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Select item 112510821.

Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis

Aaron L Moye, Antonella FM Dost, Robert Ietswaart, Shreoshi Sengupta, VanNashlee Ya, Chrystal Aluya, Caroline G Fahey, Sharon M Louie, Margherita Paschini, Carla F Kim

EMBO J. 2024 Jul; 43(14): 2843–2861. Published online 2024 May 16. doi: 10.1038/s44318-024-00113-5

PMCID:: PMC11251082

Abstract Article PDF–4.3M

Select item 112455432.

Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer

Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M. Ghergurovich, Xiaoyang Su, Joshua D. Rabinowitz, Eileen White, Jessie Yanxiang Guo

Nat Commun. 2024; 15: 5857. Published online 2024 Jul 12. doi: 10.1038/s41467-024-50157-8

PMCID:: PMC11245543

Abstract Article PDF–3.3M

Select item 112168953.

CRACD Loss Induces Neuroendocrine Cell Plasticity of Lung Adenocarcinoma

Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Youn-Sang Jung, Jinho Jang, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Kwon-Sik Park, Jae-Il Park

Cell Rep. Author manuscript; available in PMC 2024 Jul 2.

Published in final edited form as: Cell Rep. 2024 Jun 25; 43(6): 114286. Published online 2024 May 25. doi: 10.1016/j.celrep.2024.114286

PMCID:: PMC11216895

Abstract Article PDF–2.9M

Select item 111940144.

The Janus kinase 1 is critical for pancreatic cancer initiation and progression

Hridaya Shrestha, Patrick D. Rädler, Rayane Dennaoui, Madison N. Wicker, Nirakar Rajbhandari, Yunguang Sun, Amy R. Peck, Kerry Vistisen, Aleata A. Triplett, Rafic Beydoun, Esta Sterneck, Dieter Saur, Hallgeir Rui, Kay-Uwe Wagner

Cell Rep. Author manuscript; available in PMC 2024 Jun 23.

Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114202. Published online 2024 May 10. doi: 10.1016/j.celrep.2024.114202

PMCID:: PMC11194014

Abstract Article PDF–3.3M

Select item 111903445.

Developmental effect of RASopathy mutations on neuronal network activity on a chip

Eva-Maria Weiss, Debarpan Guhathakurta, Aneta Petrušková, Verena Hundrup, Martin Zenker, Anna Fejtová

Front Cell Neurosci. 2024; 18: 1388409. Published online 2024 Jun 7. doi: 10.3389/fncel.2024.1388409

PMCID:: PMC11190344

Abstract Article PDF–2.2M

Select item 111899276.

In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer

Sebastien Martinez, Shifei Wu, Michael Geuenich, Ahmad Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N. Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G. Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran Campbell, Ulrich Elling, Daniel Schramek

Nat Commun. 2024; 15: 5266. Published online 2024 Jun 20. doi: 10.1038/s41467-024-49450-3

PMCID:: PMC11189927

Abstract Article PDF–2.3M

Select item 111899117.

Differential extracellular vesicle concentration and their biomarker expression of integrin α_v/β₅, EpCAM, and glypican-1 in pancreatic cancer models

Reed Jacobson, Sangdeuk Ha, Sakurako Tani, Shrinwanti Ghosh, Yagna P. R. Jarajapu, Randall E. Brand, Jiha Kim, Yongki Choi

Sci Rep. 2024; 14: 14273. Published online 2024 Jun 20. doi: 10.1038/s41598-024-65209-8

PMCID:: PMC11189911

Abstract Article PDF–1.2M

Select item 111765778.

Trefoil factor 1 suppresses stemness and enhances chemosensitivity of pancreatic cancer

Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Shunsuke Oishi, Masaki Sunagawa, Takashi Mizuno, Shunsuke Onoe, Nobuyuki Watanabe, Atsushi Ogura, Tomoki Ebata

Cancer Med. 2024 Jun; 13(11): e7395. Published online 2024 Jun 13. doi: 10.1002/cam4.7395

PMCID:: PMC11176577

Abstract Article PDF–17M

Select item 111597859.

K‐ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment

Soukaina Réjiba, Séverine Wack, Marc Aprahamian, Amor Hajri

Cancer Sci. 2007 Jul; 98(7): 1128–1136. Published online 2007 May 8. doi: 10.1111/j.1349-7006.2007.00506.x

PMCID:: PMC11159785

Abstract Article PDF–371K

Select item 1113989310.

Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression

Jong Ho Park, Mahsa Mortaja, Heehwa G. Son, Xutu Zhao, Lauren M. Sloat, Marjan Azin, Jun Wang, Michael R. Collier, Krishna S. Tummala, Anna Mandinova, Nabeel Bardeesy, Yevgeniy R. Semenov, Mari Mino-Kenudson, Shadmehr Demehri

Nat Commun. 2024; 15: 4099. Published online 2024 May 30. doi: 10.1038/s41467-024-48441-8

PMCID:: PMC11139893

Abstract Article PDF–2.6M

Select item 1113612811.

