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Items: 1 to 20 of 262

1.
Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse
Kevin J. Bielamowicz, Mary Beth Littrell, Gregory W. Albert, Lora S. Parker, Sateesh Jayappa, Kenneth Aldape, Murat Gokden
J Neurooncol. 2024; 168(2): 367–373. Published online 2024 Apr 19. doi: 10.1007/s11060-024-04667-6
PMCID:
PMC11147842
AbstractArticlePDF–1.2M
2.
Interaction network of human early embryonic transcription factors
Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo
EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0
PMCID:
PMC10933267
AbstractArticlePDF–2.9M
3.
The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer
Chandra Sekhar Amara, Karthik Reddy Kami Reddy, Yang Yuntao, Yuen San Chan, Danthasinghe Waduge Badrajee Piyarathna, Lacey Elizabeth Dobrolecki, David J. H. Shih, Zhongcheng Shi, Jun Xu, Shixia Huang, Matthew J. Ellis, Andrea B. Apolo, Leomar Y. Ballester, Jianjun Gao, Donna E. Hansel, Yair Lotan, H. Courtney Hodges, Seth P. Lerner, Chad J. Creighton, Arun Sreekumar, W. Jim Zheng, Pavlos Msaouel, Shyam M. Kavuri, Nagireddy Putluri
Nat Commun. 2024; 15: 1373. Published online 2024 Feb 14. doi: 10.1038/s41467-024-45132-2
PMCID:
PMC10867091
AbstractArticlePDF–2.8M
4.
SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors
Ning Qing Liu, Irene Paassen, Lars Custers, Peter Zeller, Hans Teunissen, Dilara Ayyildiz, Jiayou He, Juliane Laura Buhl, Eelco Wieger Hoving, Alexander van Oudenaarden, Elzo de Wit, Jarno Drost
Nat Commun. 2023; 14: 7762. Published online 2023 Dec 1. doi: 10.1038/s41467-023-43498-3
PMCID:
PMC10692191
AbstractArticlePDF–7.9M
5.
Recent insights into the SWI/SNF complex and the molecular mechanism of hSNF5 deficiency in rhabdoid tumors
Yasumichi Kuwahara, Tomoko Iehara, Akifumi Matsumoto, Tsukasa Okuda
Cancer Med. 2023 Aug; 12(15): 16323–16336. Published online 2023 Jun 14. doi: 10.1002/cam4.6255
PMCID:
PMC10469780
AbstractArticlePDF–7.4M
6.
SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance
Bujamin H. Vokshi, Guillaume Davidson, Nassim Tawanaie Pour Sedehi, Alexandra Helleux, Marc Rippinger, Alexandre R. Haller, Justine Gantzer, Jonathan Thouvenin, Philippe Baltzinger, Rachida Bouarich, Valeria Manriquez, Sakina Zaidi, Priya Rao, Pavlos Msaouel, Xiaoping Su, Hervé Lang, Thibault Tricard, Véronique Lindner, Didier Surdez, Jean-Emmanuel Kurtz, Franck Bourdeaut, Nizar M. Tannir, Irwin Davidson, Gabriel G. Malouf
Nat Commun. 2023; 14: 3034. Published online 2023 May 26. doi: 10.1038/s41467-023-38472-y
PMCID:
PMC10220073
AbstractArticlePDF–11M
7.
SMARCB1 regulates the hypoxic stress response in sickle cell trait
Melinda Soeung, Luigi Perelli, Ziheng Chen, Eleonora Dondossola, I-Lin Ho, Federica Carbone, Li Zhang, Hania Khan, Courtney N. Le, Cihui Zhu, Michael D. Peoples, Ningping Feng, Shan Jiang, Niki Millward Zacharias, Rosalba Minelli, Daniel D. Shapiro, Angela K. Deem, Sisi Gao, Emily H. Cheng, Donatella Lucchetti, Cheryl L. Walker, Alessandro Carugo, Virginia Giuliani, Timothy P. Heffernan, Andrea Viale, Nizar M. Tannir, Giulio F. Draetta, Pavlos Msaouel, Giannicola Genovese
Proc Natl Acad Sci U S A. 2023 May 23; 120(21): e2209639120. Published online 2023 May 15. doi: 10.1073/pnas.2209639120
PMCID:
PMC10214195
AbstractArticlePDF–4.4M
8.
SMARCB1 Loss in Poorly Differentiated Chordomas Drives Tumor Progression
Tara A. Walhart, Bryanna Vacca, Austin J. Hepperla, Samera H. Hamad, James Petrongelli, Yemin Wang, Erin L. McKean, Michelle Moksa, Qi Cao, Stephen Yip, Martin Hirst, Bernard E. Weissman
Am J Pathol. 2023 Apr; 193(4): 456–473. doi: 10.1016/j.ajpath.2022.12.012
PMCID:
PMC10123523
AbstractArticlePDF–2.4M
9.
