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Select item 102595141.

Dysfunction of programmed embryo senescence is linked to genetic developmental defects

Cristina de Lope, Rebeca García-Lucena, Marta Magariños, Yolanda León, Nuria Casa-Rodríguez, Nuria Contreras, Carmen Escudero-Iriarte, Isabel Varela-Nieto, Pascal Maire, Ignacio Palmero

Development. 2023 May 1; 150(9): dev200903. Published online 2023 May 3. doi: 10.1242/dev.200903

PMCID:: PMC10259514

Abstract Article

Select item 98887252.

Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent

Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer

PLoS Genet. 2023 Jan; 19(1): e1010595. Published online 2023 Jan 19. doi: 10.1371/journal.pgen.1010595

PMCID:: PMC9888725

Abstract Article PDF–6.9M

Select item 92489763.

Realization of the T-lineage program involves GATA-3 induction of Bcl11b and repression of Cdkn2b expression

Patrycja K. Thompson, Edward L.Y. Chen, Renée F. de Pooter, Catherine Frelin, Walter K. Vogel, Christina R. Lee, Thomas Venables, Divya K. Shah, Norman N. Iscove, Mark Leid, Michele K. Anderson, Juan Carlos Zúñiga-Pflücker

J Immunol. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: J Immunol. 2022 Jul 1; 209(1): 77–92. Published online 2022 Jun 15. doi: 10.4049/jimmunol.2100366

PMCID:: PMC9248976

Abstract Article PDF–2.2M

Select item 85641174.

Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons

Remi Akagawa, Yo-ichi Nabeshima, Takeshi Kawauchi

Front Cell Dev Biol. 2021; 9: 753175. Published online 2021 Oct 20. doi: 10.3389/fcell.2021.753175

PMCID:: PMC8564117

Abstract Article PDF–2.2M

Select item 80417715.

The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling

Nanchao Hong, Erge Zhang, Huilin Xie, Lihui Jin, Qi Zhang, Yanan Lu, Alex F. Chen, Yongguo Yu, Bin Zhou, Sun Chen, Yu Yu, Kun Sun

Cell Death Dis. 2021 Apr; 12(4): 393. Published online 2021 Apr 12. doi: 10.1038/s41419-021-03658-z

PMCID:: PMC8041771

Abstract Article PDF–7.2M

Select item 80242816.

Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis

Yong Xia, Yan Liu, Chao Yang, Diane M. Simeone, Tung-Tien Sun, David J. DeGraff, Moon-shong Tang, Yingkai Zhang, Xue-Ru Wu

Nat Commun. 2021; 12: 2047. Published online 2021 Apr 6. doi: 10.1038/s41467-021-22327-5

PMCID:: PMC8024281

Abstract Article PDF–4.7M

Select item 79711327.

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

Jitendra Badhai, Gaurav Kumar Pandey, Ji-Ying Song, Oscar Krijgsman, Rajith Bhaskaran, Gayathri Chandrasekaran, Min-chul Kwon, Lorenzo Bombardelli, Kim Monkhorst, Cristoforo Grasso, John Zevenhoven, Jan van der Vliet, Miranda Cozijnsen, Paul Krimpenfort, Daniel Peeper, Maarten van Lohuizen, Anton Berns

J Exp Med. 2020 Jun 1; 217(6): e20191257. Published online 2020 Apr 9. doi: 10.1084/jem.20191257

PMCID:: PMC7971132

Abstract Article PDF–3.7M

Select item 76403738.

Brief Report: Loss of p15Ink4b Accelerates Development of Myeloid Neoplasms in Nup98-HoxD13 Transgenic Mice

Rita Humeniuk, Richard Koller, Juraj Bies, Peter Aplan, Linda Wolff

Stem Cells. Author manuscript; available in PMC 2020 Nov 4.

Published in final edited form as: Stem Cells. 2014 May; 32(5): 1361–1366. doi: 10.1002/stem.1635

PMCID:: PMC7640373

Abstract Article PDF–1.0M

Select item 68681349.

Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras^G12D

Jianguo Huang, Mark Chen, Eric S. Xu, Lixia Luo, Yan Ma, Wesley Huang, Warren Floyd, Tyler S. Klann, So Young Kim, Charles A. Gersbach, Diana M. Cardona, David G. Kirsch

Sci Rep. 2019; 9: 17220. Published online 2019 Nov 20. doi: 10.1038/s41598-019-53572-w

PMCID:: PMC6868134

Abstract Article PDF–2.9M

Select item 644105510.

