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Select item 115339851.

CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer

Xueying Yuan, Xiaoxin Hao, Hilda L. Chan, Na Zhao, Diego A. Pedroza, Fengshuo Liu, Kang Le, Alex J. Smith, Sebastian J. Calderon, Nadia Lieu, Michael J. Soth, Philip Jones, Xiang H.F. Zhang, Jeffrey M. Rosen

JCI Insight. 2024 Oct 22; 9(20): e182621. Published online 2024 Sep 17. doi: 10.1172/jci.insight.182621

PMCID:: PMC11533985

Abstract Article PDF–3.3M

Select item 114936792.

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer

Sumaira Sardar, Christopher M. McNair, Lakshmi Ravindranath, Saswati N. Chand, Wei Yuan, Denisa Bogdan, Jon Welti, Adam Sharp, Natalie K. Ryan, Liam A. Knudsen, Matthew J. Schiewer, Elise G. DeArment, Thomas Janas, Xiaofeng A. Su, Lisa M. Butler, Johann S. de Bono, Kris Frese, Nigel Brooks, Neil Pegg, Karen E. Knudsen, Ayesha A. Shafi

Oncogene. 2024; 43(43): 3197–3213. Published online 2024 Sep 13. doi: 10.1038/s41388-024-03148-4

PMCID:: PMC11493679

Abstract Article PDF–8.7M

Select item 114885813.

KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300

Wendan Yu, Shilong Han, Sheng Hu, Liyuan Ru, Chunyu Hua, Guoqing Xue, Guohui Zhang, Kuan Lv, Hanxiao Ge, Meiyi Wang, Lina Zheng, Jie Zhou, Shuai Hou, Yun Teng, Wuguo Deng, Wei Guo

Int J Biol Sci. 2024; 20(13): 5127–5144. Published online 2024 Sep 23. doi: 10.7150/ijbs.98668

PMCID:: PMC11488581

Abstract Article PDF–13M

Select item 111389054.

Role of Akt/protein kinase B in the activity of transcriptional coactivator p300

J. Chen, S. S. Halappanavar, J. R. St-Germain, B. K. Tsang, Q. Li

Cell Mol Life Sci. 2004 Jun; 61(13): 1675–1683. doi: 10.1007/s00018-004-4103-9

PMCID:: PMC11138905

Abstract Article PDF–406K

Select item 111052055.

CREBBP and p300 lysine acetyl transferases in the DNA damage response

Ilaria Dutto, Claudia Scalera, Ennio Prosperi

Cell Mol Life Sci. 2018 Apr; 75(8): 1325–1338. Published online 2017 Nov 23. doi: 10.1007/s00018-017-2717-4

PMCID:: PMC11105205

Abstract Article PDF–1015K

Select item 109861386.

EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia

Zhijie Hou, Yifei Ren, Xuehong Zhang, Dan Huang, Fanzhi Yan, Wentao Sun, Wenjuan Zhang, Qingqing Zhang, Xihui Fu, Zhenghui Lang, Chenyang Chu, Boyang Zou, Beibei Gao, Bilian Jin, Zhijie Kang, Quentin Liu, Jinsong Yan

Cell Commun Signal. 2024; 22: 211. Published online 2024 Apr 2. doi: 10.1186/s12964-024-01596-9

PMCID:: PMC10986138

Abstract Article PDF–14M

Select item 109332677.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 108698008.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett

Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4

PMCID:: PMC10869800

Abstract Article PDF–9.3M

Select item 108160639.

Acetyltransferase P300 Regulates Glucose Metabolic Reprogramming through Catalyzing Succinylation in Lung Cancer

Qingzhi Ma, Qingmei Zeng, Kun Wang, Meirui Qian, Jingzhuo Li, Hao Wang, Huijie Zhang, Jianli Jiang, Zhinan Chen, Wan Huang

Int J Mol Sci. 2024 Jan; 25(2): 1057. Published online 2024 Jan 15. doi: 10.3390/ijms25021057

PMCID:: PMC10816063

Abstract Article PDF–9.3M

Select item 1068698310.

HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis

Michael F. Emmons, Richard L. Bennett, Alberto Riva, Kanchan Gupta, Larissa Anastasio Da Costa Carvalho, Chao Zhang, Robert Macaulay, Daphne Dupéré-Richér, Bin Fang, Edward Seto, John M. Koomen, Jiannong Li, Y. Ann Chen, Peter A. Forsyth, Jonathan D. Licht, Keiran S. M. Smalley

Nat Commun. 2023; 14: 7759. Published online 2023 Nov 29. doi: 10.1038/s41467-023-43519-1

PMCID:: PMC10686983

Abstract Article PDF–4.2M

Select item 1056587611.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1056487412.

