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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 95464332.

Functional characterization of the schizophrenia associated gene AS3MT identifies a role in neuronal development

Sam J. Washer, Robert Flynn, Asami Oguro‐Ando, Eilis Hannon, Joe Burrage, Aaron Jeffries, Jonathan Mill, Emma L. Dempster

Am J Med Genet B Neuropsychiatr Genet. 2022 Jul; 189(5): 151–162. Published online 2022 Jun 19. doi: 10.1002/ajmg.b.32905

PMCID:: PMC9546433

Abstract Article PDF–4.4M

Select item 91052353.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 88827204.

AS3MT facilitates NLRP3 inflammasome activation by m⁶A modification during arsenic-induced hepatic insulin resistance

Tianming Qiu, Chenbing Wu, Xiaofeng Yao, Qiuyue Han, Ningning Wang, Weizhuo Yuan, Jingyuan Zhang, Yan Shi, Liping Jiang, Xiaofang Liu, Guang Yang, Xiance Sun

Cell Biol Toxicol. 2022 Feb 28 : 1–17. doi: 10.1007/s10565-022-09703-7 [Epub ahead of print]

PMCID:: PMC8882720

Abstract Article PDF–8.5M

Select item 86261355.

Association between the polymorphism of three genes involved in the methylation and efflux of arsenic (As3MT, MRP1 and P-gp) with lung cancer in a Mexican cohort

Rogelio Recio-Vega, Sandra Hernandez-Gonzalez, Gladis Michel-Ramirez, Edgar Olivas-Calderón, R. Clark Lantz, A. Jay Gandolfi

J Appl Toxicol. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: J Appl Toxicol. 2021 Sep; 41(9): 1357–1366. Published online 2020 Dec 19. doi: 10.1002/jat.4127

PMCID:: PMC8626135

Abstract Article PDF–367K

Select item 83812886.

The VNTR of the AS3MT gene is associated with brain activations during a memory span task and their training-induced plasticity

Wan Zhao, Qiumei Zhang, Xiongying Chen, Yang Li, Xiaohong Li, Boqi Du, Xiaoxiang Deng, Feng Ji, Chuanyue Wang, Yu-Tao Xiang, Qi Dong, Chuansheng Chen, Jun Li

Psychol Med. 2021 Aug; 51(11): 1927–1932. Published online 2020 Apr 20. doi: 10.1017/S0033291720000720

PMCID:: PMC8381288

Abstract Article PDF–252K

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78250938.

A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MT^d2d3 and Mushroom Dendritic Spine Density

Xin Cai, Zhi-Hui Yang, Hui-Juan Li, Xiao Xiao, Ming Li, Hong Chang

Schizophr Bull. 2021 Jan; 47(1): 219–227. Published online 2020 Jul 14. doi: 10.1093/schbul/sbaa098

PMCID:: PMC7825093

Abstract Article PDF–845K

Select item 77590059.

Predicted AS3MT Proteins Methylate Arsenic and Support Two Major Phylogenetic AS3MT Groups

Jesper Torbøl Pedersen, Jessica De Loma, Michael Levi, Michael Palmgren, Karin Broberg

Chem Res Toxicol. 2020 Dec 21; 33(12): 3041–3047. Published online 2020 Nov 6. doi: 10.1021/acs.chemrestox.0c00375

PMCID:: PMC7759005

Abstract Article PDF–2.5M

Select item 756398910.

Arsenic Methyltransferase and Methylation of Inorganic Arsenic

Nirmal K. Roy, Anthony Murphy, Max Costa

Biomolecules. 2020 Sep; 10(9): 1351. Published online 2020 Sep 22. doi: 10.3390/biom10091351

PMCID:: PMC7563989

Abstract Article PDF–734K

Select item 753133111.

Genetic Determinants of Reduced Arsenic Metabolism Efficiency in the 10q24.32 Region Are Associated With Reduced AS3MT Expression in Multiple Human Tissue Types

Meytal Chernoff, Lin Tong, Kathryn Demanelis, Donald Vander Griend, Habib Ahsan, Brandon L Pierce

Toxicol Sci. 2020 Aug; 176(2): 382–395. Published online 2020 May 20. doi: 10.1093/toxsci/kfaa075

PMCID:: PMC7531331

Abstract Article PDF–856K

Select item 740231812.

As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking Groundwater

Farith González-Martínez, Daniel Sánchez-Rodas, Nelson M. Varela, Christopher A. Sandoval, Luis A. Quiñones, Boris Johnson-Restrepo

Int J Mol Sci. 2020 Jul; 21(14): 4832. Published online 2020 Jul 8. doi: 10.3390/ijms21144832

PMCID:: PMC7402318

Abstract Article PDF–2.3M

Select item 709997613.

The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: a PET imaging study

Enrico D'Ambrosio, Tarik Dahoun, Antonio F. Pardiñas, Mattia Veronese, Michael A. P. Bloomfield, Sameer Jauhar, Ilaria Bonoldi, Maria Rogdaki, Sean Froudist-Walsh, James T.R. Walters, Oliver D. Howes

Psychiatry Res Neuroimaging. Author manuscript; available in PMC 2020 Sep 30.

