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Select item 112342091.

Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma

Ming-Hao Xu, Yi-Min Zheng, Bu-Gang Liang, Wen-Xin Xu, Jun Cao, Pei Wang, Zi-Ying Dong, Chen-Hao Zhou, Hui-Chuan Sun, Ning Ren, Ai-Wu Ke, Ying-Hao Shen

Int J Biol Sci. 2024; 20(9): 3269–3284. Published online 2024 Jun 3. doi: 10.7150/ijbs.96031

PMCID:: PMC11234209

Abstract Article PDF–9.9M

Select item 111825072.

Hong xiang Hou, Li Pang, Liang Zhao, Jihong Xing

PLoS One. 2024; 19(6): e0301647. Published online 2024 Jun 17. doi: 10.1371/journal.pone.0301647

PMCID:: PMC11182507

Abstract Article PDF–4.8M

Select item 111582903.

Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer

Fusanori Yotsumoto, Tatsuya Fukami, Hiroshi Yagi, Akihiro Funakoshi, Toshiyuki Yoshizato, Masahide Kuroki, Shingo Miyamoto

Cancer Sci. 2010 Nov; 101(11): 2351–2360. Published online 2010 Jul 7. doi: 10.1111/j.1349-7006.2010.01671.x

PMCID:: PMC11158290

Abstract Article PDF–769K

Select item 111580714.

Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis

Yasunari Mizumoto, Satoru Kyo, Noriko Mori, Junko Sakaguchi, Satoshi Ohno, Yoshiko Maida, Manabu Hashimoto, Masahiro Takakura, Masaki Inoue

Cancer Sci. 2007 May; 98(5): 652–658. Published online 2007 Mar 27. doi: 10.1111/j.1349-7006.2007.00445.x

PMCID:: PMC11158071

Abstract Article PDF–278K

Select item 111317605.

CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK

J. Huang, T. Shi, T. Ma, Y. Zhang, X. Ma, Y. Lu, Q. Song, W. Liu, D. Ma, X. Qiu

Cell Mol Life Sci. 2008 Jan; 65(2): 338–349. Published online 2007 Dec 18. doi: 10.1007/s00018-007-7448-5

PMCID:: PMC11131760

Abstract Article PDF–2.1M

Select item 111157706.

Endocytosis of hepatitis C virus non-enveloped capsid-like particles induces MAPK–ERK1/2 signaling events

Konstantina Katsarou, Alexandros Α. Lavdas, Panagiota Tsitoura, Elisavet Serti, Panagiotis Markoulatos, Penelope Mavromara, Urania Georgopoulou

Cell Mol Life Sci. 2010 Jul; 67(14): 2491–2506. Published online 2010 Apr 1. doi: 10.1007/s00018-010-0351-5

PMCID:: PMC11115770

Abstract Article PDF–938K

Select item 110773717.

Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1

Yanling He, Xinyuan Zhang, Weijun Pan, Jiebiao Zhang, Weiliang Zhu, Jian Zhang, Jian Shi

Int J Biol Sci. 2024; 20(7): 2403–2421. Published online 2024 Apr 8. doi: 10.7150/ijbs.87442

PMCID:: PMC11077371

Abstract Article PDF–10M

Select item 110028938.

ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2

Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüne

Redox Biol. 2024 Jun; 72: 103149. Published online 2024 Apr 3. doi: 10.1016/j.redox.2024.103149

PMCID:: PMC11002893

Abstract Article PDF–8.3M

Select item 108675879.

LncNFYB promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via LncNFYB/ANXA2/ERK1/2 axis

Shibai Xiao, Qingqing Ouyang, Yi Feng, Xiaoxi Lu, Yipeng Han, Hao Ren, Qin Huang, Jinjun Zhao, Changhong Xiao, Min Yang

J Biol Chem. 2024 Feb; 300(2): 105591. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105591

PMCID:: PMC10867587

Abstract Article PDF–5.7M

Select item 1073990210.

Mir-142-3P regulates MAPK protein family by inhibiting 14-3-3η to enhance bone marrow mesenchymal stem cells osteogenesis

Ya-qian Liu, Yue-chen Xu, Zong-wen Shuai

Sci Rep. 2023; 13: 22862. Published online 2023 Dec 21. doi: 10.1038/s41598-023-48950-4

PMCID:: PMC10739902

Abstract Article PDF–1.8M

Select item 1061235711.

