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Select item 109071641.

Bulky hydrophobic side chains in the β1-sandwich of microsomal triglyceride transfer protein are critical for the transfer of both triglycerides and phospholipids

Narasimha Anaganti, Swati Valmiki, Rosario Recacha, Shahidul Islam, Steven Farber, Lloyd Ruddock, M. Mahmood Hussain

J Biol Chem. 2024 Mar; 300(3): 105726. Published online 2024 Feb 5. doi: 10.1016/j.jbc.2024.105726

PMCID:: PMC10907164

Abstract Article PDF–5.6M

Select item 105814322.

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven

Hepatology. 2023 Nov; 78(5): 1418–1432. Published online 2022 Oct 12. doi: 10.1002/hep.32709

PMCID:: PMC10581432

Abstract Article PDF–1.9M

Select item 105078313.

Association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in hepatitis C: a systematic review and meta-analysis

Xiaoxia Wang, Yu Cao, Jia Guo, Dezhao Li, Haitao Zhang, Qingkun Song, Jun Lu

Lipids Health Dis. 2023; 22: 154. Published online 2023 Sep 19. doi: 10.1186/s12944-023-01916-x

PMCID:: PMC10507831

Abstract Article PDF–2.3M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 94243425.

Effect of MTTP -493G/T, I128T, Q95H and Q244E polymorphisms on hepatic steatosis in patients with chronic hepatitis

Thamiris Vaz Gago Prata, Caroline Manchiero, Bianca Peixoto Dantas, Arielle Karen da Silva Nunes, Fátima Mitiko Tengan, Mariana Cavalheiro Magri

Clinics (Sao Paulo) 2022 Jan-Dec; 77: 100094. Published online 2022 Aug 23. doi: 10.1016/j.clinsp.2022.100094

PMCID:: PMC9424342

Abstract Article PDF–385K

Select item 85695536.

An improved assay to measure the phospholipid transfer activity of microsomal triglyceride transport protein

Narasimha Anaganti, Sujith Rajan, M. Mahmood Hussain

J Lipid Res. 2021; 62: 100136. Published online 2021 Oct 18. doi: 10.1016/j.jlr.2021.100136

PMCID:: PMC8569553

Abstract Article PDF–1.8M

Select item 83046457.

17β-Estradiol-Induced Conformational Changes of Human Microsomal Triglyceride Transfer Protein: A Computational Molecular Modelling Study

Yong-Xiao Yang, Peng Li, Pan Wang, Bao-Ting Zhu

Cells. 2021 Jul; 10(7): 1566. Published online 2021 Jun 22. doi: 10.3390/cells10071566

PMCID:: PMC8304645

Abstract Article PDF–5.1M

Select item 80747758.

Impact of IL10, MTP, SOD2, and APOE Gene Polymorphisms on the Severity of Liver Fibrosis Induced by HCV Genotype 4

Amr Ali Hemeda, Amal Ahmad Mohamed, Ramy Karam Aziz, Mohamed S. Abdel-Hakeem, Marwa Ali-Tammam

Viruses. 2021 Apr; 13(4): 714. Published online 2021 Apr 20. doi: 10.3390/v13040714

PMCID:: PMC8074775

Abstract Article PDF–755K

Select item 79629949.

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy

Yanke Chen, Ting Jiang, Hongyi Zhang, Xingchun Gou, Cong Han, Jianhui Wang, Ann T. Chen, Jun Ma, Jun Liu, Zeming Chen, Xintao Jing, Hong Lei, Zhenzhen Wang, Youmei Bao, Mehdi Baqri, Yong Zhu, Ranjit S. Bindra, James E. Hansen, Jun Dou, Chen Huang, Jiangbing Zhou

Nat Cell Biol. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: Nat Cell Biol. 2020 Oct; 22(10): 1276–1285. Published online 2020 Oct 1. doi: 10.1038/s41556-020-00586-6

PMCID:: PMC7962994

Abstract Article PDF–5.5M

Select item 795798210.

A novel p.Gly417Valfs*12 mutation in the MTTP gene causing abetalipoproteinemia: Presentation of the first patient in Mexico and analysis of the previously reported cases

Perla Graciela Rodríguez Gutiérrez, Juan Ramón González García, Yolanda Alicia Castillo De León, Juan Rafael Zárate Guerrero, María Teresa Magaña Torres

J Clin Lab Anal. 2021 Mar; 35(3): e23672. Published online 2020 Nov 30. doi: 10.1002/jcla.23672

PMCID:: PMC7957982

Abstract Article PDF–443K

Select item 744458711.

