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Items: 1 to 20 of 113

1.
Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis
Samira Benhamouche-Trouillet, Evan O'Loughlin, Ching-Hui Liu, William Polacheck, Julien Fitamant, Mary McKee, Nabeel El-Bardeesy, Christopher S. Chen, Andrea I. McClatchey
Development. 2018 May 1; 145(9): dev162123. Published online 2018 Apr 30. doi: 10.1242/dev.162123
PMCID:
PMC10682933
AbstractArticle
2.
Proteasomal pathway inhibition as a potential therapy for NF2-associated meningioma and schwannoma
Srirupa Bhattacharyya, Janet L Oblinger, Roberta L Beauchamp, Zhenzhen Yin, Serkan Erdin, Priya Koundinya, Anna D Ware, Marc Ferrer, Justin T Jordan, Scott R Plotkin, Lei Xu, Long-Sheng Chang, Vijaya Ramesh
Neuro Oncol. 2023 Sep; 25(9): 1617–1630. Published online 2023 Feb 20. doi: 10.1093/neuonc/noad037
PMCID:
PMC10479743
AbstractArticlePDF–7.7M
3.
Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in Nf2-Mutant Mice
Monserrat Gerardo-Ramírez, Vanessa Giam, Diana Becker, Marco Groth, Nils Hartmann, Helen Morrison, Helen L. May-Simera, Markus P. Radsak, Jens U. Marquardt, Peter R. Galle, Peter Herrlich, Beate K. Straub, Monika Hartmann
Cells. 2023 May; 12(9): 1257. Published online 2023 Apr 26. doi: 10.3390/cells12091257
PMCID:
PMC10177437
AbstractArticlePDF–13M
4.
Inflammation as a chemoprevention target in asbestos-induced malignant mesothelioma
Yuwaraj Kadariya, Eleonora Sementino, Ujjawal Shrestha, Greg Gorman, Jonathan M White, Eric A Ross, Margie L Clapper, Nouri Neamati, Mark Steven Miller, Joseph R Testa
Carcinogenesis. 2022 Dec; 43(12): 1137–1148. Published online 2022 Nov 10. doi: 10.1093/carcin/bgac089
PMCID:
PMC10122428
AbstractArticlePDF–39M
5.
CD44 Contributes to the Regulation of MDR1 Protein and Doxorubicin Chemoresistance in Osteosarcoma
Monserrat Gerardo-Ramírez, Friederike L. Keggenhoff, Vanessa Giam, Diana Becker, Marco Groth, Nils Hartmann, Beate K. Straub, Helen Morrison, Peter R. Galle, Jens U. Marquardt, Peter Herrlich, Monika Hartmann
Int J Mol Sci. 2022 Aug; 23(15): 8616. Published online 2022 Aug 3. doi: 10.3390/ijms23158616
PMCID:
PMC9368984
AbstractArticlePDF–4.1M
6.
PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2)
Eric Hawley, Jeffrey Gehlhausen, Sofiia Karchugina, Hoi-Yee Chow, Daniela Araiza-Olivera, Maria Radu, Abbi Smith, Ciersten Burks, Li Jiang, Xiaohong Li, Waylan Bessler, Andrea Masters, Donna Edwards, Callie Burgin, David Jones, Charles Yates, D Wade Clapp, Jonathan Chernoff, Su-Jung Park
Hum Mol Genet. 2021 Sep 1; 30(17): 1607–1617. Published online 2021 Jun 1. doi: 10.1093/hmg/ddab106
PMCID:
PMC8369838
AbstractArticlePDF–1.6M
7.
The pathogenesis of mesothelioma is driven by a dysregulated translatome
Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Gavin D. Garland, Angela Rubio Tenor, Ryan Mordue, Tanya Chernova, Nobu Morone, Marco Sereno, Claire P. Smith, Leah Officer, Pooyeh Farahmand, Claire Rooney, David Sumpton, Madhumita Das, Ana Teodósio, Catherine Ficken, Maria Guerra Martin, Ruth V. Spriggs, Xiao-Ming Sun, Martin Bushell, Owen J. Sansom, Daniel Murphy, Marion MacFarlane, John P. C. Le Quesne, Anne E. Willis
Nat Commun. 2021; 12: 4920. Published online 2021 Aug 13. doi: 10.1038/s41467-021-25173-7
PMCID:
PMC8363647
AbstractArticlePDF–3.0M
8.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
9.
Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK
Long-Sheng Chang, Janet L. Oblinger, Abbi E. Smith, Marc Ferrer, Steven P. Angus, Eric Hawley, Alejandra M. Petrilli, Roberta L. Beauchamp, Lars Björn Riecken, Serkan Erdin, Ming Poi, Jie Huang, Waylan K. Bessler, Xiaohu Zhang, Rajarshi Guha, Craig Thomas, Sarah S. Burns, Thomas S. K. Gilbert, Li Jiang, Xiaohong Li, Qingbo Lu, Jin Yuan, Yongzheng He, Shelley A. H. Dixon, Andrea Masters, David R. Jones, Charles W. Yates, Stephen J. Haggarty, Salvatore La Rosa, D. Bradley Welling, Anat O. Stemmer-Rachamimov, Scott R. Plotkin, James F. Gusella, Justin Guinney, Helen Morrison, Vijaya Ramesh, Cristina Fernandez-Valle, Gary L. Johnson, Jaishri O. Blakeley, D. Wade Clapp, on behalf of the Synodos for NF2 Consortium
PLoS One. 2021; 16(7): e0252048. Published online 2021 Jul 15. doi: 10.1371/journal.pone.0252048
PMCID:
PMC8282008
AbstractArticlePDF–4.5M
10.
