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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 99906562.

Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma

Alex Frias, Luca Di Leo, Asier Antoranz, Loulieta Nazerai, Marco Carretta, Valérie Bodemeyer, Chiara Pagliuca, Christina Dahl, Giuseppina Claps, Giulio Eugenio Mandelli, Madhavi Dipak Andhari, Maria Pires Pacheco, Thomas Sauter, Caroline Robert, Per Guldberg, Daniel Hargbøl Madsen, Francesco Cecconi, Francesca Maria Bosisio, Daniela De Zio

J Immunother Cancer. 2023; 11(3): e006389. Published online 2023 Mar 3. doi: 10.1136/jitc-2022-006389

PMCID:: PMC9990656

Abstract Article PDF–11M

Select item 99806153.

Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration

Ignacio Ramírez-Pardo, Beatriz Villarejo-Zori, Juan Ignacio Jiménez-Loygorri, Elena Sierra-Filardi, Sandra Alonso-Gil, Guillermo Mariño, Pedro de la Villa, Patrick S Fitze, José Manuel Fuentes, Ramón García-Escudero, Deborah A. Ferrington, Raquel Gomez-Sintes, Patricia Boya

Autophagy. 2023; 19(3): 784–804. Published online 2022 Jul 24. doi: 10.1080/15548627.2022.2103307

PMCID:: PMC9980615

Abstract Article PDF–7.8M

Select item 99415734.

Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism

Annabella Pignataro, Paraskevi Krashia, Margherita De Introna, Annalisa Nobili, Annamaria Sabetta, Francesca Stabile, Livia La Barbera, Sebastian Luca D’Addario, Rossella Ventura, Francesco Cecconi, Marcello D’Amelio, Martine Ammassari-Teule

Transl Psychiatry. 2023; 13: 63. Published online 2023 Feb 20. doi: 10.1038/s41398-023-02357-x

PMCID:: PMC9941573

Abstract Article PDF–3.8M

Select item 94819335.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 94347246.

Ambra1 deficiency impairs mitophagy in skeletal muscle

Lisa Gambarotto, Samuele Metti, Martina Chrisam, Cristina Cerqua, Patrizia Sabatelli, Andrea Armani, Carlo Zanon, Marianna Spizzotin, Silvia Castagnaro, Flavie Strappazzon, Paolo Grumati, Matilde Cescon, Paola Braghetta, Eva Trevisson, Francesco Cecconi, Paolo Bonaldo

J Cachexia Sarcopenia Muscle. 2022 Aug; 13(4): 2211–2224. Published online 2022 May 20. doi: 10.1002/jcsm.13010

PMCID:: PMC9434724

Abstract Article PDF–9.7M

Select item 90145597.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 88752978.

CRL4^AMBRA1 is a master regulator of D-type cyclins

Daniele Simoneschi, Gergely Rona, Nan Zhou, Yeon-Tae Jeong, Shaowen Jiang, Giacomo Milletti, Arnaldo A. Arbini, Alfie O’Sullivan, Andrew A. Wang, Sorasicha Nithikasem, Sarah Keegan, Yik Siu, Valentina Cianfanelli, Emiliano Maiani, Francesca Nazio, Francesco Cecconi, Francesco Boccalatte, David Fenyö, Drew R. Jones, Luca Busino, Michele Pagano

Nature. Author manuscript; available in PMC 2022 Apr 14.

Published in final edited form as: Nature. 2021 Apr; 592(7856): 789–793. Published online 2021 Apr 14. doi: 10.1038/s41586-021-03445-y

PMCID:: PMC8875297

Abstract Article PDF–6.0M

Select item 88645519.

