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Select item 106562261.

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder

Ami Oguro, Taichi Fujiyama, Yasuhiro Ishihara, Chisato Kataoka, Megumi Yamamoto, Komyo Eto, Yoshihiro Komohara, Susumu Imaoka, Toshihide Sakuragi, Mayumi Tsuji, Eiji Shibata, Yaichiro Kotake, Takeshi Yamazaki

J Lipid Res. 2023 Nov; 64(11): 100458. Published online 2023 Oct 12. doi: 10.1016/j.jlr.2023.100458

PMCID:: PMC10656226

Abstract Article PDF–2.6M

Select item 80873452.

High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis

Xue Chen, George K. Acquaah-Mensah, Krista L. Denning, Jonathan M. Peterson, Kesheng Wang, James Denvir, Feng Hong, Arthur I. Cederbaum, Yongke Lu

Am J Physiol Gastrointest Liver Physiol. 2020 Nov 1; 319(5): G626–G635. Published online 2020 Sep 2. doi: 10.1152/ajpgi.00213.2020

PMCID:: PMC8087345

Abstract Article

Select item 77222323.

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs

Alexandra N. Nail, Brett T. Spear, Martha L. Peterson

Gene. Author manuscript; available in PMC 2022 Jan 30.

Published in final edited form as: Gene. 2021 Jan 30; 767: 145162. Published online 2020 Sep 25. doi: 10.1016/j.gene.2020.145162

PMCID:: PMC7722232

Abstract Article PDF–1.7M

Select item 64335184.

Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine-and cotinine-enhanced alcoholic fatty liver in mice

Xue Chen, Kesheng Wang, Arthur I. Cederbaum, Yongke Lu

Biochem Biophys Res Commun. Author manuscript; available in PMC 2020 Apr 23.

Published in final edited form as: Biochem Biophys Res Commun. 2019 Apr 23; 512(1): 119–124. Published online 2019 Mar 12. doi: 10.1016/j.bbrc.2019.03.021

PMCID:: PMC6433518

Abstract Article PDF–2.0M

Select item 61773195.

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5

Xue Chen, Emmanuel Owoseni, Julia salamat, Arthur I. Cederbaum, Yongke Lu

Arch Biochem Biophys. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Arch Biochem Biophys. 2018 Nov 1; 657: 65–73. Published online 2018 Sep 15. doi: 10.1016/j.abb.2018.09.012

PMCID:: PMC6177319

Abstract Article PDF–819K

Select item 55183176.

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver

Kate Townsend Creasy, Jieyun Jiang, Hui Ren, Martha L. Peterson, Brett T. Spear

Gene Expr. 2016; 17(1): 7–17. Published online 2016 May 17. doi: 10.3727/105221616X691712

PMCID:: PMC5518317

Abstract Article PDF–8.5M

Select item 53537977.

Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver

Katia S. Poça, Thiago E. M. Parente, Lucas F. Chagas, Bruna S. Leal, Hellen S. Leal, Francisco J. R. Paumgartten, Ana C. A. X. De-Oliveira

BMC Res Notes. 2017; 10: 125. Published online 2017 Mar 15. doi: 10.1186/s13104-017-2435-x

PMCID:: PMC5353797

Abstract Article PDF–1.4M

Select item 53199058.

Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: the role of the PPARα-FGF21 axis

Xue Chen, Stephen C. Ward, Arthur I. Cederbaum, Huabao Xiong, Yongke Lu

Toxicology. Author manuscript; available in PMC 2018 Mar 15.

Published in final edited form as: Toxicology. 2017 Mar 15; 379: 12–21. Published online 2017 Jan 25. doi: 10.1016/j.tox.2017.01.016

PMCID:: PMC5319905

Abstract Article PDF–1.0M

Select item 51302699.

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

Kazuhiro Kanemoto, Katsuhiro Fukuta, Noriyasu Kawai, Keiichi Tozawa, Masako Ochiai, Koji Okamoto, Sumiko Ohnami, Hiromi Sakamoto, Teruhiko Yoshida, Yae Kanai, Masaru Katoh, Takahiro Yasui, Kenjiro Kohri, Tadao Kakizoe, Hitoshi Nakagama

PLoS One. 2016; 11(11): e0167374. Published online 2016 Nov 30. doi: 10.1371/journal.pone.0167374

PMCID:: PMC5130269

Abstract Article PDF–3.7M

Select item 499020610.

