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Select item 109331811.

Protective effects of Gα_i3 deficiency in a murine heart-failure model of β₁-adrenoceptor overexpression

Tobias Schröper, Dennis Mehrkens, Veronika Leiss, Frederik Tellkamp, Stefan Engelhardt, Stefan Herzig, Lutz Birnbaumer, Bernd Nürnberg, Jan Matthes

Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(4): 2401–2420. Published online 2023 Oct 16. doi: 10.1007/s00210-023-02751-8

PMCID:: PMC10933181

Abstract Article PDF–5.5M

Select item 101577252.

Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis

Ya Li, Jin-long Chai, Xin Shi, Yu Feng, Jia-jun Li, Li-na Zhou, Cong Cao, Ke-ran Li

Theranostics. 2023; 13(7): 2319–2336. Published online 2023 Apr 17. doi: 10.7150/thno.80749

PMCID:: PMC10157725

Abstract Article PDF–10M

Select item 99382163.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes

Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x

PMCID:: PMC9938216

Abstract Article PDF–5.3M

Select item 95814784.

RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells

Anil Akturk, Matthew Day, Basile Tarchini

Sci Adv. 2022 Oct; 8(42): eabq2826. Published online 2022 Oct 19. doi: 10.1126/sciadv.abq2826

PMCID:: PMC9581478

Abstract Article PDF–4.3M

Select item 82756205.

Analyses of Gnai3-iresGFP reporter mice reveal unknown Gα_i3 expression sites

Veronika Leiss, Ellen Reisinger, Annika Speidel, Sandra Beer-Hammer, Bernd Nürnberg

Sci Rep. 2021; 11: 14271. Published online 2021 Jul 12. doi: 10.1038/s41598-021-93591-0

PMCID:: PMC8275620

Abstract Article PDF–2.9M

Select item 81291416.

EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia

Katie S. Kindt, Anil Akturk, Amandine Jarysta, Matthew Day, Alisha Beirl, Michaela Flonard, Basile Tarchini

Nat Commun. 2021; 12: 2861. Published online 2021 May 17. doi: 10.1038/s41467-021-22997-1

PMCID:: PMC8129141

Abstract Article PDF–12M

Select item 79782947.

Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response

Jin-yu Bai, Ya Li, Guan-hua Xue, Ke-ran Li, Yu-Fan Zheng, Zhi-qing Zhang, Qin Jiang, Yuan-yuan Liu, Xiao-zhong Zhou, Cong Cao

Theranostics. 2021; 11(10): 4894–4909. Published online 2021 Mar 4. doi: 10.7150/thno.56383

PMCID:: PMC7978294

Abstract Article PDF–3.2M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 76597109.

Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling

Andre Landin Malt, Arielle K. Hogan, Connor D. Smith, Maxwell S. Madani, Xiaowei Lu

J Cell Biol. 2020 Oct 5; 219(10): e201912071. Published online 2020 Aug 17. doi: 10.1083/jcb.201912071

PMCID:: PMC7659710

Abstract Article PDF–5.1M

Select item 756148010.

Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea

Elvis Huarcaya Najarro, Jennifer Huang, Adrian Jacobo, Lee A. Quiruz, Nicolas Grillet, Alan G. Cheng

Development. 2020 Oct 1; 147(19): dev191981. Published online 2020 Oct 5. doi: 10.1242/dev.191981

PMCID:: PMC7561480

Abstract Article

Select item 734864011.

GINIP, a G_αi-Interacting Protein, Functions as a Key Modulator of Peripheral GABA_B Receptor-Mediated Analgesia

Stéphane Gaillard, Laure Lo Re, Annabelle Mantilleri, Régine Hepp, Louise Urien, Pascale Malapert, Serge Alonso, Michael Deage, Charline Kambrun, Marc Landry, Sarah A. Low, Abdelkrim Alloui, Bertrand Lambolez, Grégory Scherrer, Yves Le Feuvre, Emmanuel Bourinet, Aziz Moqrich

Neuron. Author manuscript; available in PMC 2020 Jul 10.

Published in final edited form as: Neuron. 2014 Oct 1; 84(1): 123–136. Published online 2014 Sep 18. doi: 10.1016/j.neuron.2014.08.056

PMCID:: PMC7348640

Abstract Article PDF–3.1M

Select item 726179512.

Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor–mediated chemotaxis

Esther van den Bos, Benjamin Ambrosy, Markus Horsthemke, Stefan Walbaum, Anne C. Bachg, Nina Wettschureck, Giulio Innamorati, Thomas M. Wilkie, Peter J. Hanley

J Biol Chem. 2020 May 29; 295(22): 7726–7742. Published online 2020 Apr 24. doi: 10.1074/jbc.RA119.011984

PMCID:: PMC7261795

Abstract Article PDF–5.0M

Select item 672691013.

