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Select item 109586171.

The immunopathological landscape of human pre-TCRα deficiency: from rare to common variants

Marie Materna, Ottavia M. Delmonte, Marita Bosticardo, Mana Momenilandi, Peyton E. Conrey, Bénédicte Charmeteau-De Muylder, Clotilde Bravetti, Rebecca Bellworthy, Axel Cederholm, Frederik Staels, Christian A. Ganoza, Samuel Darko, Samir Sayed, Corentin Le Floc’h, Masato Ogishi, Darawan Rinchai, Andrea Guenoun, Alexandre Bolze, Taushif Khan, Adrian Gervais, Renate Krüger, Mirjam Völler, Boaz Palterer, Mahnaz Sadeghi-Shabestari, Anne Langlois de Septenville, Chaim A. Schramm, Sanjana Shah, John J. Tello-Cajiao, Francesca Pala, Kayla Amini, Jose S. Campos, Noemia Santana Lima, Daniel Eriksson, Romain Lévy, Yoann Seeleuthner, Soma Jyonouchi, Manar Ata, Fatima Al Ali, Caroline Deswarte, Anaïs Pereira, Jérôme Mégre t, Tom Le Voyer, Paul Bastard, Laureline Berteloot, Michaël Dussiot, Natasha Vladikine, Paula P. Cardenas, Emmanuelle Jouanguy, Mashael Alqahtani, Amal Hasan, Thangavel Alphonse Thanaraj, Jérémie Rosain, Fahd Al Qureshah, Vito Sabato, Marie Alexandra Alyanakian, Marianne Leruez-Ville, Flore Rozenberg, Elie Haddad, Jose R. Regueiro, Maria L. Toribio, Judith R. Kelsen, Mansoor Salehi, Shahram Nasiri, Mehdi Torabizadeh, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Nasimeh Vatandoost, Hossein Moravej, Seyed Mohammad Akrami, Mohsen Mazloomrezaei, Aurélie Cobat, Isabelle Meyts, Toyofuku Etsushi, Madoka Nishimura, Kunihiko Moriya, Tomoyuki Mizukami, Kohsuke Imai, Laurent Abel, Bernard Malissen, Fahd Al-Mulla, Fowzan Sami Alkuraya, Nima Parvaneh, Horst von Bernuth, Christian Beetz, Frédéric Davi, Daniel C. Douek, Rémi Cheynier, David Langlais, Nils Landegren, Nico Marr, Tomohiro Morio, Mohammad Shahrooei, Rik Schrijvers, Sarah E. Henrickson, Hervé Luche, Luigi D. Notarangelo, Jean-Laurent Casanova, Vivien Béziat

Science. Author manuscript; available in PMC 2024 Mar 22.

Published in final edited form as: Science. 2024 Mar; 383(6686): eadh4059. Published online 2024 Mar 1. doi: 10.1126/science.adh4059

PMCID:: PMC10958617

Abstract Article PDF–3.7M

Select item 98655432.

Ca²⁺ Homeostasis by Plasma Membrane Ca²⁺ ATPase (PMCA) 1 Is Essential for the Development of DP Thymocytes

David Beckmann, Kristina Langnaese, Anna Gottfried, Johannes Hradsky, Kerry Tedford, Nikhil Tiwari, Ulrich Thomas, Klaus-Dieter Fischer, Mark Korthals

Int J Mol Sci. 2023 Jan; 24(2): 1442. Published online 2023 Jan 11. doi: 10.3390/ijms24021442

PMCID:: PMC9865543

Abstract Article PDF–2.7M

Select item 93793373.

T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation

Clemens Cammann, Nicole Israel, Sarah Frentzel, Andreas Jeron, Eylin Topfstedt, Thomas Schüler, Luca Simeoni, Martin Zenker, Hans Joerg Fehling, Burkhart Schraven, Dunja Bruder, Ulrike Seifert

Front Immunol. 2022; 13: 958616. Published online 2022 Aug 2. doi: 10.3389/fimmu.2022.958616

PMCID:: PMC9379337

Abstract Article PDF–2.4M

Select item 88278044.

