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Items: 1 to 20 of 46

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders
Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz
Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700
PMCID:
PMC10769350
AbstractArticlePDF–11M
3.
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling
Qinnan Yan, Huanqing Gao, Qing Yao, Kun Ling, Guozhi Xiao
J Biol Chem. 2022 Mar; 298(3): 101639. Published online 2022 Jan 25. doi: 10.1016/j.jbc.2022.101639
PMCID:
PMC8867119
AbstractArticlePDF–3.9M
4.
Adipocyte-specific deletion of PIP5K1c reduces diet-induced obesity and insulin resistance by increasing energy expenditure
Guan Huang, Cuishan Yang, Sheng Guo, Miaoling Huang, Liping Deng, Ying Huang, Puxin Chen, Feng Chen, Xiaohong Huang
Lipids Health Dis. 2022; 21: 6. Published online 2022 Jan 7. doi: 10.1186/s12944-021-01616-4
PMCID:
PMC8742433
AbstractArticlePDF–4.3M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Control of Rab7a activity and localization through endosomal type Igamma PIP 5-kinase is required for endosome maturation and lysosome function
Ming Sun, Gary Luong, Faiz Plastikwala, Yue Sun
FASEB J. Author manuscript; available in PMC 2021 Feb 1.
Published in final edited form as: FASEB J. 2020 Feb; 34(2): 2730–2748. Published online 2019 Dec 19. doi: 10.1096/fj.201901830R
PMCID:
PMC7018547
AbstractArticlePDF–3.7M
7.
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics
Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea
Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253
PMCID:
PMC6692770
AbstractArticlePDF–7.7M
8.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
9.
PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites
Mira Sohn, Marek Korzeniowski, James P. Zewe, Rachel C. Wills, Gerald R.V. Hammond, Jana Humpolickova, Lukas Vrzal, Dominika Chalupska, Vaclav Veverka, Gregory D. Fairn, Evzen Boura, Tamas Balla
J Cell Biol. 2018 May 7; 217(5): 1797–1813. doi: 10.1083/jcb.201710095
PMCID:
PMC5940310
AbstractArticlePDF–2.8M
10.
Conditional deletion of Pip5k1c in sensory ganglia and effects on nociception and inflammatory sensitization
Lipin Loo, Mark J Zylka
Mol Pain. 2017; 13: 1744806917737907. Published online 2017 Oct 11. doi: 10.1177/1744806917737907
PMCID:
PMC5656109
AbstractArticlePDF–730K
11.
Loss of the tumor suppressor BAP1 causes myeloid transformation
Anwesha Dey, Dhaya Seshasayee, Rajkumar Noubade, Dorothy M. French, Jinfeng Liu, Mira S. Chaurushiya, Donald S. Kirkpatrick, Victoria C. Pham, Jennie R. Lill, Corey E. Bakalarski, Jiansheng Wu, Lilian Phu, Paula Katavolos, Lindsay M. Saunders, Omar Abdel-Wahab, Zora Modrusan, Somasekar Seshagiri, Ken Dong, Zhonghua Lin, Mercedesz Balazs, Rowena Suriben, Kim Newton, Sarah Hymowitz, Guillermo Garcia-Manero, Flavius Martin, Ross L. Levine, Vishva M. Dixit
Science. Author manuscript; available in PMC 2016 Dec 30.
Published in final edited form as: Science. 2012 Sep 21; 337(6101): 1541–1546. Published online 2012 Aug 9. doi: 10.1126/science.1221711
PMCID:
PMC5201002
AbstractArticlePDF–1.7M
12.
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
Qingwen Xu, Yuxia Zhang, Qing Wei, Yan Huang, Jinghua Hu, Kun Ling
Nat Commun. 2016; 7: 10777. Published online 2016 Feb 26. doi: 10.1038/ncomms10777
PMCID:
PMC4773430
AbstractArticlePDF–2.8M
13.
Crosstalk between Shp1 and PIPKIγ controls leukocyte recruitment.
Anika Stadtmann, Helena Block, Stephanie Volmering, Clare Abram, Charlotte Sohlbach, Mark Boras, Clifford A. Lowell, Alexander Zarbock
J Immunol. Author manuscript; available in PMC 2016 Aug 1.
Published in final edited form as: J Immunol. 2015 Aug 1; 195(3): 1152–1161. Published online 2015 Jun 22. doi: 10.4049/jimmunol.1500606
PMCID:
PMC4506862
AbstractArticlePDF–2.2M
14.
Targeting Type I? Phosphatidylinositol Phosphate Kinase Inhibits Breast Cancer Metastasis
Chunhua Chen, Xiangling Wang, Xunhao Xiong, Qingbo Liu, Yan Huang, Qingwen Xu, Jinghua Hu, Gaoxiang Ge, Kun Ling
Oncogene. Author manuscript; available in PMC 2016 Feb 27.
Published in final edited form as: Oncogene. 2015 Aug 27; 34(35): 4635–4646. Published online 2014 Dec 8. doi: 10.1038/onc.2014.393
PMCID:
PMC4459944
AbstractArticlePDF–3.8M
15.
The lipid kinase PIP5K1C regulates pain signaling and sensitization
Brittany D. Wright, Lipin Loo, Sarah E. Street, Anqi Ma, Bonnie Taylor-Blake, Michael A. Stashko, Jian Jin, William P. Janzen, Stephen V. Frye, Mark J. Zylka
Neuron. Author manuscript; available in PMC 2015 May 21.
Published in final edited form as: Neuron. 2014 May 21; 82(4): 836–847. doi: 10.1016/j.neuron.2014.04.006
PMCID:
PMC4074510
AbstractArticlePDF–2.5M
16.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
17.
Determinants of phosphatidylinositol-4-phosphate 5-kinase type Iγ90 uropod location in T-lymphocytes and its role in uropod formation
Lucia Mathis, Sarah Wernimont, Sarah Affentranger, Anna Huttenlocher, Verena Niggli
PeerJ. 2013; 1: e131. Published online 2013 Aug 29. doi: 10.7717/peerj.131
PMCID:
PMC3757496
AbstractArticlePDF–4.9M
18.
Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion
Yanfeng Wang, Liang Zhao, Aae Suzuki, Lurong Lian, Sang H. Min, Ziqian Wang, Rustem I. Litvinov, Timothy J. Stalker, Tadayuki Yago, Arkadiusz G. Klopocki, David W. Schmidtke, Helen Yin, John K. Choi, Rodger P. McEver, John W. Weisel, John H. Hartwig, Charles S. Abrams
Blood. 2013 Apr 4; 121(14): 2743–2752. Prepublished online 2013 Jan 31. doi: 10.1182/blood-2012-07-445205
PMCID:
PMC3617636
AbstractArticle
19.
Type I Phosphotidylinosotol 4-Phosphate 5-Kinase γ Regulates Osteoclasts in a Bifunctional Manner
Tingting Zhu, Jean C. Chappel, Fong-Fu Hsu, John Turk, Rajeev Aurora, Krzysztof Hyrc, Pietro De Camilli, Thomas J. Broekelmann, Robert P. Mecham, Steven L. Teitelbaum, Wei Zou
J Biol Chem. 2013 Feb 22; 288(8): 5268–5277. Published online 2013 Jan 8. doi: 10.1074/jbc.M112.446054
PMCID:
PMC3581369
AbstractArticlePDF–2.5M
20.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M

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