Fibril treatment changes protein interactions of tau and α-synuclein in human neurons
Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson
J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888
PMCID:
PMC9978635
AbstractArticlePDF–10M
10.
Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2
Xinxin Wang, Zhiyuan Wen, Huizhen Cao, Jie Luo, Lei Shuai, Chong Wang, Jinying Ge, Xijun Wang, Zhigao Bu, Jinliang Wang
J Virol. 2023 Feb; 97(2): e01611-22. Published online 2023 Feb 13. doi: 10.1128/jvi.01611-22
PMCID:
PMC9972945
AbstractArticlePDF–3.0M
11.
FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia
Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen
J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0
PMCID:
PMC9922468
AbstractArticlePDF–4.9M
12.
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke
Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188
PMCID:
PMC9881136
AbstractArticlePDF–4.4M
13.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation
Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang
Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005
PMCID:
PMC9772558
AbstractArticlePDF–8.2M
14.
The genetic landscape of SMARCB1 alterations in SMARCB1-deficient spectrum of mesenchymal neoplasms
Josephine K. Dermawan, Samuel Singer, William D. Tap, Benjamin A. Nacev, Ping Chi, Leonard H. Wexler, Michael V. Ortiz, Mrinal Gounder, Cristina R. Antonescu
Mod Pathol. Author manuscript; available in PMC 2023 Dec 1.
Published in final edited form as: Mod Pathol. 2022 Dec; 35(12): 1900–1909. Published online 2022 Sep 10. doi: 10.1038/s41379-022-01148-x
PMCID:
PMC9712236
AbstractArticlePDF–836K
15.
EZH2 non-canonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
Jun Wang, Xufen Yu, Weida Gong, Xijuan Liu, Kwang-Su Park, Anqi Ma, Yi-Hsuan Tsai, Yudao Shen, Takashi Onikubo, Wen-Chieh Pi, David F. Allison, Jing Liu, Wei-Yi Chen, Ling Cai, Robert G. Roeder, Jian Jin, Gang Greg Wang
Nat Cell Biol. Author manuscript; available in PMC 2022 Nov 30.
Published in final edited form as: Nat Cell Biol. 2022 Mar; 24(3): 384–399. Published online 2022 Feb 24. doi: 10.1038/s41556-022-00850-x
PMCID:
PMC9710513
AbstractArticlePDF–7.9M
16.
Molecular and immunophenotypic characterization of SMARCB1 (INI1) - deficient intrathoracic Neoplasms
Martina Haberecker, Marco Matteo Bühler, Alicia Pliego Mendieta, Roman Guggenberger, Fabian Arnold, Eva Markert, Markus Rechsteiner, Martin Zoche, Christian Britschgi, Chantal Pauli
Mod Pathol. 2022; 35(12): 1860–1869. Published online 2022 Jul 21. doi: 10.1038/s41379-022-01133-4
PMCID:
PMC9708576
AbstractArticlePDF–2.8M
17.
Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression
Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng
Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651
PMCID:
PMC9629121
AbstractArticlePDF–8.1M
18.
The in vivo Interaction Landscape of Histones H3.1 and H3.3
Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins
Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411
PMCID:
PMC9540345
AbstractArticlePDF–3.9M
19.
NSD1 mediates antagonism between SWI/SNF and Polycomb complexes and is required for transcriptional activation upon EZH2 inhibition
Yiannis Drosos, Jacquelyn A. Myers, Beisi Xu, Kaeli M. Mathias, Emma C. Beane, Sandi Radko-Juettner, Robert J. Mobley, Margaret E. Larsen, Federica Piccioni, Xiaotu Ma, Jonathan Low, Baranda S. Hansen, Samuel T. Peters, Natarajan V. Bhanu, Sandeep K. Dhanda, Taosheng Chen, Santhosh A. Upadhyaya, Shondra M. Pruett-Miller, David E. Root, Benjamin A. Garcia, Janet F. Partridge, Charles W.M. Roberts
Mol Cell. Author manuscript; available in PMC 2023 Jul 7.
Published in final edited form as: Mol Cell. 2022 Jul 7; 82(13): 2472–2489.e8. Published online 2022 May 9. doi: 10.1016/j.molcel.2022.04.015
PMCID:
PMC9520607
AbstractArticlePDF–2.9M
20.
FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Hua Jiang, Weixiang Bian, Yue Sui, Huanle Li, Han Zhao, Wenqi Wang, Xu Li
Sci Adv. 2022 Sep; 8(38): eabq4831. Published online 2022 Sep 21. doi: 10.1126/sciadv.abq4831
PMCID:
PMC9491713
AbstractArticlePDF–12M

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