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Select item 112038601.

Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against Clostridium perfringens Infection

Zhaoguo Ma, Yanan Lou, Na Wang, Yi Zhao, Shuxin Zhang, Mingyue Zhang, Jiaqi Li, Qian Xu, Aobo He, Shuixing Yu

Int J Mol Sci. 2024 Jun; 25(12): 6571. Published online 2024 Jun 14. doi: 10.3390/ijms25126571

PMCID:: PMC11203860

Abstract Article PDF–9.5M

Select item 110622522.

Frontline Science: Anthrax lethal toxin-induced, NLRP1-mediated IL-1β release is a neutrophil and PAD4-dependent event

Allison J. Greaney, Makayla K. Portley, Danielle O’Mard, Devorah Crown, Nolan K. Maier, Megan A. Mendenhall, Katrin D. Mayer-Barber, Stephen H. Leppla, Mahtab Moayeri

J Leukoc Biol. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: J Leukoc Biol. 2020 Sep; 108(3): 773–786. Published online 2020 May 18. doi: 10.1002/JLB.4HI0320-028R

PMCID:: PMC11062252

Abstract Article PDF–1.0M

Select item 109528133.

The cytosolic DNA sensor AIM2 promotes Helicobacter‐induced gastric pathology via the inflammasome

Ruby E Dawson, Virginie Deswaerte, Alison C West, Ekimei Sun, Georgie Wray‐McCann, Thaleia Livis, Beena Kumar, Emiliana Rodriguez, Cem Gabay, Richard L Ferrero, Brendan J Jenkins

Immunol Cell Biol. 2023 May-Jun; 101(5): 444–457. Published online 2023 Apr 19. doi: 10.1111/imcb.12641

PMCID:: PMC10952813

Abstract Article PDF–1.7M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108142445.

A High-Protein Diet Promotes Atrial Arrhythmogenesis via Absent-in-Melanoma 2 Inflammasome

Jia Song, Jiao Wu, Dexter J. Robichaux, Tingting Li, Shuyue Wang, Maria J. Arredondo Sancristobal, Bingning Dong, Dobromir Dobrev, Jason Karch, Sandhya S. Thomas, Na Li

Cells. 2024 Jan; 13(2): 108. Published online 2024 Jan 5. doi: 10.3390/cells13020108

PMCID:: PMC10814244

Abstract Article PDF–7.8M

Select item 106015276.

AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3

Hua Ye, Wenwen Yu, Yunlei Li, Xiaoqiong Bao, Yangyang Ni, Xiangxiang Chen, Yangjie Sun, Ali Chen, Weilong Zhou, Jifa Li

Hum Vaccin Immunother. 2023; 19(3): 2269790. Published online 2023 Oct 25. doi: 10.1080/21645515.2023.2269790

PMCID:: PMC10601527

Abstract Article PDF–9.5M

Select item 105853937.

AIM2 promotes T_H17 cells differentiation by regulating RORγt transcription activity

Jefferson Antônio Leite, Luísa Menezes, Eloisa Martins, Tamara Silva Rodrigues, Lucas Tavares, Anna Ebering, Carsten Schelmbauer, Guilherme C. Martelossi Cebinelli, Valeriya Zinina, Artemiy Golden, Natalia Soshnikova, Dario S. Zamboni, Fernando Q. Cunha, Magdalena Huber, João Santana Silva, Ari Waisman, Daniela Carlos, Niels Olsen Saraiva Câmara

iScience. 2023 Nov 17; 26(11): 108134. Published online 2023 Oct 4. doi: 10.1016/j.isci.2023.108134

PMCID:: PMC10585393

Abstract Article PDF–5.0M

Select item 104944698.

Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis)

Bhesh Raj Sharma, Rajendra Karki, Yetirajam Rajesh, Thirumala-Devi Kanneganti

J Biol Chem. 2023 Sep; 299(9): 105141. Published online 2023 Aug 7. doi: 10.1016/j.jbc.2023.105141

PMCID:: PMC10494469

Abstract Article PDF–3.7M

Select item 103525629.

Absent in melanoma 2 mediates aging‐related cognitive dysfunction by acting on complement‐dependent microglial phagocytosis

Lei Ye, Shu Shu, Junqiu Jia, Min Sun, Siyi Xu, Xinyu Bao, Huijie Bian, Yi Liu, Meijuan Zhang, Xiaolei Zhu, Feng Bai, Yun Xu

Aging Cell. 2023 Jul; 22(7): e13860. Published online 2023 May 12. doi: 10.1111/acel.13860

PMCID:: PMC10352562

Abstract Article PDF–12M

Select item 1033808110.

Macrophage IL-1β contributes to tumorigenesis through paracrine AIM2 inflammasome activation in the tumor microenvironment

Zhi Huan Chew, Jianzhou Cui, Karishma Sachaphibulkij, Isabelle Tan, Shreya Kar, Kai Kiat Koh, Kritika Singh, Hong Meng Lim, Soo Chin Lee, Alan Prem Kumar, Stephan Gasser, Lina H. K. Lim

Front Immunol. 2023; 14: 1211730. Published online 2023 Jun 28. doi: 10.3389/fimmu.2023.1211730

PMCID:: PMC10338081

Abstract Article PDF–3.5M

Select item 1002976411.

Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model

Yu Chen, Jiheng Pu, Xinda Li, Lili Lian, Chaoxiang Ge, Zuimeng Liu, Weizhuo Wang, Ling Hou, Wei Chen, Jinyang Li

Invest Ophthalmol Vis Sci. 2023 Mar; 64(3): 26. Published online 2023 Mar 15. doi: 10.1167/iovs.64.3.26

PMCID:: PMC10029764

Abstract Article PDF–16M

Select item 961552612.

AIM2 inflammasome activation may mediate high mobility group box 1 release in murine allergic rhinitis

Yan Wang, Shan Chen, Ping-Li Yang, Jian-Jun Chen, Wei-Jia Kong, Yan-Jun Wang

Braz J Otorhinolaryngol. 2022 Nov-Dec; 88(6): 925–931. Published online 2021 Feb 15. doi: 10.1016/j.bjorl.2020.12.014

PMCID:: PMC9615526

Abstract Article PDF–1.6M

Select item 933826513.

Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling

Shouya Feng, Daniel Enosi Tuipulotu, Abhimanu Pandey, Weidong Jing, Cheng Shen, Chinh Ngo, Melkamu B. Tessema, Fei-Ju Li, Daniel Fox, Anukriti Mathur, Anyang Zhao, Runli Wang, Klaus Pfeffer, Daniel Degrandi, Masahiro Yamamoto, Patrick C. Reading, Gaetan Burgio, Si Ming Man

Nat Commun. 2022; 13: 4395. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32127-0

PMCID:: PMC9338265

Abstract Article PDF–3.0M

Select item 908978114.

The AIM2 inflammasome is activated in astrocytes during the late phase of EAE

William E. Barclay, Nupur Aggarwal, M. Elizabeth Deerhake, Makoto Inoue, Toshiaki Nonaka, Kengo Nozaki, Nathan A. Luzum, Edward A. Miao, Mari L. Shinohara

JCI Insight. 2022 Apr 22; 7(8): e155563. Published online 2022 Apr 22. doi: 10.1172/jci.insight.155563

PMCID:: PMC9089781

Abstract Article PDF–3.0M

Select item 895835215.

The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease

Haijing Wu, Yaxiong Deng, Di Long, Ming Yang, Qianwen Li, Yu Feng, Yongjian Chen, Hong Qiu, Xin Huang, Zhenghao He, Longyuan Hu, Heng Yin, Guangdi Li, Yunkai Guo, Wenhan Du, Ming Zhao, Liwei Lu, Qianjin Lu

Clin Transl Med. 2022 Mar; 12(3): e781. Published online 2022 Mar 28. doi: 10.1002/ctm2.781

PMCID:: PMC8958352

Abstract Article PDF–6.2M

Select item 887678916.

Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells

Beatriz Lozano-Ruiz, Amalia Tzoumpa, Claudia Martínez-Cardona, David Moreno, Ana M. Aransay, Ana R. Cortazar, Joanna Picó, Gloria Peiró, Juanjo Lozano, Pedro Zapater, Rubén Francés, José M. González-Navajas

Int J Mol Sci. 2022 Feb; 23(4): 2230. Published online 2022 Feb 17. doi: 10.3390/ijms23042230

PMCID:: PMC8876789

Abstract Article PDF–2.0M

Select item 885363417.

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

Rajendra Karki, Balamurugan Sundaram, Bhesh Raj Sharma, SangJoon Lee, R.K. Subbarao Malireddi, Lam Nhat Nguyen, Shelbi Christgen, Min Zheng, Yaqiu Wang, Parimal Samir, Geoffrey Neale, Peter Vogel, Thirumala-Devi Kanneganti

Cell Rep. Author manuscript; available in PMC 2022 Feb 17.

Published in final edited form as: Cell Rep. 2021 Oct 19; 37(3): 109858. doi: 10.1016/j.celrep.2021.109858

PMCID:: PMC8853634

Abstract Article PDF–2.8M

Select item 860394218.

AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense

SangJoon Lee, Rajendra Karki, Yaqiu Wang, Lam Nhat Nguyen, Ravi C. Kalathur, Thirumala-Devi Kanneganti

Nature. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Nature. 2021 Sep; 597(7876): 415–419. Published online 2021 Sep 1. doi: 10.1038/s41586-021-03875-8

PMCID:: PMC8603942

Abstract Article PDF–7.4M

Select item 859611819.

Nuclear AIM2‐Like Receptors Drive Genotoxic Tissue Injury by Inhibiting DNA Repair

Hui Jiang, Patrycja Swacha, Nelson O. Gekara

Adv Sci (Weinh) 2021 Nov; 8(22): 2102534. Published online 2021 Oct 18. doi: 10.1002/advs.202102534

PMCID:: PMC8596118

Abstract Article PDF–2.8M

Select item 844622120.

AIM2 deletion enhances blood‐brain barrier integrity in experimental ischemic stroke

Si‐yi Xu, Hui‐jie Bian, Shu Shu, Sheng‐nan Xia, Yue Gu, Mei‐juan Zhang, Yun Xu, Xiang Cao

CNS Neurosci Ther. 2021 Oct; 27(10): 1224–1237. Published online 2021 Jun 22. doi: 10.1111/cns.13699

PMCID:: PMC8446221

Abstract Article PDF–3.3M

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