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Select item 115435401.

Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity

Karina Orlowska, Rance Nault, Jesmin Ara, John J. LaPres, Jack Harkema, Elena Y. Demireva, Huirong Xie, Rachel H. Wilson, Christopher A. Bradfield, Dianne Yap, Aditya Joshi, Cornelis J. Elferink, Tim Zacharewski

Redox Biol. 2024 Nov; 77: 103405. Published online 2024 Oct 22. doi: 10.1016/j.redox.2024.103405

PMCID:: PMC11543540

Abstract Article PDF–5.9M

Select item 115161112.

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation

Shigetoshi Yokoyama, Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain A. Murray, Stephanie L. Collins, Denise M. Coslo, Mari Kono, Jeffrey M. Peters, Richard L. Proia, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson

Adv Sci (Weinh) 2024 Oct; 11(40): 2400794. Published online 2024 Aug 29. doi: 10.1002/advs.202400794

PMCID:: PMC11516111

Abstract Article PDF–11M

Select item 114515523.

MerTK⁺ macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation

Naming Wu, Jun Li, Lu Li, Liu Yang, Liyun Dong, Chen Shen, Shanshan Sha, Yangxue Fu, Enzhu Dong, Fang Zheng, Zheng Tan, Juan Tao

Sci Adv. 2024 Oct 4; 10(40): eado8366. Published online 2024 Oct 4. doi: 10.1126/sciadv.ado8366

PMCID:: PMC11451552

Abstract Article PDF–16M

Select item 114325714.

Involvement of Aryl Hydrocarbon Receptor in Longevity and Healthspan: Insights from Humans, Mice, and C. elegans

Eva Serna, David Verdú, Alicia Valls, Ángel Belenguer-Varea, Francisco José Tarazona-Santabalbina, Consuelo Borrás, José Viña

Int J Mol Sci. 2024 Sep; 25(18): 9943. Published online 2024 Sep 14. doi: 10.3390/ijms25189943

PMCID:: PMC11432571

Abstract Article PDF–4.0M

Select item 114324805.

Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3′-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation

Erika L. Garcia-Villatoro, Zachary S. Bomstein, Kimberly F. Allred, Evelyn S. Callaway, Stephen Safe, Robert S. Chapkin, Arul Jayaraman, Clinton D. Allred

Int J Mol Sci. 2024 Sep; 25(18): 10153. Published online 2024 Sep 21. doi: 10.3390/ijms251810153

PMCID:: PMC11432480

Abstract Article PDF–2.9M

Select item 114077936.

Joshua W. Callahan, Juan Carlos Morales, Jeremy F. Atherton, Dorothy Wang, Selena Kostic, Mark D. Bevan

Cell Rep. Author manuscript; available in PMC 2024 Sep 17.

Published in final edited form as: Cell Rep. 2024 Aug 27; 43(8): 114495. Published online 2024 Jul 26. doi: 10.1016/j.celrep.2024.114495

PMCID:: PMC11407793

Abstract Article PDF–3.4M

Select item 113353257.

Aryl Hydrocarbon Receptor Activation in Pulmonary Alveolar Epithelial Cells Limits Inflammation and Preserves Lung Epithelial Cell Integrity

Elizabeth Zimmerman, Anne Sturrock, Christopher A. Reilly, Katherine L. Burrell-Gerbers, Kristi Warren, Mustafa Mir-Kasimov, Mingyang A. Zhang, Megan S. Pierce, My N. Helms, Robert Paine, III

J Immunol. 2024 Sep 1; 213(5): 600–611. Published online 2024 Jul 19. doi: 10.4049/jimmunol.2300325

PMCID:: PMC11335325

Abstract Article PDF–1.9M

Select item 112719778.

The AHR repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils

Heike Weighardt, Michael Shapiro, Michelle Mayer, Irmgard Förster, Brigitta Stockinger, Nicola Laura Diny

J Leukoc Biol. 2024 Aug; 116(2): 369–378. Published online 2024 May 3. doi: 10.1093/jleuko/qiae105

PMCID:: PMC11271977

Abstract Article PDF–1.1M

Select item 112684109.

Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity

Cathy Yea Won Sung, Naoki Hayase, Peter S. T. Yuen, John Lee, Katharine Fernandez, Xuzhen Hu, Hui Cheng, Robert A. Star, Mark E. Warchol, Lisa L. Cunningham

Sci Adv. 2024 Jul 26; 10(30): eadk9878. Published online 2024 Jul 24. doi: 10.1126/sciadv.adk9878

PMCID:: PMC11268410

Abstract Article PDF–4.4M

Select item 1121348410.

Deletion of the aryl hydrocarbon receptor in endothelial cells improves ischemic angiogenesis in chronic kidney disease

Victoria R. Palzkill, Jianna Tan, Qingping Yang, Juliana Morcos, Orlando Laitano, Terence E. Ryan

Am J Physiol Heart Circ Physiol. 2024 Jan 1; 326(1): H44–H60. Published online 2023 Nov 3. doi: 10.1152/ajpheart.00530.2023

PMCID:: PMC11213484

Abstract Article

Select item 1113491311.

