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Select item 112167481.

Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell

Mayank Verma, Yoko Asakura, Xuerui Wang, Kasey Zhou, Mahmut Ünverdi, Allison P Kann, Robert S Krauss, Atsushi Asakura

eLife. 2024; 13: e73592. Published online 2024 Jun 6. doi: 10.7554/eLife.73592

PMCID:: PMC11216748

Abstract Article PDF–3.6M

Select item 111418682.

Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models

Hoa T.T. Ha, SiYi Liu, Xuan T.A. Nguyen, Linh K. Vo, Nancy C.P. Leong, Dat T. Nguyen, Shivaranjani Balamurugan, Pei Yen Lim, YaJun Wu, Eunju Seong, Toan Q. Nguyen, Jeongah Oh, Markus R. Wenk, Amaury Cazenave-Gassiot, Zuhal Yapici, Wei-Yi Ong, Margit Burmeister, Long N. Nguyen

JCI Insight. 2024 Apr 22; 9(8): e175462. Published online 2024 Mar 7. doi: 10.1172/jci.insight.175462

PMCID:: PMC11141868

Abstract Article PDF–2.8M

Select item 111315543.

Interaction of galectin-1 with caveolae induces mouse embryonic stem cell proliferation through the Src, ERas, Akt and mTOR signaling pathways

M. Y. Lee, S. H. Lee, J. H. Park, H. J. Han

Cell Mol Life Sci. 2009 Apr; 66(8): 1467–1478. Published online 2009 Mar 9. doi: 10.1007/s00018-009-8691-8

PMCID:: PMC11131554

Abstract Article PDF–2.6M

Select item 111156394.

Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells

Giovanni Di Maira, Francesca Brustolon, Lorenzo A. Pinna, Maria Ruzzene

Cell Mol Life Sci. 2009 Oct; 66(20): 3363–3373. Published online 2009 Aug 8. doi: 10.1007/s00018-009-0108-1

PMCID:: PMC11115639

Abstract Article PDF–492K

Select item 111016725.

DNA‐PKcs/AKT1 inhibits epithelial–mesenchymal transition during radiation‐induced pulmonary fibrosis by inducing ubiquitination and degradation of Twist1

Ziyan Yan, Jiaojiao Zhu, Yuhao Liu, Zhongqiu Li, Xinxin Liang, Shenghui Zhou, Yifan Hou, Huixi Chen, Lin Zhou, Ping Wang, Xingkun Ao, Shanshan Gao, Xin Huang, Ping‐Kun Zhou, Yongqing Gu

Clin Transl Med. 2024 May; 14(5): e1690. Published online 2024 May 17. doi: 10.1002/ctm2.1690

PMCID:: PMC11101672

Abstract Article PDF–6.9M

Select item 110613476.

Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice

Yi Lv, Qian Wang, Chensheng Lin, Xi Zheng, Yanding Zhang, Xuefeng Hu

Front Cell Dev Biol. 2024; 12: 1376814. Published online 2024 Apr 17. doi: 10.3389/fcell.2024.1376814

PMCID:: PMC11061347

Abstract Article PDF–11M

Select item 109320357.

Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway

Taha Rehmani, Ana Paula Dias, Marsel Kamal, Maysoon Salih, Balwant S. Tuana

Int J Mol Sci. 2024 Mar; 25(5): 2888. Published online 2024 Mar 1. doi: 10.3390/ijms25052888

PMCID:: PMC10932035

Abstract Article PDF–4.4M

Select item 109015138.

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis

Pengfei Guo, Rebecca C Lim, Keshari Rajawasam, Tiffany Trinh, Hong Sun, Hui Zhang

eLife. 2024; 13: e86168. Published online 2024 Feb 12. doi: 10.7554/eLife.86168

PMCID:: PMC10901513

Abstract Article PDF–9.2M

Select item 108974469.

Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation

María Jesús Ruiz-Rodríguez, Jorge Oller, Sara Martínez-Martínez, Iván Alarcón-Ruiz, Marta Toral, Yilin Sun, Ángel Colmenar, María José Méndez-Olivares, Dolores López-Maderuelo, Christine B Kern, J Francisco Nistal, Arturo Evangelista, Gisela Teixido-Tura, Miguel R Campanero, Juan Miguel Redondo

EMBO Mol Med. 2024 Jan; 16(1): 132–157. Published online 2024 Jan 2. doi: 10.1038/s44321-023-00009-7

PMCID:: PMC10897446

Abstract Article PDF–14M

Select item 1086436310.

Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

Yan Guo, Pan Xiang, Xiaojiao Sun, Wei Liu, Jiafeng Zhou, Bin Yin, Lin Hou, Boqin Qiang, Huiliang Li, Pengcheng Shu, Xiaozhong Peng

Signal Transduct Target Ther. 2024; 9: 32. Published online 2024 Feb 14. doi: 10.1038/s41392-024-01742-2

PMCID:: PMC10864363

Abstract Article PDF–9.9M

Select item 1084285311.

PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis

Xiaonan Xu, Ilah Bok, Neel Jasani, Kaizhen Wang, Manon Chadourne, Nicol Mecozzi, Ou Deng, Eric A. Welsh, Fumi Kinose, Uwe Rix, Florian A. Karreth

Cancer Res. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Cancer Res. 2024 Feb 1; 84(3): 388–404. doi: 10.1158/0008-5472.CAN-23-1730

PMCID:: PMC10842853

Abstract Article PDF–3.5M

Select item 1083633412.

Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke

Jaclyn A. Connelly, Xuejing Zhang, Yuzhou Chen, Yapeng Chao, Yejie Shi, Tija C. Jacob, Q. Jane Wang

Neurobiol Dis. Author manuscript; available in PMC 2024 Feb 2.

Published in final edited form as: Neurobiol Dis. 2023 Oct 15; 187: 106305. Published online 2023 Sep 18. doi: 10.1016/j.nbd.2023.106305

PMCID:: PMC10836334

Abstract Article PDF–2.3M

Select item 1075630213.

Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing

Abhinava K. Mishra, Melanie Rodriguez, Alba Yurani Torres, Morgan Smith, Anthony Rodriguez, Annalise Bond, Meghan A. Morrissey, Denise J. Montell

Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52): e2310221120. Published online 2023 Dec 18. doi: 10.1073/pnas.2310221120

PMCID:: PMC10756302

Abstract Article PDF–4.6M

Select item 1074378114.

Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch

Ismael Bracho-Valdés, Rodolfo Daniel Cervantes-Villagrana, Yarely Mabell Beltrán-Navarro, Adán Olguín-Olguín, Estanislao Escobar-Islas, Jorge Carretero-Ortega, J. Alberto Olivares-Reyes, Guadalupe Reyes-Cruz, J. Silvio Gutkind, José Vázquez-Prado

Int J Mol Sci. 2023 Dec; 24(24): 17531. Published online 2023 Dec 15. doi: 10.3390/ijms242417531

PMCID:: PMC10743781

Abstract Article PDF–3.1M

Select item 1069850815.

A multi‐layered network model identifies Akt1 as a common modulator of neurodegeneration

Dokyun Na, Do‐Hwan Lim, Jae‐Sang Hong, Hyang‐Mi Lee, Daeahn Cho, Myeong‐Sang Yu, Bilal Shaker, Jun Ren, Bomi Lee, Jae Gwang Song, Yuna Oh, Kyungeun Lee, Kwang‐Seok Oh, Mi Young Lee, Min‐Seok Choi, Han Saem Choi, Yang‐Hee Kim, Jennifer M Bui, Kangseok Lee, Hyung Wook Kim, Young Sik Lee, Jörg Gsponer

Mol Syst Biol. 2023 Dec; 19(12): e11801. Published online 2023 Nov 20. doi: 10.15252/msb.202311801

PMCID:: PMC10698508

Abstract Article PDF–7.0M

Select item 1068364516.

Endothelial nitric oxide synthase (eNOS) S1176 phosphorylation status governs atherosclerotic lesion formation

Tung D. Nguyen, Nur-Taz Rahman, William C. Sessa, Monica Y. Lee

Front Cardiovasc Med. 2023; 10: 1279868. Published online 2023 Nov 14. doi: 10.3389/fcvm.2023.1279868

PMCID:: PMC10683645

Abstract Article PDF–66M

Select item 1067987917.

FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway: FUNDC2 mediates TNBC progression via the AKT/GSK3β/GLI1 pathway

Liyang Yin, Renxian Cao, Zhuoqing Liu, Gang Luo, Yu Li, Xiaolong Zhou, Xiguang Chen, Ying Wu, Jun He, Xuyu Zu, Yingying Shen

Acta Biochim Biophys Sin (Shanghai) 2023 Nov 25; 55(11): 1770–1783. Published online 2023 Sep 11. doi: 10.3724/abbs.2023142

PMCID:: PMC10679879

Abstract Article PDF–4.0M

Select item 1061224618.

Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism

Yu-Han Chen, Albert P. Ta, Yumay Chen, Hsiao-Chen Lee, Wenjun Fan, Phang-Lang Chen, Maria C. Jordan, Kenneth P. Roos, Grant R. MacGregor, Qin Yang, Robert A. Edwards, Junfeng Li, Ping H. Wang

Cardiovasc Diabetol. 2023; 22: 294. Published online 2023 Oct 27. doi: 10.1186/s12933-023-02020-1

PMCID:: PMC10612246

Abstract Article PDF–7.7M

Select item 1058967319.

Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction

Inna Radzishevsky, Maali Odeh, Oded Bodner, Salman Zubedat, Lihi Shaulov, Maxim Litvak, Kayoko Esaki, Takeo Yoshikawa, Bella Agranovich, Wen-Hong Li, Alex Radzishevsky, Eyal Gottlieb, Avi Avital, Herman Wolosker

Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2302780120. Published online 2023 Oct 9. doi: 10.1073/pnas.2302780120

PMCID:: PMC10589673

Abstract Article PDF–6.8M

Select item 1058481120.

Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis

Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki

Nat Commun. 2023; 14: 6584. Published online 2023 Oct 18. doi: 10.1038/s41467-023-42334-y

PMCID:: PMC10584811

Abstract Article PDF–4.4M

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