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Select item 111149911.

LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment

A. Grabner, S. Brast, S. Sucic, S. Bierer, B. Hirsch, H. Pavenstädt, H. H. Sitte, E. Schlatter, G. Ciarimboli

Cell Mol Life Sci. 2011 Dec; 68(24): 4079–4090. Published online 2011 May 8. doi: 10.1007/s00018-011-0694-6

PMCID:: PMC11114991

Abstract Article PDF–649K

Select item 110470582.

Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing

Aishwarya Jayagopal, Paul R. Brakeman, Peter Soler, Nicholas Ferrell, William Fissell, Deanna L. Kroetz, Shuvo Roy

J Pharmacol Exp Ther. 2019 Jun; 369(3): 523–530. Published online 2019 Jun. doi: 10.1124/jpet.118.255026

PMCID:: PMC11047058

Abstract Article PDF–1.1M

Select item 91902333.

Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier

Raymond K. Hau, Robert R. Klein, Stephen H. Wright, Nathan J. Cherrington

Drug Metab Dispos. 2022 Jun; 50(6): 770–780. Published online 2022 Jun. doi: 10.1124/dmd.121.000748

PMCID:: PMC9190233

Abstract Article PDF–2.8M

Select item 88361794.

Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells

Xiaohong Zhang, Stephen H. Wright

Int J Mol Sci. 2022 Feb; 23(3): 1472. Published online 2022 Jan 27. doi: 10.3390/ijms23031472

PMCID:: PMC8836179

Abstract Article PDF–2.2M

Select item 88347595.

Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives

Sara Ahmed Eltayeb, Giuliano Ciarimboli, Katrin Beul, Giovana Seno Di Marco, Vivien Barz

Int J Mol Sci. 2022 Feb; 23(3): 1090. Published online 2022 Jan 19. doi: 10.3390/ijms23031090

PMCID:: PMC8834759

Abstract Article PDF–1.8M

Select item 86579126.

Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity

Charles R. Lefèvre, Marc Le Vée, Sophie Gaubert, Elodie Jouan, Arnaud Bruyere, Caroline Moreau, Olivier Fardel

Int J Mol Sci. 2021 Dec; 22(23): 12926. Published online 2021 Nov 29. doi: 10.3390/ijms222312926

PMCID:: PMC8657912

Abstract Article PDF–1.5M

Select item 84321727.

Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model

Tim N. Koepp, Alexander Tokaj, Pavel I. Nedvetsky, Ana Carolina Conchon Costa, Beatrice Snieder, Rita Schröter, Giuliano Ciarimboli

Int J Mol Sci. 2021 Sep; 22(17): 9658. Published online 2021 Sep 6. doi: 10.3390/ijms22179658

PMCID:: PMC8432172

Abstract Article PDF–5.7M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79737969.

Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy

Maiko Abumiya, Naoto Takahashi, Saori Takahashi, Tomoko Yoshioka, Yoshihiro Kameoka, Masatomo Miura

Sci Rep. 2021; 11: 6362. Published online 2021 Mar 18. doi: 10.1038/s41598-021-85757-7

PMCID:: PMC7973796

Abstract Article PDF–1.1M

Select item 749784810.

Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer

Mitsukuni Suenaga, Marta Schirripa, Shu Cao, Wu Zhang, Dongyun Yang, Vincenzo Dadduzio, Lisa Salvatore, Beatrice Borelli, Filippo Pietrantonio, Yan Ning, Satoshi Okazaki, Martin D. Berger, Yuji Miyamoto, Roel Gopez, Jr, Afsaneh Barzi, Toshiharu Yamaguchi, Fotios Loupakis, Heinz-Josef Lenz

Eur J Cancer. Author manuscript; available in PMC 2020 Sep 17.

Published in final edited form as: Eur J Cancer. 2017 Nov; 86: 197–206. Published online 2017 Oct 6. doi: 10.1016/j.ejca.2017.08.033

PMCID:: PMC7497848

Abstract Article PDF–1019K

Select item 706907811.

