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Items: 1 to 20 of 48

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes
Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong
Cell Death Dis. 2023 Nov; 14(11): 722. Published online 2023 Nov 7. doi: 10.1038/s41419-023-06249-2
PMCID:
PMC10630521
AbstractArticlePDF–5.3M
3.
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
Maria J Forteza, Martin Berg, Andreas Edsfeldt, Jangming Sun, Roland Baumgartner, Ilona Kareinen, Felipe Beccaria Casagrande, Ulf Hedin, Song Zhang, Ivan Vuckovic, Petras P Dzeja, Konstantinos A Polyzos, Anton Gisterå, Mette Trauelsen, Thue W Schwartz, Lea Dib, Joerg Herrmann, Claudia Monaco, Ljubica Matic, Isabel Gonçalves, Daniel F J Ketelhuth
Cardiovasc Res. 2023 Jun; 119(7): 1524–1536. Published online 2023 Mar 2. doi: 10.1093/cvr/cvad038
PMCID:
PMC10318388
AbstractArticlePDF–83M
4.
Analysis of a genetic region affecting mouse body weight
Connie L. K. Leung, Subashini Karunakaran, Michael G. Atser, Leyla Innala, Xiaoke Hu, Victor Viau, James D. Johnson, Susanne M. Clee
Physiol Genomics. 2023 Mar 1; 55(3): 132–146. Published online 2023 Jan 30. doi: 10.1152/physiolgenomics.00137.2022
PMCID:
PMC10042608
AbstractArticle
5.
TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway
Suhong Zhang, Haiting Dai, Wenya Li, Runming Wang, Hanyu Wu, Ming Shen, Ye Hu, Lixin Xie, Yiming Xing
Cell Death Dis. 2021 Dec; 12(12): 1086. Published online 2021 Nov 16. doi: 10.1038/s41419-021-04369-1
PMCID:
PMC8599864
AbstractArticlePDF–5.8M
6.
Adhesion G protein–coupled receptor Gpr126/Adgrg6 is essential for placental development
Rebeca Torregrosa-Carrión, Rebeca Piñeiro-Sabarís, Marcos Siguero-Álvarez, Joaquím Grego-Bessa, Luis Luna-Zurita, Vitor Samuel Fernandes, Donal MacGrogan, Didier Y. R. Stainier, José Luis de la Pompa
Sci Adv. 2021 Nov; 7(46): eabj5445. Published online 2021 Nov 12. doi: 10.1126/sciadv.abj5445
PMCID:
PMC8589310
AbstractArticlePDF–19M
7.
Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes
Hyeon-Ji Kang, Byong-Keol Min, Won-Il Choi, Jae-Han Jeon, Dong Wook Kim, Sungmi Park, Yun-Kyung Lee, Hwa-jin Kim, Ju-Eun Byeon, Younghoon Go, Hye Jin Ham, Yong Hyun Jeon, Mi-Jin Kim, Jung Yi Lee, Adam R. Wende, Sung Hee Choi, Robert A. Harris, In-Kyu Lee
Exp Mol Med. 2021 Sep; 53(9): 1390–1401. Published online 2021 Sep 22. doi: 10.1038/s12276-021-00672-1
PMCID:
PMC8492875
AbstractArticlePDF–5.5M
8.
The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis
Peiran Feng, Quanli Yang, Liang Luo, Yadong Sun, Wenkai Lv, Shuo Wan, Zerong Guan, Zhiqiang Xiao, Feng Liu, Zehua Li, Zhongjun Dong, Meixiang Yang
Theranostics. 2021; 11(19): 9503–9518. Published online 2021 Sep 13. doi: 10.7150/thno.63992
PMCID:
PMC8490516
AbstractArticlePDF–3.9M
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
10.
Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice
Ivan Menendez-Montes, Beatriz Escobar, Manuel J. Gomez, Teresa Albendea-Gomez, Beatriz Palacios, Elena Bonzon-Kulichenko, Jose Luis Izquierdo-Garcia, Ana Vanessa Alonso, Alessia Ferrarini, Luis Jesus Jimenez-Borreguero, Jesus Ruiz-Cabello, Jesus Vázquez, Silvia Martin-Puig
iScience. 2021 Feb 19; 24(2): 102124. Published online 2021 Feb 3. doi: 10.1016/j.isci.2021.102124
PMCID:
PMC7900219
AbstractArticlePDF–6.0M
11.
