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Items: 1 to 20 of 115

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Differential Modulation of miR-122 Transcription by TGFβ1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis
Martha Paluschinski, Claus Kordes, Mihael Vucur, Veronika Buettner, Christoph Roderburg, Haifeng C. Xu, Prashant V. Shinte, Philipp A. Lang, Tom Luedde, Mirco Castoldi
Cells. 2023 Aug; 12(15): 1955. Published online 2023 Jul 27. doi: 10.3390/cells12151955
PMCID:
PMC10416984
AbstractArticlePDF–4.8M
3.
The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2
Kunjan Harit, Rituparna Bhattacharjee, Kai Matuschewski, Jennifer Becker, Ulrich Kalinke, Dirk Schlüter, Gopala Nishanth
Cell Death Dis. 2023 Jul; 14(7): 480. Published online 2023 Jul 29. doi: 10.1038/s41419-023-06014-5
PMCID:
PMC10387084
AbstractArticlePDF–3.8M
4.
TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2
Yisong Qian, Ziwei Wang, Hongru Lin, Tianhua Lei, Zhou Zhou, Weilu Huang, Xuehan Wu, Li Zuo, Jie Wu, Yu Liu, Ling-Fang Wang, Xiao-Hui Guan, Ke-Yu Deng, Mingui Fu, Hong-Bo Xin
Signal Transduct Target Ther. 2022; 7: 148. Published online 2022 May 6. doi: 10.1038/s41392-022-00953-9
PMCID:
PMC9072678
AbstractArticlePDF–5.6M
5.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
6.
TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis
Xiucui Ma, David R. Rawnsley, Attila Kovacs, Moydul Islam, John T. Murphy, Chen Zhao, Minu Kumari, Layla Foroughi, Haiyan Liu, Kevin Qi, Aaradhya Diwan, Krzysztof Hyrc, Sarah Evans, Takashi Satoh, Brent A. French, Kenneth B. Margulies, Ali Javaheri, Babak Razani, Douglas L. Mann, Kartik Mani, Abhinav Diwan
JACC Basic Transl Sci. 2022 Mar; 7(3): 223–243. Published online 2021 Dec 17. doi: 10.1016/j.jacbts.2021.12.002
PMCID:
PMC8993766
AbstractArticlePDF–7.0M
7.
TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells
Xiaoping Xie, Lele Zhu, Zuliang Jie, Yanchuan Li, Meidi Gu, Xiaofei Zhou, Hui Wang, Jae-Hoon Chang, Chun-Jung Ko, Xuhong Cheng, Shao-Cong Sun
Cell Mol Immunol. 2021 Sep; 18(9): 2262–2274. Published online 2020 Nov 17. doi: 10.1038/s41423-020-00583-7
PMCID:
PMC8429472
AbstractArticlePDF–4.3M
8.
TRAF3 acts as a checkpoint of B cell receptor signaling to control antibody class switch recombination and anergy
Zhangguo Chen, Alexandra Krinsky, Rachel A. Woolaver, Xiaoguang Wang, Samantha M.Y. Chen, Vince Popolizio, Ping Xie, Jing H Wang
J Immunol. Author manuscript; available in PMC 2021 Aug 1.
Published in final edited form as: J Immunol. 2020 Aug 1; 205(3): 830–841. Published online 2020 Jun 26. doi: 10.4049/jimmunol.2000322
PMCID:
PMC7369235
AbstractArticlePDF–1.3M
9.
TRAF2 Ser-11 Phosphorylation Promotes Cytosolic Translocation of the CD40 Complex To Regulate Downstream Signaling Pathways
Lauren M. Workman, Laiqun Zhang, Yumei Fan, Weizhou Zhang, Hasem Habelhah
Mol Cell Biol. 2020 May; 40(9): e00429-19. Prepublished online 2020 Feb 10. Published online 2020 Apr 13. doi: 10.1128/MCB.00429-19
PMCID:
PMC7156217
AbstractArticlePDF–3.1M
10.
TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis
Jie Li, Jingyu Zhang, Yusuo Zhang, Zichuang Wang, Yanmei Song, Shanwen Wei, Meijun He, Shoujiang You, Jia Jia, Jian Cheng
Cell Death Dis. 2019 May; 10(5): 328. Published online 2019 Apr 15. doi: 10.1038/s41419-019-1558-5
PMCID:
PMC6465397
AbstractArticlePDF–4.9M
11.
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development
Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi, Rebecca Feltham
Cell Death Differ. 2019 May; 26(5): 877–889. Published online 2018 Sep 5. doi: 10.1038/s41418-018-0166-8
Correction in:
Cell Death Differ. 2024 Nov 7
PMCID:
PMC6461919
AbstractArticlePDF–6.5M
12.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
13.
