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Select item 114058441.

A retrospective analysis suggests PTEN expression is associated with favorable clinicopathological features of breast cancer

Leonard Derkyi-Kwarteng, Frank Naku Ghartey, Eric Aidoo, Ernest Addae, Emmanuel Gustav Imbeah, Ato Ampomah Brown, Samuel Acquah

Sci Rep. 2024; 14: 21645. Published online 2024 Sep 17. doi: 10.1038/s41598-024-69252-3

PMCID:: PMC11405844

Abstract Article PDF–1.2M

Select item 113943862.

HOTAIR Promotes the Hyperactivation of PI3K/Akt and Wnt/β-Catenin Signaling Pathways via PTEN Hypermethylation in Cervical Cancer

Samuel Trujano-Camacho, David Cantú-de León, Eloy Pérez-Yepez, Carlos Contreras-Romero, Jossimar Coronel-Hernandez, Oliver Millan-Catalan, Mauricio Rodríguez-Dorantes, Cesar López-Camarillo, Concepción Gutiérrez-Ruiz, Nadia Jacobo-Herrera, Carlos Pérez-Plasencia

Cells. 2024 Sep; 13(17): 1484. Published online 2024 Sep 4. doi: 10.3390/cells13171484

PMCID:: PMC11394386

Abstract Article PDF–3.1M

Select item 113233563.

RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade

Ziwei Lv, Yuanyuan Ren, Yang Li, Fanglin Niu, Zhuozhuo Li, Man Li, Xiaofang Li, Qinhua Li, Deqing Huang, Yi Yu, Yuyan Xiong, Lu Qian

Mol Med. 2024; 30: 124. Published online 2024 Aug 13. doi: 10.1186/s10020-024-00889-6

PMCID:: PMC11323356

Abstract Article PDF–9.0M

Select item 112768104.

The Role of PTEN in Chemoresistance Mediated by the HIF-1α/YY1 Axis in Pediatric Acute Lymphoblastic Leukemia

Gabriela Antonio-Andres, Mario Morales-Martinez, Elva Jimenez-Hernandez, Sara Huerta-Yepez

Int J Mol Sci. 2024 Jul; 25(14): 7767. Published online 2024 Jul 16. doi: 10.3390/ijms25147767

PMCID:: PMC11276810

Abstract Article PDF–1.7M

Select item 111599195.

Involvement of Pin1 induction in epithelial–mesenchymal transition of tamoxifen‐resistant breast cancer cells

Mi Ra Kim, Hoo‐Kyun Choi, Kyoung Bin Cho, Hyung Sik Kim, Keon Wook Kang

Cancer Sci. 2009 Oct; 100(10): 1834–1841. Published online 2009 Jun 24. doi: 10.1111/j.1349-7006.2009.01260.x

PMCID:: PMC11159919

Abstract Article PDF–1.5M

Select item 111593116.

Infrequent hypermethylation of the PTEN gene in Korean non‐small‐cell lung cancers

Dong Sun Kim, Su Man Lee, Ghil Suk Yoon, Jin Eun Choi, Jae Yong Park

Cancer Sci. 2010 Feb; 101(2): 568–572. Published online 2009 Oct 20. doi: 10.1111/j.1349-7006.2009.01406.x

PMCID:: PMC11159311

Abstract Article PDF–329K

Select item 111587267.

Concomitant activation of AKT with extracellular‐regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss

Noriko Mori, Satoru Kyo, Junko Sakaguchi, Yasunari Mizumoto, Satoshi Ohno, Yoshiko Maida, Manabu Hashimoto, Masahiro Takakura, Masaki Inoue

Cancer Sci. 2007 Dec; 98(12): 1881–1888. Published online 2007 Oct 9. doi: 10.1111/j.1349-7006.2007.00630.x

PMCID:: PMC11158726

Abstract Article PDF–2.2M

Select item 111583788.

Correlation between NDRG1 and PTEN expression in endometrial carcinoma

Jiawei Chen, Shuxia Li, Zhaorui Yang, Guangzhong Lu, Honghui Hu

Cancer Sci. 2008 Apr; 99(4): 706–710. Published online 2008 Mar 28. doi: 10.1111/j.1349-7006.2008.00749.x

PMCID:: PMC11158378

Abstract Article PDF–2.0M

Select item 111377369.

A miRNA-21-Mediated PTEN/Akt/NF-κB Axis Promotes Chronic Obstructive Pulmonary Disease Pathogenesis

Xiaoyan Sai, Chu Qin, Zixiao Zhang, Haoda Yu, Tao Bian

Int J Chron Obstruct Pulmon Dis. 2024; 19: 1141–1151. Published online 2024 May 25. doi: 10.2147/COPD.S453593

PMCID:: PMC11137736

Abstract Article PDF–5.5M

Select item 1111465310.