PDK1 is a negative regulator of axon regeneration
Hyemin Kim, Jinyoung Lee, Yongcheol Cho
Mol Brain. 2021; 14: 31. Published online 2021 Feb 12. doi: 10.1186/s13041-021-00748-z
PMCID:
PMC7881570
AbstractArticlePDF–3.7M
12.
Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis
Wei Gao, Yuliang Zhang, Hongjie Luo, Min Niu, Xiwang Zheng, Wanglai Hu, Jiajia Cui, Xuting Xue, Yunfeng Bo, Fengsheng Dai, Yan Lu, Dongli Yang, Yujia Guo, Huina Guo, Huizheng Li, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen, Changming An, Teng Ma, Lei Jin, Wei Xu, Yongyan Wu
Cell Death Dis. 2020 Oct; 11(10): 919. Published online 2020 Oct 26. doi: 10.1038/s41419-020-03104-6
PMCID:
PMC7589524
AbstractArticlePDF–5.2M
13.
Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages
Yi Rang Na, Daun Jung, Juha Song, Jong-Wan Park, Jung Joo Hong, Seung Hyeok Seok
J Mol Cell Biol. 2020 Jul; 12(7): 543–555. Published online 2020 Jan 3. doi: 10.1093/jmcb/mjz113
PMCID:
PMC7493030
AbstractArticlePDF–1.5M
14.
The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase–leukotriene B4 axis
Tetsuya Hosooka, Yusei Hosokawa, Kaku Matsugi, Masakazu Shinohara, Yoko Senga, Yoshikazu Tamori, Chikako Aoki, Sho Matsui, Tsutomu Sasaki, Tadahiro Kitamura, Masashi Kuroda, Hiroshi Sakaue, Kazuhiro Nomura, Kei Yoshino, Yuko Nabatame, Yoshito Itoh, Kanji Yamaguchi, Yoshitake Hayashi, Jun Nakae, Domenico Accili, Takehiko Yokomizo, Susumu Seino, Masato Kasuga, Wataru Ogawa
Proc Natl Acad Sci U S A. 2020 May 26; 117(21): 11674–11684. Published online 2020 May 11. doi: 10.1073/pnas.1921015117
PMCID:
PMC7261087
AbstractArticlePDF–1.8M
15.
PDK1 regulates the survival of the developing cortical interneurons
Yongjie Wei, Xiaoning Han, Chunjie Zhao
Mol Brain. 2020; 13: 65. Published online 2020 May 4. doi: 10.1186/s13041-020-00604-6
PMCID:
PMC7197138
AbstractArticlePDF–9.2M
16.
Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade
Stanislao Igor Travisano, Vera Lucia Oliveira, Belén Prados, Joaquim Grego-Bessa, Rebeca Piñeiro-Sabarís, Vanesa Bou, Manuel J Gómez, Fátima Sánchez-Cabo, Donal MacGrogan, José Luis de la Pompa
eLife. 2019; 8: e49977. Published online 2019 Dec 4. doi: 10.7554/eLife.49977
PMCID:
PMC6917494
AbstractArticlePDF–19M
17.
Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation
Kasey Cargill, Shelby L. Hemker, Andrew Clugston, Anjana Murali, Elina Mukherjee, Jiao Liu, Daniel Bushnell, Andrew J. Bodnar, Zubaida Saifudeen, Jacqueline Ho, Carlton M. Bates, Dennis Kostka, Eric S. Goetzman, Sunder Sims-Lucas
J Am Soc Nephrol. 2019 Jul; 30(7): 1192–1205. Published online 2019 May 29. doi: 10.1681/ASN.2018111170
PMCID:
PMC6622426
AbstractArticle
18.
New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules
Richa Das, Lukas Schwintzer, Stanislav Vinopal, Eva Aguado Roca, Marc Sylvester, Ana-Maria Oprisoreanu, Susanne Schoch, Frank Bradke, Meike Broemer
J Cell Sci. 2019 Jun 15; 132(12): jcs229252. Published online 2019 Jun 17. doi: 10.1242/jcs.229252
PMCID:
PMC6602300
AbstractArticle
19.
Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex
Alla Klyuyeva, Alina Tuganova, Natalia Kedishvili, Kirill M. Popov
J Biol Chem. 2019 Jan 18; 294(3): 838–851. Published online 2018 Nov 27. doi: 10.1074/jbc.RA118.006433
PMCID:
PMC6341403
AbstractArticlePDF–2.7M
20.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M

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