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Select item 109453491.

NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover

Bei Liu, Duanyi Hua, Linyan Shen, Tingting Li, Zheying Tao, Chenyang Fu, Zhongzheng Tang, Jie Yang, Li Zhang, Aifang Nie, Yiran Jiang, Jiqiu Wang, Yang Li, Yanyun Gu, Guang Ning

Theranostics. 2024; 14(5): 2058–2074. Published online 2024 Feb 24. doi: 10.7150/thno.90946

PMCID:: PMC10945349

Abstract Article PDF–9.7M

Select item 104824292.

Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

Wilma Tixi, Maricela Maldonado, Ya-Ting Chang, Amy Chiu, Wilson Yeung, Nazia Parveen, Michael S Nelson, Ryan Hart, Shihao Wang, Wu Jih Hsu, Patrick Fueger, Janel L Kopp, Mark O Huising, Sangeeta Dhawan, Hung Ping Shih

eLife. 2023; 12: e90006. Published online 2023 Aug 23. doi: 10.7554/eLife.90006

PMCID:: PMC10482429

Abstract Article PDF–26M

Select item 103931933.

Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain

Vladimir Abarinov, Joshua A. Levine, Angela J. Churchill, Bryce Hopwood, Cailin S. Deiter, Michelle A. Guney, Kristen L. Wells, Jessica M. Schrunk, Yuchun Guo, Jennifer Hammelman, David K. Gifford, Mark A. Magnuson, Hynek Wichterle, Lori Sussel

Genes Dev. 2023 Jun 1; 37(11-12): 490–504. doi: 10.1101/gad.350569.123

PMCID:: PMC10393193

Abstract Article PDF–22M

Select item 103904924.

Three-dimensional molecular architecture of mouse organogenesis

Fangfang Qu, Wenjia Li, Jian Xu, Ruifang Zhang, Jincan Ke, Xiaodie Ren, Xiaogao Meng, Lexin Qin, Jingna Zhang, Fangru Lu, Xin Zhou, Xi Luo, Zhen Zhang, Minhan Wang, Guangming Wu, Duanqing Pei, Jiekai Chen, Guizhong Cui, Shengbao Suo, Guangdun Peng

Nat Commun. 2023; 14: 4599. Published online 2023 Jul 31. doi: 10.1038/s41467-023-40155-7

PMCID:: PMC10390492

Abstract Article PDF–13M

Select item 101476045.

USP7 controls NGN3 stability and pancreatic endocrine lineage development

Teodora Manea, Jessica Kristine Nelson, Cristina Maria Garrone, Karin Hansson, Ian Evans, Axel Behrens, Rocio Sancho

Nat Commun. 2023; 14: 2457. Published online 2023 Apr 28. doi: 10.1038/s41467-023-38146-9

PMCID:: PMC10147604

Abstract Article PDF–9.0M

Select item 101304876.

DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity

Nazia Parveen, Jean Kimi Wang, Supriyo Bhattacharya, Janielle Cuala, Mohan Singh Rajkumar, Alexandra E. Butler, Xiwei Wu, Hung-Ping Shih, Senta K. Georgia, Sangeeta Dhawan

Diabetes. 2023 May; 72(5): 575–589. Published online 2023 Jan 6. doi: 10.2337/db22-0506

Correction in:: Diabetes. 2023 Dec; 72(12): 1882.

PMCID:: PMC10130487

Abstract Article PDF–1.8M

Select item 101214687.

Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia

Sophie Patzek, Zhe Liu, Sean de la O, Sean Chang, Lauren E. Byrnes, Xiuqin Zhang, David M. Ornitz, Julie B. Sneddon

iScience. 2023 Apr 21; 26(4): 106500. Published online 2023 Mar 25. doi: 10.1016/j.isci.2023.106500

PMCID:: PMC10121468

Abstract Article PDF–12M

Select item 99995288.

ISL1 controls pancreatic alpha cell fate and beta cell maturation

Romana Bohuslavova, Valeria Fabriciova, Laura Lebrón-Mora, Jessica Malfatti, Ondrej Smolik, Lukas Valihrach, Sarka Benesova, Daniel Zucha, Zuzana Berkova, Frantisek Saudek, Sylvia M Evans, Gabriela Pavlinkova

Cell Biosci. 2023; 13: 53. Published online 2023 Mar 10. doi: 10.1186/s13578-023-01003-9

PMCID:: PMC9999528

Abstract Article PDF–7.7M

Select item 98677749.

Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Xiaochan Xu, Philip Allan Seymour, Kim Sneppen, Ala Trusina, Anuska la Rosa Egeskov-Madsen, Mette Christine Jørgensen, Mogens Høgh Jensen, Palle Serup

Nat Commun. 2023; 14: 348. Published online 2023 Jan 21. doi: 10.1038/s41467-023-35963-w

PMCID:: PMC9867774

Abstract Article PDF–4.4M

Select item 980121910.

Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas

Aneta M. Dobosz, Justyna Janikiewicz, Ewelina Krogulec, Anna Dziewulska, Anna Ajduk, Marcin Szpila, Hanna Nieznańska, Andrzej A. Szczepankiewicz, Dorota Wypych, Agnieszka Dobrzyn

Mol Metab. 2023 Jan; 67: 101659. Published online 2022 Dec 15. doi: 10.1016/j.molmet.2022.101659

PMCID:: PMC9801219

Abstract Article PDF–3.9M

Select item 948233611.