Loss of ribosomal protein paralog Rpl22-Like1 blocks lymphoid development without affecting protein synthesis

Shawn P. Fahl, Robert Sertori, Yong Zhang, Alejandra V. Contreras, Bryan Harris, Minshi Wang, Jacqueline Perrigoue, Siddharth Balachandran, Brian K. Kennedy, David L. Wiest

J Immunol. Author manuscript; available in PMC 2023 Feb 15.

Published in final edited form as: J Immunol. 2022 Feb 15; 208(4): 870–880. Published online 2022 Jan 19. doi: 10.4049/jimmunol.2100668

PMCID:: PMC8827804

Abstract Article PDF–1.7M

Select item 79196115.

The E protein-TCF1 axis controls γδ T cell development and effector fate

Shawn P. Fahl, Alejandra V. Contreras, Anjali Verma, Xiang Qiu, Christelle Harly, Freddy Radtke, Juan Carlos Zúñiga-Pflücker, Cornelis Murre, Hai-Hui Xue, Jyoti Misra Sen, David L. Wiest

Cell Rep. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: Cell Rep. 2021 Feb 2; 34(5): 108716. doi: 10.1016/j.celrep.2021.108716

PMCID:: PMC7919611

Abstract Article PDF–2.0M

Select item 64005356.

The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection

Fabian Klein, Mladen Mitrovic, Julien Roux, Corinne Engdahl, Lilly von Muenchow, Llucia Alberti-Servera, Hans Jörg Fehling, Pawel Pelczar, Antonius Rolink, Panagiotis Tsapogas

J Exp Med. 2019 Mar 4; 216(3): 638–655. doi: 10.1084/jem.20181444

PMCID:: PMC6400535

Abstract Article PDF–4.5M

Select item 45197847.

Identification of a novel lymphoid population in the murine epidermis

Francisca F. Almeida, Mari Tenno, Joanna Brzostek, Jackson LiangYao Li, Gabriele Allies, Guillaume Hoeffel, Peter See, Lai Guan Ng, Hans Jörg Fehling, Nicholas R. J. Gascoigne, Ichiro Taniuchi, Florent Ginhoux

Sci Rep. 2015; 5: 12554. Published online 2015 Jul 30. doi: 10.1038/srep12554

PMCID:: PMC4519784

Abstract Article PDF–2.8M

Select item 42736518.

Non-canonical mode of ERK action controls alternative αβ and γδ T lineage fates

Sang-Yun Lee, Francis Coffey, Shawn P. Fahl, Suraj Peri, Michele Rhodes, Kathy Q. Cai, Michael Carleton, Stephen M Hedrick, Hans Joerg Fehling, Juan Carlos Zúñiga-Pflücker, Dietmar J Kappes, David L. Wiest

Immunity. Author manuscript; available in PMC 2015 Dec 18.

Published in final edited form as: Immunity. 2014 Dec 18; 41(6): 934–946. Published online 2014 Nov 28. doi: 10.1016/j.immuni.2014.10.021

PMCID:: PMC4273651

Abstract Article PDF–1.2M

Select item 36203549.

In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis

Hervé Luche, Tata Nageswara Rao, Suresh Kumar, Alpaslan Tasdogan, Franziska Beckel, Carmen Blum, Vera C. Martins, Hans-Reimer Rodewald, Hans Jörg Fehling

J Exp Med. 2013 Apr 8; 210(4): 699–714. doi: 10.1084/jem.20122609

PMCID:: PMC3620354

Abstract Article PDF–4.3M

Select item 357956610.

Lunatic Fringe Enhances Competition for Delta-Like Notch Ligands but Does Not Overcome Defective Pre-TCR Signaling during Thymocyte β-Selection In Vivo

Ioana Visan, Julie S. Yuan, Ying Liu, Pamela Stanley, Cynthia J. Guidos

J Immunol. Author manuscript; available in PMC 2013 Feb 22.

