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Items: 1 to 20 of 92

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation
Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Fanghui Zhang, Luis M. Fernandez-Aguilar, Martyna Chotomska, Isaac Narbona-Sánchez, Lichen Zhang, Bernard Malissen, Yinming Liang, Enrique Aguado
Front Immunol. 2022; 13: 1054920. Published online 2022 Dec 7. doi: 10.3389/fimmu.2022.1054920
PMCID:
PMC9768323
AbstractArticlePDF–9.3M
3.
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism
Claude Gregoire, Lionel Spinelli, Sergio Villazala-Merino, Laurine Gil, María Pía Holgado, Myriam Moussa, Chuang Dong, Ana Zarubica, Mathieu Fallet, Jean-Marc Navarro, Bernard Malissen, Pierre Milpied, Mauro Gaya
Immunity. 2022 Jul 12; 55(7): 1216–1233.e9. Published online 2022 Jun 28. doi: 10.1016/j.immuni.2022.06.002
PMCID:
PMC9396418
AbstractArticlePDF–8.9M
4.
ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis
Alyssa Imbert, Magali Rompais, Mohammed Selloum, Florence Castelli, Emmanuelle Mouton-Barbosa, Marion Brandolini-Bunlon, Emeline Chu-Van, Charlotte Joly, Aurélie Hirschler, Pierrick Roger, Thomas Burger, Sophie Leblanc, Tania Sorg, Sadia Ouzia, Yves Vandenbrouck, Claudine Médigue, Christophe Junot, Myriam Ferro, Estelle Pujos-Guillot, Anne Gonzalez de Peredo, François Fenaille, Christine Carapito, Yann Herault, Etienne A. Thévenot
Sci Data. 2021; 8: 311. Published online 2021 Dec 3. doi: 10.1038/s41597-021-01095-3
PMCID:
PMC8642540
AbstractArticlePDF–3.0M
5.
Pathogenic roles and therapeutic potential of the CCL8–CCR8 axis in a murine model of IgG4-related sialadenitis
Fumika Honda, Hiroto Tsuboi, Yuko Ono, Saori Abe, Hiroyuki Takahashi, Kiyoaki Ito, Kazunori Yamada, Mitsuhiro Kawano, Yuya Kondo, Kenichi Asano, Masato Tanaka, Marie Malissen, Bernard Malissen, Isao Matsumoto, Takayuki Sumida
Arthritis Res Ther. 2021; 23: 214. Published online 2021 Aug 14. doi: 10.1186/s13075-021-02597-6
PMCID:
PMC8364087
AbstractArticlePDF–2.2M
6.
Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
Elliot Dine, Ellen H. Reed, Jared E. Toettcher
Cell Rep. Author manuscript; available in PMC 2021 Jul 21.
Published in final edited form as: Cell Rep. 2021 Jun 22; 35(12): 109280. doi: 10.1016/j.celrep.2021.109280
PMCID:
PMC8292983
AbstractArticlePDF–2.7M
7.
Spontaneous Differentiation of T Follicular Helper Cells in LATY136F Mutant Mice
Sarah A. O’Brien, Minghua Zhu, Weiguo Zhang
Front Immunol. 2021; 12: 656817. Published online 2021 Apr 12. doi: 10.3389/fimmu.2021.656817
PMCID:
PMC8072119
AbstractArticlePDF–4.9M
8.
The pronounced lung lesions developing in LATY136F knock-in mice mimic human IgG4-related lung disease
Yuko Waseda, Kazunori Yamada, Keishi Mizuguchi, Kiyoaki Ito, Satoshi Watanabe, Masahiko Zuka, Tamotsu Ishizuka, Marie Malissen, Bernard Malissen, Mitsuhiro Kawano, Shoko Matsui
PLoS One. 2021; 16(3): e0247173. Published online 2021 Mar 4. doi: 10.1371/journal.pone.0247173
PMCID:
PMC7932159
AbstractArticlePDF–3.5M
9.
LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumors and pathogens
Chang Liu, Xiaoyan Xu, Lei Han, Xiaopeng Wan, Lingming Zheng, Chunyang Li, Zhaohui Liao, Jun Xiao, Ruiyue Zhong, Xin Zheng, Qiong Wang, Zonghai Li, Hualan Chen, Bin Wei, Hongyan Wang
Proc Natl Acad Sci U S A. 2020 Aug 11; 117(32): 19388–19398. Published online 2020 Jul 29. doi: 10.1073/pnas.2000970117
PMCID:
PMC7431024
AbstractArticlePDF–2.4M
10.
A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments
Christelle Harly, Devin Kenney, Yueqiang Wang, Yi Ding, Yongge Zhao, Parirokh Awasthi, Avinash Bhandoola
Front Immunol. 2020; 11: 470. Published online 2020 Mar 20. doi: 10.3389/fimmu.2020.00470
PMCID:
PMC7099406
AbstractArticlePDF–6.2M
11.
mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse
D. Thumkeo, Y. Katsura, Y. Nishimura, P. Kanchanawong, K. Tohyama, T. Ishizaki, S. Kitajima, C. Takahashi, T. Hirata, N. Watanabe, M. F. Krummel, S. Narumiya
Sci Adv. 2020 Jan; 6(1): eaay2432. Published online 2020 Jan 1. doi: 10.1126/sciadv.aay2432
PMCID:
PMC6938706
AbstractArticlePDF–3.9M
12.
Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination
Wan-Lin Lo, Neel H. Shah, Sara A. Rubin, Weiguo Zhang, Veronika Horkova, Ian R. Fallahee, Ondrej Stepanek, Leonard I. Zon, John Kuriyan, Arthur Weiss
Nat Immunol. Author manuscript; available in PMC 2020 Apr 14.
Published in final edited form as: Nat Immunol. 2019 Nov; 20(11): 1481–1493. Published online 2019 Oct 14. doi: 10.1038/s41590-019-0502-2
PMCID:
PMC6858552
AbstractArticlePDF–2.7M
13.
Protein 4.1R negatively regulates CD8+ T‐cell activation by modulating phosphorylation of linker for activation of T cells
Dandan Fan, Jianhui Li, Yi Li, Yaxin Guo, Xiaolin Zhang, Wen Wang, Xiaojie Liu, Jingjing Liu, Liping Dai, Liguo Zhang, Qiaozhen Kang, Zhenyu Ji
Immunology. 2019 Aug; 157(4): 312–321. Published online 2019 Jun 24. doi: 10.1111/imm.13085
PMCID:
PMC6620184
AbstractArticlePDF–1.3M
14.
Implications for Gene Therapy-Limiting Expression of IL-2Rγc Delineate Differences in Signaling Thresholds Required for Lymphocyte Development and Maintenance
Selinda J. Orr, Stephen Roessler, Laura Quigley, Tim Chan, Jill W. Ford, Geraldine M. O’Connor, Daniel W. McVicar
J Immunol. Author manuscript; available in PMC 2019 Mar 14.
Published in final edited form as: J Immunol. 2010 Aug 1; 185(3): 1393–1403. Published online 2010 Jun 30. doi: 10.4049/jimmunol.0903528
PMCID:
PMC6417809
AbstractArticlePDF–1.9M
15.
Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
Wan-Lin Lo, Neel H. Shah, Nagib Ahsan, Veronika Horkova, Ondrej Stepanek, Arthur R. Salomon, John Kuriyan, Arthur Weiss
Nat Immunol. Author manuscript; available in PMC 2018 Dec 18.
Published in final edited form as: Nat Immunol. 2018 Jul; 19(7): 733–741. Published online 2018 Jun 18. doi: 10.1038/s41590-018-0131-1
PMCID:
PMC6202249
AbstractArticlePDF–1.0M
16.
LatY136F knock-in mouse model for human IgG4-related disease
Kazunori Yamada, Masahiko Zuka, Kiyoaki Ito, Keishi Mizuguchi, Yasushi Kakuchi, Tamehito Onoe, Yasunori Suzuki, Masakazu Yamagishi, Shozo Izui, Marie Malissen, Bernard Malissen, Mitsuhiro Kawano
PLoS One. 2018; 13(6): e0198417. Published online 2018 Jun 14. doi: 10.1371/journal.pone.0198417
PMCID:
PMC6002065
AbstractArticlePDF–25M
17.
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation
Jean-Marie Carpier, Andres E. Zucchetti, Laurence Bataille, Stéphanie Dogniaux, Massiullah Shafaq-Zadah, Sabine Bardin, Marco Lucchino, Mathieu Maurin, Leonel D. Joannas, Joao Gamelas Magalhaes, Ludger Johannes, Thierry Galli, Bruno Goud, Claire Hivroz
J Exp Med. 2018 Apr 2; 215(4): 1245–1265. doi: 10.1084/jem.20162042
PMCID:
PMC5881459
AbstractArticlePDF–2.9M
18.
The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs
Maria Nicla Loviglio, Thomas Arbogast, Aia Elise Jønch, Stephan C. Collins, Konstantin Popadin, Camille S. Bonnet, Giuliana Giannuzzi, Anne M. Maillard, Sébastien Jacquemont, 16p11.2 Consortium, Binnaz Yalcin, Nicholas Katsanis, Christelle Golzio, Alexandre Reymond
Am J Hum Genet. 2017 Oct 5; 101(4): 564–577. Published online 2017 Sep 28. doi: 10.1016/j.ajhg.2017.08.016
PMCID:
PMC5630231
AbstractArticlePDF–2.1M
19.
Tonic LAT-HDAC7 signals sustain Nur77 and Irf4 expression to tune naïve CD4 T cells
Darienne R. Myers, Tannia Lau, Evan Markegard, Hyung W. Lim, Herbert Kasler, Minghua Zhu, Andrea Barczak, John P. Huizar, Julie Zikherman, David J. Erle, Weiguo Zhang, Eric Verdin, Jeroen P. Roose
Cell Rep. Author manuscript; available in PMC 2017 Sep 6.
Published in final edited form as: Cell Rep. 2017 May 23; 19(8): 1558–1571. doi: 10.1016/j.celrep.2017.04.076
PMCID:
PMC5587137
AbstractArticlePDF–979K
20.
Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells
Jacquelyn Freund, Rebecca M. May, Enjun Yang, Hongchuan Li, Matthew McCullen, Bin Zhang, Todd Lenvik, Frank Cichocki, Stephen K. Anderson, Taku Kambayashi
PLoS Biol. 2016 Aug; 14(8): e1002526. Published online 2016 Aug 8. doi: 10.1371/journal.pbio.1002526
Correction in:
PLoS Biol. 2016 Dec; 14(12): e1002590.
PMCID:
PMC4976927
AbstractArticlePDF–1.4M

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