Focal adhesion kinase-mediated signaling controls the onset of pancreatic cell differentiation

Uylissa A. Rodriguez, Shakti Dahiya, Michelle L. Raymond, Chenxi Gao, Christina P. Martins-Cargill, Jon D. Piganelli, George K. Gittes, Jing Hu, Farzad Esni

Development. 2022 Sep 1; 149(17): dev200761. Published online 2022 Sep 9. doi: 10.1242/dev.200761

PMCID:: PMC9482336

Abstract Article

Select item 942656212.

Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster

Irene Miguel-Escalada, Miguel Ángel Maestro, Diego Balboa, Anamaria Elek, Aina Bernal, Edgar Bernardo, Vanessa Grau, Javier García-Hurtado, Arnau Sebé-Pedrós, Jorge Ferrer

Dev Cell. 2022 Aug 22; 57(16): 1922–1936.e9. doi: 10.1016/j.devcel.2022.07.014

PMCID:: PMC9426562

Abstract Article PDF–9.4M

Select item 935276513.

Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis

Mostafa Bakhti, Aimée Bastidas-Ponce, Sophie Tritschler, Oliver Czarnecki, Marta Tarquis-Medina, Eva Nedvedova, Jessica Jaki, Stefanie J. Willmann, Katharina Scheibner, Perla Cota, Ciro Salinno, Karsten Boldt, Nicola Horn, Marius Ueffing, Ingo Burtscher, Fabian J. Theis, Ünal Coskun, Heiko Lickert

Nat Commun. 2022; 13: 4540. Published online 2022 Aug 4. doi: 10.1038/s41467-022-31862-8

PMCID:: PMC9352765

Abstract Article PDF–15M

Select item 857782714.

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

Christopher Gribben, Christopher Lambert, Hendrik A. Messal, Ella-Louise Hubber, Chloe Rackham, Ian Evans, Harry Heimberg, Peter Jones, Rocio Sancho, Axel Behrens

Cell Stem Cell. 2021 Nov 4; 28(11): 2000–2008.e4. doi: 10.1016/j.stem.2021.08.003

Correction in:: Cell Stem Cell. 2023 Apr 6; 30(4): 498–499.

PMCID:: PMC8577827

Abstract Article

Select item 841532115.

REST is a major negative regulator of endocrine differentiation during pancreas organogenesis

Meritxell Rovira, Goutham Atla, Miguel Angel Maestro, Vane Grau, Javier García-Hurtado, Maria Maqueda, Jose Luis Mosquera, Yasuhiro Yamada, Julie Kerr-Conte, Francois Pattou, Jorge Ferrer

Genes Dev. 2021 Sep 1; 35(17-18): 1229–1242. doi: 10.1101/gad.348501.121

PMCID:: PMC8415321

Abstract Article PDF–7.3M

Select item 839522316.

Ngn3-Positive Cells Arise from Pancreatic Duct Cells

Chiemi Kimura-Nakajima, Kousuke Sakaguchi, Yoshiko Hatano, Masahito Matsumoto, Yasushi Okazaki, Keisuke Tanaka, Takumi Yamane, Yuichi Oishi, Kenji Kamimoto, Ken Iwatsuki

Int J Mol Sci. 2021 Aug; 22(16): 8548. Published online 2021 Aug 9. doi: 10.3390/ijms22168548

PMCID:: PMC8395223

Abstract Article PDF–5.5M

Select item 826883717.

NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the Pancreas

Romana Bohuslavova, Ondrej Smolik, Jessica Malfatti, Zuzana Berkova, Zaneta Novakova, Frantisek Saudek, Gabriela Pavlinkova

Int J Mol Sci. 2021 Jul; 22(13): 6713. Published online 2021 Jun 23. doi: 10.3390/ijms22136713

PMCID:: PMC8268837

Abstract Article PDF–4.9M

Select item 825156218.

Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease

Evans Quilichini, Mélanie Fabre, Christoffer Nord, Thassadite Dirami, Axelle Le Marec, Silvia Cereghini, Raymond C Pasek, Maureen Gannon, Ulf Ahlgren, Cécile Haumaitre

J Pathol. 2021 May; 254(1): 31–45. Published online 2021 Mar 18. doi: 10.1002/path.5629

PMCID:: PMC8251562

Abstract Article PDF–46M

Select item 812957919.

Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation

Tiziana Sanavia, Chen Huang, Elisabetta Manduchi, Yanwen Xu, Prasanna K. Dadi, Leah A. Potter, David A. Jacobson, Barbara Di Camillo, Mark A. Magnuson, Christian J. Stoeckert, Jr, Guoqiang Gu

Front Cell Dev Biol. 2021; 9: 648791. Published online 2021 May 4. doi: 10.3389/fcell.2021.648791

PMCID:: PMC8129579

Abstract Article PDF–4.8M

Select item 801525320.

A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development

Anna B. Osipovich, Karrie D. Dudek, Emily Greenfest-Allen, Jean-Philippe Cartailler, Elisabetta Manduchi, Leah Potter Case, Eunyoung Choi, Austin G. Chapman, Hannah W. Clayton, Guoqiang Gu, Christian J. Stoeckert, Jr, Mark A. Magnuson

Development. 2021 Mar 15; 148(6): dev196964. Published online 2021 Mar 22. doi: 10.1242/dev.196964