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Select item 103640771.

E2F7 drives Autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not human carcinomas

Kuan-Hung Lin, Sue Chin Lee, Mélanie A. Dacheux, Derek D. Norman, Andrea Balogh, Mitul Bavaria, Hsinyu Lee, Gabor Tigyi

FASEB J. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: FASEB J. 2023 Jul; 37(7): e23058. doi: 10.1096/fj.202300838R

PMCID:: PMC10364077

Abstract Article PDF–2.6M

Select item 98261522.

Inhibition of polyploidization in Pten‐deficient livers reduces steatosis

Eva Moreno, Augustine B. Matondo, Laura Bongiovanni, Chris H. A. van de Lest, Martijn R. Molenaar, Mathilda J. M. Toussaint, Saskia C. van Essen, Martin Houweling, J. Bernd Helms, Bart Westendorp, Alain de Bruin

Liver Int. 2022 Nov; 42(11): 2442–2452. Published online 2022 Sep 2. doi: 10.1111/liv.15384

PMCID:: PMC9826152

Abstract Article PDF–3.8M

Select item 78988873.

E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice

Eva Moreno, Mathilda J.M. Toussaint, Saskia C. van Essen, Laura Bongiovanni, Elsbeth A. van Liere, Mirjam H. Koster, Ruixue Yuan, Jan M. van Deursen, Bart Westendorp, Alain de Bruin

Hepatology. 2021 Jan; 73(1): 303–317. Published online 2021 Feb 6. doi: 10.1002/hep.31259

PMCID:: PMC7898887

Abstract Article PDF–1.6M

Select item 65470594.

Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury

Patrick D. Wilkinson, Frances Alencastro, Evan R. Delgado, Madeleine P. Leek, Matthew P. Weirich, P. Anthony Otero, Nairita Roy, Whitney K. Brown, Michael Oertel, Andrew W. Duncan

Am J Pathol. 2019 Jun; 189(6): 1241–1255. doi: 10.1016/j.ajpath.2019.02.008

PMCID:: PMC6547059

Abstract Article PDF–2.7M

Select item 60524575.

Developmental diversification of cortical inhibitory interneurons

Christian Mayer, Christoph Hafemeister, Rachel C. Bandler, Robert Machold, Renata Batista Brito, Xavier Jaglin, Kathryn Allaway, Andrew Butler, Gord Fishell, Rahul Satija

Nature. Author manuscript; available in PMC 2018 Sep 5.

Published in final edited form as: Nature. 2018 Mar 22; 555(7697): 457–462. Published online 2018 Mar 5. doi: 10.1038/nature25999

PMCID:: PMC6052457

Abstract Article PDF–2.3M

Select item 57706006.

Atypical E2Fs inhibit tumor angiogenesis

B G M W Weijts, B Westendorp, B T Hien, L M Martínez-López, M Zijp, I Thurlings, R E Thomas, S Schulte-Merker, W J Bakker, A de Bruin

Oncogene. 2018 Jan 11; 37(2): 271–276. Published online 2017 Sep 18. doi: 10.1038/onc.2017.336

PMCID:: PMC5770600

Abstract Article PDF–1.4M

Select item 57661447.

Atypical E2f functions are critical for pancreas polyploidization

Ramadhan B. Matondo, Eva Moreno, Mathilda J. M. Toussaint, Peter C. J. Tooten, Saskia C. van Essen, Elsbeth A. van Liere, Sameh A. Youssef, Laura Bongiovanni, Alain de Bruin

PLoS One. 2018; 13(1): e0190899. Published online 2018 Jan 12. doi: 10.1371/journal.pone.0190899

PMCID:: PMC5766144

Abstract Article PDF–3.5M

Select item 56358718.

Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit

Tobias Otto, Sheyla V. Candido, Mary S. Pilarz, Ewa Sicinska, Roderick T. Bronson, Michaela Bowden, Iga A. Lachowicz, Kristin Mulry, Anne Fassl, Richard C. Han, Emmanuelle S. Jecrois, Piotr Sicinski

Proc Natl Acad Sci U S A. 2017 Oct 3; 114(40): 10660–10665. Published online 2017 Sep 18. doi: 10.1073/pnas.1702914114

PMCID:: PMC5635871

Abstract Article PDF–1.3M

Select item 53112519.

Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer

I Thurlings, L M Martínez-López, B Westendorp, M Zijp, R Kuiper, P Tooten, L N Kent, G Leone, H J Vos, B Burgering, A de Bruin

Oncogene. 2017 Feb 9; 36(6): 829–839. Published online 2016 Jul 25. doi: 10.1038/onc.2016.251

PMCID:: PMC5311251

Abstract Article PDF–1.5M

Select item 461808610.

