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Select item 112692021.

CryoET of β-amyloid and tau within postmortem Alzheimer’s disease brain

Madeleine A. G. Gilbert, Nayab Fatima, Joshua Jenkins, Thomas J. O’Sullivan, Andreas Schertel, Yehuda Halfon, Martin Wilkinson, Tjado H. J. Morrema, Mirjam Geibel, Randy J. Read, Neil A. Ranson, Sheena E. Radford, Jeroen J. M. Hoozemans, René A. W. Frank

Nature. 2024; 631(8022): 913–919. Published online 2024 Jul 10. doi: 10.1038/s41586-024-07680-x

PMCID:: PMC11269202

Abstract Article PDF–24M

Select item 111828452.

Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease

Zachary Hoglund, Nancy Ruiz-Uribe, Eric del Sastre, Benjamin Woost, Elizabeth Bader, Joshua Bailey, Bradley T. Hyman, Theodore Zwang, Rachel E. Bennett

Acta Neuropathol. 2024; 147(1): 101. Published online 2024 Jun 17. doi: 10.1007/s00401-024-02751-9

PMCID:: PMC11182845

Abstract Article PDF–8.1M

Select item 111677983.

Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold

Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D. Caro, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, Carlo Condello

Acta Neuropathol Commun. 2024; 12: 94. Published online 2024 Jun 12. doi: 10.1186/s40478-024-01806-y

PMCID:: PMC11167798

Abstract Article PDF–2.9M

Select item 111491984.

Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau

C. F. de Veij Mestdagh, M. E. Witte, W. Scheper, A. B. Smit, R. H. Henning, R. E. van Kesteren

Acta Neuropathol Commun. 2024; 12: 86. Published online 2024 Jun 4. doi: 10.1186/s40478-024-01800-4

PMCID:: PMC11149198

Abstract Article PDF–4.3M

Select item 111460735.

Microtubule associated protein tau binds to double-stranded but not single-stranded DNA

Q. Hua, R.-Q. He, N. Haque, M.-H. Qu, A. del Carmen Alonso, I. Grundke-Iqbal, K. Iqbal

Cell Mol Life Sci. 2003 Feb; 60(2): 413–421. doi: 10.1007/s000180300034

PMCID:: PMC11146073

Abstract Article PDF–358K

Select item 111158926.

d-Ribosylated Tau forms globular aggregates with high cytotoxicity

Lan Chen, Yan Wei, Xueqing Wang, Rongqiao He

Cell Mol Life Sci. 2009 Aug; 66(15): 2559–2571. Published online 2009 Jun 11. doi: 10.1007/s00018-009-0058-7

PMCID:: PMC11115892

Abstract Article PDF–686K

Select item 111138087.

Transport and diffusion of Tau protein in neurons

Tim Scholz, Eckhard Mandelkow

Cell Mol Life Sci. 2014 Aug; 71(16): 3139–3150. Published online 2014 Apr 1. doi: 10.1007/s00018-014-1610-7

PMCID:: PMC11113808

Abstract Article PDF–988K

Select item 111085338.

Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity

Yunpeng Huang, Zhihao Wu, Bing Zhou

Cell Mol Life Sci. 2016 Jan; 73(1): 1–21. Published online 2015 Sep 24. doi: 10.1007/s00018-015-2042-8

PMCID:: PMC11108533

Abstract Article PDF–1.0M

Select item 111049119.

Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model

Guru Krishnakumar Viswanathan, Dana Shwartz, Yelena Losev, Elad Arad, Chen Shemesh, Edward Pichinuk, Hamutal Engel, Avi Raveh, Raz Jelinek, Itzik Cooper, Fabien Gosselet, Ehud Gazit, Daniel Segal

Cell Mol Life Sci. 2020 Jul; 77(14): 2795–2813. Published online 2019 Sep 27. doi: 10.1007/s00018-019-03312-0

PMCID:: PMC11104911

Abstract Article PDF–2.7M

Select item 1109633010.

G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults

Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett

Commun Biol. 2024; 7: 569. Published online 2024 May 15. doi: 10.1038/s42003-024-06272-9

PMCID:: PMC11096330

Abstract Article PDF–1.1M

Select item 1109324611.