Genetic alterations of PTEN in human melanoma

Almass-Houd Aguissa-Touré, Gang Li

Cell Mol Life Sci. 2012 May; 69(9): 1475–1491. Published online 2011 Nov 11. doi: 10.1007/s00018-011-0878-0

PMCID:: PMC11114653

Abstract Article PDF–396K

Select item 1111149311.

PTEN hamartoma tumor syndrome: Clinical and genetic characterization in pediatric patients

Jesús Martín-Valbuena, Nerea Gestoso-Uzal, María Justel-Rodríguez, María Isidoro-García, Elena Marcos-Vadillo, Sandra Milagros Lorenzo-Hernández, M. Carla Criado-Muriel, Pablo Prieto-Matos

Childs Nerv Syst. 2024; 40(6): 1689–1697. Published online 2024 Feb 26. doi: 10.1007/s00381-024-06301-2

PMCID:: PMC11111493

Abstract Article PDF–729K

Select item 1110753412.

PTEN proteoforms in biology and disease

Prerna Malaney, Vladimir N. Uversky, Vrushank Davé

Cell Mol Life Sci. 2017 Aug; 74(15): 2783–2794. Published online 2017 Mar 13. doi: 10.1007/s00018-017-2500-6

PMCID:: PMC11107534

Abstract Article PDF–1.9M

Select item 1110509913.

The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation

Jue Zhang, Yin-Li Zhang, Long-Wen Zhao, Shuai-Bo Pi, Song-Ying Zhang, Chao Tong, Heng-Yu Fan

Cell Mol Life Sci. 2020 Jun; 77(11): 2181–2197. Published online 2019 Sep 6. doi: 10.1007/s00018-019-03280-5

PMCID:: PMC11105099

Abstract Article PDF–11M

Select item 1109413814.

The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif

Xiaolei Huang, Cheng Zhang, Xinci Shang, Yichang Chen, Qin Xiao, Zhengguo Wei, Guanghui Wang, Xuechu Zhen, Guoqiang Xu, Jinrong Min, Shaoming Shen, Yanli Liu

Cell Death Dis. 2024 May; 15(5): 335. Published online 2024 May 14. doi: 10.1038/s41419-024-06714-6

PMCID:: PMC11094138

Abstract Article PDF–11M

Select item 1107321715.

Reciprocal negative feedback regulation of ATF6α and PTEN promotes prostate cancer progression

Tingting Feng, Ru Zhao, Hanwen Zhang, Feifei Sun, Jing Hu, Meng Wang, Mei Qi, Ling Liu, Lin Gao, Yabo Xiao, Junhui Zhen, Weiwen Chen, Lin Wang, Bo Han

Cell Mol Life Sci. 2023 Oct; 80(10): 292. Published online 2023 Sep 16. doi: 10.1007/s00018-023-04940-3

PMCID:: PMC11073217

Abstract Article PDF–7.3M

Select item 1107009916.

miR-30a-5p attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by regulating PTEN protein expression and activating PI3K/Akt signaling pathway

Guoxin Liang, Chang Guo, Hongyue Tang, Mingming Zhang

BMC Cardiovasc Disord. 2024; 24: 236. Published online 2024 May 5. doi: 10.1186/s12872-024-03900-4

PMCID:: PMC11070099

Abstract Article PDF–3.1M

Select item 1103239117.

FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression

Jie Wu, Ting Wen, Antonio Marzio, Dingli Song, Sisi Chen, Chengcheng Yang, Fengyu Zhao, Boxiang Zhang, Guang Zhao, Alessandra Ferri, Hao Cheng, Jiao Ma, Hong Ren, Qiao Yi Chen, Yiping Yang, Sida Qin

Cell Death Dis. 2024 Apr; 15(4): 282. Published online 2024 Apr 20. doi: 10.1038/s41419-024-06635-4

PMCID:: PMC11032391

Abstract Article PDF–6.6M

Select item 1102143018.

Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review

Yue Li, Ruishuang Ma, Xia Hao

Cell Death Dis. 2024 Apr; 15(4): 268. Published online 2024 Apr 16. doi: 10.1038/s41419-024-06657-y

PMCID:: PMC11021430

Abstract Article PDF–3.6M

Select item 1101491419.

Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice

Mary Esmeralda Fuentes, Xiaoyin Lu, Natasha M. Flores, Simone Hausmann, Pawel K. Mazur

Sci Rep. 2024; 14: 8510. Published online 2024 Apr 12. doi: 10.1038/s41598-024-58874-2

PMCID:: PMC11014914

Abstract Article PDF–1.7M

Select item 1098466320.

Overexpression of HMGB1 in hepatocytes accelerates PTEN inactivation-induced liver cancer

Dipti Athavale, Inés Barahona, Zhuolun Song, Romain Desert, Wei Chen, Hui Han, Sukanta Das, Xiaodong Ge, Sai Santosh B. Komakula, Shenglan Gao, Daniel Lantvit, Grace Guzman, Natalia Nieto

Hepatol Commun. 2023 Dec; 7(12): e0311. Published online 2023 Dec 7. doi: 10.1097/HC9.0000000000000311