The Interleukin-2-mTORc1 Axis Defines the Reciprocal Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

John P. Ray, Matthew M. Staron, Justin A. Shyer, Ping-Chih Ho, Heather D. Marshall, Simon M. Gray, Brian J. Laidlaw, Koichi Araki, Rafi Ahmed, Susan M. Kaech, Joe Craft

Immunity. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Immunity. 2015 Oct 20; 43(4): 690–702. Published online 2015 Sep 22. doi: 10.1016/j.immuni.2015.08.017

PMCID:: PMC4618086

Abstract Article PDF–2.2M

Select item 431955911.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 361648712.

Canonical and Atypical E2Fs Regulate the Mammalian Endocycle

Hui-Zi Chen, Madhu M. Ouseph, Jing Li, Thierry Pécot, Veda Chokshi, Lindsey Kent, Sooin Bae, Morgan Byrne, Camille Duran, Grant Comstock, Prashant Trikha, Markus Mair, Shantibhusan Senapati, Chelsea K. Martin, Sagar Gandhi, Nicholas Wilson, Bin Liu, Yi-Wen Huang, John C. Thompson, Sundaresan Raman, Shantanu Singh, Marcelo Leone, Raghu Machiraju, Kun Huang, Xiaokui Mo, Soledad Fernandez, Ilona Kalaszczynska, Debra J. Wolgemuth, Piotr Sicinski, Tim Huang, Victor Jin, Gustavo Leone

Nat Cell Biol. Author manuscript; available in PMC 2013 May 1.

Published in final edited form as: Nat Cell Biol. 2012 Nov; 14(11): 1192–1202. Published online 2012 Oct 14. doi: 10.1038/ncb2595

PMCID:: PMC3616487

Abstract Article PDF–3.6M

Select item 357241013.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 348379614.

Atypical E2F Repressors and Activators Coordinate Placental Development

Madhu M. Ouseph, Jing Li, Hui-Zi Chen, Thierry Pécot, Pamela Wenzel, John C. Thompson, Grant Comstock, Veda Chokshi, Morgan Byrne, Braxton Forde, Jean-Leon Chong, Kun Huang, Raghu Machiraju, Alain de Bruin, Gustavo Leone

Dev Cell. Author manuscript; available in PMC 2013 Apr 17.

Published in final edited form as: Dev Cell. 2012 Apr 17; 22(4): 849–862. doi: 10.1016/j.devcel.2012.01.013

PMCID:: PMC3483796

Abstract Article PDF–5.0M

Select item 346384315.

E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1

Bart G M W Weijts, Walbert J Bakker, Peter W A Cornelissen, Kuo-Hsuan Liang, Frank H Schaftenaar, Bart Westendorp, Charlotte A C M T de Wolf, Maya Paciejewska, Colinda L G J Scheele, Lindsey Kent, Gustavo Leone, Stefan Schulte-Merker, Alain de Bruin

EMBO J. 2012 Oct 3; 31(19): 3871–3884. Published online 2012 Aug 17. doi: 10.1038/emboj.2012.231

PMCID:: PMC3463843

Abstract Article PDF–1.4M

Select item 340438316.

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

Ozlem Aksoy, Agustin Chicas, Tianying Zeng, Zhen Zhao, Mila McCurrach, Xiaowo Wang, Scott W. Lowe

Genes Dev. 2012 Jul 15; 26(14): 1546–1557. doi: 10.1101/gad.196238.112

PMCID:: PMC3404383

Abstract Article PDF–1.3M

Select item 336236617.

Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia

Tinghui Hu, Seda Ghazaryan, Chandler Sy, Charles Wiedmeyer, Victor Chang, Lizhao Wu

Blood. 2012 May 10; 119(19): 4532–4542. Prepublished online 2012 Mar 14. doi: 10.1182/blood-2011-10-388231

PMCID:: PMC3362366

Abstract Article

Select item 333389218.

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

Bart Westendorp, Michal Mokry, Marian J.A. Groot Koerkamp, Frank C.P. Holstege, Edwin Cuppen, Alain de Bruin

Nucleic Acids Res. 2012 Apr; 40(8): 3511–3523. Published online 2011 Dec 16. doi: 10.1093/nar/gkr1203

PMCID:: PMC3333892

Abstract Article PDF–890K

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311015120.

A Systems Approach Reveals that the Myogenesis Genome Network Is Regulated by the Transcriptional Repressor RP58

Shigetoshi Yokoyama, Yoshiaki Ito, Hiroe Ueno-Kudoh, Hirohito Shimizu, Kenta Uchibe, Sonia Albini, Kazuhiko Mitsuoka, Shigeru Miyaki, Minako Kiso, Akane Nagai, Tomohiro Hikata, Tadahiro Osada, Noritsugu Fukuda, Satoshi Yamashita, Daisuke Harada, Valeria Mezzano, Masataka Kasai, Pier Lorenzo Puri, Yoshihide Hayashizaki, Haruo Okado, Megumi Hashimoto, Hiroshi Asahara

Dev Cell. Author manuscript; available in PMC 2011 Jun 7.

Published in final edited form as: Dev Cell. 2009 Dec; 17(6): 836–848. doi: 10.1016/j.devcel.2009.10.011

PMCID:: PMC3110151

Abstract Article PDF–2.0M

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