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Select item 111419351.

Blocking the angiopoietin-2–dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis

Lydia Meder, Charlotte Isabelle Orschel, Christoph Julius Otto, Mirjam Koker, Johannes Brägelmann, Meryem S. Ercanoglu, Sabrina Dähling, Anik Compes, Carolin Selenz, Marieke Nill, Felix Dietlein, Alexandra Florin, Marie-Lisa Eich, Sven Borchmann, Margarete Odenthal, Raquel Blazquez, Frank Hilberg, Florian Klein, Michael Hallek, Reinhard Büttner, H. Christian Reinhardt, Roland T. Ullrich

JCI Insight. 2024 May 22; 9(10): e166402. Published online 2024 May 22. doi: 10.1172/jci.insight.166402

PMCID:: PMC11141935

Abstract Article PDF–6.7M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108940043.

Developmental expression of the Sturge–Weber syndrome-associated genetic mutation in Gnaq: a formal test of Happle's paradominant inheritance hypothesis

Sarah E Wetzel-Strong, Francesca Galeffi, Christian Benavides, Mary Patrucco, Jessica L Bullock, Carol J Gallione, Han Kyu Lee, Douglas A Marchuk

Genetics. 2023 Aug; 224(4): iyad077. Published online 2023 Apr 25. doi: 10.1093/genetics/iyad077

PMCID:: PMC10894004

Abstract Article PDF–6.8M

Select item 108587454.

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Maarja A. Mäe, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz

Circ Res. Author manuscript; available in PMC 2024 Feb 10.

Published in final edited form as: Circ Res. 2021 Feb 19; 128(4): e46–e62. Published online 2020 Dec 30. doi: 10.1161/CIRCRESAHA.120.317473

PMCID:: PMC10858745

Abstract Article PDF–2.1M

Select item 105579225.

Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization

Elizabeth A. Barnes, Carsten Knutsen, Alida Kindt, Xibing Che, Lihua Ying, Eloa Adams, Erika Gonzalez, Prajakta Oak, Anne Hilgendorff, Cristina M. Alvira, David N. Cornfield

Am J Respir Cell Mol Biol. 2023 Oct 1; 69(4): 470–483. Published online 2023 Jun 8. doi: 10.1165/rcmb.2023-0045OC

PMCID:: PMC10557922

Abstract Article PDF–3.5M

Select item 105249826.

Angiopoietin-2 blockade diminishes pro-angiogenic cerebrovascular defects associated with models of Hereditary Hemorrhagic Telangiectasia

Xingyan Zhou, Jenna C. Pucel, Aya Nomura-Kitabayashi, Pallavi Chandakkar, Adella P. Guidroz, Nikita L. Jhangiani, Duran Bao, Jia Fan, Helen M. Arthur, Christoph Ullmer, Christian Klein, Philippe Marambaud, Stryder M. Meadows

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Aug; 43(8): 1384–1403. Published online 2023 Jun 8. doi: 10.1161/ATVBAHA.123.319385

PMCID:: PMC10524982

Abstract Article PDF–1.5M

Select item 104756807.

Angiopoietin‐2 Promotes Mechanical Stress‐induced Extracellular Matrix Degradation in Annulus Fibrosus Via the HIF‐1α/NF‐κB Signaling Pathway

Xiang Ao, Yuan Li, Tao Jiang, Chenglong Li, Zhengnan Lian, Liang Wang, Zhongmin Zhang, Minjun Huang

Orthop Surg. 2023 Sep; 15(9): 2410–2422. Published online 2023 Jul 21. doi: 10.1111/os.13797

PMCID:: PMC10475680

Abstract Article PDF–2.6M

Select item 97207438.

Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility

Mariam Rusidzé, Mélanie C. Faure, Pierre Sicard, Isabelle Raymond-Letron, Frank Giton, Emilie Vessieres, Vincent Prevot, Daniel Henrion, Jean-François Arnal, Charlotte A. Cornil, Françoise Lenfant

Development. 2022 Oct 1; 149(19): dev200683. Published online 2022 Oct 13. doi: 10.1242/dev.200683

PMCID:: PMC9720743

Abstract Article

Select item 96136229.

Angiopoietin-1 is required for vortex vein and choriocapillaris development in mice

Pan Liu, Jeremy A. Lavine, Amani Fawzi, Susan E Quaggin, Benjamin R. Thomson

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2023 Nov 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Nov; 42(11): 1413–1427. Published online 2022 Sep 29. doi: 10.1161/ATVBAHA.122.318151

PMCID:: PMC9613622

Abstract Article PDF–6.8M

Select item 954735710.

Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance

Emmi Kapiainen, Harri Elamaa, Ilkka Miinalainen, Valerio Izzi, Lauri Eklund

Invest Ophthalmol Vis Sci. 2022 Oct; 63(11): 1. Published online 2022 Oct 3. doi: 10.1167/iovs.63.11.1

PMCID:: PMC9547357

Abstract Article PDF–8.7M

Select item 948601711.

Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome

Bin Ni, Shanshan Chen, Kathleen A. Ryan, Michael L. Maitland, Jared S. Farrar, Martin Witzenrath, Birgitt Gubier, Cindy Serdjebi, Karine Bertotti, Rui Wang, Fadi N. Salloum, Luigi Marino, Braxton D. Mitchell, Francesco S. Celi

Mol Metab. 2022 Nov; 65: 101588. Published online 2022 Aug 30. doi: 10.1016/j.molmet.2022.101588

PMCID:: PMC9486017

Abstract Article PDF–2.7M

Select item 911080712.

