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Select item 112769571.

Clinical and Molecular Characterization of SMAD4 Splicing Variants in Patients with Juvenile Polyposis Syndrome

Giovanna Forte, Antonia Lucia Buonadonna, Candida Fasano, Paola Sanese, Filomena Cariola, Andrea Manghisi, Anna Filomena Guglielmi, Martina Lepore Signorile, Katia De Marco, Valentina Grossi, Vittoria Disciglio, Cristiano Simone

Int J Mol Sci. 2024 Jul; 25(14): 7939. Published online 2024 Jul 20. doi: 10.3390/ijms25147939

PMCID:: PMC11276957

Abstract Article PDF–1.7M

Select item 111966422.

SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer

Kang Li, Dan Shu, Han Li, Ailin Lan, Wenjie Zhang, Zhaofu Tan, Man Huang, Maria Lauda Tomasi, Aishun Jin, Haochen Yu, Meiying Shen, Shengchun Liu

Cell Death Dis. 2024 Jun; 15(6): 444. Published online 2024 Jun 24. doi: 10.1038/s41419-024-06838-9

PMCID:: PMC11196642

Abstract Article PDF–5.8M

Select item 111599453.

Promoter‐wide analysis of Smad4 binding sites in human epithelial cells

Daizo Koinuma, Shuichi Tsutsumi, Naoko Kamimura, Takeshi Imamura, Hiroyuki Aburatani, Kohei Miyazono

Cancer Sci. 2009 Nov; 100(11): 2133–2142. Published online 2009 Jul 23. doi: 10.1111/j.1349-7006.2009.01299.x

PMCID:: PMC11159945

Abstract Article PDF–670K

Select item 111099724.

HBO1 determines SMAD action in pluripotency and mesendoderm specification

Cong Zhang, Yongli Shan, Huaisong Lin, Yanqi Zhang, Qi Xing, Jinmin Zhu, Tiancheng Zhou, Aiping Lin, Qianyu Chen, Junwei Wang, Guangjin Pan

Nucleic Acids Res. 2024 May 22; 52(9): 4935–4949. Published online 2024 Feb 29. doi: 10.1093/nar/gkae158

PMCID:: PMC11109972

Abstract Article PDF–4.1M

Select item 110100215.

Epidermal Growth Factor‐Like Repeats and Discoidin I‐Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination

Mengmeng Zhao, Zihui Zheng, Shanshan Peng, Yao Xu, Jishou Zhang, Jianfang Liu, Wei Pan, Zheng Yin, Shuwan Xu, Cheng Wei, Menglong Wang, Jun Wan, Juan‐Juan Qin

J Am Heart Assoc. 2024 Mar 19; 13(6): e031283. Published online 2024 Mar 8. doi: 10.1161/JAHA.123.031283

PMCID:: PMC11010021

Abstract Article PDF–14M

Select item 109551586.

FLRT3 and TGF‐β/SMAD4 signalling: Impacts on apoptosis, autophagy and ion channels in supraventricular tachycardia

Yang Pang, Ye Xu, Qingxing Chen, Kuan Cheng, Yunlong Ling, Jun Jang, Junbo Ge, Wenqing Zhu

J Cell Mol Med. 2024 Apr; 28(7): e18237. Published online 2024 Mar 20. doi: 10.1111/jcmm.18237

PMCID:: PMC10955158

Abstract Article PDF–5.5M

Select item 109497307.

LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4

Zhenchong Li, Zuyi Ma, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Yubin Chen, Mingqian Han, Zelong Wu, Shanzhou Huang, Qi Zhou, Baohua Hou, Chuanzhao Zhang

Biol Direct. 2024; 19: 24. Published online 2024 Mar 19. doi: 10.1186/s13062-024-00463-4

PMCID:: PMC10949730

Abstract Article PDF–11M

Select item 106455458.

Functional filter for whole-genome sequencing data identifies HHT and stress-associated non-coding SMAD4 polyadenylation site variants >5 kb from coding DNA

Sihao Xiao, Zhentian Kai, Daniel Murphy, Dongyang Li, Dilip Patel, Adrianna M. Bielowka, Maria E. Bernabeu-Herrero, Awatif Abdulmogith, Andrew D. Mumford, Sarah K. Westbury, Micheala A. Aldred, Neil Vargesson, Mark J. Caulfield, Genomics England Research Consortium, Claire L. Shovlin

Am J Hum Genet. 2023 Nov 2; 110(11): 1903–1918. Published online 2023 Oct 9. doi: 10.1016/j.ajhg.2023.09.005

PMCID:: PMC10645545

Abstract Article PDF–4.6M

Select item 106443299.

Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway

Chunxiao Ma, Min Liu, Wenxin Feng, Hanyu Rao, Wei Zhang, Changwei Liu, Yue Xu, Ziyi Wang, Yan Teng, Xiao Yang, Li Ni, Jin Xu, Wei‐Qiang Gao, Bing Lu, Li Li

Clin Transl Med. 2023 Nov; 13(11): e1475. Published online 2023 Nov 14. doi: 10.1002/ctm2.1475

PMCID:: PMC10644329

Abstract Article PDF–2.7M

Select item 1046866310.

SMAD4 regulates the progression of cholangiocarcinoma by modulating the expression of STING1

An‐da Shi, Li‐ming Zhao, Guo‐li Sheng, Ge‐ning Zhang, Yong‐chang Tang, Kang‐shuai Li, Zong‐li Zhang

J Cell Mol Med. 2023 Sep; 27(17): 2547–2561. Published online 2023 Jul 24. doi: 10.1111/jcmm.17857

PMCID:: PMC10468663

Abstract Article PDF–8.1M

Select item 1044251011.

Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors

Dimuthu Alankarage, Annabelle Enriquez, Robert D Steine, Cathy Raggio, Megan Higgins, Di Milnes, David T Humphreys, Emma L Duncan, Duncan B Sparrow, Philip F Giampietro, Gavin Chapman, Sally L Dunwoodie

Differentiation. Author manuscript; available in PMC 2023 Aug 22.

Published in final edited form as: Differentiation. 2022 Nov-Dec; 128: 1–12. Published online 2022 Sep 24. doi: 10.1016/j.diff.2022.09.002

PMCID:: PMC10442510

Abstract Article PDF–1.6M

Select item 1035978012.

KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway

Hongyuan Xu, Ran Huo, Hao Li, Yuming Jiao, Jiancong Weng, Jie Wang, Zihan Yan, Junze Zhang, Shaozhi Zhao, Qiheng He, Yingfan Sun, Shuo Wang, Yong Cao

Stroke Vasc Neurol. 2023 Jun; 8(3): 197–206. Published online 2022 Nov 23. doi: 10.1136/svn-2022-001700

PMCID:: PMC10359780

Abstract Article PDF–3.5M

Select item 1024337113.

Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells

XINXIN LIAO, YANHUI LI, JIA LIU, YINGZE ZHANG, JIANGNING TAN, DANIEL J. KASS, MAURICIO ROJAS, RAMA K. MALLAMPALLI, JING ZHAO, YUTONG ZHAO

Transl Res. Author manuscript; available in PMC 2023 Jun 6.

Published in final edited form as: Transl Res. 2020 Sep; 223: 15–24. Published online 2020 May 17. doi: 10.1016/j.trsl.2020.05.004

PMCID:: PMC10243371

Abstract Article PDF–1.2M

Select item 1023742214.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1017866515.

SMAD4 Expression in Monocytes as a Potential Biomarker for Atherosclerosis Risk in Patients with Obstructive Sleep Apnea

Elena Díaz-García, Aldara García-Sánchez, David Sánz-Rubio, Enrique Alfaro, Cristina López-Fernández, Raquel Casitas, Eva Mañas Baena, Irene Cano-Pumarega, Pablo Cubero, Marta Marin-Oto, Eduardo López-Collazo, José María Marin, Francisco García-Río, Carolina Cubillos-Zapata

Int J Mol Sci. 2023 May; 24(9): 7900. Published online 2023 Apr 26. doi: 10.3390/ijms24097900

PMCID:: PMC10178665

Abstract Article PDF–1.2M

Select item 1009827716.

SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS

Xiaohu Lin, Qianqian Pang, Jie Hu, Jiaqi Sun, Siya Dai, Yijia Yu, Jinghong Xu

J Cell Mol Med. 2023 Apr; 27(8): 1045–1055. Published online 2023 Mar 14. doi: 10.1111/jcmm.17216

PMCID:: PMC10098277

Abstract Article PDF–2.1M

Select item 1005332517.

Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling

Cong Tang, Mo Xiulei, Qiankun Niu, Alafate Wahafu, Xuan Yang, Min Qui, Andrey A. Ivanov, Yuhong Du, Haian Fu

Cell Chem Biol. Author manuscript; available in PMC 2023 Mar 29.

Published in final edited form as: Cell Chem Biol. 2021 May 20; 28(5): 636–647.e5. Published online 2020 Dec 15. doi: 10.1016/j.chembiol.2020.11.010

PMCID:: PMC10053325

Abstract Article PDF–1.9M

Select item 1000617218.

Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 via TRIM25 to facilitate hepatocarcinogenesis

Hongjuan You, Ning Zhang, Tong Yu, Lihong Ma, Qi Li, Xing Wang, Dongchen Yuan, Delong Kong, Xiangye Liu, Wei Hu, Dongsheng Liu, Fanyun Kong, Kuiyang Zheng, Renxian Tang

Br J Cancer. 2023 Apr 6; 128(6): 992–1004. Published online 2023 Jan 12. doi: 10.1038/s41416-022-02115-8