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Select item 111268161.

Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes

Shuaishuai Zhu, Emmanuelle Waeckel-Énée, Masaya Oshima, Anna Moser, Marie-Andrée Bessard, Abdelaziz Gdoura, Kevin Roger, Nina Mode, Joanna Lipecka, Ayse Yilmaz, Barbara Bertocci, Julien Diana, Benjamin Saintpierre, Ida Chiara Guerrera, Raphael Scharfmann, Stefania Francesconi, François-Xavier Mauvais, Peter van Endert

iScience. 2024 Jun 21; 27(6): 109929. Published online 2024 May 7. doi: 10.1016/j.isci.2024.109929

PMCID:: PMC11126816

Abstract Article PDF–4.6M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105660213.

Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging

Miriam Corraliza-Gomez, Teresa Bermejo, Jingtao Lilue, Noelia Rodriguez-Iglesias, Jorge Valero, Irene Cozar-Castellano, Eduardo Arranz, Diego Sanchez, Maria Dolores Ganfornina

J Neuroinflammation. 2023; 20: 233. Published online 2023 Oct 11. doi: 10.1186/s12974-023-02914-7

PMCID:: PMC10566021

Abstract Article PDF–7.2M

Select item 92831404.

Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation

Beatriz Merino, Elena Casanueva-Álvarez, Iván Quesada, Carlos M. González-Casimiro, Cristina M. Fernández-Díaz, Tamara Postigo-Casado, Malcolm A. Leissring, Klaus H. Kaestner, Germán Perdomo, Irene Cózar-Castellano

Diabetologia. 2022; 65(8): 1375–1389. Published online 2022 Jun 2. doi: 10.1007/s00125-022-05729-y

Correction in:: Diabetologia. 2024; 67(1): 218–219.

PMCID:: PMC9283140

Abstract Article PDF–1.8M

Select item 89580015.

Antibody-Mediated Inhibition of Insulin-Degrading Enzyme Improves Insulin Activity in a Diabetic Mouse Model

Ofir Fursht, Mirit Liran, Yuval Nash, Vijay Krishna Medala, Dor Ini, Tabitha Grace Royal, Guy Goldsmith, Limor Nahary, Itai Benhar, Dan Frenkel

Front Immunol. 2022; 13: 835774. Published online 2022 Mar 8. doi: 10.3389/fimmu.2022.835774

PMCID:: PMC8958001

Abstract Article PDF–2.0M

Select item 87741186.

Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells

Miriam Corraliza-Gómez, Concepción Lillo, Irene Cózar-Castellano, Eduardo Arranz, Diego Sanchez, Maria D. Ganfornina

Cells. 2022 Jan; 11(2): 227. Published online 2022 Jan 11. doi: 10.3390/cells11020227

PMCID:: PMC8774118

Abstract Article PDF–4.1M

Select item 86165987.

Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice

Beatriz Merino, Cristina M. Fernández-Díaz, Cristina Parrado-Fernández, Carlos M. González-Casimiro, Tamara Postigo-Casado, Carmen D. Lobatón, Malcolm A. Leissring, Irene Cózar-Castellano, Germán Perdomo

Metabolism. Author manuscript; available in PMC 2021 Nov 25.

Published in final edited form as: Metabolism. 2020 Dec; 113: 154352. Published online 2020 Sep 9. doi: 10.1016/j.metabol.2020.154352

PMCID:: PMC8616598

Abstract Article PDF–1.7M

Select item 86161628.

Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme

Janine Mett, Anna A. Lauer, Daniel Janitschke, Lea V. Griebsch, Elena L. Theiss, Heike S. Grimm, Hennariikka Koivisto, Heikki Tanila, Tobias Hartmann, Marcus O. W. Grimm

Cells. 2021 Nov; 10(11): 2941. Published online 2021 Oct 29. doi: 10.3390/cells10112941

PMCID:: PMC8616162

Abstract Article PDF–1.1M

Select item 83132399.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 713232710.

Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity

Cristina M. Fernández-Díaz, Beatriz Merino, José F. López-Acosta, Pilar Cidad, Miguel A. de la Fuente, Carmen D. Lobatón, Alfredo Moreno, Malcolm A. Leissring, Germán Perdomo, Irene Cózar-Castellano

Am J Physiol Endocrinol Metab. 2019 Nov 1; 317(5): E805–E819. Published online 2019 Sep 3. doi: 10.1152/ajpendo.00040.2019

PMCID:: PMC7132327

Abstract Article

Select item 673026411.

Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention

Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P. Lim, Surendra S. Ambegaokar, Oliver J. Ubeda, Sally A. Frautschy, Greg M. Cole

J Neurosci. 2004 Dec 8; 24(49): 11120–11126. doi: 10.1523/JNEUROSCI.2860-04.2004

PMCID:: PMC6730264

Abstract Article PDF–294K

Select item 655772712.

Data on metabolic profile of insulin-degrading enzyme knockout mice

Diego O. Borges, Maria João Meneses, Tânia R. Dias, Fátima O. Martins, Pedro F. Oliveira, Marco G. Alves, M. Paula Macedo

Data Brief. 2019 Aug; 25: 104023. Published online 2019 May 24. doi: 10.1016/j.dib.2019.104023

PMCID:: PMC6557727

Abstract Article PDF–400K

Select item 645951013.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 643546814.

Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer’s disease: possible mechanisms of IDE in T2D and AD

Huajie Li, Jian Wu, Linfeng Zhu, Luolin Sha, Song Yang, Jiang Wei, Lei Ji, Xiaochun Tang, Keshi Mao, Liping Cao, Ning Wei, Wei Xie, Zhilong Yang

Biosci Rep. 2018 Feb 28; 38(1): BSR20170862. Prepublished online 2017 Dec 8. Published online 2018 Jan 10. doi: 10.1042/BSR20170862

PMCID:: PMC6435468

Abstract Article PDF–989K

Select item 622422415.

Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.

K.M. Georgas, H.S. Chiu, E. Lesieur, B.A. Rumballe, M.H Little

Dev Dyn. Author manuscript; available in PMC 2018 Nov 8.

Published in final edited form as: Dev Dyn. 2011 Jun; 240(6): 1600–1612. Published online 2011 Apr 12. doi: 10.1002/dvdy.22640

PMCID:: PMC6224224

Abstract Article PDF–947K

Select item 618577216.

Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

Pablo Villa-Pérez, Beatriz Merino, Cristina M. Fernández-Díaz, Pilar Cidad, Carmen D. Lobatón, Alfredo Moreno, Harrison T. Muturi, Hilda E. Ghadieh, Sonia M. Najjar, Malcolm A. Leissring, Irene Cózar-Castellano, Germán Perdomo

Metabolism. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Metabolism. 2018 Nov; 88: 1–11. Published online 2018 Aug 8. doi: 10.1016/j.metabol.2018.08.001

PMCID:: PMC6185772

Abstract Article PDF–3.6M

Select item 566589917.

Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice

Jean Franciesco Vettorazzi, Mirian Ayumi Kurauti, Gabriela Moreira Soares, Patricia Cristine Borck, Sandra Mara Ferreira, Renato Chaves Souto Branco, Luciana de Souza Lima Michelone, Antonio Carlos Boschero, Jose Maria Costa Junior, Everardo Magalhães Carneiro

Sci Rep. 2017; 7: 14876. Published online 2017 Nov 1. doi: 10.1038/s41598-017-13974-0

PMCID:: PMC5665899

Abstract Article PDF–1.9M

Select item 538122618.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 510492019.

Hepatic ZIP14-mediated Zinc Transport Contributes to Endosomal Insulin Receptor Trafficking and Glucose Metabolism

Tolunay Beker Aydemir, Catalina Troche, Min-Hyun Kim, Robert J. Cousins

J Biol Chem. 2016 Nov 11; 291(46): 23939–23951. Published online 2016 Oct 4. doi: 10.1074/jbc.M116.748632

PMCID:: PMC5104920

Abstract Article PDF–2.9M

Select item 500789020.

Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro

Meghan F. Hogan, Daniel T. Meier, Sakeneh Zraika, Andrew T. Templin, Mahnaz Mellati, Rebecca L. Hull, Malcolm A. Leissring, Steven E. Kahn

Endocrinology. 2016 Sep; 157(9): 3462–3468. Published online 2016 Jun 12. doi: 10.1210/en.2016-1410

PMCID:: PMC5007890

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