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Select item 114808621.

ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling

Hüseyin Tayran, Elanur Yilmaz, Prabesh Bhattarai, Yuhao Min, Xue Wang, Yiyi Ma, Ni Wang, Inyoung Jeong, Nastasia Nelson, Nada Kassara, Mehmet Ilyas Cosacak, Ruya Merve Dogru, Dolly Reyes-Dumeyer, Jakob Mørkved Stenersen, Joseph S. Reddy, Min Qiao, Delaney Flaherty, Tamil Iniyan Gunasekaran, Zikun Yang, Nathalie Jurisch-Yaksi, Andrew F. Teich, Takahisa Kanekiyo, Giuseppe Tosto, Badri N. Vardarajan, Özkan İş, Nilüfer Ertekin-Taner, Richard Mayeux, Caghan Kizil

Cell Genom. 2024 Sep 11; 4(9): 100642. Published online 2024 Aug 30. doi: 10.1016/j.xgen.2024.100642

PMCID:: PMC11480862

Abstract Article PDF–9.1M

Select item 111530162.

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

Keiji Kawatani, Marie-Louise Holm, Skylar C. Starling, Yuka A. Martens, Jing Zhao, Wenyan Lu, Yingxue Ren, Zonghua Li, Peizhou Jiang, Yangying Jiang, Samantha K. Baker, Ni Wang, Bhaskar Roy, Tammee M. Parsons, Ralph B. Perkerson, III, Hanmei Bao, Xianlin Han, Guojun Bu, Takahisa Kanekiyo

Mol Psychiatry. 2024; 29(3): 809–819. Published online 2023 Dec 22. doi: 10.1038/s41380-023-02372-w

PMCID:: PMC11153016

Abstract Article PDF–6.9M

Select item 111315993.

ABCA7 Genotype Moderates the Effect of Aerobic Exercise Intervention on Generalization of Prior Learning in Healthy Older African Americans

Neha Sinha, Chelsie N. Berg, Ashlee Shaw, Mark A. Gluck

J Alzheimers Dis. Author manuscript; available in PMC 2024 May 28.

Published in final edited form as: J Alzheimers Dis. 2020; 74(1): 309–318. doi: 10.3233/JAD-190723

PMCID:: PMC11131599

Abstract Article PDF–570K

Select item 109843704.

ABCA7, a Genetic Risk Factor Associated with Alzheimer’s Disease Risk in African Americans

Kaitlyn E. Stepler, Taneisha R. Gillyard, Calla B. Reed, Tyra M. Avery, Jamaine S. Davis, Renã A.S. Robinson

J Alzheimers Dis. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: J Alzheimers Dis. 2022; 86(1): 5–19. doi: 10.3233/JAD-215306

PMCID:: PMC10984370

Abstract Article PDF–1.0M

Select item 106341835.

CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response

Lena Duchateau, Fahri Küҫükali, Arne De Roeck, Mandy M. J. Wittens, Joke Temmerman, Ilse Weets, Maarten Timmers, Sebastiaan Engelborghs, Maria Bjerke, Kristel Sleegers

Alzheimers Res Ther. 2023; 15: 195. Published online 2023 Nov 9. doi: 10.1186/s13195-023-01338-y

PMCID:: PMC10634183

Abstract Article PDF–2.2M

Select item 104863666.

Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA

Joel P. Wiener, Sindy Desire, Viktor Garliyev, Nicholas Lyssenko III, Domenico Praticò, Nicholas N. Lyssenko

Cells. 2023 Sep; 12(17): 2143. Published online 2023 Aug 25. doi: 10.3390/cells12172143

PMCID:: PMC10486366

Abstract Article PDF–5.5M

Select item 103572117.

High-Quality Sleep Mitigates ABCA7-Related Generalization Deficits in Healthy Older African Americans

Neha Sinha, Bernadette A. Fausto, Bryce Mander, Mark A. Gluck

J Alzheimers Dis. 2023; 94(1): 281–290. Prepublished online 2023 May 19. Published online 2023 Jun 27. doi: 10.3233/JAD-230043

PMCID:: PMC10357211

Abstract Article PDF–433K

Select item 102524618.

