aleksandra M. Mirończuk, Daria Augustyniak

Int J Mol Sci. 2023 Apr; 24(7): 6607. Published online 2023 Apr 1. doi: 10.3390/ijms24076607

PMCID:: PMC10094786

Abstract Article PDF–5.0M

Select item 927819814.

Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry

Katsutoshi Yoshizato, Toshio Taira, Misako Sato-Matsubara, Shizuko Sekiguchi, Yoriko Yabunaka, Yukimi Kira, Tetsu Ohashi, Atsuko Daikoku, Ken Ofusa, Chiho Kadono, Daisuke Oikawa, Tsutomu Matsubara, Yu Nakagama, Yasutoshi Kido, Fuminori Tokunaga, Kazuo Ikeda, Akira Kaneko, Norifumi Kawada

J Biochem. 2022 Oct; 172(4): 205–216. Published online 2022 Jul 6. doi: 10.1093/jb/mvac054

PMCID:: PMC9278198

Abstract Article PDF–1.5M

Select item 880335615.

Neutrophil Elastase Triggers the Release of Macrophage Extracellular Traps: Relevance to Cystic Fibrosis

Apparao B. Kummarapurugu, Shuo Zheng, Jonathan Ma, Shobha Ghosh, Adam Hawkridge, Judith A. Voynow

Am J Respir Cell Mol Biol. 2022 Jan; 66(1): 76–85. Published online 2021 Oct 1. doi: 10.1165/rcmb.2020-0410OC

PMCID:: PMC8803356

Abstract Article PDF–1.2M

Select item 878110816.

Adenovirus Co-Opts Neutrophilic Inflammation to Enhance Transduction of Epithelial Cells

James M. Readler, Meghan R. Burke, Priyanka Sharma, Katherine J. D. A. Excoffon, Abimbola O. Kolawole

Viruses. 2022 Jan; 14(1): 13. Published online 2021 Dec 22. doi: 10.3390/v14010013

PMCID:: PMC8781108

Abstract Article PDF–3.0M

Select item 856061117.

Reduced ELANE and SLPI expression compromises dental pulp cell activity

Kanokwan Sriwattanapong, Noppadol Sa‐Ard‐Iam, Lawan Boonprakong, Keskanya Subbalekha, Vorapat Trachoo, Narissara Suratannon, Thantrira Porntaveetus, Vorasuk Shotelersuk

Cell Prolif. 2021 Nov; 54(11): e13132. Published online 2021 Sep 27. doi: 10.1111/cpr.13132

PMCID:: PMC8560611

Abstract Article PDF–2.0M

Select item 854624318.

Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency

Andrew J. Sweatt, Kazuya Miyagawa, Christopher J. Rhodes, Shalina Taylor, Patricia A. Del Rosario, Andrew Hsi, Francois Haddad, Edda Spiekerkoetter, Michal Bental-Roof, Richard D. Bland, Emilia M. Swietlik, Stefan Gräf, Martin R. Wilkins, Nicholas W. Morrell, Mark R. Nicolls, Marlene Rabinovitch, Roham T. Zamanian

Chest. 2021 Oct; 160(4): 1442–1458. Published online 2021 Jun 26. doi: 10.1016/j.chest.2021.06.028

PMCID:: PMC8546243

Abstract Article PDF–1.8M

Select item 853951419.

Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases

Xiaojie Chu, Zehua Sun, Du-San Baek, Wei Li, John W. Mellors, Steven D. Shapiro, Dimiter S. Dimitrov

Int J Mol Sci. 2021 Oct; 22(20): 11136. Published online 2021 Oct 15. doi: 10.3390/ijms222011136

PMCID:: PMC8539514

Abstract Article PDF–2.1M

Select item 848683820.

ELANE: an emerging lane to selective anticancer therapy

Boqiang Peng, Jiankun Hu, Xianghui Fu

Signal Transduct Target Ther. 2021; 6: 358. Published online 2021 Oct 1. doi: 10.1038/s41392-021-00766-2

PMCID:: PMC8486838

Article PDF–551K

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