The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner

Robert Luck, Andromachi Karakatsani, Bhavin Shah, Geza Schermann, Heike Adler, Janina Kupke, Nathalie Tisch, Hyun-Woo Jeong, Michaela Kerstin Back, Florian Hetsch, Anna D’Errico, Michele De Palma, Ellen Wiedtke, Dirk Grimm, Amparo Acker-Palmer, Jakob von Engelhardt, Ralf H. Adams, Hellmut G. Augustin, Carmen Ruiz de Almodóvar

Cell Rep. Author manuscript; available in PMC 2022 Aug 17.

Published in final edited form as: Cell Rep. 2021 Aug 17; 36(7): 109522. doi: 10.1016/j.celrep.2021.109522

PMCID:: PMC9110807

Abstract Article PDF–3.0M

Select item 886401613.

Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling

Mengying Liu, Wenbo Deng, Lu Tang, Meng Liu, Haili Bao, Chuanhui Guo, Changxian Zhang, Jinhua Lu, Haibin Wang, Zhongxian Lu, Shuangbo Kong

Nat Commun. 2022; 13: 1006. Published online 2022 Feb 22. doi: 10.1038/s41467-022-28657-2

PMCID:: PMC8864016

Abstract Article PDF–9.7M

Select item 875164014.

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

Ionel Sandovici, Aikaterini Georgopoulou, Vicente Pérez-García, Antonia Hufnagel, Jorge López-Tello, Brian Y.H. Lam, Samira N. Schiefer, Chelsea Gaudreau, Fátima Santos, Katharina Hoelle, Giles S.H. Yeo, Keith Burling, Moritz Reiterer, Abigail L. Fowden, Graham J. Burton, Cristina M. Branco, Amanda N. Sferruzzi-Perri, Miguel Constância

Dev Cell. 2022 Jan 10; 57(1): 63–79.e8. doi: 10.1016/j.devcel.2021.12.005

PMCID:: PMC8751640

Abstract Article

Select item 829229015.

Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization

Fabiana Baganha, Rob C. M. de Jong, Erna A. Peters, Wietske Voorham, J. Wouter Jukema, Mirela Delibegovic, Margreet R. de Vries, Paul H. A. Quax

Angiogenesis. 2021; 24(3): 567–581. Published online 2021 Feb 7. doi: 10.1007/s10456-021-09767-9

PMCID:: PMC8292290

Abstract Article PDF–11M

Select item 787137416.

Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients

Yosuke Osawa, Sachiyo Yoshio, Yoshihiko Aoki, Masaaki Korenaga, Masatoshi Imamura, Takashi Oide, Miku Okawara, Hironari Kawai, Yuriko Tsutsui, Yuichi Yoshida, Shiori Yoshikawa, Taizo Mori, Taiji Yamazoe, Tatsuya Kanto

BMC Gastroenterol. 2021; 21: 55. Published online 2021 Feb 8. doi: 10.1186/s12876-021-01633-8

PMCID:: PMC7871374

Abstract Article PDF–1.9M

Select item 775862617.

YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling

Boksik Cha, Yen-Chun Ho, Xin Geng, Md. Riaj Mahamud, Lijuan Chen, Yeunhee Kim, Dongwon Choi, Tae Hoon Kim, Gwendalyn J. Randolph, Xinwei Cao, Hong Chen, R. Sathish Srinivasan

Development. 2020 Dec 1; 147(23): dev195453. Published online 2020 Dec 13. doi: 10.1242/dev.195453

PMCID:: PMC7758626

Abstract Article

Select item 761117518.

Tumor cell-derived Angiopoietin-2 promotes metastasis in melanoma

Ashik Ahmed Abdul Pari, Mahak Singhal, Corinne Hübers, Carolin Mogler, Benjamin Schieb, Anja Gampp, Nicolas Gengenbacher, Louise E. Reynolds, Dorothee Terhardt, Cyrill Géraud, Jochen Utikal, Markus Thomas, Sergij Goerdt, Kairbaan Hodivala-Dilke, Dr. Hellmut G. Augustin, Dr. Moritz Felcht

Cancer Res. Author manuscript; available in PMC 2021 Jul 10.

Published in final edited form as: Cancer Res. 2020 Jun 15; 80(12): 2586–2598. Published online 2020 Apr 17. doi: 10.1158/0008-5472.CAN-19-2660

PMCID:: PMC7611175

Abstract Article PDF–2.7M

Select item 729324019.

Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

Hosung Bae, Ki Yong Hong, Choong-kun Lee, Cholsoon Jang, Seung-Jun Lee, Kibaek Choe, Stefan Offermanns, Yulong He, Hyuek Jong Lee, Gou Young Koh

Nat Commun. 2020; 11: 2980. Published online 2020 Jun 12. doi: 10.1038/s41467-020-16795-4

PMCID:: PMC7293240

Abstract Article PDF–6.6M

Select item 710892520.

Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

Zhilin Li, Emilia A. Korhonen, Arianna Merlini, Judith Strauss, Eleonoora Wihuri, Harri Nurmi, Salli Antila, Jennifer Paech, Urban Deutsch, Britta Engelhardt, Sudhakar Chintharlapalli, Gou Young Koh, Alexander Flügel, Kari Alitalo

J Clin Invest. 2020 Apr 1; 130(4): 1977–1990. Published online 2020 Mar 9. doi: 10.1172/JCI130308

PMCID:: PMC7108925

Abstract Article PDF–13M

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