Retinoblastoma family proteins: insights gained through genetic manipulation of mice

K. A. Wikenheiser-Brokamp

Cell Mol Life Sci. 2006 Apr; 63(7-8): 767–780. Published online 2006 Feb 7. doi: 10.1007/s00018-005-5487-3

PMCID:: PMC11136128

Abstract Article PDF–227K

Select item 1110521812.

A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development

Amit Shrestha, Gianni Carraro, Nicolas Nottet, Ana Ivonne Vazquez-Armendariz, Susanne Herold, Julio Cordero, Indrabahadur Singh, Jochen Wilhelm, Guillermo Barreto, Rory Morty, Elie El Agha, Bernard Mari, Chengshui Chen, Jin-San Zhang, Cho-Ming Chao, Saverio Bellusci

Cell Mol Life Sci. 2019 Jul; 76(14): 2817–2832. Published online 2019 Mar 18. doi: 10.1007/s00018-019-03067-8

PMCID:: PMC11105218

Abstract Article PDF–20M

Select item 1108375813.

Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases

Geou-Yarh Liou, Crystal J. Byrd, Peter Storz, Justin K. Messex

Int J Mol Sci. 2024 May; 25(9): 4726. Published online 2024 Apr 26. doi: 10.3390/ijms25094726

PMCID:: PMC11083758

Abstract Article PDF–3.8M

Select item 1104057114.

Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis

Yoonkyung Won, Bogun Jang, Su-Hyung Lee, Michelle L. Reyzer, Kimberly S. Presentation, Hyesung Kim, Brianna Caldwell, Changqing Zhang, Hye Seung Lee, Cheol Lee, Vincent Q. Trinh, Marcus C. B. Tan, Kwangho Kim, Richard M. Caprioli, Eunyoung Choi

Gastroenterology. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Gastroenterology. 2024 May; 166(5): 772–786.e14. Published online 2024 Jan 24. doi: 10.1053/j.gastro.2024.01.027

PMCID:: PMC11040571

Abstract Article PDF–2.3M

Select item 1103967115.

Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis

Mark B. Wiley, Jessica Bauer, Valentina Alvarez, Kunaal Mehrotra, Wenxuan Cheng, Zoe Kolics, Michael Giarrizzo, Komala Ingle, Agnieszka B. Bialkowska, Barbara Jung

Sci Rep. 2024; 14: 9382. Published online 2024 Apr 23. doi: 10.1038/s41598-024-60065-y

PMCID:: PMC11039671

Abstract Article PDF–8.4M

Select item 1098875016.

Oncogenic K‐Ras^G12V cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts

Mai Ito, Nobuhiro Tanuma, Yui Kotani, Kokoro Murai, Ayumi Kondo, Mami Sumiyoshi, Hiroshi Shima, Satoshi Matsuda, Toshio Watanabe

FEBS Open Bio. 2024 Apr; 14(4): 545–554. Published online 2024 Feb 6. doi: 10.1002/2211-5463.13775

PMCID:: PMC10988750

Abstract Article PDF–1.1M

Select item 1098304017.

PRMT1 promotes pancreatic cancer development and resistance to chemotherapy

Bomin Ku, David Eisenbarth, Seonguk Baek, Tae-Keun Jeong, Ju-Gyeong Kang, Daehee Hwang, Myung-Giun Noh, Chan Choi, Sungwoo Choi, Taejun Seol, Hail Kim, Yun-Hee Kim, Sang Myung Woo, Sun-Young Kong, Dae-Sik Lim

Cell Rep Med. 2024 Mar 19; 5(3): 101461. Published online 2024 Mar 8. doi: 10.1016/j.xcrm.2024.101461

PMCID:: PMC10983040

Abstract Article PDF–8.3M

Select item 1097771918.

p53 dosage can impede Kras^G12D- and Kras^Q61R-mediated tumorigenesis

Özgün Le Roux, Jeffery I. Everitt, Christopher M. Counter

PLoS One. 2024; 19(3): e0292189. Published online 2024 Mar 28. doi: 10.1371/journal.pone.0292189

PMCID:: PMC10977719

Abstract Article PDF–1.0M

Select item 1096677419.

CDKN2A-p16 Deletion and Activated KRAS^G12D Drive Barrett’s-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer Lesions

Jing Sun, Jorge L. Sepulveda, Elena V. Komissarova, Caitlin Hills, Tyler D. Seckar, Narine M. LeFevre, Hayk Simonyan, Colin Young, Gloria Su, Armando Del Portillo, Timothy C. Wang, Antonia R. Sepulveda

Cell Mol Gastroenterol Hepatol. 2024; 17(5): 769–784. Published online 2024 Jan 29. doi: 10.1016/j.jcmgh.2024.01.014

PMCID:: PMC10966774

Abstract Article PDF–5.6M

Select item 1094065020.

Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras^G12D-driven tumors

Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna

EMBO Mol Med. 2024 Mar; 16(3): 475–505. Published online 2024 Feb 15. doi: 10.1038/s44321-024-00032-2