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Items: 1 to 20 of 61

1.
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling
Mena Abdel-Nour, Leticia A. M. Carneiro, Jeffrey Downey, Jessica Tsalikis, Ahmed Outlioua, Dave Prescott, Leandro Silva Da Costa, Elise S. Hovingh, Armin Farahvash, Ryan G. Gaudet, Raphael Molinaro, Rob van Dalen, Charles C. Y. Lau, Farshad C. Azimi, Nichole K. Escalante, Aaron Trotman-Grant, Jeffrey E. Lee, Scott D. Gray-Owen, Maziar Divangahi, Jane-Jane Chen, Dana J. Philpott, Damien Arnoult, Stephen E. Girardin
Science. Author manuscript; available in PMC 2023 Aug 17.
Published in final edited form as: Science. 2019 Jul 5; 365(6448): eaaw4144. doi: 10.1126/science.aaw4144
PMCID:
PMC10433729
AbstractArticlePDF–2.2M
2.
HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies
Barbara Tedesco, Leen Vendredy, Elias Adriaenssens, Marta Cozzi, Bob Asselbergh, Valeria Crippa, Riccardo Cristofani, Paola Rusmini, Veronica Ferrari, Elena Casarotto, Marta Chierichetti, Francesco Mina, Paola Pramaggiore, Mariarita Galbiati, Margherita Piccolella, Jonathan Baets, Femke Baeke, Riet De Rycke, Vincent Mouly, Tommaso Laurenzi, Ivano Eberini, Anna Vihola, Bjarne Udd, Lan Weiss, Virginia Kimonis, Vincent Timmerman, Angelo Poletti
Autophagy. 2023; 19(8): 2217–2239. Published online 2023 Feb 28. doi: 10.1080/15548627.2023.2179780
PMCID:
PMC10351472
AbstractArticlePDF–5.9M
3.
Macrophage-specific autophagy-related gene HSPB8 is involved in the macrophage polarization in atherosclerosis
Juping Wang, Congna Zhao, Baonan Zhang, Xiaoyan Liu
BMC Cardiovasc Disord. 2023; 23: 141. Published online 2023 Mar 18. doi: 10.1186/s12872-023-03158-2
PMCID:
PMC10024845
AbstractArticlePDF–5.9M
4.
The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA
Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay
J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027
PMCID:
PMC10005898
AbstractArticlePDF–6.7M
5.
HSPB8 counteracts tumor activity of BRAF- and NRAS-mutant melanoma cells by modulation of RAS-prenylation and autophagy
Riccardo Cristofani, Margherita Piccolella, Marina Montagnani Marelli, Barbara Tedesco, Angelo Poletti, Roberta Manuela Moretti
Cell Death Dis. 2022 Nov; 13(11): 973. Published online 2022 Nov 18. doi: 10.1038/s41419-022-05365-9
PMCID:
PMC9674643
AbstractArticlePDF–5.0M
6.
SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
Valentina Lukinović, Simone Hausmann, Gael S. Roth, Clement Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez, Jessica Vayr, Rebecca Rodell, Marianne Tardif, Pascal W.T.C. Jansen, Yohann Couté, Michiel Vermeulen, Pierre Hainaut, Pawel K. Mazur, Nima Mosammaparast, Nicolas Reynoird
Cancer Discov. 2022 Sep 2; 12(9): 2158–2179. Published online 2022 Jul 12. doi: 10.1158/2159-8290.CD-21-0205
PMCID:
PMC9437563
AbstractArticlePDF–9.5M
7.
Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells
Hongyan Li, Hong Zhang, Guomin Huang, Zhitong Bing, Duling Xu, Jiadi Liu, Hongtao Luo, Xiaoli An
J Exp Clin Cancer Res. 2022; 41: 33. Published online 2022 Jan 24. doi: 10.1186/s13046-021-02230-z
PMCID:
PMC8785590
AbstractArticlePDF–9.6M
8.
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
Edgar E Boczek, Julius Fürsch, Marie Laura Niedermeier, Louise Jawerth, Marcus Jahnel, Martine Ruer-Gruß, Kai-Michael Kammer, Peter Heid, Laura Mediani, Jie Wang, Xiao Yan, Andrej Pozniakovski, Ina Poser, Daniel Mateju, Lars Hubatsch, Serena Carra, Simon Alberti, Anthony A Hyman, Florian Stengel
eLife. 2021; 10: e69377. Published online 2021 Sep 6. doi: 10.7554/eLife.69377
PMCID:
PMC8510580
AbstractArticlePDF–3.6M
9.
