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Select item 112042981.

Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure

Yexian Yuan, Ruoci Hu, Jooman Park, Shaolei Xiong, Zilai Wang, Yanyu Qian, Zuoxiao Shi, Ruifan Wu, Zhenbo Han, Sang-Ging Ong, Shuhao Lin, Krista A. Varady, Pingwen Xu, Daniel C. Berry, Gang Shu, Yuwei Jiang

Sci Adv. 2024 Jun 28; 10(26): eadn5229. Published online 2024 Jun 26. doi: 10.1126/sciadv.adn5229

PMCID:: PMC11204298

Abstract Article PDF–19M

Select item 110687792.

Ischemic stroke outcome after promoting CD4+CD25+ Treg cell migration through CCR4 overexpression in a tMCAO animal model

Seowoo Lee, Jiwon Kim, Je Sung You, Young-Min Hyun, Jong Youl Kim, Jong Eun Lee

Sci Rep. 2024; 14: 10201. Published online 2024 May 3. doi: 10.1038/s41598-024-60358-2

PMCID:: PMC11068779

Abstract Article PDF–4.8M

Select item 108601973.

Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination

Annkristin Heine, Niels A. W. Lemmermann, Chrystel Flores, Janine Becker-Gotot, Natalio Garbi, Peter Brossart, Christian Kurts

Front Immunol. 2024; 15: 1338499. Published online 2024 Jan 29. doi: 10.3389/fimmu.2024.1338499

PMCID:: PMC10860197

Abstract Article PDF–1.5M

Select item 103257194.

CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance

Yu Li, Pablo Guaman Tipan, Hilary J Selden, Jayashree Srinivasan, Laura P Hale, Lauren IR Ehrlich

eLife. 2023; 12: e80443. Published online 2023 Jun 2. doi: 10.7554/eLife.80443

PMCID:: PMC10325719

Abstract Article PDF–12M

Select item 97343795.

Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis

Min Zhao, Fei Shao, Dou Yu, Jiaqi Zhang, Zhen Liu, Jiangwen Ma, Pengyan Xia, Shuo Wang

Nat Commun. 2022; 13: 7600. Published online 2022 Dec 9. doi: 10.1038/s41467-022-35347-6

PMCID:: PMC9734379

Abstract Article PDF–3.7M

Select item 87948946.

Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons

Jaqueline Raymondi Silva, Mircea Iftinca, Francisco I. Fernandes Gomes, Julia P. Segal, Olivia M. A. Smith, Courtney A. Bannerman, Atlante Silva Mendes, Manon Defaye, Madeline E. C. Robinson, Ian Gilron, Thiago Mattar Cunha, Christophe Altier, Nader Ghasemlou

Proc Natl Acad Sci U S A. 2022 Jan 25; 119(4): e2118238119. Published online 2022 Jan 19. doi: 10.1073/pnas.2118238119

PMCID:: PMC8794894

Abstract Article PDF–2.1M

Select item 82493887.

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Katsura Minegishi, Benjamin Rothé, Kaoru R. Komatsu, Hiroki Ono, Yayoi Ikawa, Hiromi Nishimura, Takanobu A. Katoh, Eriko Kajikawa, Xiaorei Sai, Emi Miyashita, Katsuyoshi Takaoka, Kana Bando, Hiroshi Kiyonari, Tadashi Yamamoto, Hirohide Saito, Daniel B. Constam, Hiroshi Hamada

Nat Commun. 2021; 12: 4071. Published online 2021 Jul 1. doi: 10.1038/s41467-021-24295-2

PMCID:: PMC8249388

Abstract Article PDF–4.7M

Select item 78512398.

Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice

Shuixiang Deng, Prativa Sherchan, Peng Jin, Lei Huang, Zachary Travis, John H. Zhang, Ye Gong, Jiping Tang

Neurotherapeutics. 2020 Oct; 17(4): 1940–1953. Published online 2020 Aug 11. doi: 10.1007/s13311-020-00908-4

PMCID:: PMC7851239

Abstract Article PDF–5.8M

Select item 76929939.

Tumors establish resistance to immunotherapy by regulating T_reg recruitment via CCR4

Lisa A Marshall, Sachie Marubayashi, Aparna Jorapur, Scott Jacobson, Mikhail Zibinsky, Omar Robles, Dennis Xiaozhou Hu, Jeffrey J Jackson, Deepa Pookot, Jerick Sanchez, Martin Brovarney, Angela Wadsworth, David Chian, David Wustrow, Paul D Kassner, Gene Cutler, Brian Wong, Dirk G Brockstedt, Oezcan Talay

J Immunother Cancer. 2020; 8(2): e000764. Published online 2020 Nov 26. doi: 10.1136/jitc-2020-000764

PMCID:: PMC7692993

Abstract Article PDF–1.3M

Select item 715507210.

A degradatory fate for CCR4 suggests a primary role in Th2 inflammation

Caroline A. Anderson, Pallavi Patel, Jonathan M. Viney, Rhian M. Phillips, Roberto Solari, James E. Pease

J Leukoc Biol. 2020 Mar; 107(3): 455–466. Published online 2020 Feb 13. doi: 10.1002/JLB.2A0120-089RR

PMCID:: PMC7155072

Abstract Article PDF–1.5M

Select item 688897611.