Merlin deficiency alters the redox management program in breast cancer
Mateus Mota, Brandon J. Metge, Dominique C. Hinshaw, Heba A. Alsheikh, Dongquan Chen, Rajeev S. Samant, Lalita A. Shevde
Mol Oncol. 2021 Apr; 15(4): 942–956. Published online 2021 Feb 1. doi: 10.1002/1878-0261.12896
PMCID:
PMC8024723
AbstractArticlePDF–1.6M
11.
Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice
Jitendra Badhai, Gaurav Kumar Pandey, Ji-Ying Song, Oscar Krijgsman, Rajith Bhaskaran, Gayathri Chandrasekaran, Min-chul Kwon, Lorenzo Bombardelli, Kim Monkhorst, Cristoforo Grasso, John Zevenhoven, Jan van der Vliet, Miranda Cozijnsen, Paul Krimpenfort, Daniel Peeper, Maarten van Lohuizen, Anton Berns
J Exp Med. 2020 Jun 1; 217(6): e20191257. Published online 2020 Apr 9. doi: 10.1084/jem.20191257
PMCID:
PMC7971132
AbstractArticlePDF–3.7M
12.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
13.
PLPP/CIN-mediated NF2-serine 10 dephosphorylation regulates F-actin stability and Mdm2 degradation in an activity-dependent manner
Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim, Tae-Cheon Kang
Cell Death Dis. 2021 Jan; 12(1): 37. Published online 2021 Jan 4. doi: 10.1038/s41419-020-03325-9
PMCID:
PMC7791067
AbstractArticlePDF–5.1M
14.
Nf2 fine-tunes proliferation and tissue alignment during closure of the optic fissure in the embryonic mouse eye
Wesley R Sun, Sara Ramirez, Kelly E Spiller, Yan Zhao, Sabine Fuhrmann
Hum Mol Genet. 2020 Oct 15; 29(20): 3373–3387. Published online 2020 Oct 19. doi: 10.1093/hmg/ddaa228
PMCID:
PMC7749708
AbstractArticlePDF–2.1M
15.
SWI/SNF as mechanoregulated inhibitor of YAP/TAZ
Lei Chang, Luca Azzolin, Daniele Di Biagio, Francesca Zanconato, Giusy Battilana, Romy Lucon Xiccato, Mariaceleste Aragona, Stefano Giulitti, Tito Panciera, Alessandro Gandin, Gianluca Sigismondo, Jeroen Krijgsveld, Matteo Fassan, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo
Nature. Author manuscript; available in PMC 2022 Jul 4.
Published in final edited form as: Nature. 2018 Nov 1; 563(7730): 265–269. Published online 2018 Oct 31. doi: 10.1038/s41586-018-0658-1
PMCID:
PMC7612964
AbstractArticlePDF–4.7M
16.
Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling
Zhiguo Chen, Stephen Li, Juan Mo, Eric Hawley, Yong Wang, Yongzheng He, Jean-Philippe Brosseau, Tracey Shipman, D. Wade Clapp, Thomas J. Carroll, Lu Q. Le
JCI Insight. 2020 Oct 15; 5(20): e141514. Published online 2020 Oct 15. doi: 10.1172/jci.insight.141514
PMCID:
PMC7605536
AbstractArticlePDF–125M
17.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
18.
WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice
Jaeoh Park, Jeong Sik Kim, Ji Hae Nahm, Sang-Kyum Kim, Da-Hye Lee, Dae-Sik Lim
Mol Cells. 2020 May 31; 43(5): 491–499. Published online 2020 May 15. doi: 10.14348/molcells.2020.0093
PMCID:
PMC7264477
AbstractArticlePDF–21M
19.
A functional interaction between Na,K-ATPase β2-subunit/AMOG and NF2/Merlin regulates growth factor signaling in cerebellar granule cells
Alisa Litan, Zhiqin Li, Elmira Tokhtaeva, Patience Kelly, Olga Vagin, Sigrid A. Langhans
Mol Neurobiol. Author manuscript; available in PMC 2020 Nov 1.
Published in final edited form as: Mol Neurobiol. 2019 Nov; 56(11): 7557–7571. Published online 2019 May 6. doi: 10.1007/s12035-019-1592-4
PMCID:
PMC6815692
AbstractArticlePDF–2.1M
20.
Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models
Anna-Mariya Kukuyan, Eleonora Sementino, Yuwaraj Kadariya, Craig W. Menges, Mitchell Cheung, Yinfei Tan, Kathy Q. Cai, Michael J. Slifker, Suraj Peri, Andres J. Klein-Szanto, Frank J. Rauscher, III, Joseph R. Testa
Cancer Res. Author manuscript; available in PMC 2020 Feb 15.
Published in final edited form as: Cancer Res. 2019 Aug 15; 79(16): 4113–4123. Published online 2019 May 31. doi: 10.1158/0008-5472.CAN-18-4093
PMCID:
PMC6697648
AbstractArticlePDF–1.2M

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