The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants

Maria Petrosino, Leonore Novak, Alessandra Pasquo, Paola Turina, Emidio Capriotti, Velia Minicozzi, Valerio Consalvi, Roberta Chiaraluce

Hum Genomics. 2023; 17: 95. Published online 2023 Oct 27. doi: 10.1186/s40246-023-00544-x

PMCID:: PMC10612357

Abstract Article PDF–4.7M

Select item 1059472712.

Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis

Ran Liu, Chuanzheng Yin, Peng Zhao, Bing Guo, Wenbo Ke, Xichuan Zheng, Dawei Xie, Yaofeng Wang, Gengqiao Wang, Yinzhao Jia, Yang Gao, Wenjun Hu, Gang Logan Liu, Zifang Song

Biol Direct. 2023; 18: 67. Published online 2023 Oct 24. doi: 10.1186/s13062-023-00428-z

PMCID:: PMC10594727

Abstract Article PDF–15M

Select item 1045872213.

A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities

Nadine Soudah, Alexey Baskin, Karin Smorodinsky-Atias, Jonah Beenstock, Yifat Ganon, Ruchama Hayouka, Mohammed Aboraya, Oded Livnah, Ronit Ilouz, David Engelberg

J Biol Chem. 2023 Sep; 299(9): 105072. Published online 2023 Jul 18. doi: 10.1016/j.jbc.2023.105072

PMCID:: PMC10458722

Abstract Article PDF–4.2M

Select item 1031806914.

TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1

Xiaowei Fei, Ya-nan Dou, Kai Sun, Jialiang Wei, Qingdong Guo, Li Wang, Xiuquan Wu, Weihao Lv, Xiaofan Jiang, Zhou Fei

Exp Mol Med. 2023 Jun; 55(6): 1203–1217. Published online 2023 Jun 1. doi: 10.1038/s12276-023-01007-y

PMCID:: PMC10318069

Abstract Article PDF–7.6M

Select item 1023742215.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1008090816.

The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia

Sadek Amhaz, Batiste Boëda, Mouna Chouchène, Sabrina Colasse, Florent Dingli, Damarys Loew, Julien Henri, Céline Prunier, Laurence Levy

BMC Biol. 2023; 21: 73. Published online 2023 Apr 7. doi: 10.1186/s12915-023-01576-4

PMCID:: PMC10080908

Abstract Article PDF–3.2M

Select item 1007747817.

Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a CXCR4^Leu317fsX3 mutation causing WHIM syndrome

Rajesh Kumar, Samantha Milanesi, Martyna Szpakowska, Laura Dotta, Dario Di Silvestre, Anna Maria Trotta, Anna Maria Bello, Mauro Giacomelli, Manuela Benedito, Joana Azevedo, Alexandra Pereira, Emilia Cortesao, Alessandro Vacchini, Alessandra Castagna, Marinella Pinelli, Daniele Moratto, Raffaella Bonecchi, Massimo Locati, Stefania Scala, Andy Chevigné, Elena M. Borroni, Raffaele Badolato

JCI Insight. 2023 Mar 8; 8(5): e145688. Published online 2023 Mar 8. doi: 10.1172/jci.insight.145688

PMCID:: PMC10077478

Abstract Article PDF–1.1M

Select item 1007498818.

Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma

Zhou Zeng, Mengling You, Cong Fan, Rong Rong, Haibo Li, Xiaobo Xia

Redox Biol. 2023 Jun; 62: 102687. Published online 2023 Mar 21. doi: 10.1016/j.redox.2023.102687

PMCID:: PMC10074988

Abstract Article PDF–14M

Select item 1007290619.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 989187320.

Tripartite motif containing 69 elicits ERK2-dependent EYA4 turnover to impart pancreatic tumorigenesis

Yu Jia, Hui-Yan Li, Jue Wang, Xing Chen, Lu Lou, Yan-Yan Wei, Ying Wang, Shi-Jing Mo

J Cancer. 2023; 14(2): 200–218. Published online 2023 Jan 1. doi: 10.7150/jca.79905

PMCID:: PMC9891873

Abstract Article PDF–5.6M

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