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Select item 111482821.

TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Qiuhua Cao

Front Pharmacol. 2024; 15: 1392328. Published online 2024 May 21. doi: 10.3389/fphar.2024.1392328

PMCID:: PMC11148282

Abstract Article PDF–5.1M

Select item 110478372.

Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy

Pratish Thakore, James E. Clark, Aisah A. Aubdool, Dibesh Thapa, Anna Starr, Paul A. Fraser, Keith Farrell-Dillon, Elizabeth S. Fernandes, Ian McFadzean, Susan D. Brain

Biomolecules. 2024 Apr; 14(4): 442. Published online 2024 Apr 4. doi: 10.3390/biom14040442

PMCID:: PMC11047837

Abstract Article PDF–4.0M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102179944.

The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels

Zhong-Jiao Jiang, Liang-Wei Gong

J Neurosci. 2023 May 24; 43(21): 3807–3824. doi: 10.1523/JNEUROSCI.1494-22.2023

PMCID:: PMC10217994

Abstract Article PDF–5.5M

Select item 102007255.

The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5

Onur K. Polat, Elena Isaeva, Yashwanth R. Sudhini, Brenna Knott, Ke Zhu, Manuel Noben, Varsha Suresh Kumar, Nicole Endlich, Steve Mangos, Tejasree Vallapu Reddy, Beata Samelko, Changli Wei, Mehmet M. Altintas, Stuart E. Dryer, Sanja Sever, Alexander Staruschenko, Jochen Reiser

Kidney Int. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Kidney Int. 2023 Jun; 103(6): 1056–1062. Published online 2023 Feb 5. doi: 10.1016/j.kint.2023.01.016

PMCID:: PMC10200725

Abstract Article PDF–958K

Select item 95747776.

Store-operated Ca²⁺ entry and Ca²⁺ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1−/− and heptaTRPC knockout mice

Lucía Núñez, Gary S. Bird, Elena Hernando-Pérez, Enrique Pérez-Riesgo, James W. Putney, Jr, Carlos Villalobos

Biochim Biophys Acta Mol Cell Res. Author manuscript; available in PMC 2022 Oct 17.

Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2019 Jul; 1866(7): 1124–1136. Published online 2018 Nov 17. doi: 10.1016/j.bbamcr.2018.11.006

PMCID:: PMC9574777

Abstract Article PDF–1.8M

Select item 89230027.

Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice

Katelyn E. Sadler, Francie Moehring, Stephanie I. Shiers, Lauren J. Laskowski, Alexander R. Mikesell, Zakary R. Plautz, Allison N. Brezinski, Christina M. Mecca, Gregory Dussor, Theodore J. Price, John D. McCorvy, Cheryl L. Stucky

Sci Transl Med. Author manuscript; available in PMC 2022 May 26.

Published in final edited form as: Sci Transl Med. 2021 May 26; 13(595): eabd7702. doi: 10.1126/scitranslmed.abd7702

PMCID:: PMC8923002

Abstract Article PDF–3.0M

Select item 86206458.

Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice

Shiji Huo, Jiling Ren, Yunqing Ma, Ahsawle Ozathaley, Wenjian Yuan, Hong Ni, Dong Li, Zhaowei Liu

J Neuroinflammation. 2021; 18: 275. Published online 2021 Nov 26. doi: 10.1186/s12974-021-02321-w

PMCID:: PMC8620645

Abstract Article PDF–14M

Select item 85900799.

Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

Yanbin Dong, Jamie Carty, Nitsan Goldstein, Zhenyan He, Eunsang Hwang, Dominic Chau, Briana Wallace, Anita Kabahizi, Linh Lieu, Yunqian Peng, Yong Gao, Ling Hu, J. Nicholas Betley, Kevin W. Williams

Mol Metab. 2021 Dec; 54: 101352. Published online 2021 Oct 6. doi: 10.1016/j.molmet.2021.101352

PMCID:: PMC8590079

Abstract Article PDF–4.6M

Select item 826078310.

Lactate sensing mechanisms in arterial chemoreceptor cells

Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, Lin Gao, José López-Barneo

Nat Commun. 2021; 12: 4166. Published online 2021 Jul 6. doi: 10.1038/s41467-021-24444-7

PMCID:: PMC8260783

Abstract Article PDF–6.1M

Select item 823328311.