Proteostasis is essential during cochlear development for neuron survival and hair cell polarity

Stephen Freeman, Susana Mateo Sánchez, Ronald Pouyo, Pierre‐Bernard Van Lerberghe, Kevin Hanon, Nicolas Thelen, Marc Thiry, Giovanni Morelli, Laura Van Hees, Sophie Laguesse, Alain Chariot, Laurent Nguyen, Laurence Delacroix, Brigitte Malgrange

EMBO Rep. 2019 Sep; 20(9): e47097. Published online 2019 Jul 19. doi: 10.15252/embr.201847097

PMCID:: PMC6726910

Abstract Article PDF–16M

Select item 672539414.

Telencephalic Embryonic Subtractive Sequences: A Unique Collection of Neurodevelopmental Genes

Alessandro Bulfone, Pietro Carotenuto, Andrea Faedo, Veruska Aglio, Livia Garzia, Anna Maria Bello, Andrea Basile, Alessandra Andrè, Massimo Cocchia, Ombretta Guardiola, Andrea Ballabio, John L. R. Rubenstein, Massimo Zollo

J Neurosci. 2005 Aug 17; 25(33): 7586–7600. doi: 10.1523/JNEUROSCI.0522-05.2005

PMCID:: PMC6725394

Abstract Article PDF–682K

Select item 662826015.

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2

Zhi-Wei Li, Beicheng Sun, Ting Gong, Sheng Guo, Jianhua Zhang, Junlong Wang, Atsushi Sugawara, Meisheng Jiang, Junjun Yan, Alexandra Gurary, Xin Zheng, Bifeng Gao, Shu-Yuan Xiao, Wenlian Chen, Chi Ma, Christine Farrar, Chenjun Zhu, Owen T. M. Chan, Can Xin, Andrew Winnicki, John Winnicki, Mingxin Tang, Ryan Park, Mary Winnicki, Katrina Diener, Zhanwei Wang, Qicai Liu, Catherine H. Chu, Zhaohui L. Arter, Peibin Yue, Lindsay Alpert, George S. Hui, Peiwen Fei, James Turkson, Wentian Yang, Guangyu Wu, Ailin Tao, Joe W. Ramos, Stefan Moisyadi, Randall F. Holcombe, Wei Jia, Lutz Birnbaumer, Xiqiao Zhou, Wen-Ming Chu

Gastroenterology. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Gastroenterology. 2019 Jun; 156(8): 2297–2312. Published online 2019 Mar 2. doi: 10.1053/j.gastro.2019.02.040

PMCID:: PMC6628260

Abstract Article PDF–4.3M

Select item 651653016.

GPSM2-GNAI specifies the tallest stereocilia and defines hair bundle row identity

Abigail L.D. Tadenev, Anil Akturk, Nicholas Devanney, Pranav Dinesh Mathur, Anna M. Clark, Jun Yang, Basile Tarchini

Curr Biol. Author manuscript; available in PMC 2020 Mar 18.

Published in final edited form as: Curr Biol. 2019 Mar 18; 29(6): 921–934.e4. Published online 2019 Feb 28. doi: 10.1016/j.cub.2019.01.051

PMCID:: PMC6516530

Abstract Article PDF–2.2M

Select item 650011117.

Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells

Philippe Jean, Özge Demet Özçete, Basile Tarchini, Tobias Moser

Proc Natl Acad Sci U S A. 2019 Apr 30; 116(18): 9084–9093. Published online 2019 Apr 11. doi: 10.1073/pnas.1818358116

PMCID:: PMC6500111

Abstract Article PDF–17M

Select item 642141218.

Par3 is essential for the establishment of planar cell polarity of inner ear hair cells

Andre Landin Malt, Zachary Dailey, Julia Holbrook-Rasmussen, Yuqiong Zheng, Arielle Hogan, Quansheng Du, Xiaowei Lu

Proc Natl Acad Sci U S A. 2019 Mar 12; 116(11): 4999–5008. Published online 2019 Feb 27. doi: 10.1073/pnas.1816333116

PMCID:: PMC6421412

Abstract Article PDF–3.8M

Select item 638256319.

Gα_i2 signaling regulates inflammasome priming and cytokine production by biasing macrophage phenotype determination

Ali Vural, Neel R. Nabar, Il-Young Hwang, Silke Sohn, Chung Park, Mikael C. I. Karlsson, Joe B. Blumer, John H. Kehrl

J Immunol. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: J Immunol. 2019 Mar 1; 202(5): 1510–1520. Published online 2019 Jan 25. doi: 10.4049/jimmunol.1801145

PMCID:: PMC6382563

Abstract Article PDF–1.2M

Select item 633346020.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

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