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Items: 1 to 20 of 306

1.
Conditional loss of Brca1 in oocytes causes reduced litter size, ovarian reserve depletion and impaired oocyte in vitro maturation with advanced reproductive age in mice
Amy L. Winship, Lauren R. Alesi, Jessica M. Stringer, Yujie Cao, Yasmin M. Lewis, Lisa Tu, Elyse O.K. Swindells, Saranya Giridharan, Xuebi Cai, Meaghan J. Griffiths, Nadeen Zerafa, Leslie Gilham, Martha Hickey, Karla J. Hutt
eBioMedicine. 2024 Aug; 106: 105262. Published online 2024 Jul 30. doi: 10.1016/j.ebiom.2024.105262
PMCID:
PMC11342213
AbstractArticlePDF–3.0M
2.
BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
Hussein Chehade, Radhika Gogoi, Nicholas K. Adzibolosu, Sandra Galoforo, Rouba-Ali Fehmi, Mira Kheil, Alexandra Fox, Seongho Kim, Ramandeep Rattan, Zhanjun Hou, Robert T. Morris, Larry H. Matherly, Gil Mor, Ayesha B. Alvero
Cancer Res Commun. 2024 Aug; 4(8): 2075–2088. Published online 2024 Aug 13. doi: 10.1158/2767-9764.CRC-24-0111
PMCID:
PMC11320024
AbstractArticlePDF–23M
3.
BRCA1 and 53BP1 Regulate Reprogramming Efficiency by Mediating DNA Repair Pathway Choice at Replication-associated Double-Strand Breaks
Daniela Georgieva, Ning Wang, Angelo Taglialatela, Stepan Jerabek, Colleen R. Reczek, Pei Xin Lim, Julie Sung, Qian Du, Michiko Horiguchi, Maria Jasin, Alberto Ciccia, Richard Baer, Dieter Egli
Cell Rep. Author manuscript; available in PMC 2024 Jul 25.
Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 114006. Published online 2024 Mar 30. doi: 10.1016/j.celrep.2024.114006
PMCID:
PMC11272184
AbstractArticlePDF–2.7M
4.
IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors
Robert Wiesheu, Sarah C Edwards, Ann Hedley, Holly Hall, Marie Tosolini, Marcelo Gregorio Filho Fares da Silva, Nital Sumaria, Suzanne M Castenmiller, Leyma Wardak, Yasmin Optaczy, Amy Lynn, David G Hill, Alan J Hayes, Jodie Hay, Anna Kilbey, Robin Shaw, Declan Whyte, Peter J Walsh, Alison M Michie, Gerard J Graham, Anand Manoharan, Christina Halsey, Karen Blyth, Monika C Wolkers, Crispin Miller, Daniel J Pennington, Gareth W Jones, Jean-Jacques Fournie, Vasileios Bekiaris, Seth B Coffelt
EMBO J. 2024 Jul; 43(14): 2878–2907. Published online 2024 May 30. doi: 10.1038/s44318-024-00133-1
PMCID:
PMC11251046
AbstractArticlePDF–8.1M
5.
Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions
Saori Yoshimura, Ryuki Shimada, Koji Kikuchi, Soichiro Kawagoe, Hironori Abe, Sakie Iisaka, Sayoko Fujimura, Kei-ichiro Yasunaga, Shingo Usuki, Naoki Tani, Takashi Ohba, Eiji Kondoh, Tomohide Saio, Kimi Araki, Kei-ichiro Ishiguro
Nat Commun. 2024; 15: 3330. Published online 2024 Apr 29. doi: 10.1038/s41467-024-47601-0
PMCID:
PMC11059408
AbstractArticlePDF–8.4M
6.
GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer
Xuejie Wang, Feng Bai, Xiong Liu, Bin Peng, Xingzhi Xu, Hongquan Zhang, Li Fu, Wei-Guo Zhu, Bin Wang, Xin-Hai Pei
BMC Biol. 2024; 22: 85. Published online 2024 Apr 16. doi: 10.1186/s12915-024-01881-6
PMCID:
PMC11020915
AbstractArticlePDF–6.2M
7.
Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection
Tirza Bidany-Mizrahi, Aya Shweiki, Kian Maroun, Lina Abu-Tair, Bella Mali, Rami I. Aqeilan
Cell Death Discov. 2024; 10: 145. Published online 2024 Mar 18. doi: 10.1038/s41420-024-01878-8
PMCID:
PMC10948869
AbstractArticlePDF–4.5M
8.
BRCA1 protein dose-dependent risk for embryonic oxidative DNA damage, embryopathies and neurodevelopmental disorders with and without ethanol exposure
Danielle M. Drake, Kian Afsharian, Benjamin Or, Aaron M. Shapiro, Michelle L. Lai, Lutfiya Miller, Peter G. Wells
Redox Biol. 2024 Apr; 70: 103070. Published online 2024 Feb 8. doi: 10.1016/j.redox.2024.103070
PMCID:
PMC10877410
AbstractArticlePDF–5.5M
9.
Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model
Giusy Tornillo, Lauren Warrington, Howard Kendrick, Adam T. Higgins, Trevor Hay, Sam Beck, Matthew J. Smalley
Dis Model Mech. 2024 Jan 1; 17(1): dmm050211. Published online 2024 Jan 25. doi: 10.1242/dmm.050211
PMCID:
PMC10846530
AbstractArticle
10.
Exploiting Synthetic Lethality between Germline BRCA1 Haploinsufficiency and PARP Inhibition in JAK2V617F-Positive Myeloproliferative Neoplasms
Max Bermes, Maria Jimena Rodriguez, Marcelo Augusto Szymanski de Toledo, Sabrina Ernst, Gerhard Müller-Newen, Tim Henrik Brümmendorf, Nicolas Chatain, Steffen Koschmieder, Julian Baumeister
Int J Mol Sci. 2023 Dec; 24(24): 17560. Published online 2023 Dec 16. doi: 10.3390/ijms242417560
PMCID:
PMC10743753
AbstractArticlePDF–8.2M
11.
Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting
George E. Ronson, Katarzyna Starowicz, Elizabeth J. Anthony, Ann Liza Piberger, Lucy C. Clarke, Alexander J. Garvin, Andrew D. Beggs, Celina M. Whalley, Matthew J. Edmonds, James F. J. Beesley, Joanna R. Morris
Nat Commun. 2023; 14: 7834. Published online 2023 Nov 29. doi: 10.1038/s41467-023-43677-2
PMCID:
PMC10687250
AbstractArticlePDF–4.6M
12.
A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancer
Jianhao Zeng, Shambhavi Singh, Xian Zhou, Ying Jiang, Eli Casarez, Kristen A. Atkins, Kevin A. Janes, Hui Zong
Dis Model Mech. 2023 Nov 1; 16(11): dmm050219. Published online 2023 Nov 13. doi: 10.1242/dmm.050219
PMCID:
PMC10668031
AbstractArticle
13.
Targeted inhibition of Wnt signaling with a Clostridioides difficile toxin B fragment suppresses breast cancer tumor growth
Aina He, Songhai Tian, Oded Kopper, Daniel J. Horan, Peng Chen, Roderick T. Bronson, Ren Sheng, Hao Wu, Lufei Sui, Kun Zhou, Liang Tao, Quan Wu, Yujing Huang, Zan Shen, Sen Han, Xueqing Chen, Hong Chen, Xi He, Alexander G. Robling, Rongsheng Jin, Hans Clevers, Dongxi Xiang, Zhe Li, Min Dong
PLoS Biol. 2023 Nov; 21(11): e3002353. Published online 2023 Nov 9. doi: 10.1371/journal.pbio.3002353
PMCID:
PMC10635564
AbstractArticlePDF–3.4M
14.
