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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103132312.

Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice

George Firth, Eleni Georgiadou, Alexander Griffiths, Maral Amrahli, Jana Kim, Zilin Yu, Ming Hu, Theodora J. Stewart, Isabelle Leclerc, Haruka Okamoto, Daniel Gomez, Philip J. Blower, Guy A. Rutter

Front Endocrinol (Lausanne) 2023; 14: 1171933. Published online 2023 Jun 16. doi: 10.3389/fendo.2023.1171933

PMCID:: PMC10313231

Abstract Article PDF–17M

Select item 96724213.

Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration

Yong Kyung Kim, Jay A. Walters, Nicole D. Moss, Kristen L. Wells, Ryan Sheridan, Jose G. Miranda, Richard K.P. Benninger, Laura L. Pyle, Richard M. O'Brien, Lori Sussel, Howard W. Davidson

Mol Metab. 2022 Dec; 66: 101632. Published online 2022 Nov 5. doi: 10.1016/j.molmet.2022.101632

PMCID:: PMC9672421

Abstract Article PDF–2.1M

Select item 88599194.

Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death

Maria Karsai, Richard A Zuellig, Roger Lehmann, Federica Cuozzo, Daniela Nasteska, Edlira Luca, Constanze Hantel, David J Hodson, Giatgen A Spinas, Guy A Rutter, Philipp A Gerber

J Endocrinol. 2022 Apr 1; 253(1): 1–11. Published online 2022 Jan 11. doi: 10.1530/JOE-21-0271

PMCID:: PMC8859919

Abstract Article PDF–2.2M

Select item 82623505.

Pancreatic β cell–selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis

Jie Xu, Nadeeja Wijesekara, Romario Regeenes, Dana Al Rijjal, Anthony L. Piro, Youchen Song, Anne Wu, Alpana Bhattacharjee, Ying Liu, Lucy Marzban, Jonathan V. Rocheleau, Paul E. Fraser, Feihan F. Dai, Cheng Hu, Michael B. Wheeler

JCI Insight. 2021 May 24; 6(10): e143037. Published online 2021 May 24. doi: 10.1172/jci.insight.143037

PMCID:: PMC8262350

Abstract Article PDF–6.7M

Select item 82515626.

Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease

Evans Quilichini, Mélanie Fabre, Christoffer Nord, Thassadite Dirami, Axelle Le Marec, Silvia Cereghini, Raymond C Pasek, Maureen Gannon, Ulf Ahlgren, Cécile Haumaitre

J Pathol. 2021 May; 254(1): 31–45. Published online 2021 Mar 18. doi: 10.1002/path.5629

PMCID:: PMC8251562

Abstract Article PDF–46M

Select item 73678357.

Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease

Xiuli Zhang, Tingwen Guan, Boxuan Yang, Harvest F. Gu, Zhihong Chi

Cell Death Dis. 2020 Jul; 11(7): 544. Published online 2020 Jul 17. doi: 10.1038/s41419-020-2731-6

PMCID:: PMC7367835

Abstract Article PDF–1.7M

Select item 68619488.

ZnT8 Haploinsufficiency Impacts MIN6 Cell Zinc Content and β-Cell Phenotype via ZIP-ZnT8 Coregulation

Rebecca Lawson, Wolfgang Maret, Christer Hogstrand

Int J Mol Sci. 2019 Nov; 20(21): 5485. Published online 2019 Nov 4. doi: 10.3390/ijms20215485

PMCID:: PMC6861948

Abstract Article PDF–1.6M

Select item 68588749.

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Om Prakash Dwivedi, Mikko Lehtovirta, Benoit Hastoy, Vikash Chandra, Nicole A. J. Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie Richard, Fernando Abaitua, Nicola L. Beer, Antje Grotz, Rashmi B. Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, Isabella Artner, Anu Suoranta, Daniel Gomez, Aris Baras, Benoite Champon, Anthony J Payne, Daniela Moralli, Soren K. Thomsen, Philipp Kramer, Ioannis Spiliotis, Reshma Ramracheya, Pauline Chabosseau, Andria Theodoulou, Rebecca Cheung, Martijn van de Bunt, Jason Flannick, Maddalena Trombetta, Enzo Bonora, Claes B. Wolheim, Leena Sarelin, Riccardo C. Bonadonna, Patrik Rorsman, Benjamin Davies, Julia Brosnan, Mark I. McCarthy, Timo Otonkoski, Jens O. Lagerstedt, Guy A Rutter, Jesper Gromada, Anna L. Gloyn, Tiinamaija Tuomi, Leif Groop

Nat Genet. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Nat Genet. 2019 Nov; 51(11): 1596–1606. Published online 2019 Nov 1. doi: 10.1038/s41588-019-0513-9

PMCID:: PMC6858874

Abstract Article PDF–5.1M

Select item 645951010.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 610121611.

Beta cell specific ZnT8 deletion in mice causes marked defects in insulin processing, crystallization and secretion

N. Wijesekara, F.F. Dai, A.B. Hardy, P. R. Giglou, A. Bhattacharjee, V. Koshkin, F. Chimienti, H.Y. Gaisano, G.A. Rutter, M.B. Wheeler

Diabetologia. Author manuscript; available in PMC 2018 Aug 20.

