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Items: 1 to 20 of 122

1.
Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension
Elizabeth A. Barnes, Reiji Ito, Xibing Che, Cristina M. Alvira, David N. Cornfield
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 1; 325(6): L741–L755. Published online 2023 Oct 17. doi: 10.1152/ajplung.00428.2022
PMCID:
PMC11068430
AbstractArticle
2.
CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa
Nicholas D. Nolan, Xuan Cui, Brian M. Robbings, Aykut Demirkol, Kriti Pandey, Wen-Hsuan Wu, Hannah F. Hu, Laura A. Jenny, Chyuan-Sheng Lin, Daniel T. Hass, Jianhai Du, James B. Hurley, Stephen H. Tsang
Cell Rep Med. 2024 Apr 16; 5(4): 101459. Published online 2024 Mar 21. doi: 10.1016/j.xcrm.2024.101459
PMCID:
PMC11031380
AbstractArticlePDF–6.3M
3.
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
Tao Zhang, Daichao Xu, Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Dongxian Guan, Cong Jiang, Xiaoming Dai, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao, Gyongyi Szabo, Guo-Hua Fong, Antoine E. Karnoub, Yu-Ru Lee, Lifeng Pan, William G. Kaelin, Jr., Junying Yuan, Wenyi Wei
Nat Cell Biol. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Nat Cell Biol. 2023 Jul; 25(7): 950–962. Published online 2023 Jul 3. doi: 10.1038/s41556-023-01170-4
PMCID:
PMC10617019
AbstractArticlePDF–8.3M
4.
Single‐cell RNA‐sequencing analysis reveals enhanced non‐canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury
Xuecheng Qiu, Yaling Guo, Ming‐Feng Liu, Bingge Zhang, Jingzhen Li, Jian‐Feng Wei, Meng Li
CNS Neurosci Ther. 2023 Nov; 29(11): 3446–3459. Published online 2023 Jun 2. doi: 10.1111/cns.14278
PMCID:
PMC10580338
AbstractArticlePDF–9.8M
5.
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents
Yachao He, Ibrahim Kaya, Reza Shariatgorji, Johan Lundkvist, Lars U. Wahlberg, Anna Nilsson, Dejan Mamula, Jan Kehr, Justyna Zareba-Paslawska, Henrik Biverstål, Karima Chergui, Xiaoqun Zhang, Per E. Andren, Per Svenningsson
Nat Commun. 2023; 14: 5804. Published online 2023 Sep 19. doi: 10.1038/s41467-023-41539-5
PMCID:
PMC10509278
AbstractArticlePDF–4.8M
6.
Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct
Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi, Martino L. Morella, Iris Ruf, Doris Brugger, Sophia von der Mark, Ralf Thoma, Arne Rufer, Dominik Heer, Nina Pfahler, Anton Jochner, Jens Niewoehner, Luise Wolf, Matthias Fueth, Martin Ebeling, Roberto Villaseñor, Yanping Zhu, Matthew C. Deen, Xiaoyang Shan, Zahra Ehsaei, Verdon Taylor, Ellen Sidransky, David J. Vocadlo, Per-Ola Freskgård, Ravi Jagasia
Nat Commun. 2023; 14: 2057. Published online 2023 Apr 12. doi: 10.1038/s41467-023-37632-4
PMCID:
PMC10097658
AbstractArticlePDF–3.6M
7.
The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, Jonathan M. Harnoss
JCI Insight. 2022 Nov 22; 7(22): e153337. Published online 2022 Nov 22. doi: 10.1172/jci.insight.153337
PMCID:
PMC9746807
AbstractArticlePDF–4.9M
8.
Treatment of a genetic brain disease by CNS-wide microglia replacement
Yohei Shibuya, Kevin K Kumar, Marius Marc-Daniel Mader, Yongjin Yoo, Luis Angel Ayala, Mu Zhou, Manuel Alexander Mohr, Gernot Neumayer, Ishan Kumar, Ryo Yamamoto, Paul Marcoux, Benjamin Liou, F Chris Bennett, Hiromitsu Nakauchi, Ying Sun, Xiaoke Chen, Frank L. Heppner, Tony Wyss-Coray, Thomas C. Südhof, Marius Wernig
Sci Transl Med. Author manuscript; available in PMC 2022 Oct 30.
Published in final edited form as: Sci Transl Med. 2022 Mar 16; 14(636): eabl9945. Published online 2022 Mar 16. doi: 10.1126/scitranslmed.abl9945
PMCID:
PMC9618306
AbstractArticlePDF–4.1M
9.
Decreased Prosaposin and Progranulin in the Cingulate Cortex Are Associated with Schizophrenia Pathophysiology
Yachao He, Xiaoqun Zhang, Ivana Flais, Per Svenningsson
Int J Mol Sci. 2022 Oct; 23(19): 12056. Published online 2022 Oct 10. doi: 10.3390/ijms231912056
PMCID:
PMC9570388
AbstractArticlePDF–2.4M
10.
Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia
Ann-Helen Rosendahl, Mia Monnius, Anu Laitala, Antti Railo, Ilkka Miinalainen, Ritva Heljasvaara, Joni M. Mäki, Johanna Myllyharju
J Biol Chem. 2022 Apr; 298(4): 101787. Published online 2022 Mar 2. doi: 10.1016/j.jbc.2022.101787
PMCID:
PMC8988008
AbstractArticlePDF–6.1M
11.
Adaptation of the Oxygen Sensing System during Lung Development
Karin M. Kirschner, Simon Kelterborn, Herrmann Stehr, Johanna L. T. Penzlin, Charlotte L. J. Jacobi, Stefanie Endesfelder, Miriam Sieg, Jochen Kruppa, Christof Dame, Lina K. Sciesielski
Oxid Med Cell Longev. 2022; 2022: 9714669. Published online 2022 Feb 18. doi: 10.1155/2022/9714669
PMCID:
PMC8886745
AbstractArticlePDF–2.8M
12.
Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function
Monica Hoang, Emelien Jentz, Sarah M Janssen, Daniela Nasteska, Federica Cuozzo, David J Hodson, A Russell Tupling, Guo-Hua Fong, Jamie W Joseph
Endocrinology. 2022 Jan; 163(1): bqab226. Published online 2021 Oct 28. doi: 10.1210/endocr/bqab226
PMCID:
PMC8643417
AbstractArticle
13.
PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle
Haejin Yoon, Jessica B. Spinelli, Elma Zaganjor, Samantha J. Wong, Natalie J. German, Elizabeth C. Randall, Afsah Dean, Allen Clermont, Joao A. Paulo, Daniel Garcia, Hao Li, Olivia Rombold, Nathalie Y. R. Agar, Laurie J. Goodyear, Reuben J. Shaw, Steven P. Gygi, Johan Auwerx, Marcia C. Haigis
Cell Metab. Author manuscript; available in PMC 2021 Apr 24.
Published in final edited form as: Cell Metab. 2020 Aug 4; 32(2): 215–228.e7. Published online 2020 Jul 13. doi: 10.1016/j.cmet.2020.06.017
PMCID:
PMC8065255
AbstractArticlePDF–1.3M
14.
Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery
George Z. Wei, Sujata Saraswat Ohri, Nicolas K. Khattar, Adam W. Listerman, Catherine H. Doyle, Kariena R. Andres, Saravanan S. Karuppagounder, Rajiv R. Ratan, Scott R. Whittemore, Michal Hetman
PLoS One. 2021; 16(4): e0249591. Published online 2021 Apr 5. doi: 10.1371/journal.pone.0249591
PMCID:
PMC8021188
AbstractArticlePDF–820K
15.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
16.
Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes
Nadiya Byts, Subodh Sharma, Jenny Laurila, Prodeep Paudel, Ilkka Miinalainen, Veli-Pekka Ronkainen, Reetta Hinttala, Kid Törnquist, Peppi Koivunen, Johanna Myllyharju
eNeuro. 2021 Jan-Feb; 8(1): ENEURO.0253-20.2020. Prepublished online 2020 Dec 8. Published online 2021 Jan 5. doi: 10.1523/ENEURO.0253-20.2020
PMCID:
PMC7814479
AbstractArticlePDF–4.9M
17.
Loss of the oxygen sensor PHD3 augments macrophage-mediated systemic inflammatory responses in mice
Judit Kiss, Martin Mollenhauer, Sarah R. Walmsley, Johanna Kirchberg, Praveen Radhakrishnan, Thomas Niemietz, Gunnar Steinert, Moira K.B. Whyte, Peter Carmeliet, Massimiliano Mazzone, Jürgen Weitz, Martin Schneider
J Immunol. Author manuscript; available in PMC 2021 Sep 8.
Published in final edited form as: J Immunol. 2012 Aug 15; 189(4): 1955–65. Published online 2012 Jul 11. doi: 10.4049/jimmunol.1103471
PMCID:
PMC7611627
AbstractArticlePDF–2.5M
18.
Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury
Yongzhen Zhao, Heng Zeng, Bo Liu, Xiaochen He, Jian-Xiong Chen
Am J Physiol Renal Physiol. 2020 Aug 1; 319(2): F345–F357. Published online 2020 Jul 27. doi: 10.1152/ajprenal.00032.2020
PMCID:
PMC7473903
AbstractArticle
19.
Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value
Tina Loeffler, Irene Schilcher, Stefanie Flunkert, Birgit Hutter-Paier
Front Neurosci. 2020; 14: 579. Published online 2020 Jun 11. doi: 10.3389/fnins.2020.00579
PMCID:
PMC7300175
AbstractArticlePDF–577K
20.
Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease
Victoria Schiffer, Estibaliz Santiago-Mujika, Stefanie Flunkert, Staffan Schmidt, Martina Farcher, Tina Loeffler, Irene Schilcher, Maria Posch, Joerg Neddens, Ying Sun, Jan Kehr, Birgit Hutter-Paier
PLoS One. 2020; 15(1): e0227077. Published online 2020 Jan 13. doi: 10.1371/journal.pone.0227077
PMCID:
PMC6957154
AbstractArticlePDF–5.4M

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