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Select item 107925471.

Maladaptive lymphangiogenesis is associated with synovial iron accumulation and delayed Clearance in FVIII^−/− mice after induced hemarthrosis

Esther J Cooke, Bilgimol C Joseph, Chanond A Nasamran, Kathleen M Fisch, Annette von Drygalski

J Thromb Haemost. Author manuscript; available in PMC 2024 Jan 17.

Published in final edited form as: J Thromb Haemost. 2023 Sep; 21(9): 2390–2404. Published online 2023 Apr 26. doi: 10.1016/j.jtha.2023.04.022

PMCID:: PMC10792547

Abstract Article PDF–1.9M

Select item 106600122.

von Willebrand factor modulates immune complexes and the recall response against factor VIII in a murine hemophilia A model

Olga Oleshko, Nadine Vollack-Hesse, Andreas Tiede, Jan Hegermann, Ute Curth, Sonja Werwitzke

Blood Adv. 2023 Nov 14; 7(21): 6771–6781. Published online 2023 Sep 28. doi: 10.1182/bloodadvances.2023010388

PMCID:: PMC10660012

Abstract Article PDF–771K

Select item 105014823.

Factor VIII antibody immune complexes modulate the humoral response to factor VIII in an epitope-dependent manner

Glaivy Batsuli, Jasmine Ito, Elizabeth S. York, Courtney Cox, Wallace Baldwin, Surinder Gill, Pete Lollar, Shannon L. Meeks

Front Immunol. 2023; 14: 1233356. Published online 2023 Aug 31. doi: 10.3389/fimmu.2023.1233356

PMCID:: PMC10501482

Abstract Article PDF–3.6M

Select item 100269614.

Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice—Brief Report

Soracha E. Ward, Thomas Guest, Ciara Byrne, Patricia Lopes, Jamie M. O’Sullivan, Dearbhla Doherty, David O’Connell, Sara Gutierrez Llaneza, Alain Chion, Judicael Fazavana, Padraic G. Fallon, Roger J.S. Preston, Jill M. Johnsen, Steven W. Pipe, Peter L. Turecek, James S. O’Donnell

Arterioscler Thromb Vasc Biol. 2023 Apr; 43(4): 540–546. Published online 2023 Feb 2. doi: 10.1161/ATVBAHA.122.317807

PMCID:: PMC10026961

Abstract Article PDF–1.4M

Select item 97340255.

IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice

John S.S. Butterfield, Kentaro Yamada, Thais B. Bertolini, Farooq Syed, Sandeep R.P. Kumar, Xin Li, Sreevani Arisa, Annie R. Piñeros, Alejandro Tapia, Christopher A. Rogers, Ning Li, Jyoti Rana, Moanaro Biswas, Cox Terhorst, Randal J. Kaufman, Ype P. de Jong, Roland W. Herzog

Mol Ther. 2022 Dec 7; 30(12): 3552–3569. Published online 2022 Jul 12. doi: 10.1016/j.ymthe.2022.07.005

PMCID:: PMC9734025

Abstract Article PDF–5.1M

Select item 97102356.

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3⁺ T regulatory cells

Hideto Matsui, Masaru Shibata, Brian Brown, Andrea Labelle, Carol Hegadorn, Chandler Andrews, Marinee Chuah, Thierry VandenDriessche, Carol H. Miao, Christine Hough, David Lillicrap

Blood. 2009 Jul 16; 114(3): 677–685. Published online 2020 Nov 28. doi: 10.1182/blood-2009-03-202267

PMCID:: PMC9710235

Abstract Article

Select item 96631537.

Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1⁺ Tregs

Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Andreas Pannek, Thilo Albert, Chrystel Flores, Frank A. Schildberg, Paul A. Gleeson, Birgit M. Reipert, Johannes Oldenburg, Christian Kurts

J Clin Invest. 2022 Nov 15; 132(22): e159925. Published online 2022 Nov 15. doi: 10.1172/JCI159925

PMCID:: PMC9663153

Abstract Article PDF–3.5M

Select item 90744038.

Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy in mice

Jhansi Magisetty, Vijay Kondreddy, Shiva Keshava, Kaushik Das, Charles T. Esmon, Usha R. Pendurthi, L. Vijaya Mohan Rao

Blood. 2022 May 5; 139(18): 2830–2841. doi: 10.1182/blood.2021013119

Correction in:: Blood. 2024 Aug 1; 144(5): 588.

PMCID:: PMC9074403

Abstract Article

Select item 90687919.

Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates

Michela Milani, Cesare Canepari, Tongyao Liu, Mauro Biffi, Fabio Russo, Tiziana Plati, Rosalia Curto, Susannah Patarroyo-White, Douglas Drager, Ilaria Visigalli, Chiara Brombin, Paola Albertini, Antonia Follenzi, Eduard Ayuso, Christian Mueller, Andrea Annoni, Luigi Naldini, Alessio Cantore

Nat Commun. 2022; 13: 2454. Published online 2022 May 4. doi: 10.1038/s41467-022-30102-3

PMCID:: PMC9068791

Abstract Article PDF–2.6M

Select item 888596510.

Removal of single-site N-linked glycans on factor VIII alters binding of domain-specific monoclonal antibodies

Jasmine Ito, W. Hunter Baldwin, Courtney Cox, John F. Healey, Ernest T. Parker, Emily R. Legan, Renhao Li, Surinder Gill, Glaivy Batsuli

J Thromb Haemost. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: J Thromb Haemost. 2022 Mar; 20(3): 574–588. Published online 2021 Dec 17. doi: 10.1111/jth.15616

PMCID:: PMC8885965

Abstract Article PDF–1.1M

Select item 829532511.