Published in final edited form as: Diabetologia. 2010 Aug; 53(8): 1656–1668. Published online 2010 Apr 28. doi: 10.1007/s00125-010-1733-9

PMCID:: PMC6101216

Abstract Article PDF–2.5M

Select item 609414712.

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity

Sandra Kleiner, Daniel Gomez, Bezawit Megra, Erqian Na, Ramandeep Bhavsar, Katie Cavino, Yurong Xin, Jose Rojas, Giselle Dominguez-Gutierrez, Brian Zambrowicz, Gaelle Carrat, Pauline Chabosseau, Ming Hu, Andrew J. Murphy, George D. Yancopoulos, Guy A. Rutter, Jesper Gromada

Proc Natl Acad Sci U S A. 2018 Aug 7; 115(32): E7642–E7649. Published online 2018 Jul 23. doi: 10.1073/pnas.1721418115

PMCID:: PMC6094147

Abstract Article PDF–1.5M

Select item 553686513.

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets

Katie L. Sinagoga, William J. Stone, Jacqueline V. Schiesser, Jamie I. Schweitzer, Leesa Sampson, Yi Zheng, James M. Wells

Development. 2017 Jul 1; 144(13): 2402–2414. doi: 10.1242/dev.146316

PMCID:: PMC5536865

Abstract Article

Select item 513334914.

Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion

Kristen E. Syring, Kayla A. Boortz, James K. Oeser, Alessandro Ustione, Kenneth A. Platt, Melanie K. Shadoan, Owen P. McGuinness, David W. Piston, David R. Powell, Richard M. O'Brien

Endocrinology. 2016 Dec; 157(12): 4534–4541. Published online 2016 Oct 18. doi: 10.1210/en.2016-1573

PMCID:: PMC5133349

Abstract Article

Select item 499524015.

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance

Ryan K. Mitchell, Ming Hu, Pauline L. Chabosseau, Matthew C. Cane, Gargi Meur, Elisa A. Bellomo, Raffaella Carzaniga, Lucy M. Collinson, Wen-Hong Li, David J. Hodson, Guy A. Rutter

Mol Endocrinol. 2016 Jan; 30(1): 77–91. Published online 2015 Nov 19. doi: 10.1210/me.2015-1227

PMCID:: PMC4995240

Abstract Article

Select item 491741916.

Threshold-dependent cooperativity of Pdx1 and Oc1 in pancreatic progenitors establishes competency for endocrine differentiation and β-cell function

Kathryn D. Henley, Diana E. Stanescu, Peter A. Kropp, Christopher V.E. Wright, Kyoung-Jae Won, Doris A. Stoffers, Maureen Gannon

Cell Rep. Author manuscript; available in PMC 2016 Jun 22.

Published in final edited form as: Cell Rep. 2016 Jun 21; 15(12): 2637–2650. Published online 2016 Jun 9. doi: 10.1016/j.celrep.2016.05.040

PMCID:: PMC4917419

Abstract Article PDF–1.1M

Select item 476414817.

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

Leena Paul, Emily M. Walker, Yiannis Drosos, Holly A. Cyphert, Geoffrey Neale, Roland Stein, Jack South, Gerard Grosveld, Pedro L. Herrera, Beatriz Sosa-Pineda

Diabetes. 2016 Mar; 65(3): 687–698. Published online 2015 Dec 2. doi: 10.2337/db15-0713

PMCID:: PMC4764148

Abstract Article PDF–2.3M

Select item 476311118.

β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development

Ahmed M. Abdellatif, Hisashi Oishi, Takahiro Itagaki, Yunshin Jung, Hossam H. Shawki, Yukari Okita, Yoshikazu Hasegawa, Hiroyuki Suzuki, Salah E. El-Morsy, Mesbah A. El-Sayed, Mahmoud B. Shoaib, Fumihiro Sugiyama, Satoru Takahashi

PLoS One. 2016; 11(2): e0150010. Published online 2016 Feb 22. doi: 10.1371/journal.pone.0150010

PMCID:: PMC4763111

Abstract Article PDF–14M

Select item 467579919.

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells

Elizabeth Conrad, Chunhua Dai, Jason Spaeth, Min Guo, Holly A. Cyphert, David Scoville, Julie Carroll, Wei-Ming Yu, Lisa V. Goodrich, David M. Harlan, Kevin L. Grove, Charles T. Roberts, Jr., Alvin C. Powers, Guoqiang Gu, Roland Stein

Am J Physiol Endocrinol Metab. 2016 Jan 1; 310(1): E91–E102. Published online 2015 Nov 10. doi: 10.1152/ajpendo.00285.2015

PMCID:: PMC4675799

Abstract Article

Select item 457187120.

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

Antonia Solomou, Gargi Meur, Elisa Bellomo, David J. Hodson, Alejandra Tomas, Stéphanie Migrenne Li, Erwann Philippe, Pedro L. Herrera, Christophe Magnan, Guy A. Rutter

J Biol Chem. 2015 Aug 28; 290(35): 21432–21442. Published online 2015 Jul 15. doi: 10.1074/jbc.M115.645291

PMCID:: PMC4571871

Abstract Article PDF–1.9M

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