Resveratrol improves health and survival of mice on a high-calorie diet

Joseph A. Baur, Kevin J. Pearson, Nathan L. Price, Hamish A. Jamieson, Carles Lerin, Avash Kalra, Vinayakumar V. Prabhu, Joanne S. Allard, Guillermo Lopez-Lluch, Kaitlyn Lewis, Paul J. Pistell, Suresh Poosala, Kevin G. Becker, Olivier Boss, Dana Gwinn, Mingyi Wang, Sharan Ramaswamy, Kenneth W. Fishbein, Richard G. Spencer, Edward G. Lakatta, David Le Couteur, Reuben J. Shaw, Placido Navas, Pere Puigserver, Donald K. Ingram, Rafael de Cabo, David A. Sinclair

Nature. Author manuscript; available in PMC 2016 Aug 18.

Published in final edited form as: Nature. 2006 Nov 16; 444(7117): 337–342. Published online 2006 Nov 1. doi: 10.1038/nature05354

PMCID:: PMC4990206

Abstract Article PDF–598K

Select item 470355911.

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference

Feng Hong, Chuanping Si, Pengfei Gao, Arthur I. Cederbaum, Huabao Xiong, Yongke Lu

Naunyn Schmiedebergs Arch Pharmacol. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Naunyn Schmiedebergs Arch Pharmacol. 2016 Jan; 389(1): 33–43. Published online 2015 Sep 12. doi: 10.1007/s00210-015-1172-8

PMCID:: PMC4703559

Abstract Article PDF–3.6M

Select item 444274012.

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice

Feng Hong, Xiyu Liu, Stephen Ward, Huabao Xiong, Arthur I. Cederbaum, Yongke Lu

Dig Liver Dis. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Dig Liver Dis. 2015 Jun; 47(6): 470–477. Published online 2015 Mar 6. doi: 10.1016/j.dld.2015.02.012

PMCID:: PMC4442740

Abstract Article PDF–2.8M

Select item 431197713.

Modulation of Cytochrome P450 2A5 Activity by Lipopolysaccharide: Low-Dose Effects and Non-Monotonic Dose-Response Relationship

Ana C. A. X. De-Oliveira, Kátia S. Poça, Paulo R. R. Totino, Francisco J. R. Paumgartten

PLoS One. 2015; 10(1): e0117842. Published online 2015 Jan 30. doi: 10.1371/journal.pone.0117842

PMCID:: PMC4311977

Abstract Article PDF–761K

Select item 411526614.

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

Joanne Walsh, Rosalind E. Jenkins, Michael Wong, Adedamola Olayanju, Helen Powell, Ian Copple, Paul M. O’Neill, Christopher E.P. Goldring, Neil R. Kitteringham, B. Kevin Park

J Proteomics. 2014 Aug 28; 108(100): 171–187. doi: 10.1016/j.jprot.2014.05.007

PMCID:: PMC4115266

Abstract Article PDF–859K

Select item 390982515.

Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5

Takashi Ashino, Haruyo Ohkubo-Morita, Masayuki Yamamoto, Takemi Yoshida, Satoshi Numazawa

Redox Biol. 2014; 2: 284–288. Published online 2014 Jan 10. doi: 10.1016/j.redox.2013.12.025

PMCID:: PMC3909825

Abstract Article PDF–359K

Select item 387679116.

Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene

Jinping Hu, Li Sheng, Lei Li, Xin Zhou, Fang Xie, Jaime D’Agostino, Yan Li, Xinxin Ding

Drug Metab Dispos. 2014 Jan; 42(1): 23–27. Published online 2014 Jan. doi: 10.1124/dmd.113.054429

PMCID:: PMC3876791

Abstract Article PDF–985K

Select item 387193517.

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model

Vandana Megaraj, Xin Zhou, Fang Xie, Zhihua Liu, Weizhu Yang, Xinxin Ding

Carcinogenesis. 2014 Jan; 35(1): 131–137. Published online 2013 Aug 28. doi: 10.1093/carcin/bgt269

PMCID:: PMC3871935

Abstract Article PDF–759K

Select item 383630818.

Impact of Nicotine Metabolism on Nicotine’s Pharmacological Effects and Behavioral Responses: Insights from a Cyp2a(4/5)bgs-Null Mouse

Lei Li, Kunzhi Jia, Xin Zhou, Sarah E. McCallum, Lindsay B. Hough, Xinxin Ding

J Pharmacol Exp Ther. 2013 Dec; 347(3): 746–754. Published online 2013 Dec. doi: 10.1124/jpet.113.208256

PMCID:: PMC3836308

Abstract Article PDF–915K

Select item 381495719.

Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation

Yizhe Cui, Qiuju Wang, Xiaochong Li, Xiuying Zhang

Redox Biol. 2013; 1(1): 433–440. Published online 2013 Aug 24. doi: 10.1016/j.redox.2013.08.003

PMCID:: PMC3814957

Abstract Article PDF–1.2M

Select item 357241020.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

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