Characterization and visualization of murine coagulation factor VIII-producing cells in vivo

Morisada Hayakawa, Asuka Sakata, Hiroko Hayakawa, Hikari Matsumoto, Takafumi Hiramoto, Yuji Kashiwakura, Nemekhbayar Baatartsogt, Noriyoshi Fukushima, Yoichi Sakata, Katsue Suzuki-Inoue, Tsukasa Ohmori

Sci Rep. 2021; 11: 14824. Published online 2021 Jul 21. doi: 10.1038/s41598-021-94307-0

PMCID:: PMC8295325

Abstract Article PDF–4.6M

Select item 810901712.

Activated protein C has a regulatory role in factor VIII function

Amelia R. Wilhelm, Nicole A. Parsons, Benjamin J. Samelson-Jones, Robert J. Davidson, Charles T. Esmon, Rodney M. Camire, Lindsey A. George

Blood. 2021 May 6; 137(18): 2532–2543. Prepublished online 2021 Jan 11. doi: 10.1182/blood.2020007562

PMCID:: PMC8109017

Abstract Article

Select item 767370713.

The endothelial protein C receptor plays an essential role in the maintenance of pregnancy

Michelle M. Castillo, Qiuhui Yang, Abril Solis Sigala, Dosia T. McKinney, Min Zhan, Kristen L. Chen, Jason A. Jarzembowski, Rashmi Sood

Sci Adv. 2020 Nov; 6(45): eabb6196. Published online 2020 Nov 6. doi: 10.1126/sciadv.abb6196

PMCID:: PMC7673707

Abstract Article PDF–1.6M

Select item 746057414.

A Foundational Study for Normal F8-Containing Mouse Models for the miRNA Regulation of Hemophilia A: Identification and Analysis of Mouse miRNAs that Downregulate the Murine F8 Gene

Katarzyna I. Jankowska, Maitreyi Chattopadhyay, Zuben E. Sauna, Chintamani D. Atreya

Int J Mol Sci. 2020 Aug; 21(16): 5621. Published online 2020 Aug 6. doi: 10.3390/ijms21165621

PMCID:: PMC7460574

Abstract Article PDF–1.8M

Select item 731620515.

EPCR deficiency or function-blocking antibody protects against joint bleeding–induced pathology in hemophilia mice

Jhansi Magisetty, Usha R. Pendurthi, Charles T. Esmon, L. Vijaya Mohan Rao

Blood. 2020 Jun 18; 135(25): 2211–2223. Prepublished online 2020 Apr 15. doi: 10.1182/blood.2019003824

PMCID:: PMC7316205

Abstract Article

Select item 729589716.

Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation

Patricia E. Zerra, Connie M. Arthur, Satheesh Chonat, Cheryl L. Maier, Amanda Mener, Sooncheon Shin, Jerry William L. Allen, W. Hunter Baldwin, Courtney Cox, Hans Verkerke, Ryan P. Jajosky, Christopher A. Tormey, Shannon L. Meeks, Sean R. Stowell

Front Immunol. 2020; 11: 905. Published online 2020 Jun 9. doi: 10.3389/fimmu.2020.00905

PMCID:: PMC7295897

Abstract Article PDF–1.2M

Select item 725255817.

Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic mice

Qizhen Shi, Christopher V. Carman, Yingyu Chen, Peter T. Sage, Feng Xue, Xin M. Liang, Gary E. Gilbert

Blood Adv. 2020 May 26; 4(10): 2272–2285. Published online 2020 May 26. doi: 10.1182/bloodadvances.2020001468

PMCID:: PMC7252558

Abstract Article PDF–1.5M

Select item 691295118.

Curing hemophilia A by NHEJ-mediated ectopic F8 insertion in the mouse

Jian-Ping Zhang, Xin-Xin Cheng, Mei Zhao, Guo-Hua Li, Jing Xu, Feng Zhang, Meng-Di Yin, Fei-Ying Meng, Xin-Yue Dai, Ya-Wen Fu, Zhi-Xue Yang, Cameron Arakaki, Ruijun Jeanna Su, Wei Wen, Wen-Tian Wang, Wanqiu Chen, Hannah Choi, Charles Wang, Guangping Gao, Lei Zhang, Tao Cheng, Xiao-Bing Zhang

Genome Biol. 2019; 20: 276. Published online 2019 Dec 16. doi: 10.1186/s13059-019-1907-9

PMCID:: PMC6912951

Abstract Article PDF–3.8M

Select item 679539619.

TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding

Tine Wyseure, Tingyi Yang, Jenny Y. Zhou, Esther J. Cooke, Bettina Wanko, Merissa Olmer, Ruchi Agashe, Yosuke Morodomi, Niels Behrendt, Martin Lotz, John Morser, Annette von Drygalski, Laurent O. Mosnier

JCI Insight. 2019 Oct 3; 4(19): e128379. Published online 2019 Oct 3. doi: 10.1172/jci.insight.128379

PMCID:: PMC6795396

Abstract Article PDF–11M

Select item 678355420.

Hemophilia A and B mice, but not VWF^−/−mice, display bone defects in congenital development and remodeling after injury

Sarah Taves, Junjiang Sun, Eric W. Livingston, Xin Chen, Jerome Amiaud, Regis Brion, William B. Hannah, Ted A. Bateman, Dominique Heymann, Paul E. Monahan

Sci Rep. 2019; 9: 14428. Published online 2019 Oct 8. doi: 10.1038/s41598-019-50787-9