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Items: 1 to 20 of 95

1.
CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa
Nicholas D. Nolan, Xuan Cui, Brian M. Robbings, Aykut Demirkol, Kriti Pandey, Wen-Hsuan Wu, Hannah F. Hu, Laura A. Jenny, Chyuan-Sheng Lin, Daniel T. Hass, Jianhai Du, James B. Hurley, Stephen H. Tsang
Cell Rep Med. 2024 Apr 16; 5(4): 101459. Published online 2024 Mar 21. doi: 10.1016/j.xcrm.2024.101459
PMCID:
PMC11031380
AbstractArticlePDF–6.3M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
Tao Zhang, Daichao Xu, Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Dongxian Guan, Cong Jiang, Xiaoming Dai, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao, Gyongyi Szabo, Guo-Hua Fong, Antoine E. Karnoub, Yu-Ru Lee, Lifeng Pan, William G. Kaelin, Jr., Junying Yuan, Wenyi Wei
Nat Cell Biol. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Nat Cell Biol. 2023 Jul; 25(7): 950–962. Published online 2023 Jul 3. doi: 10.1038/s41556-023-01170-4
PMCID:
PMC10617019
AbstractArticlePDF–8.3M
4.
Three-dimensional molecular architecture of mouse organogenesis
Fangfang Qu, Wenjia Li, Jian Xu, Ruifang Zhang, Jincan Ke, Xiaodie Ren, Xiaogao Meng, Lexin Qin, Jingna Zhang, Fangru Lu, Xin Zhou, Xi Luo, Zhen Zhang, Minhan Wang, Guangming Wu, Duanqing Pei, Jiekai Chen, Guizhong Cui, Shengbao Suo, Guangdun Peng
Nat Commun. 2023; 14: 4599. Published online 2023 Jul 31. doi: 10.1038/s41467-023-40155-7
PMCID:
PMC10390492
AbstractArticlePDF–13M
5.
Targeted Disruption of the MORG1 Gene in Mice Causes Embryonic Resorption in Early Phase of Development
Sophie Wulf, Luisa Mizko, Karl-Heinz Herrmann, Marta Sánchez-Carbonell, Anja Urbach, Cornelius Lemke, Alexander Berndt, Ivonne Loeffler, Gunter Wolf
Biomolecules. 2023 Jul; 13(7): 1037. Published online 2023 Jun 24. doi: 10.3390/biom13071037
PMCID:
PMC10377003
AbstractArticlePDF–2.0M
6.
Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism
Yaqian Xue, Aoyuan Cui, Shuang Wei, Fengguang Ma, Zhengshuai Liu, Xia Fang, Shaofeng Huo, Xiaoyang Sun, Wenjing Li, Zhimin Hu, Yuxiao Liu, Genxiang Cai, Weitong Su, Jiuxiang Zhao, Xi Yan, Chenlin Gao, Jian Wen, Haibing Zhang, Hong Li, Yi Liu, Xu Lin, Yong Xu, Wenguang Fu, Jing Fang, Yu Li
Proc Natl Acad Sci U S A. 2023 Jun 6; 120(23): e2219419120. Published online 2023 May 30. doi: 10.1073/pnas.2219419120
PMCID:
PMC10266032
AbstractArticlePDF–4.9M
7.
The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, Jonathan M. Harnoss
JCI Insight. 2022 Nov 22; 7(22): e153337. Published online 2022 Nov 22. doi: 10.1172/jci.insight.153337
PMCID:
PMC9746807
AbstractArticlePDF–4.9M
8.
Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia
Ann-Helen Rosendahl, Mia Monnius, Anu Laitala, Antti Railo, Ilkka Miinalainen, Ritva Heljasvaara, Joni M. Mäki, Johanna Myllyharju
J Biol Chem. 2022 Apr; 298(4): 101787. Published online 2022 Mar 2. doi: 10.1016/j.jbc.2022.101787
PMCID:
PMC8988008
AbstractArticlePDF–6.1M
9.
Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth
Ying Jin, Yamu Pan, Shuang Zheng, Yao Liu, Jie Xu, Yazhi Peng, Zemei Zhang, Yadong Wang, Yulian Xiong, Lei Xu, Kaiyu Mu, Suwen Chen, Fei Zheng, Ye Yuan, Jian Fu
Oncogene. 2022; 41(12): 1752–1766. Published online 2022 Feb 5. doi: 10.1038/s41388-022-02203-2
PMCID:
PMC8933280
AbstractArticlePDF–8.6M
10.
Adaptation of the Oxygen Sensing System during Lung Development
Karin M. Kirschner, Simon Kelterborn, Herrmann Stehr, Johanna L. T. Penzlin, Charlotte L. J. Jacobi, Stefanie Endesfelder, Miriam Sieg, Jochen Kruppa, Christof Dame, Lina K. Sciesielski
Oxid Med Cell Longev. 2022; 2022: 9714669. Published online 2022 Feb 18. doi: 10.1155/2022/9714669
PMCID:
PMC8886745
AbstractArticlePDF–2.8M
11.
PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes
Aude Angelini, Pradip K. Saha, Antrix Jain, Sung Yun Jung, Randall L. Mynatt, Xinchun Pi, Liang Xie
Cell Rep. Author manuscript; available in PMC 2021 Dec 9.
Published in final edited form as: Cell Rep. 2021 Oct 5; 37(1): 109767. doi: 10.1016/j.celrep.2021.109767
PMCID:
PMC8658754
AbstractArticlePDF–2.3M
12.
Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function
Monica Hoang, Emelien Jentz, Sarah M Janssen, Daniela Nasteska, Federica Cuozzo, David J Hodson, A Russell Tupling, Guo-Hua Fong, Jamie W Joseph
Endocrinology. 2022 Jan; 163(1): bqab226. Published online 2021 Oct 28. doi: 10.1210/endocr/bqab226
PMCID:
PMC8643417
AbstractArticle
13.
Prolyl Hydroxylase Domain-Containing Protein 3 Gene Expression in Chondrocytes Is Not Essential for Bone Development in Mice
Weirong Xing, Sheila Pourteymoor, Gustavo A. Gomez, Yian Chen, Subburaman Mohan
Cells. 2021 Sep; 10(9): 2200. Published online 2021 Aug 26. doi: 10.3390/cells10092200
PMCID:
PMC8470734
AbstractArticlePDF–2.4M
14.
Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice
Daniela Nasteska, Federica Cuozzo, Katrina Viloria, Elspeth M. Johnson, Alpesh Thakker, Rula Bany Bakar, Rebecca L. Westbrook, Jonathan P. Barlow, Monica Hoang, Jamie W. Joseph, Gareth G. Lavery, Ildem Akerman, James Cantley, Leanne Hodson, Daniel A. Tennant, David J. Hodson
JCI Insight. 2021 Aug 23; 6(16): e140288. Published online 2021 Aug 23. doi: 10.1172/jci.insight.140288
PMCID:
PMC8409982
AbstractArticlePDF–10M
15.
Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection
Bibo Zhu, Yue Wu, Su Huang, Ruixuan Zhang, Young Min Son, Chaofan Li, In Su Cheon, Xiaochen Gao, Min Wang, Yao Chen, Xian Zhou, Quynh Nguyen, Anthony T. Phan, Supriya Behl, M. Mark Taketo, Matthias Mack, Virginia S. Shapiro, Hu Zeng, Hideki Ebihara, John J. Mullon, Eric S. Edell, Janani S. Reisenauer, Nadir Demirel, Ryan M. Kern, Rana Chakraborty, Weiguo Cui, Mark H. Kaplan, Xiaobo Zhou, Ananda W. Goldrath, Jie Sun
Immunity. 2021 Jun 8; 54(6): 1200–1218.e9. Published online 2021 May 4. doi: 10.1016/j.immuni.2021.04.001
PMCID:
PMC8192557
AbstractArticlePDF–7.4M
16.
PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle
Haejin Yoon, Jessica B. Spinelli, Elma Zaganjor, Samantha J. Wong, Natalie J. German, Elizabeth C. Randall, Afsah Dean, Allen Clermont, Joao A. Paulo, Daniel Garcia, Hao Li, Olivia Rombold, Nathalie Y. R. Agar, Laurie J. Goodyear, Reuben J. Shaw, Steven P. Gygi, Johan Auwerx, Marcia C. Haigis
Cell Metab. Author manuscript; available in PMC 2021 Apr 24.
Published in final edited form as: Cell Metab. 2020 Aug 4; 32(2): 215–228.e7. Published online 2020 Jul 13. doi: 10.1016/j.cmet.2020.06.017
PMCID:
PMC8065255
AbstractArticlePDF–1.3M
17.
HIF1α is a direct regulator of steroidogenesis in the adrenal gland
Deepika Watts, Johanna Stein, Ana Meneses, Nicole Bechmann, Ales Neuwirth, Denise Kaden, Anja Krüger, Anupam Sinha, Vasileia Ismini Alexaki, Luis Gustavo Perez-Rivas, Stefan Kircher, Antoine Martinez, Marily Theodoropoulou, Graeme Eisenhofer, Mirko Peitzsch, Ali El-Armouche, Triantafyllos Chavakis, Ben Wielockx
Cell Mol Life Sci. 2021 Apr; 78(7): 3577–3590. Published online 2021 Jan 19. doi: 10.1007/s00018-020-03750-1
PMCID:
PMC8038963
AbstractArticlePDF–1.5M
18.
Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery
George Z. Wei, Sujata Saraswat Ohri, Nicolas K. Khattar, Adam W. Listerman, Catherine H. Doyle, Kariena R. Andres, Saravanan S. Karuppagounder, Rajiv R. Ratan, Scott R. Whittemore, Michal Hetman
PLoS One. 2021; 16(4): e0249591. Published online 2021 Apr 5. doi: 10.1371/journal.pone.0249591
PMCID:
PMC8021188
AbstractArticlePDF–820K
19.
Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice
Ivan Menendez-Montes, Beatriz Escobar, Manuel J. Gomez, Teresa Albendea-Gomez, Beatriz Palacios, Elena Bonzon-Kulichenko, Jose Luis Izquierdo-Garcia, Ana Vanessa Alonso, Alessia Ferrarini, Luis Jesus Jimenez-Borreguero, Jesus Ruiz-Cabello, Jesus Vázquez, Silvia Martin-Puig
iScience. 2021 Feb 19; 24(2): 102124. Published online 2021 Feb 3. doi: 10.1016/j.isci.2021.102124
PMCID:
PMC7900219
AbstractArticlePDF–6.0M
20.
The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation
Steffi Heidenreich, Pamela Weber, Heike Stephanowitz, Konstantin M. Petricek, Till Schütte, Moritz Oster, Antti M. Salo, Miriam Knauer, Isabel Goehring, Na Yang, Nicole Witte, Anne Schumann, Manuela Sommerfeld, Matthias Muenzner, Johanna Myllyharju, Eberhard Krause, Michael Schupp
J Biol Chem. 2020 Dec 11; 295(50): 17158–17168. Published online 2020 Oct 6. doi: 10.1074/jbc.RA120.014402
PMCID:
PMC7863887
AbstractArticlePDF–2.8M

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