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Items: 1 to 20 of 142

1.
Hif-2α programs oxygen chemosensitivity in chromaffin cells
Maria Prange-Barczynska, Holly A. Jones, Yoichiro Sugimoto, Xiaotong Cheng, Joanna D.C.C. Lima, Indrika Ratnayaka, Gillian Douglas, Keith J. Buckler, Peter J. Ratcliffe, Thomas P. Keeley, Tammie Bishop
J Clin Invest. 2024 Sep 17; 134(18): e174661. Published online 2024 Aug 6. doi: 10.1172/JCI174661
PMCID:
PMC11405041
AbstractArticlePDF–3.9M
2.
PHD2 safeguards modest mesendoderm development
Meng Li, Huaizhang Jin, Yun Zhao, Guoping Zhu, Yu Liu, Hongan Long, Xiaopeng Shen
Commun Biol. 2024; 7: 1100. Published online 2024 Sep 7. doi: 10.1038/s42003-024-06824-z
PMCID:
PMC11380689
AbstractArticlePDF–4.1M
3.
Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality
Rongling Wang, Mario Gomez Salazar, Iris Pruñonosa Cervera, Amanda Coutts, Karen French, Marlene Magalhaes Pinto, Sabrina Gohlke, Ruben García-Martín, Matthias Blüher, Christopher J. Schofield, Ioannis Kourtzelis, Roland H. Stimson, Cécile Bénézech, Mark Christian, Tim J. Schulz, Elias F. Gudmundsson, Lori L. Jennings, Vilmundur G. Gudnason, Triantafyllos Chavakis, Nicholas M. Morton, Valur Emilsson, Zoi Michailidou
Nat Commun. 2024; 15: 7483. Published online 2024 Aug 29. doi: 10.1038/s41467-024-51718-7
PMCID:
PMC11362468
AbstractArticlePDF–2.0M
4.
Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance
Lihong Pan, Xiaochen He, Rui Xu, Umesh Bhattarai, Ziru Niu, Jussara do Carmo, Yuxiang Sun, Heng Zeng, John S. Clemmer, Jian-Xiong Chen, Yingjie Chen
GeroScience. 2024 Aug; 46(4): 3945–3956. Published online 2024 Mar 11. doi: 10.1007/s11357-024-01108-0
PMCID:
PMC11226575
AbstractArticlePDF–6.7M
5.
Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension
Elizabeth A. Barnes, Reiji Ito, Xibing Che, Cristina M. Alvira, David N. Cornfield
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 1; 325(6): L741–L755. Published online 2023 Oct 17. doi: 10.1152/ajplung.00428.2022
PMCID:
PMC11068430
AbstractArticle
6.
CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa
Nicholas D. Nolan, Xuan Cui, Brian M. Robbings, Aykut Demirkol, Kriti Pandey, Wen-Hsuan Wu, Hannah F. Hu, Laura A. Jenny, Chyuan-Sheng Lin, Daniel T. Hass, Jianhai Du, James B. Hurley, Stephen H. Tsang
Cell Rep Med. 2024 Apr 16; 5(4): 101459. Published online 2024 Mar 21. doi: 10.1016/j.xcrm.2024.101459
PMCID:
PMC11031380
AbstractArticlePDF–6.3M
7.
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
Tao Zhang, Daichao Xu, Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Dongxian Guan, Cong Jiang, Xiaoming Dai, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao, Gyongyi Szabo, Guo-Hua Fong, Antoine E. Karnoub, Yu-Ru Lee, Lifeng Pan, William G. Kaelin, Jr., Junying Yuan, Wenyi Wei
Nat Cell Biol. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Nat Cell Biol. 2023 Jul; 25(7): 950–962. Published online 2023 Jul 3. doi: 10.1038/s41556-023-01170-4
PMCID:
PMC10617019
AbstractArticlePDF–8.3M
8.
Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1
Fan Li, Fenglin Zhang, Xin Yi, Lu Lu Quan, Xiaohua Yang, Cong Yin, Zewei Ma, Ruifan Wu, Weijie Zhao, Mingfa Ling, Limin Lang, Abdelaziz Hussein, Shengchun Feng, Yiming Fu, Junfeng Wang, Shuyi Liang, Canjun Zhu, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi, Yongliang Zhang, Lin Zhang, Gang Shu, Qingyan Jiang, Songbo Wang
Mol Metab. 2023 Jul; 73: 101747. Published online 2023 Jun 4. doi: 10.1016/j.molmet.2023.101747
PMCID:
PMC10293773
AbstractArticlePDF–4.0M
9.