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
Rehna Krishnan, Mariah Lapierre, Brandon Gautreau, Kevin C J Nixon, Samah El Ghamrasni, Parasvi S Patel, Jun Hao, V Talya Yerlici, Kiran Kumar Naidu Guturi, Jonathan St-Germain, Francesca Mateo, Amine Saad, Arash Algouneh, Rebecca Earnshaw, Duan Shili, Alma Seitova, Joshua Miller, Negin Khosraviani, Adam Penn, Brandon Ho, Otto Sanchez, M Prakash Hande, Jean-Yves Masson, Grant W Brown, Moulay Alaoui-Jamali, John J Reynolds, Cheryl Arrowsmith, Brian Raught, Miguel A Pujana, Karim Mekhail, Grant S Stewart, Anne Hakem, Razqallah Hakem
Nucleic Acids Res. 2023 Oct 27; 51(19): 10484–10505. Published online 2023 Sep 11. doi: 10.1093/nar/gkad733
PMCID:
PMC10602868
AbstractArticlePDF–2.1M
15.
BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injury
Emily Leung, Daria Taskina, Nicole Schwab, Lili-Naz Hazrati
Front Neurosci. 2023; 17: 1225226. Published online 2023 Aug 10. doi: 10.3389/fnins.2023.1225226
PMCID:
PMC10450634
AbstractArticlePDF–15M
16.
p18INK4C and BRCA1 inhibit follicular cell proliferation and dedifferentiation in thyroid cancer
Feng Bai, Xiong Liu, Xu Zhang, Zhuo Mao, He Wen, Jinshan Ma, Xin-Hai Pei
Cell Cycle. 2023; 22(13): 1637–1653. Published online 2023 Jun 22. doi: 10.1080/15384101.2023.2225938
PMCID:
PMC10361144
AbstractArticlePDF–4.2M
17.
Granulosa Cell-Specific Brca1 Loss Alone or Combined with Trp53 Haploinsufficiency and Transgenic FSH Expression Fails to Induce Ovarian Tumors
Dannielle H. Upton, Emily S. Fuller, Emily K. Colvin, Kirsty A. Walters, Mark Jimenez, Reena Desai, David J. Handelsman, Viive M. Howell, Charles M. Allan
Horm Cancer. 2015 Aug; 6(4): 142–152. Published online 2015 May 6. doi: 10.1007/s12672-015-0222-5
PMCID:
PMC10355885
AbstractArticlePDF–1.3M
18.
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer
Goutam Dey, Rashmi Bharti, Chad Braley, Ravi Alluri, Emily Esakov, Katie Crean-Tate, Keith McCrae, Amy Joehlin-Price, Peter G. Rose, Justin Lathia, Zihua Gong, Ofer Reizes
J Ovarian Res. 2023; 16: 122. Published online 2023 Jun 27. doi: 10.1186/s13048-023-01194-2
PMCID:
PMC10294509
AbstractArticlePDF–8.5M
19.
Dichotomous ovarian cancer-initiating potential of Pax8+ cells revealed by a mouse genetic mosaic model
Jianhao Zeng, Astrid Catalina Alvarez-Yela, Eli Casarez, Ying Jiang, Lixin Wang, Brianna E. Kelly, Taylor Jenkins, Eugene Ke, Kristen A. Atkins, Kevin A. Janes, Jill K. Slack-Davis, Hui Zong
iScience. 2023 May 19; 26(5): 106742. Published online 2023 Apr 25. doi: 10.1016/j.isci.2023.106742
PMCID:
PMC10189502
AbstractArticlePDF–7.8M
20.
BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity
Bogang Wu, Leilei Qi, Huai-Chin Chiang, Haihui Pan, Xiaowen Zhang, Alexandra Greenbaum, Elizabeth Stark, Li-Ju Wang, Yidong Chen, Bassem R. Haddad, Dionyssia Clagett, Claudine Isaacs, Richard Elledge, Anelia Horvath, Yanfen Hu, Rong Li
J Immunother Cancer. 2023; 11(2): e005852. Published online 2023 Feb 2. doi: 10.1136/jitc-2022-005852
PMCID:
PMC9896206
AbstractArticlePDF–1.9M

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