The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma

Lu Chen, Zeyang Wang, Qingwen Xu, Yuxi Liu, Le Chen, Suhang Guo, Hua Wang, Kui Zeng, Junqing Liu, Su Zeng, Lushan Yu

Theranostics. 2020; 10(8): 3562–3578. Published online 2020 Feb 18. doi: 10.7150/thno.39944

PMCID:: PMC7069078

Abstract Article PDF–2.7M

Select item 684357112.

Effects of Single Nucleotide Polymorphism Ala270Ser (rs316019) on the Function and Regulation of hOCT2

Dominik Frenzel, Christina Köppen, Oliver Bolle Bauer, Uwe Karst, Rita Schröter, Mladen V. Tzvetkov, Giuliano Ciarimboli

Biomolecules. 2019 Oct; 9(10): 578. Published online 2019 Oct 7. doi: 10.3390/biom9100578

PMCID:: PMC6843571

Abstract Article PDF–1.4M

Select item 677813713.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 661553514.

Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinoma

Qianying Zhu, Lushan Yu, Zhiyuan Qin, Lu Chen, Haihong Hu, Xiaoli Zheng, Su Zeng

Epigenetics. 2019; 14(8): 791–803. Published online 2019 May 15. doi: 10.1080/15592294.2019.1615354

PMCID:: PMC6615535

Abstract Article PDF–4.1M

Select item 656279315.

Outcome Definition Influences the Relationship between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients

Zulfan Zazuli, Leila S. Otten, Britt I. Drögemöller, Mara Medeiros, Jose G. Monzon, Galen E. B. Wright, Christian K. Kollmannsberger, Philippe L. Bedard, Zhuo Chen, Karen A. Gelmon, Nicole McGoldrick, Abhijat Kitchlu, Susanne J. H. Vijverberg, Rosalinde Masereeuw, Colin J. D. Ross, Geoffrey Liu, Bruce C. Carleton, Anke H. Maitland-van der Zee

Genes (Basel) 2019 May; 10(5): 364. Published online 2019 May 10. doi: 10.3390/genes10050364

PMCID:: PMC6562793

Abstract Article PDF–567K

Select item 633509916.

Blood-Brain Barrier: From Physiology to Disease and Back

Melanie D. Sweeney, Zhen Zhao, Axel Montagne, Amy R. Nelson, Berislav V. Zlokovic

Physiol Rev. 2019 Jan 1; 99(1): 21–78. Published online 2018 Oct 3. doi: 10.1152/physrev.00050.2017

PMCID:: PMC6335099

Abstract Article

Select item 607772217.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 572853418.

Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine

Marleen Julia Meyer, Tina Seitz, Jürgen Brockmöller, Mladen Vassilev Tzvetkov

PLoS One. 2017; 12(12): e0189521. Published online 2017 Dec 13. doi: 10.1371/journal.pone.0189521

PMCID:: PMC5728534

Abstract Article PDF–7.0M

Select item 501076919.

Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients

Chen-Yue Qian, Yi Zheng, Ying Wang, Juan Chen, Jun-Yan Liu, Hong-Hao Zhou, Ji-Ye Yin, Zhao-Qian Liu

Chin J Cancer. 2016; 35(1): 85. Published online 2016 Sep 2. doi: 10.1186/s40880-016-0145-8

PMCID:: PMC5010769

Abstract Article PDF–1.6M

Select item 486579820.

Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity

Claudia Lanvers-Kaminsky, Jason A Sprowl, Ingrid Malath, Dirk Deuster, Maria Eveslage, Eberhard Schlatter, Ron HJ Mathijssen, Joachim Boos, Heribert Jürgens, Antionette G am Zehnhoff-Dinnesen, Alex Sparreboom, Giuliano Ciarimboli

Pharmacogenomics. Author manuscript; available in PMC 2016 May 13.

Published in final edited form as: Pharmacogenomics. 2015; 16(4): 323–332. doi: 10.2217/pgs.14.182

PMCID:: PMC4865798

Abstract Article PDF–646K

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