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels

Monika Krošel, Marcel Gabathuler, Larissa Moser, Malgorzata Maciukiewicz, Thomas Züllig, Tanja Seifritz, Matija Tomšič, Oliver Distler, Caroline Ospelt, Kerstin Klein

Sci Rep. 2023; 13: 17112. Published online 2023 Oct 10. doi: 10.1038/s41598-023-44412-z

PMCID:: PMC10564874

Abstract Article PDF–2.4M

Select item 1056379813.

Inhibition of p300 increases cytotoxicity of cisplatin in pancreatic cancer cells

Taylor Bugbee, Mary Gathoni, Carlie Payne, Morgan Blubaugh, Kaydn Matlock, Taylor Wixson, Andrea Lu, Steven Stancic, Peter A. Chung, Rachel Palinski, Nicholas Wallace

Gene. Author manuscript; available in PMC 2024 Dec 20.

Published in final edited form as: Gene. 2023 Dec 20; 888: 147762. Published online 2023 Sep 2. doi: 10.1016/j.gene.2023.147762

PMCID:: PMC10563798

Abstract Article PDF–1.2M

Select item 1055813314.

Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway

Jin Wu, Yingying Han, Hao Xu, Hongyang Sun, Rui Wang, Haigang Ren, Guanghui Wang

Sci Adv. 2023 Oct 6; 9(40): eadi8343. Published online 2023 Oct 6. doi: 10.1126/sciadv.adi8343

PMCID:: PMC10558133

Abstract Article PDF–2.7M

Select item 1049608115.

Novel heterozygous variants in the EP300 gene cause Rubinstein–Taybi syndrome 2: Reports from two Chinese children

Caiqi Du, Zhuoguang Li, Biao Zou, Xuesong Li, Fan Chen, Yan Liang, Xiaoping Luo, Sainan Shu

Mol Genet Genomic Med. 2023 Sep; 11(9): e2192. Published online 2023 May 10. doi: 10.1002/mgg3.2192

PMCID:: PMC10496081

Abstract Article PDF–952K

Select item 1049539616.

EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer

Yuan Wang, Yang Liu, Cong Wang, Rui Kang, Daolin Tang, Jiao Liu

Sci Rep. 2023; 13: 15004. Published online 2023 Sep 11. doi: 10.1038/s41598-023-42136-8

PMCID:: PMC10495396

Abstract Article PDF–1.7M

Select item 1047507517.

TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition

Longxia Xu, Hongwen Xuan, Wei He, Liang Zhang, Mengying Huang, Kuai Li, Hong Wen, Han Xu, Xiaobing Shi

Nat Commun. 2023; 14: 5362. Published online 2023 Sep 2. doi: 10.1038/s41467-023-41245-2

PMCID:: PMC10475075

Abstract Article PDF–2.7M

Select item 1047429218.

The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis

Soo Yeon Lee, Soo-Yeon Park, Seung-Hyun Lee, Hyunsik Kim, Jae-Hwan Kwon, Jung-Yoon Yoo, Kyunggon Kim, Moo Suk Park, Chun Geun Lee, Jack A. Elias, Myung Hyun Sohn, Hyo Sup Shim, Ho-Geun Yoon

Exp Mol Med. 2023 Aug; 55(8): 1795–1805. Published online 2023 Aug 1. doi: 10.1038/s12276-023-01066-1

PMCID:: PMC10474292

Abstract Article PDF–3.4M

Select item 1046073219.

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4

Wenhu Chen, Liqiang Hu, Xuemei Lu, Xiaofei Wang, Changan Zhao, Chen Guo, Xiaoyan Li, Yuqin Ding, Hongguang Zhao, Dongdong Tong, Lifang Wang, Chen Huang

Breast Cancer Res Treat. 2023; 201(3): 353–366. Published online 2023 Jul 11. doi: 10.1007/s10549-023-07028-5

PMCID:: PMC10460732

Abstract Article PDF–5.6M

Select item 1041864720.

EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs

Karla Rubio, Alejandro Molina-Herrera, Andrea Pérez-González, Hury Viridiana Hernández-Galdámez, Carolina Piña-Vázquez, Tania Araujo-Ramos, Indrabahadur Singh

Int J Mol Sci. 2023 Aug; 24(15): 12302. Published online 2023 Aug 1. doi: 10.3390/ijms241512302