A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein

Meredith H. Wilson, Sujith Rajan, Aidan Danoff, Richard J. White, Monica R. Hensley, Vanessa H. Quinlivan, Rosario Recacha, James H. Thierer, Frederick J. Tan, Elisabeth M. Busch-Nentwich, Lloyd Ruddock, M. Mahmood Hussain, Steven A. Farber

PLoS Genet. 2020 Aug; 16(8): e1008941. Published online 2020 Aug 6. doi: 10.1371/journal.pgen.1008941

PMCID:: PMC7444587

Abstract Article PDF–5.1M

Select item 739927212.

MTP Gene Variants and Response to Lomitapide in Patients with Homozygous Familial Hypercholesterolemia

Genovefa D Kolovou, Vana Kolovou, Anna Papadopoulou, Gerald F Watts

J Atheroscler Thromb. 2016 Jul 1; 23(7): 878–883. doi: 10.5551/jat.34777

PMCID:: PMC7399272

Abstract Article PDF–91K

Select item 710530413.

Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids

Jahangir Iqbal, Eduardo Mascareno, Streamson Chua, M. Mahmood Hussain

J Biol Chem. 2020 Mar 27; 295(13): 4101–4113. Published online 2020 Feb 11. doi: 10.1074/jbc.RA119.011881

PMCID:: PMC7105304

Abstract Article PDF–2.9M

Select item 679508214.

In search of a genetic explanation for LDLc variability in an FH family: common SNPs and a rare mutation in MTTP explain only part of LDL variability in an FH family

Michael Winther, Shoshi Shpitzen, Or Yaacov, Jakob Landau, Limor Oren, Linda Foroozan-Rosenberg, Naama Lev Cohain, Daniel Schurr, Vardiela Meiner, Auryan Szalat, Shai Carmi, Michael R. Hayden, Eran Leitersdorf, Ronen Durst

J Lipid Res. 2019 Oct; 60(10): 1733–1740. Published online 2019 Aug 6. doi: 10.1194/jlr.M092049

PMCID:: PMC6795082

Abstract Article PDF–696K

Select item 671730015.

The crystal structure of human microsomal triglyceride transfer protein

Ekaterina I. Biterova, Michail N. Isupov, Ronan M. Keegan, Andrey A. Lebedev, Anil A. Sohail, Inam Liaqat, Heli I. Alanen, Lloyd W. Ruddock

Proc Natl Acad Sci U S A. 2019 Aug 27; 116(35): 17251–17260. Published online 2019 Aug 8. doi: 10.1073/pnas.1903029116

PMCID:: PMC6717300

Abstract Article PDF–2.5M

Select item 668925416.

Identification of antisense transcripts of the microsomal triglyceride transfer protein genes in humans and mice

Shuai Zhang, M. Mahmood Hussain

Biochem Biophys Res Commun. Author manuscript; available in PMC 2020 Sep 17.

Published in final edited form as: Biochem Biophys Res Commun. 2019 Sep 17; 517(2): 317–323. Published online 2019 Jul 25. doi: 10.1016/j.bbrc.2019.07.069

PMCID:: PMC6689254

Abstract Article PDF–1.5M

Select item 616668217.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 585308018.

Complex genetic architecture in severe hypobetalipoproteinemia

Linda R. Wang, Adam D. McIntyre, Robert A. Hegele

Lipids Health Dis. 2018; 17: 48. Published online 2018 Mar 14. doi: 10.1186/s12944-018-0680-1

PMCID:: PMC5853080

Abstract Article PDF–674K

Select item 584947819.

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease

Graham F. Brady, Raymond Kwan, Peter J. Ulintz, Phirum Nguyen, Shirin Bassirian, Venkatesha Basrur, Alexey I. Nesvizhskii, Rohit Loomba, M. Bishr Omary

Hepatology. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Hepatology. 2018 May; 67(5): 1710–1725. Published online 2018 Mar 24. doi: 10.1002/hep.29522

PMCID:: PMC5849478

Abstract Article PDF–1.7M

Select item 561720320.

Association of MTTP gene variants with pediatric NAFLD: A candidate-gene-based analysis of single nucleotide variations in obese children

Dongling Dai, Feiqiu Wen, Shaoming Zhou, Zhe Su, Guosheng Liu, Mingbang Wang, Jianli Zhou, Fusheng He

PLoS One. 2017; 12(9): e0185396. Published online 2017 Sep 27. doi: 10.1371/journal.pone.0185396

PMCID:: PMC5617203

Abstract Article PDF–1.3M

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