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Select item 116074301.

Cell-type specific, inducible and acute degradation of targeted protein in mice by two degron systems

Motoi Yamashita, Chihiro Ogawa, Baihao Zhang, Tetsuro Kobayashi, Aneela Nomura, Clive Barker, Chengcheng Zou, Satoshi Yamanaka, Ken-ichiro Hayashi, Yoichi Shinkai, Kazuyo Moro, Sidonia Fargarasan, Koshi Imami, Jun Seita, Fumiyuki Shirai, Tatsuya Sawasaki, Masato T. Kanemaki, Ichiro Taniuchi

Nat Commun. 2024; 15: 10129. Published online 2024 Nov 29. doi: 10.1038/s41467-024-54308-9

PMCID:: PMC11607430

Abstract Article PDF–2.5M

Select item 115856352.

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness

Xingxing Zhu, Yue Wu, Yanfeng Li, Xian Zhou, Jens O. Watzlawik, Yin Maggie Chen, Ariel L. Raybuck, Daniel D. Billadeau, Virginia Smith Shapiro, Wolfdieter Springer, Jie Sun, Mark R. Boothby, Hu Zeng

Nat Commun. 2024; 15: 10163. Published online 2024 Nov 23. doi: 10.1038/s41467-024-54344-5

PMCID:: PMC11585635

Abstract Article PDF–5.8M

Select item 115669943.

H₂S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T cell immunotherapeutic response

Nathaniel Oberholtzer, Paramita Chakraborty, Mohamed Faisal Kassir, James Dressman, Satyajit Das, Stephanie Mills, Susana Comte-Walters, Monika Gooz, Seungho Choi, Rasesh Y. Parikh, Zacharia Hedley, Silvia Vaena, Reid DeMass, Gina Scurti, Martin Romeo, Vamsi K. Gangaraju, Stefano Berto, Elizabeth Hill, Lauren E. Ball, Anand S. Mehta, Eduardo N. Maldonado, Michael I. Nishimura, Besim Ogretmen, Shikhar Mehrotra

Sci Adv. 2024 Nov 15; 10(46): eadp1152. Published online 2024 Nov 15. doi: 10.1126/sciadv.adp1152

PMCID:: PMC11566994

Abstract Article PDF–6.2M

Select item 115546754.

Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects

Jan Mašek, Iva Filipovic, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Daniel V Oliveira, Anna Maria Frontino, Simona Hankeova, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, Niklas K Björkström, Martin Gregor, Jan Dobeš, Emma R Andersson

EMBO Mol Med. 2024 Nov; 16(11): 2946–2975. Published online 2024 Oct 2. doi: 10.1038/s44321-024-00145-8

PMCID:: PMC11554675

Abstract Article PDF–8.1M

Select item 115259205.

N-acetyltransferase 10 is implicated in the pathogenesis of cycling T cell-mediated autoimmune and inflammatory disorders in mice

Wen-ping Li, Xin-tao Mao, Jia-huan Xie, Jie-yu Li, Bao-qin Liu, Le-xi Wu, Bing Yang, Yi-yuan Li, Jin Jin

Nat Commun. 2024; 15: 9388. Published online 2024 Oct 30. doi: 10.1038/s41467-024-53350-x

PMCID:: PMC11525920

Abstract Article PDF–4.6M

Select item 114955916.

Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate

Danielle L. Porier, Awadalkareem Adam, Lin Kang, Pawel Michalak, Juselyn Tupik, Matthew A. Santos, Manette Tanelus, Krisangel López, Dawn I. Auguste, Christy Lee, Irving C. Allen, Tian Wang, Albert J. Auguste

PLoS Pathog. 2024 Oct; 20(10): e1012566. Published online 2024 Oct 10. doi: 10.1371/journal.ppat.1012566

PMCID:: PMC11495591

Abstract Article PDF–2.3M

Select item 114304507.

Pregnancy enhances antiviral immunity independent of type I IFN but dependent on IL-17–producing γδ⁺ T cells in the nasal mucosa

Julia Chronopoulos, Erwan Pernet, Kim A. Tran, Toby K. McGovern, Arina Morozan, Sadie Wang, Oscar Tsai, Kosuke Makita, Maziar Divangahi, James G. Martin

Sci Adv. 2024 Sep 27; 10(39): eado7087. Published online 2024 Sep 27. doi: 10.1126/sciadv.ado7087

PMCID:: PMC11430450

Abstract Article PDF–1.3M

Select item 114147418.

Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis

Katrina T. Evans, Kerrigan Blake, Aaron Longworth, Morgan A. Coburn, Jacob Insua-Rodríguez, Timothy P. McMullen, Quy H. Nguyen, Dennis Ma, Tatyana Lev, Grace A. Hernandez, Armani K. Oganyan, Davit Orujyan, Robert A. Edwards, Clare Pridans, Kim N. Green, S. Armando Villalta, Mathew Blurton-Jones, Devon A. Lawson

Nat Cell Biol. Author manuscript; available in PMC 2024 Sep 20.

Published in final edited form as: Nat Cell Biol. 2023 Dec; 25(12): 1848–1859. Published online 2023 Nov 13. doi: 10.1038/s41556-023-01273-y

PMCID:: PMC11414741

Abstract Article PDF–6.8M

Select item 114147389.

Cancer-associated SF3B1-K700E mutation controls immune responses by regulating T_reg function via aberrant Anapc13 splicing

Yun Shi, Wencan Zhang, Qiong Jia, Xiancai Zhong, Prajish Iyer, Hongmin Wu, Yate-Ching Yuan, Yuqi Zhao, Lianjun Zhang, Lili Wang, Zhenyu Jia, Ya-Huei Kuo, Zuoming Sun

Sci Adv. 2024 Sep 20; 10(38): eado4274. Published online 2024 Sep 20. doi: 10.1126/sciadv.ado4274

PMCID:: PMC11414738

Abstract Article PDF–11M

Select item 1138151710.

TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma

Kaifan Bao, Xiaoqun Gu, Yajun Song, Yijing Zhou, Yanyan Chen, Xi Yu, Weiyuan Yuan, Liyun Shi, Jie Zheng, Min Hong

Nat Commun. 2024; 15: 7850. Published online 2024 Sep 8. doi: 10.1038/s41467-024-52252-2

PMCID:: PMC11381517

Abstract Article PDF–5.5M

Select item 1137550311.

Early-life infection depletes preleukemic cells in a mouse model of hyperdiploid B-cell acute lymphoblastic leukemia

Ali Farrokhi, Tanmaya Atre, Samuel Salitra, Maryam Aletaha, Ana Citlali Márquez, Matthew Gynn, Mario Fidanza, Sumin Jo, Nina Rolf, Karen Simmons, Jesus Duque-Afonso, Michael L. Cleary, Alix E. Seif, Tobias Kollmann, Soren Gantt, Gregor S. D. Reid

Blood. 2024 Aug 22; 144(8): 809–821. Published online 2024 Jun 18. doi: 10.1182/blood.2024025038

PMCID:: PMC11375503

Abstract Article

Select item 1137171612.

Antisense targeting of FOXP3+ Tregs to boost anti-tumor immunity

Tatiana Akimova, Liqing Wang, Zhanna Bartosh, Lanette M. Christensen, Evgeniy Eruslanov, Sunil Singhal, Veenu Aishwarya, Wayne W. Hancock

Front Immunol. 2024; 15: 1426657. Published online 2024 Aug 21. doi: 10.3389/fimmu.2024.1426657

PMCID:: PMC11371716

Abstract Article PDF–14M

Select item 1135556813.

Determinants of pegivirus persistence, cross-species infection, and adaptation in the laboratory mouse

Kylie Nennig, Satyapramod Murthy, Sara Maloney, Teressa M. Shaw, Mark Sharobim, Eduard Matkovic, Simi Fadiran, Malorie Larsen, Mitchell D. Ramuta, Arthur S. Kim, John R. Teijaro, Joe Grove, Matthew Stremlau, Himanshu Sharma, Sheetal Trivedi, Michael J. Blum, David H. O’Connor, Jennifer L. Hyde, Jack T. Stapleton, Amit Kapoor, Adam L. Bailey

PLoS Pathog. 2024 Aug; 20(8): e1012436. Published online 2024 Aug 28. doi: 10.1371/journal.ppat.1012436

PMCID:: PMC11355568

Abstract Article PDF–4.3M

Select item 1135004114.

CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator

Lixia Zhang, Xinyue Zhou, Sajesan Aryal, Virginia Veasey, Pengcheng Zhang, Fu Jun Li, Yu Luan, Ravi Bhatia, Yang Zhou, Rui Lu

Cell Death Dis. 2024 Aug; 15(8): 627. Published online 2024 Aug 27. doi: 10.1038/s41419-024-06995-x

PMCID:: PMC11350041

Abstract Article PDF–3.1M

Select item 1131544715.

Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

Prabhat K. Purbey, Joowon Seo, Manash K. Paul, Keisuke S. Iwamoto, Allison E. Daly, An-Chieh Feng, Ameya S. Champhekar, Justin Langerman, Katie M. Campbell, Dörthe Schaue, William H. McBride, Steven M. Dubinett, Antoni Ribas, Stephen T. Smale, Philip O. Scumpia

Cell Rep. Author manuscript; available in PMC 2024 Aug 9.

Published in final edited form as: Cell Rep. 2024 Jun 25; 43(6): 114289. Published online 2024 Jun 2. doi: 10.1016/j.celrep.2024.114289

PMCID:: PMC11315447

Abstract Article PDF–3.3M

Select item 1129332116.

PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies

Raghavendra Basavaraja, Hongru Zhang, Ágnes Holczbauer, Zhen Lu, Enrico Radaelli, Charles-Antoine Assenmacher, Subin S. George, Vamshidhar C. Nallamala, Daniel P. Beiting, Mirella L. Meyer-Ficca, Ralph G. Meyer, Wei Guo, Yi Fan, Andrew J. Modzelewski, Vladimir S. Spiegelman, Michael S. Cohen, Serge Y. Fuchs

Cell Rep Med. 2024 Jul 16; 5(7): 101649. Published online 2024 Jul 16. doi: 10.1016/j.xcrm.2024.101649

PMCID:: PMC11293321

Abstract Article PDF–5.7M

Select item 1129096317.

An attenuated lymphocytic choriomeningitis virus vector enhances tumor control in mice partly via IFN-I

Young Rock Chung, Bakare Awakoaiye, Tanushree Dangi, Nahid Irani, Slim Fourati, Pablo Penaloza-MacMaster

J Clin Invest. 2024 Aug 1; 134(15): e178945. Published online 2024 Jun 11. doi: 10.1172/JCI178945

PMCID:: PMC11290963

Abstract Article PDF–2.0M

Select item 1128913318.

Harnessing intestinal tryptophan catabolism to relieve atherosclerosis in mice

Mouna Chajadine, Ludivine Laurans, Tobias Radecke, Nirmala Mouttoulingam, Rida Al-Rifai, Emilie Bacquer, Clara Delaroque, Héloïse Rytter, Marius Bredon, Camille Knosp, José Vilar, Coralie Fontaine, Nadine Suffee, Marie Vandestienne, Bruno Esposito, Julien Dairou, Jean Marie Launay, Jacques Callebert, Alain Tedgui, Hafid Ait-Oufella, Harry Sokol, Benoit Chassaing, Soraya Taleb

Nat Commun. 2024; 15: 6390. Published online 2024 Jul 29. doi: 10.1038/s41467-024-50807-x

PMCID:: PMC11289133

Abstract Article PDF–3.5M

Select item 1128481819.

Reprogramming Tumor-Associated Macrophages to Outcompete Endovascular Endothelial Progenitor Cells and Suppress Tumor Neoangiogenesis

Mytrang H. Do, Wei Shi, Liangliang Ji, Erik Ladewig, Xian Zhang, Raghvendra M. Srivastava, Kristelle J. Capistrano, Chaucie Edwards, Isha Malik, Briana G. Nixon, Efstathios G. Stamatiades, Ming Liu, Shun Li, Peng Li, Chun Chou, Ke Xu, Ting-Wei Hsu, Xinxin Wang, Timothy A. Chan, Christina S. Leslie, Ming O. Li

Immunity. Author manuscript; available in PMC 2024 Nov 14.

Published in final edited form as: Immunity. 2023 Nov 14; 56(11): 2555–2569.e5. doi: 10.1016/j.immuni.2023.10.010

PMCID:: PMC11284818

Abstract Article PDF–3.8M

Select item 1126433120.

Circadian-clock-controlled endocrine and cytokine signals regulate multipotential innate lymphoid cell progenitors in the bone marrow

Qingyang Liu, Shams Tabrez, Patrick Niekamp, Chang H. Kim

Cell Rep. Author manuscript; available in PMC 2024 Jul 23.

Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114200. Published online 2024 May 7. doi: 10.1016/j.celrep.2024.114200

PMCID:: PMC11264331

Abstract Article PDF–2.9M

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