Cognitive phenotype and neurodegeneration associated with Tau in Huntington's disease

Saul Martinez‐Horta, Jesús Perez‐Perez, Rocío Perez‐Gonzalez, Frederic Sampedro, Andrea Horta‐Barba, Antonia Campolongo, Elisa Rivas‐Asensio, Arnau Puig‐Davi, Javier Pagonabarraga, Jaime Kulisevsky

Ann Clin Transl Neurol. 2024 May; 11(5): 1160–1171. Published online 2024 Mar 27. doi: 10.1002/acn3.52031

PMCID:: PMC11093246

Abstract Article PDF–1.4M

Select item 1107343712.

The structure and phase of tau: from monomer to amyloid filament

Yifan Zeng, Jing Yang, Bailing Zhang, Meng Gao, Zhengding Su, Yongqi Huang

Cell Mol Life Sci. 2021 Mar; 78(5): 1873–1886. Published online 2020 Oct 19. doi: 10.1007/s00018-020-03681-x

PMCID:: PMC11073437

Abstract Article PDF–992K

Select item 1107287513.

Differential effects of putative N-glycosylation sites in human Tau on Alzheimer’s disease-related neurodegeneration

Yelena Losev, Moran Frenkel-Pinter, Malak Abu-Hussien, Guru Krishnakumar Viswanathan, Donna Elyashiv-Revivo, Rana Geries, Isam Khalaila, Ehud Gazit, Daniel Segal

Cell Mol Life Sci. 2021 Mar; 78(5): 2231–2245. Published online 2020 Sep 14. doi: 10.1007/s00018-020-03643-3

PMCID:: PMC11072875

Abstract Article PDF–3.2M

Select item 1107250614.

FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin

Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E. Williams, Yao-ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yong

Cell Mol Life Sci. 2022 Mar; 79(3): 175. Published online 2022 Mar 4. doi: 10.1007/s00018-022-04167-8

PMCID:: PMC11072506

Abstract Article PDF–8.7M

Select item 1106123115.

Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway

Dina W. Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D. Allen, Mathew Sajish, Taras Y. Nazarko, Angela M. Mabb

J Biol Chem. 2024 May; 300(5): 107237. Published online 2024 Mar 27. doi: 10.1016/j.jbc.2024.107237

PMCID:: PMC11061231

Abstract Article PDF–4.4M

Select item 1104301816.

DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau

Sanming Li, Ethan R. Roy, Yanyu Wang, Trent Watkins, Wei Cao

Mol Neurobiol. 2024; 61(5): 2978–2995. Published online 2023 Nov 13. doi: 10.1007/s12035-023-03720-1

PMCID:: PMC11043018

Abstract Article PDF–13M

Select item 1103257817.

Speech patterns during memory recall relates to early tau burden across adulthood

Christina B. Young, Viktorija Smith, Cody Karjadi, Selah‐Marie Grogan, Ting Fang Alvin Ang, Philip S. Insel, Victor W. Henderson, Meghan Sumner, Kathleen L. Poston, Rhoda Au, Elizabeth C. Mormino

Alzheimers Dement. 2024 Apr; 20(4): 2552–2563. Published online 2024 Feb 13. doi: 10.1002/alz.13731

PMCID:: PMC11032578

Abstract Article PDF–19M

Select item 1103252718.

Tau accumulation and atrophy predict amyloid independent cognitive decline in aging

Corrina S. Fonseca, Suzanne L. Baker, Lindsey Dobyns, Mustafa Janabi, William J. Jagust, Theresa M. Harrison

Alzheimers Dement. 2024 Apr; 20(4): 2526–2537. Published online 2024 Feb 9. doi: 10.1002/alz.13654

PMCID:: PMC11032527

Abstract Article PDF–3.2M

Select item 1100393619.

Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1β and BDNF

Shuxia Zhang, Yeru Chen, Yongjie Wang, Hongwei Wang, Dandan Yao, Gang Chen

Neurosci Bull. 2024 Apr; 40(4): 466–482. Published online 2023 Dec 26. doi: 10.1007/s12264-023-01152-4

PMCID:: PMC11003936

Abstract Article PDF–16M

Select item 1095335320.

Identification of phosphorylated tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission

Rowan A. W. Radford, Stephanie L. Rayner, Paulina Szwaja, Marco Morsch, Flora Cheng, Tianyi Zhu, Jocelyn Widagdo, Victor Anggono, Dean L. Pountney, Roger Chung, Albert Lee

J Neurochem. 2023 May; 165(4): 563–586. Published online 2023 Mar 21. doi: 10.1111/jnc.15796