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

Emiliano Maiani, Giacomo Milletti, Francesca Nazio, Søs Grønbæk Holdgaard, Jirina Bartkova, Salvatore Rizza, Valentina Cianfanelli, Mar Lorente, Daniele Simoneschi, Miriam Di Marco, Pasquale D’Acunzo, Luca Di Leo, Rikke Rasmussen, Costanza Montagna, Marilena Raciti, Cristiano De Stefanis, Estibaliz Gabicagogeascoa, Gergely Rona, Nélida Salvador, Emanuela Pupo, Joanna Maria Merchut-Maya, Colin J. Daniel, Marianna Carinci, Valeriana Cesarini, Alfie O’sullivan, Yeon-Tae Jeong, Matteo Bordi, Francesco Russo, Silvia Campello, Angela Gallo, Giuseppe Filomeni, Letizia Lanzetti, Rosalie C. Sears, Petra Hamerlik, Armando Bartolazzi, Robert E. Hynds, David R. Pearce, Charles Swanton, Michele Pagano, Guillermo Velasco, Elena Papaleo, Daniela De Zio, Apolinar Maya-Mendoza, Franco Locatelli, Jiri Bartek, Francesco Cecconi

Nature. Author manuscript; available in PMC 2022 Apr 14.

Published in final edited form as: Nature. 2021 Apr; 592(7856): 799–803. Published online 2021 Apr 14. doi: 10.1038/s41586-021-03422-5

PMCID:: PMC8864551

Article PDF–3.6M

Select item 824659710.

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D

Andrea C. Chaikovsky, Chuan Li, Edwin E. Jeng, Samuel Loebell, Myung Chang Lee, Christopher W. Murray, Ran Cheng, Janos Demeter, Danielle L. Swaney, Si-Han Chen, Billy W. Newton, Jeffrey R. Johnson, Alexandros P. Drainas, Yan Ting Shue, Jose A. Seoane, Preethi Srinivasan, Andy He, Akihiro Yoshida, Susan Q. Hipkins, Edel McCrea, Carson D. Poltorack, Nevan J. Krogan, J. Alan Diehl, Christina Kong, Peter K. Jackson, Christina Curtis, Dmitri A. Petrov, Michael C. Bassik, Monte M. Winslow, Julien Sage

Nature. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: Nature. 2021 Apr; 592(7856): 794–798. Published online 2021 Apr 14. doi: 10.1038/s41586-021-03474-7

PMCID:: PMC8246597

Article PDF–4.9M

Select item 810010211.

Loss of Ambra1 promotes melanoma growth and invasion

Luca Di Leo, Valérie Bodemeyer, Francesca M. Bosisio, Giuseppina Claps, Marco Carretta, Salvatore Rizza, Fiorella Faienza, Alex Frias, Shawez Khan, Matteo Bordi, Maria P. Pacheco, Julie Di Martino, Jose J. Bravo-Cordero, Colin J. Daniel, Rosalie C. Sears, Marco Donia, Daniel H. Madsen, Per Guldberg, Giuseppe Filomeni, Thomas Sauter, Caroline Robert, Daniela De Zio, Francesco Cecconi

Nat Commun. 2021; 12: 2550. Published online 2021 May 5. doi: 10.1038/s41467-021-22772-2

PMCID:: PMC8100102

Abstract Article PDF–4.7M

Select item 802836812.

AMBRA1, a novel α‐synuclein‐binding protein, is implicated in the pathogenesis of multiple system atrophy

Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Yota Tatara, Jun Utsumi, Hidenao Sasaki, Akiyoshi Kakita, Hitoshi Takahashi, Gian Maria Fimia, Koichi Wakabayashi

Brain Pathol. 2018 Jan; 28(1): 28–42. Published online 2017 Mar 15. doi: 10.1111/bpa.12461

PMCID:: PMC8028368

Abstract Article PDF–936K

Select item 793877013.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 744350114.

The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes

Christina Schoenherr, Adam Byron, Billie Griffith, Alexander Loftus, Jimi C. Wills, Alison F. Munro, Alex von Kriegsheim, Margaret C. Frame

J Biol Chem. 2020 Aug 21; 295(34): 12045–12057. Published online 2020 Jul 2. doi: 10.1074/jbc.RA120.012565

PMCID:: PMC7443501

Abstract Article PDF–3.4M

Select item 662306615.