Behavioral and cortical arousal from sleep, muscimol-induced coma, and anesthesia by direct optogenetic stimulation of cortical neurons

Rong Mao, Matias Lorenzo Cavelli, Graham Findlay, Kort Driessen, Michael J. Peterson, William Marshall, Giulio Tononi, Chiara Cirelli

iScience. 2024 Jun 21; 27(6): 109919. Published online 2024 May 7. doi: 10.1016/j.isci.2024.109919

PMCID:: PMC11134913

Abstract Article PDF–9.5M

Select item 1101465712.

A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis

Jingwen Yang, Lingxin Zhu, Haichun Pan, Hiroki Ueharu, Masako Toda, Qian Yang, Shawn A. Hallett, Lorin E. Olson, Yuji Mishina

J Clin Invest. 2024 Apr 15; 134(8): e165787. Published online 2024 Mar 11. doi: 10.1172/JCI165787

PMCID:: PMC11014657

Abstract Article PDF–16M

Select item 1095187613.

Indoxyl sulphate‐initiated activation of cardiac fibroblasts is modulated by aryl hydrocarbon receptor and nuclear factor‐erythroid‐2‐related factor 2

Chiara Barisione, Daniela Verzola, Silvano Garibaldi, Paola Altieri, Anna Lisa Furfaro, Mariapaola Nitti, Giovanni Pratesi, Domenico Palombo, Pietro Ameri

J Cell Mol Med. 2024 Apr; 28(7): e18192. Published online 2024 Mar 20. doi: 10.1111/jcmm.18192

PMCID:: PMC10951876

Abstract Article PDF–1.5M

Select item 1094343114.

Adaptation of sequential action benefits from timing variability related to lateral basal ganglia circuitry

Lachlan A. Ferguson, Miriam Matamales, Christopher Nolan, Bernard W. Balleine, Jesus Bertran-Gonzalez

iScience. 2024 Mar 15; 27(3): 109274. Published online 2024 Feb 20. doi: 10.1016/j.isci.2024.109274

PMCID:: PMC10943431

Abstract Article PDF–28M

Select item 1086757315.

The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice

Myriam P. Hoyeck, Ma. Enrica Angela Ching, Lahari Basu, Kyle van Allen, Jana Palaniyandi, Ineli Perera, Emilia Poleo-Giordani, Antonio A. Hanson, Peyman Ghorbani, Morgan D. Fullerton, Jennifer E. Bruin

Mol Metab. 2024 Mar; 81: 101893. Published online 2024 Feb 2. doi: 10.1016/j.molmet.2024.101893

PMCID:: PMC10867573

Abstract Article PDF–4.2M

Select item 1084278216.

Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis

Ruoxi Zhang, Chunhua Yu, Herbert J Zeh, Haichao Wang, Guido Kroemer, Daniel J. Klionsky, Timothy R Billiar, Rui Kang, Daolin Tang

Immunity. Author manuscript; available in PMC 2024 Dec 12.

Published in final edited form as: Immunity. 2023 Dec 12; 56(12): 2736–2754.e8. Published online 2023 Nov 27. doi: 10.1016/j.immuni.2023.11.001

PMCID:: PMC10842782

Abstract Article PDF–3.6M

Select item 1079583117.

Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival

Charles H. Danan, Kaitlyn E. Naughton, Katharina E. Hayer, Sangeevan Vellappan, Emily A. McMillan, Yusen Zhou, Rina Matsuda, Shaneice K. Nettleford, Kay Katada, Louis R. Parham, Xianghui Ma, Afrah Chowdhury, Benjamin J. Wilkins, Premal Shah, Matthew D. Weitzman, Kathryn E. Hamilton

JCI Insight. 2023 Dec 8; 8(23): e171657. Published online 2023 Dec 8. doi: 10.1172/jci.insight.171657

PMCID:: PMC10795831

Abstract Article PDF–5.8M

Select item 1079224518.

Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response

Sarah A. Kazzaz, Kashif A. Shaikh, Jesse White, Qinjie Zhou, Wade H. Powell, Edward W. Harhaj

J Biol Chem. 2024 Jan; 300(1): 105525. Published online 2023 Dec 1. doi: 10.1016/j.jbc.2023.105525

PMCID:: PMC10792245

Abstract Article PDF–2.8M

Select item 1071049319.

The aryl hydrocarbon receptor controls mesenchymal stromal cell-mediated immunomodulation via ubiquitination of eukaryotic elongation factor-2 kinase

Enkhmaa Lkhagva-Yondon, Myeong Seong Seo, Yena Oh, Jonghun Jung, Eunhae Jeon, Kwangmin Na, Hyun Seung Yoo, Woo Chul Kim, Charlotte Esser, Sun U. Song, Myung-Shin Jeon

Cell Death Dis. 2023 Dec; 14(12): 812. Published online 2023 Dec 9. doi: 10.1038/s41419-023-06341-7

PMCID:: PMC10710493

Abstract Article PDF–2.6M

Select item 1070661520.

AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors

Michele C. Larsen, Catherine M. Rondelli, Ahmed Almeldin, Yong-Seok Song, Alhaji N’Jai, David L. Alexander, E. Camilla Forsberg, Nader Sheibani, Colin R. Jefcoate

Int J Mol Sci. 2023 Dec; 24(23): 16884. Published online 2023 Nov 28. doi: 10.3390/ijms242316884