Aberrant DNA Methylation, Expression, and Occurrence of Transcript Variants of the ABC Transporter ABCA7 in Breast Cancer

Katja Zappe, Antonio Kopic, Alexandra Scheichel, Ann-Katrin Schier, Lukas Emanuel Schmidt, Yasmin Borutzki, Heidi Miedl, Martin Schreiber, Theresa Mendrina, Christine Pirker, Georg Pfeiler, Stefan Hacker, Werner Haslik, Dietmar Pils, Andrea Bileck, Christopher Gerner, Samuel Meier-Menches, Petra Heffeter, Margit Cichna-Markl

Cells. 2023 Jun; 12(11): 1462. Published online 2023 May 24. doi: 10.3390/cells12111462

PMCID:: PMC10252461

Abstract Article PDF–5.4M

Select item 98902309.

Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms

Le Thi My Le, James Robert Thompson, Sepehr Dehghani‐Ghahnaviyeh, Shashank Pant, Phuoc Xuan Dang, Jarrod Bradley French, Takahisa Kanikeyo, Emad Tajkhorshid, Amer Alam

EMBO J. 2023 Feb; 42(3): e111065. Published online 2022 Dec 9. doi: 10.15252/embj.2022111065

PMCID:: PMC9890230

Abstract Article PDF–9.1M

Select item 969115610.

SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans

Dima L. Chaar, Kim Nguyen, Yi-Zhe Wang, Scott M. Ratliff, Thomas H. Mosley, Sharon L. R. Kardia, Jennifer A. Smith, Wei Zhao

Genes (Basel) 2022 Nov; 13(11): 2150. Published online 2022 Nov 18. doi: 10.3390/genes13112150

PMCID:: PMC9691156

Abstract Article PDF–1.3M

Select item 951328011.

ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex

Jahangir Iqbal, Manuel D. Suarez, Pradeep K. Yadav, Meghan T. Walsh, Yimeng Li, Yiyang Wu, Zhengwei Huang, Antonisamy William James, Victor Escobar, Ashwag Mokbe, Adam M. Brickman, José A. Luchsinger, Kezhi Dai, Herman Moreno, M. Mahmood Hussain

J Biol Chem. 2022 Oct; 298(10): 102411. Published online 2022 Aug 23. doi: 10.1016/j.jbc.2022.102411

PMCID:: PMC9513280

Abstract Article PDF–3.3M

Select item 926261412.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 923162313.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 897382214.

Rare missense mutations in ABCA7 might increase Alzheimer’s disease risk by plasma membrane exclusion

Liene Bossaerts, Elisabeth Hendrickx Van de Craen, Rita Cacace, Bob Asselbergh, Christine Van Broeckhoven

Acta Neuropathol Commun. 2022; 10: 43. Published online 2022 Mar 31. doi: 10.1186/s40478-022-01346-3

PMCID:: PMC8973822

Abstract Article PDF–3.0M

Select item 892511515.

Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease: Data from the PUMCH Dementia Cohort

Liling Dong, Chenhui Mao, Caiyan Liu, Jie Li, Xinying Huang, Jie Wang, Dan Lei, Shanshan Chu, Longze Sha, Qi Xu, Bin Peng, Liying Cui, Jing Gao

J Alzheimers Dis. 2022; 85(4): 1511–1518. Prepublished online 2021 Dec 21. Published online 2022 Feb 15. doi: 10.3233/JAD-215067

PMCID:: PMC8925115

Abstract Article PDF–288K

Select item 831454716.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Abstract Article PDF–3.7M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812483718.

Role of ABCA7 in Human Health and in Alzheimer’s Disease

Shiraz Dib, Jens Pahnke, Fabien Gosselet

Int J Mol Sci. 2021 May; 22(9): 4603. Published online 2021 Apr 27. doi: 10.3390/ijms22094603

PMCID:: PMC8124837

Abstract Article PDF–12M

Select item 795906419.

ABCA7 links sterol metabolism to the host defense system: Molecular background for potential management measure of Alzheimer’s disease

Sumiko Abe-Dohmae, Shinji Yokoyama

Gene. Author manuscript; available in PMC 2022 Feb 5.

Published in final edited form as: Gene. 2021 Feb 5; 768: 145316. Published online 2020 Nov 20. doi: 10.1016/j.gene.2020.145316

PMCID:: PMC7959064

Abstract Article PDF–1.4M

Select item 694204420.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

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