A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2–mediated inflammation

Lisa Knipfer, Anja Schulz-Kuhnt, Markus Kindermann, Vicky Greif, Cornelia Symowski, David Voehringer, Markus F. Neurath, Imke Atreya, Stefan Wirtz

J Exp Med. 2019 Dec 2; 216(12): 2763–2777. Published online 2019 Sep 19. doi: 10.1084/jem.20182111

PMCID:: PMC6888976

Abstract Article PDF–3.0M

Select item 679184212.

Dendritic cells and regulatory T cells expressing CCR4 provide resistance to coxsackievirus B5-induced pancreatitis

Marcela C. S. Françozo, Frederico R. C. Costa, Isabel C. Guerra-Gomes, João S. Silva, Renata Sesti-Costa

Sci Rep. 2019; 9: 14766. Published online 2019 Oct 14. doi: 10.1038/s41598-019-51311-9

PMCID:: PMC6791842

Abstract Article PDF–4.8M

Select item 662914013.

CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection

Vyacheslav Palchevskiy, Ying Ying Xue, Rita Kern, Stephen S. Weigt, Aric L. Gregson, Sophie X. Song, Michael C. Fishbein, Cory M. Hogaboam, David M. Sayah, Joseph P. Lynch, III, Michael P. Keane, David G. Brooks, John A. Belperio

JCI Insight. 2019 Jun 20; 4(12): e121782. Published online 2019 Jun 20. doi: 10.1172/jci.insight.121782

PMCID:: PMC6629140

Abstract Article PDF–20M

Select item 637577914.

The emergence of pathogenic TNF/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4

Bruno Galvão-Filho, Júlia Teixeira de Castro, Maria Marta Figueiredo, Claudio Gonçalves Rosmaninho, Lis Ribeiro do Valle Antonelli, Ricardo Tostes Gazzinelli

Mucosal Immunol. 2019 Mar; 12(2): 312–322. Published online 2022 Dec 31. doi: 10.1038/s41385-018-0093-5

PMCID:: PMC6375779

Abstract Article PDF–2.0M

Select item 631505815.

CCR4-dependent reduction in the number and suppressor function of CD4⁺Foxp3⁺ cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis

Thais B. Bertolini, Annie R. Piñeros, Rafael Q. Prado, Ana Flávia Gembre, Leandra N. Z. Ramalho, José Carlos Alves-Filho, Vânia L. D. Bonato

Cell Death Dis. 2019 Jan; 10(1): 11. Published online 2018 Dec 21. doi: 10.1038/s41419-018-1240-3

PMCID:: PMC6315058

Abstract Article PDF–2.4M

Select item 609412516.

Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation

Jian Sima, Zhijiang Yan, Yaohui Chen, Elin Lehrmann, Yongqing Zhang, Ramaiah Nagaraja, Weidong Wang, Zhong Wang, David Schlessinger

Proc Natl Acad Sci U S A. 2018 Aug 7; 115(32): 8173–8178. Published online 2018 Jul 23. doi: 10.1073/pnas.1800930115

PMCID:: PMC6094125

Abstract Article PDF–1.5M

Select item 600266117.

β-Arrestin-2–Dependent Signaling Promotes CCR4–mediated Chemotaxis of Murine T-Helper Type 2 Cells

Rui Lin, Yeon ho Choi, David A. Zidar, Julia K. L. Walker

Am J Respir Cell Mol Biol. 2018 Jun; 58(6): 745–755. doi: 10.1165/rcmb.2017-0240OC

PMCID:: PMC6002661

Abstract Article PDF–1.0M

Select item 584661918.

Targeted reduction of CCR4⁺ cells is sufficient to suppress allergic airway inflammation

Akifumi Honjo, Hirohisa Ogawa, Masahiko Azuma, Toshifumi Tezuka, Saburo Sone, Arya Biragyn, Yasuhiko Nishioka

Respir Investig. Author manuscript; available in PMC 2018 Mar 12.

Published in final edited form as: Respir Investig. 2013 Dec; 51(4): 241–249. Published online 2013 Jun 22. doi: 10.1016/j.resinv.2013.04.007

PMCID:: PMC5846619

Abstract Article PDF–1.4M

Select item 533072719.

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

Chiara Berlato, Moddasar N. Khan, Tiziana Schioppa, Richard Thompson, Eleni Maniati, Anne Montfort, Maryam Jangani, Monica Canosa, Hagen Kulbe, Urs B. Hagemann, Alexander R. Duncan, Laura Fletcher, Robert W. Wilkinson, Thomas Powles, Sergio A. Quezada, Frances R. Balkwill

J Clin Invest. 2017 Mar 1; 127(3): 801–813. Published online 2017 Jan 30. doi: 10.1172/JCI82976

PMCID:: PMC5330727

Abstract Article PDF–1.4M

Select item 515970620.

DR3 signaling modulates the function of Foxp3⁺ regulatory T cells and the severity of acute graft-versus-host disease

Hidekazu Nishikii, Byung-Su Kim, Yasuhisa Yokoyama, Yan Chen, Jeanette Baker, Antonio Pierini, Maite Alvarez, Melissa Mavers, Kristina Maas-Bauer, Yuqiong Pan, Shigeru Chiba, Robert S. Negrin

Blood. 2016 Dec 15; 128(24): 2846–2858. Prepublished online 2016 Oct 19. doi: 10.1182/blood-2016-06-723783