Egln1Tie2Cre Mice Exhibit Similar Therapeutic Responses to Sildenafil, Ambrisentan, and Treprostinil as Pulmonary Arterial Hypertension (PAH) Patients, Supporting Egln1Tie2Cre Mice as a Useful PAH Model
Yi Peng, Jingbo Dai, You-Yang Zhao
Int J Mol Sci. 2023 Feb; 24(3): 2391. Published online 2023 Jan 25. doi: 10.3390/ijms24032391
PMCID:
PMC9916894
AbstractArticlePDF–3.2M
10.
Tailless and hypoxia inducible factor-2α cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice
Li-Juan Duan, Yida Jiang, Yanhong Shi, Guo-Hua Fong
Biol Open. 2023 Jan 1; 12(1): bio059684. Published online 2023 Jan 10. doi: 10.1242/bio.059684
PMCID:
PMC9867894
AbstractArticlePDF–5.9M
11.
HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2
Julien Sallais, Chanho Park, Sruthi Alahari, Tyler Porter, Ruizhe Liu, Merve Kurt, Abby Farrell, Martin Post, Isabella Caniggia
JCI Insight. 2022 Dec 8; 7(23): e158908. Published online 2022 Dec 8. doi: 10.1172/jci.insight.158908
PMCID:
PMC9746916
AbstractArticlePDF–7.1M
12.
The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, Jonathan M. Harnoss
JCI Insight. 2022 Nov 22; 7(22): e153337. Published online 2022 Nov 22. doi: 10.1172/jci.insight.153337
PMCID:
PMC9746807
AbstractArticlePDF–4.9M
13.
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2
Tianshi Feng, Xuemei Zhao, Ping Gu, Wah Yang, Cunchuan Wang, Qingyu Guo, Qiaoyun Long, Qing Liu, Ying Cheng, Jin Li, Cynthia Kwan Yui Cheung, Donghai Wu, Xinyu Kong, Yong Xu, Dewei Ye, Shuang Hua, Kerry Loomes, Aimin Xu, Xiaoyan Hui
Nat Commun. 2022; 13: 5208. Published online 2022 Sep 5. doi: 10.1038/s41467-022-32871-3
PMCID:
PMC9445001
AbstractArticlePDF–5.7M
14.
AMP‐activated protein kinase α1 phosphorylates PHD2 to maintain systemic iron homeostasis
Cheng Wang, Wencheng Zhang, Wenjing Xu, Zhaoyu Liu, Kai Huang
Clin Transl Med. 2022 May; 12(5): e854. Published online 2022 May 11. doi: 10.1002/ctm2.854
Correction in:
Clin Transl Med. 2023 Jun; 13(6): e1306.
PMCID:
PMC9091988
AbstractArticlePDF–3.0M
15.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
16.
Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia
Ann-Helen Rosendahl, Mia Monnius, Anu Laitala, Antti Railo, Ilkka Miinalainen, Ritva Heljasvaara, Joni M. Mäki, Johanna Myllyharju
J Biol Chem. 2022 Apr; 298(4): 101787. Published online 2022 Mar 2. doi: 10.1016/j.jbc.2022.101787
PMCID:
PMC8988008
AbstractArticlePDF–6.1M
17.
The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells
Yousra Ajouaou, Abdulkader Azouz, Anaëlle Taquin, Sebastien Denanglaire, Hind Hussein, Mohammad Krayem, Fabienne Andris, Muriel Moser, Stanislas Goriely, Oberdan Leo
eLife. 2022; 11: e70555. Published online 2022 Feb 22. doi: 10.7554/eLife.70555
PMCID:
PMC8896828
AbstractArticlePDF–2.5M
18.
Adaptation of the Oxygen Sensing System during Lung Development
Karin M. Kirschner, Simon Kelterborn, Herrmann Stehr, Johanna L. T. Penzlin, Charlotte L. J. Jacobi, Stefanie Endesfelder, Miriam Sieg, Jochen Kruppa, Christof Dame, Lina K. Sciesielski
Oxid Med Cell Longev. 2022; 2022: 9714669. Published online 2022 Feb 18. doi: 10.1155/2022/9714669
PMCID:
PMC8886745
AbstractArticlePDF–2.8M
19.
Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes
Xiaowei Zheng, Sampath Narayanan, Cheng Xu, Sofie Eliasson Angelstig, Jacob Grünler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A Forsberg, Ao Zhang, Kerstin Brismar, Tomas A Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina
eLife. 2022; 11: e70714. Published online 2022 Feb 15. doi: 10.7554/eLife.70714
PMCID:
PMC8846593
AbstractArticlePDF–7.0M
20.
PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes
Aude Angelini, Pradip K. Saha, Antrix Jain, Sung Yun Jung, Randall L. Mynatt, Xinchun Pi, Liang Xie
Cell Rep. Author manuscript; available in PMC 2021 Dec 9.
Published in final edited form as: Cell Rep. 2021 Oct 5; 37(1): 109767. doi: 10.1016/j.celrep.2021.109767
PMCID:
PMC8658754
AbstractArticlePDF–2.3M

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