Small heat shock protein 22 kDa can modulate the aggregation and liquid–liquid phase separation behavior of tau
April L. Darling, Jan Dahrendorff, Stefan G. Creodore, Chad A. Dickey, Laura J. Blair, Vladimir N. Uversky
Protein Sci. 2021 Jul; 30(7): 1350–1359. Published online 2021 Mar 15. doi: 10.1002/pro.4060
PMCID:
PMC8197419
AbstractArticlePDF–5.2M
10.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
11.
BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes
Laura Mediani, Veronica Galli, Arianna Dorotea Carrà, Ilaria Bigi, Jonathan Vinet, Massimo Ganassi, Francesco Antoniani, Tatiana Tiago, Marco Cimino, Daniel Mateju, Cristina Cereda, Orietta Pansarasa, Simon Alberti, Jessica Mandrioli, Serena Carra
Cell Stress Chaperones. 2020 Nov; 25(6): 1045–1058. Published online 2020 Jul 21. doi: 10.1007/s12192-020-01141-w
PMCID:
PMC7591658
AbstractArticlePDF–9.0M
12.
Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels
Jack M. Webster, April L. Darling, Taylor A. Sanders, Danielle M. Blazier, Yamile Vidal-Aguiar, David Beaulieu-Abdelahad, Drew G. Plemmons, Shannon E. Hill, Vladimir N. Uversky, Paula C. Bickford, Chad A. Dickey, Laura J. Blair
Int J Mol Sci. 2020 Aug; 21(15): 5442. Published online 2020 Jul 30. doi: 10.3390/ijms21155442
PMCID:
PMC7432035
AbstractArticlePDF–4.0M
13.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
14.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
15.
The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis
Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino
Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9
PMCID:
PMC6778137
AbstractArticlePDF–7.8M
16.
Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies
Mansour Haidar, Bob Asselbergh, Elias Adriaenssens, Vicky De Winter, Jean-Pierre Timmermans, Michaela Auer-Grumbach, Manisha Juneja, Vincent Timmerman
Autophagy. 2019; 15(6): 1051–1068. Published online 2019 Jan 31. doi: 10.1080/15548627.2019.1569930
PMCID:
PMC6526868
AbstractArticlePDF–4.0M
17.
A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response
Julia Roewenstrunk, Chiara Di Vona, Jie Chen, Eva Borras, Chao Dong, Krisztina Arató, Eduard Sabidó, Michael S. Y. Huen, Susana de la Luna
Sci Rep. 2019; 9: 6014. Published online 2019 Apr 12. doi: 10.1038/s41598-019-42445-x
PMCID:
PMC6461666
AbstractArticlePDF–3.3M
18.
High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines
Shixiong Wang, Sachin Kumar Singh, Madhumohan R. Katika, Sandra Lopez-Aviles, Antoni Hurtado
Int J Mol Sci. 2018 Dec; 19(12): 4123. Published online 2018 Dec 19. doi: 10.3390/ijms19124123
PMCID:
PMC6321185
AbstractArticlePDF–2.8M
19.
Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks
Melanie Meister-Broekema, Rebecca Freilich, Chandhuru Jagadeesan, Jennifer N. Rauch, Rocio Bengoechea, William W. Motley, E. F. Elsiena Kuiper, Melania Minoia, Gabriel V. Furtado, Maria A. W. H. van Waarde, Shawn J. Bird, Adriana Rebelo, Stephan Zuchner, Peter Pytel, Steven S. Scherer, Federica F. Morelli, Serena Carra, Conrad C. Weihl, Steven Bergink, Jason E. Gestwicki, Harm H. Kampinga
Nat Commun. 2018; 9: 5342. Published online 2018 Dec 17. doi: 10.1038/s41467-018-07718-5
PMCID:
PMC6297355
AbstractArticlePDF–3.6M
20.
Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function
Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner, Petra Beli
EMBO Rep. 2018 Apr; 19(4): e44754. Published online 2018 Feb 21. doi: 10.15252/embr.201744754
PMCID:
PMC5891417
AbstractArticlePDF–1.0M

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