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Items: 1 to 20 of 47

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble
Medha Sharma, Chinmoy Sankar Dey
Cell Commun Signal. 2022; 20: 179. Published online 2022 Nov 14. doi: 10.1186/s12964-022-00987-0
PMCID:
PMC9664818
AbstractArticlePDF–3.9M
3.
Myeloid Lineage Ablation of Phlpp1 Regulates M-CSF Signaling and Tempers Bone Resorption in Female Mice
Ismael Y. Karkache, Jeyaram R. Damodaran, David H. H. Molstad, Kim C. Mansky, Elizabeth W. Bradley
Int J Mol Sci. 2021 Sep; 22(18): 9702. Published online 2021 Sep 8. doi: 10.3390/ijms22189702
PMCID:
PMC8468863
AbstractArticlePDF–5.6M
4.
Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
Blaz Lupse, Karthika Annamalai, Hazem Ibrahim, Supreet Kaur, Shirin Geravandi, Bhavishya Sarma, Anasua Pal, Sushil Awal, Arundhati Joshi, Sahar Rafizadeh, Murali Krishna Madduri, Mona Khazaei, Huan Liu, Ting Yuan, Wei He, Kanaka Durga Devi Gorrepati, Zahra Azizi, Qi Qi, Keqiang Ye, Jose Oberholzer, Kathrin Maedler, Amin Ardestani
Cell Rep. Author manuscript; available in PMC 2021 Sep 6.
Published in final edited form as: Cell Rep. 2021 Aug 3; 36(5): 109490. doi: 10.1016/j.celrep.2021.109490
PMCID:
PMC8421018
AbstractArticlePDF–3.1M
5.
Phlpp1 is induced by estrogen in osteoclasts and its loss in Ctsk-expressing cells does not protect against ovariectomy-induced bone loss
Marcelline K. Hanson, Ismael Y. Karkache, David H. H. Molstad, Andrew A. Norton, Kim C. Mansky, Elizabeth W. Bradley
PLoS One. 2021; 16(6): e0251732. Published online 2021 Jun 18. doi: 10.1371/journal.pone.0251732
PMCID:
PMC8213150
AbstractArticlePDF–1.6M
6.
PH domain and leucine rich repeat phosphatase 1 (Phlpp1) suppresses parathyroid hormone receptor 1 (Pth1r) expression and signaling during bone growth
Samantha R. Weaver, Earnest L. Taylor, Elizabeth L. Zars, Katherine M. Arnold, Elizabeth W. Bradley, Jennifer J. Westendorf
J Bone Miner Res. Author manuscript; available in PMC 2022 May 1.
Published in final edited form as: J Bone Miner Res. 2021 Jan 12 : 10.1002/jbmr.4248. Published online 2021 Jan 12. doi: 10.1002/jbmr.4248
Correction in:
J Bone Miner Res. 2021 Jun 4
PMCID:
PMC8131217
AbstractArticlePDF–1.1M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
USP1 deubiquitinates Akt to inhibit PI3K‐Akt‐FoxO signaling in muscle during prolonged starvation
Dana Goldbraikh, Danielle Neufeld, Yara Eid‐Mutlak, Inbal Lasry, Jennifer E Gilda, Anna Parnis, Shenhav Cohen
EMBO Rep. 2020 Apr 3; 21(4): e48791. Published online 2020 Mar 5. doi: 10.15252/embr.201948791
PMCID:
PMC7132338
AbstractArticlePDF–1.6M
9.
Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice
Changli Zhang, Madeline P. Smith, George K. Zhou, Alon Lai, Robert C. Hoy, Victoria Mroz, Olivia M. Torre, Damien M. Laudier, Elizabeth W. Bradley, Jennifer J. Westendorf, James C. Iatridis, Svenja Illien-Jünger
Cell Death Dis. 2019 Oct; 10(10): 754. Published online 2019 Oct 3. doi: 10.1038/s41419-019-1985-3
PMCID:
PMC6776553
AbstractArticlePDF–3.9M
10.
Enhanced Neutrophil Immune Homeostasis Due to Deletion of PHLPP
Taojing Ran, Yao Zhang, Na Diao, Shuo Geng, Keqiang Chen, Christina Lee, Liwu Li
Front Immunol. 2019; 10: 2127. Published online 2019 Sep 6. doi: 10.3389/fimmu.2019.02127
PMCID:
PMC6742689
AbstractArticlePDF–4.9M
11.
PHLPP1 counter-regulates STAT1-mediated inflammatory signaling
Ksenya Cohen Katsenelson, Joshua D Stender, Agnieszka T Kawashima, Gema Lordén, Satoshi Uchiyama, Victor Nizet, Christopher K Glass, Alexandra C Newton
eLife. 2019; 8: e48609. Published online 2019 Aug 13. doi: 10.7554/eLife.48609
PMCID:
PMC6692130
AbstractArticlePDF–4.2M
12.
Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice
Anna M. Mattson, Dana L. Begun, David H. H. Molstad, Margaret A. Meyer, Merry Jo Oursler, Jennifer J. Westendorf, Elizabeth W. Bradley
J Biol Chem. 2019 Aug 2; 294(31): 11772–11784. Published online 2019 Jun 12. doi: 10.1074/jbc.RA119.007660
PMCID:
PMC6682736
AbstractArticlePDF–5.2M
13.
DNA Methylation and FoxO3a Regulate PHLPP1 Expression in Chondrocytes
Clara Castillejo Becerra, Anna M. Mattson, David H. H. Molstad, Ian M. Lorang, Jennifer J. Westendorf, Elizabeth W. Bradley
J Cell Biochem. Author manuscript; available in PMC 2019 Sep 1.
Published in final edited form as: J Cell Biochem. 2018 Sep; 119(9): 7470–7478. Published online 2018 May 18. doi: 10.1002/jcb.27056
PMCID:
PMC6150803
AbstractArticlePDF–1.1M
14.
Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice
Travis C. Jackson, C. Edward Dixon, Keri Janesko-Feldman, Vincent Vagni, Shawn E. Kotermanski, Edwin K. Jackson, Patrick M. Kochanek
Sci Rep. 2018; 8: 7158. Published online 2018 May 8. doi: 10.1038/s41598-018-25371-2
PMCID:
PMC5940799
AbstractArticlePDF–3.2M
15.
Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C
Xiaopeng Xiong, Xin Li, Yang-An Wen, Tianyan Gao
J Biol Chem. 2016 Nov 25; 291(48): 25167–25178. Published online 2016 Oct 19. doi: 10.1074/jbc.M116.740639
PMCID:
PMC5122783
AbstractArticlePDF–3.4M
16.
Targeting CAG repeat RNAs reduces Huntington’s disease phenotype independently of huntingtin levels
Laura Rué, Mónica Bañez-Coronel, Jordi Creus-Muncunill, Albert Giralt, Rafael Alcalá-Vida, Gartze Mentxaka, Birgit Kagerbauer, M. Teresa Zomeño-Abellán, Zeus Aranda, Veronica Venturi, Esther Pérez-Navarro, Xavier Estivill, Eulàlia Martí
J Clin Invest. 2016 Nov 1; 126(11): 4319–4330. Published online 2016 Oct 10. doi: 10.1172/JCI83185
PMCID:
PMC5096913
AbstractArticlePDF–1.2M
17.
SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory
Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Maya Yamazaki, Shigeki Shimba, Kenji Sakimura, Yoshitaka Fukada
Nat Commun. 2016; 7: 12926. Published online 2016 Sep 30. doi: 10.1038/ncomms12926
PMCID:
PMC5056436
AbstractArticlePDF–1.0M
18.
SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior
Jun J. Nakano, Kimiko Shimizu, Shigeki Shimba, Yoshitaka Fukada
Sci Rep. 2016; 6: 33500. Published online 2016 Sep 19. doi: 10.1038/srep33500
PMCID:
PMC5027591
AbstractArticlePDF–1.2M
19.
Deleting both PHLPP1 and CANP1 rescues impairments in long-term potentiation and learning in both single knockout mice
Yan Liu, Jiandong Sun, Yubin Wang, Dulce Lopez, Jennifer Tran, Xiaoning Bi, Michel Baudry
Learn Mem. 2016 Aug; 23(8): 399–404. Published online 2016 Aug. doi: 10.1101/lm.042721.116
PMCID:
PMC4947237
AbstractArticlePDF–643K
20.
Defects in the CAPN1 gene result in alterations in cerebellar development and in cerebellar ataxia in mice and humans
Yubin Wang, Joshua Hersheson, Dulce Lopez, Monia Ben Hamad, Yan Liu, Ka-Hung Lee, Vanessa Pinto, Jeff Seinfeld, Sarah Wiethoff, Jiandong Sun, Rim Amouri, Faycal Hentati, Neema Baudry, Jennifer Tran, Andrew B Singleton, Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr, Xiaoning Bi, Henry Houlden, Michel Baudry
Cell Rep. Author manuscript; available in PMC 2016 Jun 29.
Published in final edited form as: Cell Rep. 2016 Jun 28; 16(1): 79–91. Published online 2016 Jun 16. doi: 10.1016/j.celrep.2016.05.044
PMCID:
PMC4927383
AbstractArticlePDF–2.0M

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