Published in final edited form as: Psychiatry Res Neuroimaging. 2019 Sep 30; 291: 34–41. Published online 2019 Jul 19. doi: 10.1016/j.pscychresns.2019.07.005

PMCID:: PMC7099976

Abstract Article PDF–647K

Select item 551525014.

Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a Chilean population

Rosemarie de la Rosa, Craig Steinmaus, Nicholas K Akers, Lucia Conde, Catterina Ferreccio, David Kalman, Kevin R Zhang, Christine F Skibola, Allan H Smith, Luoping Zhang, Martyn T Smith

Environ Mol Mutagen. Author manuscript; available in PMC 2018 Jul 1.

Published in final edited form as: Environ Mol Mutagen. 2017 Jul; 58(6): 411–422. Published online 2017 Jun 22. doi: 10.1002/em.22104

PMCID:: PMC5515250

Abstract Article PDF–729K

Select item 529788915.

A Comprehensive Family-Based Replication Study of Schizophrenia Genes

Karolina A. Aberg, Youfang Liu, Jozsef Bukszár, Joseph L. McClay, Amit N. Khachane, Ole A. Andreassen, Douglas Blackwood, Aiden Corvin, Srdjan Djurovic, Hugh Gurling, Roel Ophoff, Carlos N. Pato, Michele T. Pato, Brien Riley, Todd Webb, Kenneth Kendler, Mick O’Donovan, Nick Craddock, George Kirov, Mike Owen, Dan Rujescu, David St Clair, Thomas Werge, Christina M. Hultman, Lynn E. Delisi, Patrick Sullivan, Edwin J. van den Oord

JAMA Psychiatry. Author manuscript; available in PMC 2017 Feb 8.

Published in final edited form as: JAMA Psychiatry. 2013 Jun; 70(6): 573–581. doi: 10.1001/jamapsychiatry.2013.288

PMCID:: PMC5297889

Abstract Article PDF–470K

Select item 521664816.

Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China

Xushen Chen, Xiaojuan Guo, Ping He, Jing Nie, Xiaoyan Yan, Jinqiu Zhu, Luoping Zhang, Guangyun Mao, Hongmei Wu, Zhiyue Liu, Diana Aga, Peilin Xu, Martyn Smith, Xuefeng Ren

Toxicol Sci. 2017 Jan; 155(1): 124–134. Published online 2016 Sep 16. doi: 10.1093/toxsci/kfw181

PMCID:: PMC5216648

Abstract Article PDF–270K

Select item 498838517.

Genome‐wide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cis‐regulation of BORCS7, AS3MT, and NT5C2 in the human brain

Rodrigo R. R. Duarte, Claire Troakes, Matthew Nolan, Deepak P. Srivastava, Robin M. Murray, Nicholas J. Bray

Am J Med Genet B Neuropsychiatr Genet. 2016 Sep; 171(6): 806–814. Published online 2016 Mar 22. doi: 10.1002/ajmg.b.32445

PMCID:: PMC4988385

Abstract Article PDF–725K

Select item 497042918.

Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: implications for risk analysis

Zuzana Drobná, Elizabeth Martin, Kyung Su Kim, Lisa Smeester, Paige Bommarito, Marisela Rubio-Andrade, Gonzalo G. García-Vargas, Miroslav Stýblo, Fei Zou, Rebecca C. Fry

Reprod Toxicol. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: Reprod Toxicol. 2016 Jun; 61: 28–38. Published online 2016 Feb 27. doi: 10.1016/j.reprotox.2016.02.017

PMCID:: PMC4970429

Abstract Article PDF–595K

Select item 489638319.

Positive selection of AS3MT to arsenic water in Andean populations

Christina A. Eichstaedt, Tiago Antao, Alexia Cardona, Luca Pagani, Toomas Kivisild, Maru Mormina

Mutat Res. Author manuscript; available in PMC 2016 Jun 7.

Published in final edited form as: Mutat Res. 2015 Oct; 780: 97–102. Published online 2015 Jul 29. doi: 10.1016/j.mrfmmm.2015.07.007

PMCID:: PMC4896383

Abstract Article PDF–1.0M

Select item 473140720.

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study

Matthew O. Gribble, Venkata Saroja Voruganti, Shelley A. Cole, Karin Haack, Poojitha Balakrishnan, Sandra L. Laston, Maria Tellez-Plaza, Kevin A. Francesconi, Walter Goessler, Jason G. Umans, Duncan C. Thomas, Frank Gilliland, Kari E. North, Nora Franceschini, Ana Navas-Acien

Toxicol Sci. 2015 Nov; 148(1): 89–100. Published online 2015 Jul 23. doi: 10.1093/toxsci/kfv164

PMCID:: PMC4731407

Abstract Article PDF–843K

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