A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

Paul Krimpenfort, Margriet Snoek, Jan-Paul Lambooij, Ji-Ying Song, Robin van der Weide, Rajith Bhaskaran, Hans Teunissen, David J. Adams, Elzo de Wit, Anton Berns

Nat Commun. 2019; 10: 1425. Published online 2019 Mar 29. doi: 10.1038/s41467-019-09321-8

PMCID:: PMC6441055

Abstract Article PDF–6.6M

Select item 609633911.

Loss of CDKN2B Promotes Fibrosis via Increased Fibroblast Differentiation Rather Than Proliferation

Anne M. Scruggs, Hailey B. Koh, Priya Tripathi, Nicholas J. Leeper, Eric S. White, Steven K. Huang

Am J Respir Cell Mol Biol. 2018 Aug; 59(2): 200–214. doi: 10.1165/rcmb.2017-0298OC

PMCID:: PMC6096339

Abstract Article PDF–3.1M

Select item 592490512.

Neddylation mediates ventricular chamber maturation through repression of Hippo signaling

Jianqiu Zou, Wenxia Ma, Jie Li, Rodney Littlejohn, Hongyi Zhou, Il-man Kim, David J. R. Fulton, Weiqin Chen, Neal L. Weintraub, Jiliang Zhou, Huabo Su

Proc Natl Acad Sci U S A. 2018 Apr 24; 115(17): E4101–E4110. Published online 2018 Apr 9. doi: 10.1073/pnas.1719309115

PMCID:: PMC5924905

Abstract Article PDF–2.3M

Select item 575902813.

CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A

Q Tu, J Hao, X Zhou, L Yan, H Dai, B Sun, D Yang, S An, L Lv, B Jiao, C Chen, R Lai, P Shi, X Zhao

Oncogene. 2018 Jan 4; 37(1): 128–138. Published online 2017 Sep 11. doi: 10.1038/onc.2017.316

PMCID:: PMC5759028

Abstract Article PDF–4.6M

Select item 569081614.

Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development and craniofacial morphogenesis

Zachary J. Milstone, Grace Lawson, Chinmay M. Trivedi

Dev Dyn. Author manuscript; available in PMC 2018 Dec 1.

Published in final edited form as: Dev Dyn. 2017 Dec; 246(12): 1015–1026. Published online 2017 Sep 5. doi: 10.1002/dvdy.24563

PMCID:: PMC5690816

Abstract Article PDF–2.4M

Select item 552774515.

Divergent Requirements for EZH1 in Heart Development Versus Regeneration

Shanshan Ai, Xianhong Yu, Yumei Li, Yong Peng, Chen Li, Yanzhu Yue, Ge Tao, Chuanyun Li, William T. Pu, Aibin He

Circ Res. Author manuscript; available in PMC 2018 Jul 7.

Published in final edited form as: Circ Res. 2017 Jul 7; 121(2): 106–112. Published online 2017 May 16. doi: 10.1161/CIRCRESAHA.117.311212

PMCID:: PMC5527745

Abstract Article PDF–1.6M

Select item 546774616.

Insensitivity of Astrocytes to Interleukin-10 Signaling following Peripheral Immune Challenge Results in Prolonged Microglial Activation in the Aged Brain

Diana M. Norden, Paige J. Trojanowski, Frederick R. Walker, Jonathan P. Godbout

Neurobiol Aging. Author manuscript; available in PMC 2017 Aug 1.

Published in final edited form as: Neurobiol Aging. 2016 Aug; 44: 22–41. Published online 2016 Apr 27. doi: 10.1016/j.neurobiolaging.2016.04.014

PMCID:: PMC5467746

Abstract Article PDF–2.0M

Select item 538630517.

Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus

Anchel De Jaime-Soguero, Francesco Aulicino, Gokhan Ertaylan, Anna Griego, Aniello Cerrato, Aravind Tallam, Antonio del Sol, Maria Pia Cosma, Frederic Lluis

PLoS Genet. 2017 Mar; 13(3): e1006682. Published online 2017 Mar 27. doi: 10.1371/journal.pgen.1006682