Parkin Interacts with Ambra1 to Induce Mitophagy

Cindy Van Humbeeck, Tom Cornelissen, Hilde Hofkens, Wim Mandemakers, Kris Gevaert, Bart De Strooper, Wim Vandenberghe

J Neurosci. 2011 Jul 13; 31(28): 10249–10261. doi: 10.1523/JNEUROSCI.1917-11.2011

PMCID:: PMC6623066

Abstract Article PDF–3.5M

Select item 652743916.

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains

M. Di Rienzo, M. Antonioli, C. Fusco, Y. Liu, M. Mari, I. Orhon, G. Refolo, F. Germani, M. Corazzari, A. Romagnoli, F. Ciccosanti, B. Mandriani, M. T. Pellico, R. De La Torre, H. Ding, M. Dentice, M. Neri, A. Ferlini, F. Reggiori, M. Kulesz-Martin, M. Piacentini, G. Merla, G. M. Fimia

Sci Adv. 2019 May; 5(5): eaau8857. Published online 2019 May 8. doi: 10.1126/sciadv.aau8857

PMCID:: PMC6527439

Abstract Article PDF–4.3M

Select item 629414417.

GIT1 contributes to autophagy in osteoclast through disruption of the binding of Beclin1 and Bcl2 under starvation condition

Shu-Jie Zhao, Fan-Qi Kong, Wei Cai, Tao Xu, Zhi-Min Zhou, Zi-Bin Wang, An-Di Xu, Ya-Qing Yang, Jian Chen, Peng-Yu Tang, Qian Wang, Lin Cheng, Yong-Jun Luo, Zheng Zhou, Lin-Wei Li, Yi-Fan Huang, Xuan Zhao, Guo-Yong Yin, Ming-Xin Xue, Jin Fan

Cell Death Dis. 2018 Dec; 9(12): 1195. Published online 2018 Dec 13. doi: 10.1038/s41419-018-1256-8

PMCID:: PMC6294144

Abstract Article PDF–2.3M

Select item 628790218.

Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice

Roberto Coccurello, Francesca Nazio, Claudia Rossi, Federica De Angelis, Valentina Vacca, Giacomo Giacovazzo, Patrizia Procacci, Valerio Magnaghi, Domenico Ciavardelli, Sara Marinelli

PLoS One. 2018; 13(12): e0208596. Published online 2018 Dec 10. doi: 10.1371/journal.pone.0208596

PMCID:: PMC6287902

Abstract Article PDF–5.3M

Select item 615534919.

Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival

Rossella Russo, Giuseppe Pasquale Varano, Annagrazia Adornetto, Francesca Nazio, Gianluca Tettamanti, Rossana Girardello, Valentina Cianfanelli, Federica Cavaliere, Luigi Antonio Morrone, Maria Tiziana Corasaniti, Francesco Cecconi, Giacinto Bagetta, Carlo Nucci

Cell Death Dis. 2018 Oct; 9(10): 981. Published online 2018 Sep 24. doi: 10.1038/s41419-018-1044-5

PMCID:: PMC6155349

Abstract Article PDF–7.8M

Select item 613277720.

Ambra1 Shapes Hippocampal Inhibition/Excitation Balance: Role in Neurodevelopmental Disorders

Annalisa Nobili, Paraskevi Krashia, Alberto Cordella, Livia La Barbera, Maria Concetta Dell’Acqua, Angela Caruso, Annabella Pignataro, Ramona Marino, Francesca Sciarra, Filippo Biamonte, Maria Luisa Scattoni, Martine Ammassari-Teule, Francesco Cecconi, Nicola Berretta, Flavio Keller, Nicola Biagio Mercuri, Marcello D’Amelio

Mol Neurobiol. 2018; 55(10): 7921–7940. Published online 2018 Feb 27. doi: 10.1007/s12035-018-0911-5