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Items: 1 to 20 of 45

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
Lizhi Pang, Songlin Guo, Fatima Khan, Madeline Dunterman, Heba Ali, Yang Liu, Yuyun Huang, Peiwen Chen
Cell Rep Med. 2023 Nov 21; 4(11): 101238. Published online 2023 Oct 18. doi: 10.1016/j.xcrm.2023.101238
PMCID:
PMC10694605
AbstractArticlePDF–8.1M
3.
Asparagine endopeptidase protects podocytes in adriamycin-induced nephropathy by regulating actin dynamics through cleaving transgelin
Yang Qiu, Chuntao Lei, Jieyu Zeng, Yaru Xie, Yiling Cao, Qian Yuan, Hua Su, Zhentao Zhang, Chun Zhang
Mol Ther. 2023 Nov 1; 31(11): 3337–3354. Published online 2023 Sep 9. doi: 10.1016/j.ymthe.2023.09.003
PMCID:
PMC10638058
AbstractArticlePDF–7.8M
4.
Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut
Anne M. Bara, Lei Chen, Celina Ma, Julie Underwood, Rebecca S. Moreci, Kaelyn Sumigray, Tongyu Sun, Yarui Diao, Michael Verzi, Terry Lechler
Development. 2022 Dec 1; 149(23): dev201251. Published online 2022 Dec 12. doi: 10.1242/dev.201251
PMCID:
PMC10112929
AbstractArticle
5.
A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin
Jing Xiong, Jianming Liao, Xia Liu, Zhaohui Zhang, Jonathan Adams, Roberto Pacifici, Keqiang Ye
Nat Commun. 2022; 13: 4820. Published online 2022 Aug 16. doi: 10.1038/s41467-022-32435-5
PMCID:
PMC9381595
AbstractArticlePDF–4.9M
6.
A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease
Lanxia Meng, Li Zou, Min Xiong, Jiehui Chen, Xingyu Zhang, Ting Yu, Yiming Li, Congcong Liu, Guiqin Chen, Zhihao Wang, Keqiang Ye, Zhentao Zhang
Aging Cell. 2022 May; 21(5): e13619. Published online 2022 Apr 20. doi: 10.1111/acel.13619
PMCID:
PMC9124304
AbstractArticlePDF–12M
7.
Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1
Chuntao Lei, Mengran Li, Yang Qiu, Yaru Xie, Zhe Hao, Xingjie Yin, Zhentao Zhang, Hua Su, Linlin Yang, Jihong Lin, Hans-Peter Hammes, Chun Zhang
Cell Death Dis. 2022 Feb; 13(2): 184. Published online 2022 Feb 25. doi: 10.1038/s41419-022-04621-2
PMCID:
PMC8881581
AbstractArticlePDF–12M
8.
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease
Chun Chen, Yunzhe Zhou, Hualong Wang, Ashfaqul Alam, Seong Su Kang, Eun Hee Ahn, Xia Liu, Jianping Jia, Keqiang Ye
EMBO J. 2021 Sep 1; 40(17): e106320. Published online 2021 Jul 14. doi: 10.15252/embj.2020106320
PMCID:
PMC8408610
AbstractArticlePDF–5.0M
9.
ApoE4 Inhibition of VMAT2 in the Locus Coeruleus Exacerbates Tau Pathology in Alzheimer’s Disease
Seong Su Kang, Eun Hee Ahn, Xia Liu, Matthew Bryson, Gary W. Miller, David Weinshenker, Keqiang Ye
Acta Neuropathol. Author manuscript; available in PMC 2022 Jul 1.
Published in final edited form as: Acta Neuropathol. 2021 Jul; 142(1): 139–158. Published online 2021 Apr 25. doi: 10.1007/s00401-021-02315-1
PMCID:
PMC8217363
AbstractArticlePDF–1.7M
10.
Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies
Guiqin Chen, Seong Su Kang, Zhihao Wang, Eun Hee Ahn, Yiyuan Xia, Xia Liu, Ivette M. Sandoval, Fredric P. Manfredsson, Zhaohui Zhang, Keqiang Ye
Sci Adv. 2021 Apr; 7(16): eabe4499. Published online 2021 Apr 16. doi: 10.1126/sciadv.abe4499
PMCID:
PMC8051868
AbstractArticlePDF–8.1M
11.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
12.
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2
Nguyen Huu Tu, Dane D. Jensen, Bethany M. Anderson, Elyssa Chen, Nestor N. Jimenez-Vargas, Nicole N. Scheff, Kenji Inoue, Hung D. Tran, John C. Dolan, Tamaryn A. Meek, Morley D. Hollenberg, Cheng Z. Liu, Stephen J. Vanner, Malvin N. Janal, Nigel W. Bunnett, Laura E. Edgington-Mitchell, Brian L. Schmidt
J Neurosci. 2021 Jan 6; 41(1): 193–210. doi: 10.1523/JNEUROSCI.1211-20.2020
PMCID:
PMC7786216
AbstractArticlePDF–5.4M
13.
Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells
Pablo Rodríguez-Silvestre, Marco Laub, Patrycja A. Krawczyk, Alexandra K. Davies, Julia P. Schessner, Reejuana Parveen, Benjamin J. Tuck, William A. McEwan, Georg H.H. Borner, Patrycja Kozik
Science. Author manuscript; available in PMC 2023 Jul 19.
Published in final edited form as: Science. 2023 Jun 23; 380(6651): 1258–1265. Published online 2023 Jun 22. doi: 10.1126/science.adg8802
PMCID:
PMC7614779
AbstractArticlePDF–1.8M
14.
Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus
Seong Su Kang, Xia Liu, Eun Hee Ahn, Jie Xiang, Fredric P. Manfredsson, Xifei Yang, Hongbo R. Luo, L. Cameron Liles, David Weinshenker, Keqiang Ye
J Clin Invest. 2020 Jan 2; 130(1): 422–437. Published online 2019 Dec 3. doi: 10.1172/JCI130513
PMCID:
PMC6934194
AbstractArticlePDF–25M
15.
Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer’s disease
Hualong Wang, Xia Liu, Shengdi Chen, Keqiang Ye
Proc Natl Acad Sci U S A. 2018 Dec 26; 115(52): E12427–E12434. Published online 2018 Dec 10. doi: 10.1073/pnas.1815915115
Correction in:
Proc Natl Acad Sci U S A. 2019 Dec 17; 116(51): 26090.
PMCID:
PMC6310855
AbstractArticlePDF–1.5M
16.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
17.
Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
Jonathan Martínez-Fábregas, Alan Prescott, Sander van Kasteren, Deena Leslie Pedrioli, Irwin McLean, Anna Moles, Thomas Reinheckel, Valeria Poli, Colin Watts
Nat Commun. 2018; 9: 5343. Published online 2018 Dec 17. doi: 10.1038/s41467-018-07741-6
PMCID:
PMC6297226
AbstractArticlePDF–3.4M
18.
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies
Zhi-Hao Wang, Pai Liu, Xia Liu, Shan Ping Yu, Jian-Zhi Wang, Keqiang Ye
J Exp Med. 2018 Dec 3; 215(12): 3038–3056. doi: 10.1084/jem.20180539
PMCID:
PMC6279401
AbstractArticlePDF–4.0M
19.
LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow
Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher
J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214
PMCID:
PMC6262777
AbstractArticle
20.
BDNF inhibits neurodegenerative disease–associated asparaginyl endopeptidase activity via phosphorylation by AKT
Zhi-Hao Wang, Wanqiang Wu, Seong Su Kang, Xia Liu, Zhiping Wu, Junmin Peng, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Xuebo Liu, Jian-Zhi Wang, Keqiang Ye
JCI Insight. 2018 Aug 23; 3(16): e99007. Published online 2018 Aug 23. doi: 10.1172/jci.insight.99007
PMCID:
PMC6141178
AbstractArticlePDF–4.3M

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