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Items: 1 to 20 of 25

1.
Ablating N-Acetylaspartate Prevents Leukodystrophy in a Canavan Disease Model
Fuzheng Guo, Peter Bannerman, Emily Mills Ko, Laird Miers, Jie Xu, Travis Burns, Shuo Li, Ernest Freeman, Jennifer A. McDonough, David Pleasure
Ann Neurol. Author manuscript; available in PMC 2024 May 28.
Published in final edited form as: Ann Neurol. 2015 May; 77(5): 884–888. Published online 2015 Mar 27. doi: 10.1002/ana.24392
PMCID:
PMC11131957
AbstractArticlePDF–1.8M
2.
Hindering NAT8L expression in hepatocellular carcinoma increases cytosolic aspartate delivery that fosters pentose phosphate pathway and purine biosynthesis promoting cell proliferation
Pamela De Falco, Giacomo Lazzarino, Federica Felice, Enrico Desideri, Serena Castelli, Illari Salvatori, Fabio Ciccarone, Maria Rosa Ciriolo
Redox Biol. 2023 Feb; 59: 102585. Published online 2022 Dec 24. doi: 10.1016/j.redox.2022.102585
PMCID:
PMC9813579
AbstractArticlePDF–9.7M
3.
Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration
Le Qi, Misty S. Martin-Sandoval, Salma Merchant, Wen Gu, Matthias Eckhardt, Thomas P. Mathews, Zhiyu Zhao, Michalis Agathocleous, Sean J. Morrison
Cell Stem Cell. Author manuscript; available in PMC 2022 Nov 4.
Published in final edited form as: Cell Stem Cell. 2021 Nov 4; 28(11): 1982–1999.e8. Published online 2021 Aug 26. doi: 10.1016/j.stem.2021.07.011
PMCID:
PMC8571029
AbstractArticlePDF–4.5M
4.
Inhibitory effects of Shati/Nat8l overexpression in the medial prefrontal cortex on methamphetamine‐induced conditioned place preference in mice
Meriem Haddar, Kyosuke Uno, Katsunori Azuma, Shin‐ichi Muramatsu, Atsumi Nitta
Addict Biol. 2020 May; 25(3): e12749. Published online 2019 Apr 5. doi: 10.1111/adb.12749
PMCID:
PMC7187255
AbstractArticlePDF–731K
5.
N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health
Dina C. Hofer, Gabriel Zirkovits, Helmut J. Pelzmann, Katharina Huber, Ariane R. Pessentheiner, Wenmin Xia, Kyosuke Uno, Toh Miyazaki, Kanta Kon, Hiroshi Tsuneki, Tobias Pendl, Wael Al Zoughbi, Corina T. Madreiter-Sokolowski, Gert Trausinger, Mahmoud Abdellatif, Gabriele Schoiswohl, Renate Schreiber, Tobias Eisenberg, Christoph Magnes, Simon Sedej, Matthias Eckhardt, Masakiyo Sasahara, Toshiyasu Sasaoka, Atsumi Nitta, Gerald Hoefler, Wolfgang F. Graier, Dagmar Kratky, Johan Auwerx, Juliane G. Bogner-Strauss
FASEB J. 2019 Dec; 33(12): 13808–13824. Published online 2019 Nov 1. doi: 10.1096/fj.201801323R
PMCID:
PMC6894082
AbstractArticle
6.
A Novel Molecule “Shati” Is Involved in Methamphetamine-Induced Hyperlocomotion, Sensitization, and Conditioned Place Preference
Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, Yasutomo Ito, Yukihiro Noda, Taku Nagai, Toshitaka Nabeshima
J Neurosci. 2007 Jul 11; 27(28): 7604–7615. doi: 10.1523/JNEUROSCI.1575-07.2007
PMCID:
PMC6672622
AbstractArticlePDF–727K
7.
N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time
Helena Maier, Lihua Wang-Eckhardt, Dieter Hartmann, Volkmar Gieselmann, Matthias Eckhardt
J Neurosci. 2015 Oct 28; 35(43): 14501–14516. doi: 10.1523/JNEUROSCI.1056-15.2015
PMCID:
PMC6605458
AbstractArticlePDF–9.1M
8.
New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules
Richa Das, Lukas Schwintzer, Stanislav Vinopal, Eva Aguado Roca, Marc Sylvester, Ana-Maria Oprisoreanu, Susanne Schoch, Frank Bradke, Meike Broemer
J Cell Sci. 2019 Jun 15; 132(12): jcs229252. Published online 2019 Jun 17. doi: 10.1242/jcs.229252
PMCID:
PMC6602300
AbstractArticle
9.
The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition
N. K. Singhal, H. Huang, S. Li, R. Clements, J. Gadd, A. Daniels, E. E. Kooijman, P. Bannerman, T. Burns, F. Guo, D. Pleasure, E. Freeman, L. Shriver, J. McDonough
Exp Brain Res. Author manuscript; available in PMC 2018 Mar 29.
Published in final edited form as: Exp Brain Res. 2017 Jan; 235(1): 279–292. Published online 2016 Oct 5. doi: 10.1007/s00221-016-4789-z
PMCID:
PMC5875422
AbstractArticlePDF–808K
10.
Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy
Georg von Jonquieres, Ziggy H. T. Spencer, Benjamin D. Rowlands, Claudia B. Klugmann, Andre Bongers, Anne E. Harasta, Kristina E. Parley, Jennie Cederholm, Orla Teahan, Russell Pickford, Fabien Delerue, Lars M. Ittner, Dominik Fröhlich, Catriona A. McLean, Anthony S. Don, Miriam Schneider, Gary D. Housley, Caroline D. Rae, Matthias Klugmann
Acta Neuropathol. 2018; 135(1): 95–113. Published online 2017 Nov 7. doi: 10.1007/s00401-017-1784-9
PMCID:
PMC5756261
AbstractArticlePDF–12M
11.
Striatal N-Acetylaspartate Synthetase Shati/Nat8l Regulates Depression-Like Behaviors via mGluR3-Mediated Serotonergic Suppression in Mice
Yoshiaki Miyamoto, Noriyuki Iegaki, Kequan Fu, Yudai Ishikawa, Kazuyuki Sumi, Sota Azuma, Kyosuke Uno, Shin-ichi Muramatsu, Atsumi Nitta
Int J Neuropsychopharmacol. 2017 Dec; 20(12): 1027–1035. Published online 2017 Aug 31. doi: 10.1093/ijnp/pyx078
PMCID:
PMC5716104
AbstractArticlePDF–1013K
12.
Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development
Kazuyuki Sumi, Kyosuke Uno, Hiroshi Noike, Takenori Tomohiro, Yasumaru Hatanaka, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Yoshiaki Miyamoto, Atsumi Nitta
Sci Rep. 2017; 7: 16872. Published online 2017 Dec 4. doi: 10.1038/s41598-017-17151-1
PMCID:
PMC5715020
AbstractArticlePDF–3.1M
13.
Methamphetamine induces Shati/Nat8L expression in the mouse nucleus accumbens via CREB- and dopamine D1 receptor-dependent mechanism
Kyosuke Uno, Toh Miyazaki, Kengo Sodeyama, Yoshiaki Miyamoto, Atsumi Nitta
PLoS One. 2017; 12(3): e0174196. Published online 2017 Mar 20. doi: 10.1371/journal.pone.0174196
Expression of Concern in:
PLoS One. 2023; 18(1): e0279806.
PMCID:
PMC5358781
AbstractArticlePDF–1.2M
14.
Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy
Jiho Sohn, Peter Bannerman, Fuzheng Guo, Travis Burns, Laird Miers, Christopher Croteau, Naveen K. Singhal, Jennifer A. McDonough, David Pleasure
J Neurosci. 2017 Jan 11; 37(2): 413–421. doi: 10.1523/JNEUROSCI.2013-16.2016
PMCID:
PMC5242397
AbstractArticlePDF–5.6M
15.
Transcriptional Regulation of N-acetylaspartate Metabolism in the 5xFAD Model of Alzheimer's Disease: Evidence for Neuron-Glia Communication During Energetic Crisis
Samantha Zaroff, Paola Leone, Scott W. J. McPhee, Vladimir Markov, Jeremy S. Francis
Mol Cell Neurosci. Author manuscript; available in PMC 2016 Mar 10.
Published in final edited form as: Mol Cell Neurosci. 2015 Mar; 65: 143–152. Published online 2015 Mar 10. doi: 10.1016/j.mcn.2015.03.009
PMCID:
PMC4393791
AbstractArticlePDF–534K
16.
AUTS2 confers gene activation to Polycomb group proteins in the CNS
Zhonghua Gao, Pedro Lee, James M. Stafford, Melanie von Schimmelmann, Anne Schaefer, Danny Reinberg
Nature. Author manuscript; available in PMC 2015 Jun 18.
Published in final edited form as: Nature. 2014 Dec 18; 516(7531): 349–354. doi: 10.1038/nature13921
PMCID:
PMC4323097
AbstractArticlePDF–4.2M
17.
NAT8L (N-Acetyltransferase 8-Like) Accelerates Lipid Turnover and Increases Energy Expenditure in Brown Adipocytes
Ariane R. Pessentheiner, Helmut J. Pelzmann, Evelyn Walenta, Martina Schweiger, Lukas N. Groschner, Wolfgang F. Graier, Dagmar Kolb, Kyosuke Uno, Toh Miyazaki, Atsumi Nitta, Dietmar Rieder, Andreas Prokesch, Juliane G. Bogner-Strauss
J Biol Chem. 2013 Dec 13; 288(50): 36040–36051. Published online 2013 Oct 23. doi: 10.1074/jbc.M113.491324
PMCID:
PMC3861652
AbstractArticlePDF–3.9M
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
N-Acetylaspartylglutamate Synthetase II Synthesizes N-Acetylaspartylglutamylglutamate
Julia Lodder-Gadaczek, Ivonne Becker, Volkmar Gieselmann, Lihua Wang-Eckhardt, Matthias Eckhardt
J Biol Chem. 2011 May 13; 286(19): 16693–16706. Published online 2011 Mar 25. doi: 10.1074/jbc.M111.230136
PMCID:
PMC3089511
AbstractArticlePDF–9.4M
20.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M

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