Mapping the expression of transient receptor potential channels across murine placental development

Katrien De Clercq, Vicente Pérez-García, Rieta Van Bree, Federica Pollastro, Karen Peeraer, Thomas Voets, Joris Vriens

Cell Mol Life Sci. 2021 Jun; 78(11): 4993–5014. Published online 2021 Apr 21. doi: 10.1007/s00018-021-03837-3

PMCID:: PMC8233283

Abstract Article PDF–4.1M

Select item 823225912.

(-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5

João de Sousa Valente, Khadija M Alawi, Sabah Bharde, Ali A. Zarban, Xenia Kodji, Dibesh Thapa, Fulye Argunhan, Brentton Barrett, Istvan Nagy, Susan D. Brain

Int J Mol Sci. 2021 Jun; 22(12): 6380. Published online 2021 Jun 15. doi: 10.3390/ijms22126380

PMCID:: PMC8232259

Abstract Article PDF–2.3M

Select item 799751513.

Odontoblast TRPC5 channels signal cold pain in teeth

Laura Bernal, Pamela Sotelo-Hitschfeld, Christine König, Viktor Sinica, Amanda Wyatt, Zoltan Winter, Alexander Hein, Filip Touska, Susanne Reinhardt, Aaron Tragl, Ricardo Kusuda, Philipp Wartenberg, Allen Sclaroff, John D. Pfeifer, Fabien Ectors, Andreas Dahl, Marc Freichel, Viktorie Vlachova, Sebastian Brauchi, Carolina Roza, Ulrich Boehm, David E. Clapham, Jochen K. Lennerz, Katharina Zimmermann

Sci Adv. 2021 Mar; 7(13): eabf5567. Published online 2021 Mar 26. doi: 10.1126/sciadv.abf5567

PMCID:: PMC7997515

Abstract Article PDF–2.4M

Select item 740267414.

Keratinocytes contribute to normal cold and heat sensation

Katelyn E Sadler, Francie Moehring, Cheryl L Stucky

eLife. 2020; 9: e58625. Published online 2020 Jul 30. doi: 10.7554/eLife.58625

PMCID:: PMC7402674

Abstract Article PDF–1.6M

Select item 732635315.

TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations

John J. O'Malley, Frederik Seibt, Jeannie Chin, Michael Beierlein

J Neurosci. 2020 Jun 17; 40(25): 4813–4823. doi: 10.1523/JNEUROSCI.0324-20.2020

PMCID:: PMC7326353

Abstract Article PDF–2.0M

Select item 719087416.

RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways

Karina Formoso, Sebastian Susperreguy, Marc Freichel, Lutz Birnbaumer

Sci Rep. 2020; 10: 7227. Published online 2020 Apr 29. doi: 10.1038/s41598-020-61177-x

PMCID:: PMC7190874

Abstract Article PDF–4.0M

Select item 714053017.

Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis

Jizheng Guo, Jie Li, Lin Xia, Yang Wang, Jinhang Zhu, Juan Du, Yungang Lu, Guodong Liu, Xiaoqiang Yao, Bing Shen

Cells. 2020 Mar; 9(3): 547. Published online 2020 Feb 26. doi: 10.3390/cells9030547

PMCID:: PMC7140530

Abstract Article PDF–4.0M

Select item 707221618.

Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells

Alberto Arboit, Antonio Reboreda, Motoharu Yoshida

Cells. 2020 Feb; 9(2): 365. Published online 2020 Feb 5. doi: 10.3390/cells9020365

PMCID:: PMC7072216

Abstract Article PDF–1.9M

Select item 677342219.

TRPC channels regulate Ca²⁺-signaling and short-term plasticity of fast glutamatergic synapses

Yvonne Schwarz, Katharina Oleinikov, Barbara Schindeldecker, Amanda Wyatt, Petra Weißgerber, Veit Flockerzi, Ulrich Boehm, Marc Freichel, Dieter Bruns

PLoS Biol. 2019 Sep; 17(9): e3000445. Published online 2019 Sep 19. doi: 10.1371/journal.pbio.3000445

PMCID:: PMC6773422

Abstract Article PDF–6.1M

Select item 672596420.

A Cytosolic Residue Mediates Mg²⁺ Block and Regulates Inward Current Amplitude of a Transient Receptor Potential Channel

Alexander G. Obukhov, Martha C. Nowycky

J Neurosci. 2005 Feb 2; 25(5): 1234–1239. doi: 10.1523/JNEUROSCI.4451-04.2005

PMCID:: PMC6725964

Abstract Article PDF–815K

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