Published in final edited form as: J Immunol. 2010 Oct 15; 185(8): 4609–4617. Published online 2010 Sep 15. doi: 10.4049/jimmunol.1002008

PMCID:: PMC3579566

Abstract Article PDF–3.4M

Select item 347540911.

Signal initiation by preTCR and TCRγδ in early thymocyte progenitors does not require extracellular domains previously implicated in receptor oligomerization

Juliet Mahtani-Patching, Joana F. Neves, Dick John Pang, Kostadin V. Stoenchev, Ana M. Aguirre-Blanco, Bruno Silva-Santos, Daniel J. Pennington

Sci Signal. Author manuscript; available in PMC 2012 Oct 18.

Published in final edited form as: Sci Signal. 2011 Jul 19; 4(182): ra47. Published online 2011 Jul 19. doi: 10.1126/scisignal.2001765

PMCID:: PMC3475409

Abstract Article PDF–1.1M

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 313147113.

Developmental arrest of T cells in RpL22-deficient mice is dependent upon multiple p53 effectors

Jason E. Stadanlick, Zhiqiang Zhang, Sang-Yun Lee, Mike Hemann, Matthew Biery, Michael O. Carleton, Gerard P. Zambetti, Stephen J. Anderson, Tamas Oravecz, David L. Wiest

J Immunol. Author manuscript; available in PMC 2012 Jul 15.

Published in final edited form as: J Immunol. 2011 Jul 15; 187(2): 664–675. Published online 2011 Jun 20. doi: 10.4049/jimmunol.1100029

PMCID:: PMC3131471

Abstract Article PDF–4.9M

Select item 310860914.

The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Essential for V-DJβ Rearrangement

Karen S. Hathcock, Lila Farrington, Irina Ivanova, Ferenc Livak, Roza Selimyan, Ranjan Sen, Joy Williams, Xuguang Tai, Richard J. Hodes

PLoS One. 2011; 6(6): e20639. Published online 2011 Jun 3. doi: 10.1371/journal.pone.0020639

PMCID:: PMC3108609

Abstract Article PDF–885K

Select item 302253415.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 299333716.

Germ-line elimination of electric charge on pre–T-cell receptor (TCR) impairs autonomous signaling for β-selection and TCR repertoire formation

Eri Ishikawa, Yasunobu Miyake, Hiromitsu Hara, Takashi Saito, Sho Yamasaki

Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46): 19979–19984. Published online 2010 Oct 13. doi: 10.1073/pnas.1011228107

PMCID:: PMC2993337

Abstract Article PDF–1015K

Select item 255627017.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 221330718.

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development

Christine Borowski, Xiaoyan Li, Iannis Aifantis, Fotini Gounari, Harald von Boehmer

J Exp Med. 2004 Mar 1; 199(5): 607–615. doi: 10.1084/jem.20031973

PMCID:: PMC2213307

Abstract Article PDF–283K

Select item 221306319.

The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival

Malay Mandal, Christine Borowski, Teresa Palomero, Adolfo A. Ferrando, Philipp Oberdoerffer, Fanyong Meng, Antonio Ruiz-Vela, Maria Ciofani, Juan-Carlos Zuniga-Pflucker, Isabella Screpanti, A. Thomas Look, Stanley J. Korsmeyer, Klaus Rajewsky, Harald von Boehmer, Iannis Aifantis

J Exp Med. 2005 Feb 21; 201(4): 603–614. doi: 10.1084/jem.20041924

PMCID:: PMC2213063

Abstract Article PDF–2.5M

Select item 221281720.

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation

Batu Erman, Terry I. Guinter, Alfred Singer

J Exp Med. 2004 Jun 21; 199(12): 1719–1724. doi: 10.1084/jem.20032204

PMCID:: PMC2212817

Abstract Article PDF–146K

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