Tumour necrosis factor signalling in health and disease
Jonathan Holbrook, Samuel Lara-Reyna, Heledd Jarosz-Griffiths, Michael F. McDermott
Version 1. F1000Res. 2019; 8: F1000 Faculty Rev-111. Published online 2019 Jan 28. doi: 10.12688/f1000research.17023.1
PMCID:
PMC6352924
AbstractArticlePDF–1.8M
14.
TRAF2 deficiency in B cells impairs CD40-induced isotype-switching that can be rescued by restoring NF-κB1 activation
Rachel A Woolaver, Xiaoguang Wang, Yonatan Dollin, Ping Xie, Jing H. Wang, Zhangguo Chen
J Immunol. Author manuscript; available in PMC 2019 Dec 1.
Published in final edited form as: J Immunol. 2018 Dec 1; 201(11): 3421–3430. Published online 2018 Oct 19. doi: 10.4049/jimmunol.1800337
PMCID:
PMC6246814
AbstractArticlePDF–977K
15.
Placentation defects are highly prevalent in embryonic lethal mouse mutants
Vicente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline K. White, Elizabeth Tuck, Edward J. Ryder, Diane Gleeson, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth M. Busch-Nentwich, Antonella Galli, James C. Smith, Elizabeth Robertson, David J. Adams, Wolfgang J. Weninger, Timothy Mohun, Myriam Hemberger
Nature. Author manuscript; available in PMC 2018 Sep 14.
Published in final edited form as: Nature. 2018 Mar 22; 555(7697): 463–468. Published online 2018 Mar 14. doi: 10.1038/nature26002
PMCID:
PMC5866719
AbstractArticlePDF–7.4M
16.
TNF receptor–activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling
Sarah Evans, Huei-Ping Tzeng, Deborah J. Veis, Scot Matkovich, Carla Weinheimer, Attila Kovacs, Philip M. Barger, Douglas L. Mann
JCI Insight. 2018 Feb 8; 3(3): e98278. Published online 2018 Feb 8. doi: 10.1172/jci.insight.98278
PMCID:
PMC5821173
AbstractArticlePDF–5.3M
17.
Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy
Mengjie Hu, Qiang Luo, Gulimiran Alitongbieke, Shuyi Chong, Chenting Xu, Lei Xie, Xiaohui Chen, Duo Zhang, Yuqi Zhou, Zhaokai Wang, Xiaohong Ye, Lijun Cai, Fang Zhang, Huibin Chen, Fuquan Jiang, Hui Fang, Shanjun Yang, Jie Liu, Maria T. Diaz-Meco, Ying Su, Hu Zhou, Jorge Moscat, Xiangzhi Lin, Xiao-kun Zhang
Mol Cell. Author manuscript; available in PMC 2018 Jan 10.
Published in final edited form as: Mol Cell. 2017 Apr 6; 66(1): 141–153.e6. doi: 10.1016/j.molcel.2017.03.008
PMCID:
PMC5761061
AbstractArticlePDF–1.3M
18.
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
Bin Wang, Zuliang Jie, Donghyun Joo, Alban Ordureau, Pengda Liu, Wenjian Gan, Jianping Guo, Jinfang Zhang, Brian J. North, Xiangpeng Dai, Xuhong Cheng, Xiuwu Bian, Lingqiang Zhang, J. Wade Harper, Shao-Cong Sun, Wenyi Wei
Nature. Author manuscript; available in PMC 2017 Nov 20.
Published in final edited form as: Nature. 2017 May 18; 545(7654): 365–369. Published online 2017 May 10. doi: 10.1038/nature22344
PMCID:
PMC5695540
AbstractArticlePDF–2.8M
19.
Cardioprotective Role of TRAF2 by Suppressing Apoptosis and Necroptosis
Xiaoyun Guo, Haifeng Yin, Lei Li, Yi Chen, Jing Li, Jessica Doan, Rachel Steinmetz, Qinghang Liu
Circulation. Author manuscript; available in PMC 2018 Aug 22.
Published in final edited form as: Circulation. 2017 Aug 22; 136(8): 729–742. Published online 2017 Jun 1. doi: 10.1161/CIRCULATIONAHA.116.026240
PMCID:
PMC5568494
AbstractArticlePDF–3.9M
20.
PKCζ phosphorylates TRAF2 to protect against intestinal ischemia–reperfusion–induced injury
Wei Zhou, Jihong Yao, Guangzhi Wang, Zhao Chen, Zhenlu Li, Dongcheng Feng, Yang Li, Wasim Qasim, Wenzhi Tan, Shili Ning, Xiaofeng Tian
Cell Death Dis. 2017 Jul; 8(7): e2935. Published online 2017 Jul 20. doi: 10.1038/cddis.2017.310
PMCID:
PMC5550857
AbstractArticlePDF–1.8M

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