PMC Links for GEO Profiles (Select 87630517) - PMC

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 110954565.

Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2

Dorien Pastoors, Marije Havermans, Roger Mulet-Lazaro, Duncan Brian, Willy Noort, Julius Grasel, Remco Hoogenboezem, Leonie Smeenk, Jeroen A. A. Demmers, Michael D. Milsom, Tariq Enver, Richard W. J. Groen, Eric Bindels, Ruud Delwel

Sci Adv. 2024 May 17; 10(20): eadk9076. Published online 2024 May 15. doi: 10.1126/sciadv.adk9076

PMCID:: PMC11095456

Abstract Article PDF–2.8M

Select item 109332676.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 103931857.

Perinatal-lethal nonimmune fetal hydrops attributed to MECOM-associated bone marrow failure

Camille A. Dash, Jill A. Madden, Christy Cummings, Melissa Rose, Sheria D. Wilson, Mari Mori, Pankaj B. Agrawal, Bimal P. Chaudhari, Monica H. Wojcik

Cold Spring Harb Mol Case Stud. 2023 Jun; 9(3): a006289. doi: 10.1101/mcs.a006289

PMCID:: PMC10393185

Abstract Article PDF–932K

Select item 103301908.

Expanded Phenotypic and Hematologic Abnormalities Beyond Bone Marrow Failure in MECOM-Associated Syndromes

Michell M. Lozano Chinga, Alison A. Bertuch, Zeinab Afify, Kaylee Dollerschell, Joanne I. Hsu, Tami D. John, Emily S. Rao, R. Grant Rowe, Vijay G. Sankaran, Akiko Shimamura, David A. Williams, Taizo A. Nakano

Am J Med Genet A. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: Am J Med Genet A. 2023 Jul; 191(7): 1826–1835. Published online 2023 Apr 17. doi: 10.1002/ajmg.a.63208

PMCID:: PMC10330190

Abstract Article PDF–793K

Select item 101398679.

EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment

Yosuke Masamoto, Akira Chiba, Hideaki Mizuno, Toshiya Hino, Hiroki Hayashida, Tomohiko Sato, Masashige Bando, Katsuhiko Shirahige, Mineo Kurokawa

Blood Adv. 2023 Apr 25; 7(8): 1577–1593. Published online 2022 Oct 27. doi: 10.1182/bloodadvances.2022008018

PMCID:: PMC10139867

Abstract Article PDF–1.9M

Select item 1013015010.

Epigenetic landscape reveals MECOM as an endothelial lineage regulator

Jie Lv, Shu Meng, Qilin Gu, Rongbin Zheng, Xinlei Gao, Jun-dae Kim, Min Chen, Bo Xia, Yihan Zuo, Sen Zhu, Dongyu Zhao, Yanqiang Li, Guangyu Wang, Xin Wang, Qingshu Meng, Qi Cao, John P. Cooke, Longhou Fang, Kaifu Chen, Lili Zhang

Nat Commun. 2023; 14: 2390. Published online 2023 Apr 25. doi: 10.1038/s41467-023-38002-w

Correction in:: Nat Commun. 2023; 14: 2842.

PMCID:: PMC10130150

Abstract Article PDF–4.4M

Select item 976969811.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 971209112.

SF3B1 mutations in AML are strongly associated with MECOM rearrangements and may be indicative of an MDS pre-phase

Sandra Huber, Torsten Haferlach, Manja Meggendorfer, Stephan Hutter, Gregor Hoermann, Constance Baer, Wolfgang Kern, Claudia Haferlach

Leukemia. 2022; 36(12): 2927–2930. Published online 2022 Oct 21. doi: 10.1038/s41375-022-01734-7

PMCID:: PMC9712091

Article PDF–719K

Select item 964882413.

Mapping the developing human cardiac endothelium at single-cell resolution identifies MECOM as a regulator of arteriovenous gene expression

Ian R McCracken, Ross Dobie, Matthew Bennett, Rainha Passi, Abdelaziz Beqqali, Neil C Henderson, Joanne C Mountford, Paul R Riley, Chris P Ponting, Nicola Smart, Mairi Brittan, Andrew H Baker

Cardiovasc Res. 2022 Oct; 118(14): 2960–2972. Published online 2022 Feb 25. doi: 10.1093/cvr/cvac023

PMCID:: PMC9648824

Abstract Article PDF–4.6M

Select item 911973614.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 884482715.

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase

Zhifen Zhou, Yujing Li, Huimin Xu, Xiaowei Xie, Zibin He, Song Lin, Ruofei Li, Shouheng Jin, Jun Cui, Hai Hu, Feng Liu, Su Wu, Wenbin Ma, Zhou Songyang

iScience. 2022 Feb 18; 25(2): 103813. Published online 2022 Jan 25. doi: 10.1016/j.isci.2022.103813

PMCID:: PMC8844827

Abstract Article PDF–6.0M

Select item 883524216.

EVI1 Promotes the Proliferation and Invasive Properties of Human Head and Neck Squamous Cell Carcinoma Cells

Alexander Michael Grandits, Sophie Bromberger, Gerwin Heller, Barbara Andrea Reinoehl, Erwin Tomasich, Klaudia Schossleitner, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser

Int J Mol Sci. 2022 Feb; 23(3): 1050. Published online 2022 Jan 19. doi: 10.3390/ijms23031050

PMCID:: PMC8835242

Abstract Article PDF–4.4M

Select item 882889517.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 876331718.

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1–CoREST interactome during embryonic stem cell differentiation

Claire E. Barnes, David M. English, Megan Broderick, Mark O. Collins, Shaun M. Cowley

Mol Omics. 2022 Jan 17; 18(1): 31–44. Published online 2021 Oct 14. doi: 10.1039/d1mo00236h

PMCID:: PMC8763317

Abstract Article

Select item 876007719.

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew J. Wicks, Gwendoline Hoslett, Daniel Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Calvo Pardo, Lu Yu, Tanaji T. Talele, Jiri Bartek, Jyoti S. Choudhary, Yves Pommier, Stephen J. Pettitt, Andrew N. J. Tutt, Kristijan Ramadan, Christopher J. Lord

Nat Cell Biol. 2022; 24(1): 62–73. Published online 2022 Jan 10. doi: 10.1038/s41556-021-00807-6

PMCID:: PMC8760077

Abstract Article PDF–12M

Select item 855096520.

Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia

Sandra Kiehlmeier, Mahmoud-Reza Rafiee, Ali Bakr, Jagoda Mika, Sabrina Kruse, Judith Müller, Sabrina Schweiggert, Carl Herrmann, Gianluca Sigismondo, Peter Schmezer, Jeroen Krijgsveld, Stefan Gröschel

Leukemia. 2021; 35(11): 3127–3138. Published online 2021 Apr 28. doi: 10.1038/s41375-021-01235-z

PMCID:: PMC8550965

Abstract Article PDF–1.1M

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