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Items: 1 to 20 of 25

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation
Wei-Wei Li, Xu-Xu Fan, Zhi-Sheng Xu, Zi-Xiang Zhu, Zhao-Yu Zhu, Xue-Jing Cao, Dan-Shi Pei, Yi-Zhuo Wang, Ji-Yan Zhang, Yan-Yi Wang, Hai-Xue Zheng
J Cell Biol. 2024 Feb 5; 223(2): e202302081. Published online 2023 Dec 11. doi: 10.1083/jcb.202302081
PMCID:
PMC10711807
AbstractArticlePDF–7.0M
3.
Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response
Wei-Wei Li, Xu-Xu Fan, Zi-Xiang Zhu, Xue-Jing Cao, Zhao-Yu Zhu, Dan-Shi Pei, Yi-Zhuo Wang, Ji-Yan Zhang, Yan-Yi Wang, Hai-Xue Zheng
PLoS Pathog. 2023 Oct; 19(10): e1011742. Published online 2023 Oct 23. doi: 10.1371/journal.ppat.1011742
PMCID:
PMC10621992
AbstractArticlePDF–3.9M
4.
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus
Simon H. Jiang, Vicki Athanasopoulos, Julia I. Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B. Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A. Roco, Ilenia Papa, Mehmet Yabas, Giles D. Walters, Gaetan Burgio, Kathryn McKeon, James M. Byers, Charlotte Burrin, Anselm Enders, Lisa A. Miosge, Pablo F. Canete, Marija Jelusic, Velibor Tasic, Adrian C. Lungu, Stephen I. Alexander, Arthur R. Kitching, David A. Fulcher, Nan Shen, Todor Arsov, Paul A. Gatenby, Jeff J. Babon, Dominic F. Mallon, Carmen de Lucas Collantes, Eric A. Stone, Philip Wu, Matthew A. Field, Thomas D. Andrews, Eun Cho, Virginia Pascual, Matthew C. Cook, Carola G. Vinuesa
Nat Commun. 2019; 10: 2201. Published online 2019 May 17. doi: 10.1038/s41467-019-10242-9
PMCID:
PMC6525203
AbstractArticlePDF–3.1M
5.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
AbstractArticlePDF–1.4M
6.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
7.
Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mouse and Human Dependent on BLK Expression Levels
Ying-Yu Wu, Ina Georg, Alejandro Díaz-Barreiro, Nieves Varela, Bernard Lauwerys, Ramesh Kumar, Harini Bagavant, Mireia Castillo-Martín, Fadi El Salem, Concepción Marañón, Marta E. Alarcón-Riquelme
J Immunol. Author manuscript; available in PMC 2016 Jun 15.
Published in final edited form as: J Immunol. 2015 Jun 15; 194(12): 5692–5702. Published online 2015 May 13. doi: 10.4049/jimmunol.1402736
PMCID:
PMC4458437
AbstractArticlePDF–4.4M
8.
Blk-Haploinsufficiency Impairs the Development, but Enhances the Functional Responses, of MZ B Cells
Elizabeth M. Samuelson, Renee M. Laird, Alexander C. Maue, Rosemary Rochford, Sandra M. Hayes
Immunol Cell Biol. Author manuscript; available in PMC 2014 Jul 14.
Published in final edited form as: Immunol Cell Biol. 2012 Jul; 90(6): 620–629. Published online 2011 Sep 6. doi: 10.1038/icb.2011.76
PMCID:
PMC4096015
AbstractArticlePDF–4.4M
9.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
10.
Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice
Elizabeth M. Samuelson, Renee M. Laird, Amber M. Papillion, Arthur H. Tatum, Michael F. Princiotta, Sandra M. Hayes
PLoS One. 2014; 9(3): e92054. Published online 2014 Mar 17. doi: 10.1371/journal.pone.0092054
PMCID:
PMC3956874
AbstractArticlePDF–4.1M
11.
FAK–Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique
Guangping Tai, Peter Hohenstein, Jamie A. Davies
Biol Open. 2013 Apr 15; 2(4): 416–423. Published online 2013 Feb 26. doi: 10.1242/bio.20133780
PMCID:
PMC3625870
AbstractArticlePDF–1.0M
12.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
13.
The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells
Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia Miron, Xueqing Zhang, Michael Brehm, Dongguang Li, Michael R. Green, Shaoguang Li
Nat Genet. Author manuscript; available in PMC 2013 Feb 1.
Published in final edited form as: Nat Genet. 2012 Aug; 44(8): 861–871. Published online 2012 Jul 15. doi: 10.1038/ng.2350
PMCID:
PMC3408839
AbstractArticlePDF–2.7M
14.
Tyrosine Kinase Btk Is Required for NK Cell Activation
Yan Bao, Jian Zheng, Chaofeng Han, Jing Jin, Huanxing Han, Yinping Liu, Yu-Lung Lau, Wenwei Tu, Xuetao Cao
J Biol Chem. 2012 Jul 6; 287(28): 23769–23778. Published online 2012 May 15. doi: 10.1074/jbc.M112.372425
Correction in:
J Biol Chem. 2020 Mar 6; 295(10): 3389.
PMCID:
PMC3390651
AbstractArticlePDF–3.9M
15.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
16.
Unexpected Role for the B cell-specific Src Family Kinase Blk in the Development of IL-17-Producing γδ T Cells
Renee M. Laird, Karen Laky, Sandra M. Hayes
J Immunol. Author manuscript; available in PMC 2011 Dec 1.
Published in final edited form as: J Immunol. 2010 Dec 1; 185(11): 6518–6527. Published online 2010 Oct 25. doi: 10.4049/jimmunol.1002766
PMCID:
PMC2989676
AbstractArticlePDF–1.3M
17.
The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105
Vivien W.F. Chan, Ingrid Mecklenbräuker, I-hsin Su, Gemma Texido, Michael Leitges, Rita Carsetti, Clifford A. Lowell, Klaus Rajewsky, Kensuke Miyake, Alexander Tarakhovsky
J Exp Med. 1998 Jul 1; 188(1): 93–101. doi: 10.1084/jem.188.1.93
PMCID:
PMC2525555
AbstractArticlePDF–232K
18.
Epstein-Barr Virus Latent Membrane Protein 2A Preferentially Signals through the Src Family Kinase Lyn
Mark Rovedo, Richard Longnecker
J Virol. 2008 Sep; 82(17): 8520–8528. Published online 2008 Jun 25. doi: 10.1128/JVI.00843-08
PMCID:
PMC2519656
AbstractArticlePDF–434K
19.
Mimicry of Pre–B Cell Receptor Signaling by Activation of the Tyrosine Kinase Blk
Theresa Tretter, Ashley E. Ross, Dominic I. Dordai, Stephen Desiderio
J Exp Med. 2003 Dec 15; 198(12): 1863–1873. doi: 10.1084/jem.20030729
PMCID:
PMC2194155
AbstractArticlePDF–506K
20.
BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System
Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran
PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086
PMCID:
PMC1413568
ArticlePDF–99K

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