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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102474542.

TREK-1 and TREK-2 knockout mice are not resistant to halothane or isoflurane

Kira A Spencer, Christian B Woods, Hailey M Worstman, Simon C Johnson, Jan-Marino Ramirez, Philip G Morgan, Margaret M Sedensky

Anesthesiology. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: Anesthesiology. 2023 Jul 1; 139(1): 63–76. doi: 10.1097/ALN.0000000000004577

PMCID:: PMC10247454

Abstract Article PDF–1.3M

Select item 98294833.

Activation of TREK-1 (K_2P2.1) potassium channels protects against influenza A-induced lung injury

Tatiana Zyrianova, Benjamin Lopez, Kathlyn Zou, Charles Gu, Dayna Pham, Sriharsha Talapaneni, Christopher M. Waters, Riccardo Olcese, Andreas Schwingshackl

Am J Physiol Lung Cell Mol Physiol. 2023 Jan 1; 324(1): L64–L75. Published online 2022 Nov 21. doi: 10.1152/ajplung.00116.2022

PMCID:: PMC9829483

Abstract Article

Select item 96009894.

β-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes

Seong-Seop Kim, Yeonju Bae, Osung Kwon, Seung-Hae Kwon, Jong Bok Seo, Eun Mi Hwang, Jae-Yong Park

Cells. 2022 Oct; 11(20): 3322. Published online 2022 Oct 21. doi: 10.3390/cells11203322

PMCID:: PMC9600989

Abstract Article PDF–4.9M

Select item 89961265.

TREK-1 protects the heart against ischemia reperfusion-induced injury and from adverse remodeling after myocardial infarction

Samuel Kamatham, Christopher M. Waters, Andreas Schwingshackl, Salvatore Mancarella

Pflugers Arch. Author manuscript; available in PMC 2022 Apr 11.

Published in final edited form as: Pflugers Arch. 2019 Oct; 471(10): 1263–1272. Published online 2019 Sep 12. doi: 10.1007/s00424-019-02306-y

PMCID:: PMC8996126

Abstract Article PDF–1.0M

Select item 88083356.

TREK-1 null impairs neuronal excitability, synaptic plasticity, and cognitive function

Wei Wang, Conrad M. Kiyoshi, Yixing Du, Anne T. Taylor, Erica R. Sheehan, Xiao Wu, Min Zhou

Mol Neurobiol. Author manuscript; available in PMC 2022 Feb 2.

Published in final edited form as: Mol Neurobiol. 2020 Mar; 57(3): 1332–1346. Published online 2019 Nov 15. doi: 10.1007/s12035-019-01828-x

PMCID:: PMC8808335

Abstract Article PDF–1.9M

Select item 78162047.

Genetic and pharmacological inhibition of two‐pore domain potassium channel TREK‐1 alters depression‐related behaviors and neuronal plasticity in the hippocampus in mice

Fangfang Wu, Hongbin Sun, Weigang Gong, Xiaoli Li, Zhaohui Pan, Han Shan, Zhijun Zhang

CNS Neurosci Ther. 2021 Feb; 27(2): 220–232. Published online 2020 Aug 30. doi: 10.1111/cns.13450

PMCID:: PMC7816204

Abstract Article PDF–3.0M

Select item 77385398.

K_2P2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury

Tatiana Zyrianova, Benjamin Lopez, Riccardo Olcese, John Belperio, Christopher M. Waters, Leanne Wong, Victoria Nguyen, Sriharsha Talapaneni, Andreas Schwingshackl

Sci Rep. 2020; 10: 22011. Published online 2020 Dec 15. doi: 10.1038/s41598-020-78886-y

PMCID:: PMC7738539

Abstract Article PDF–2.5M

Select item 75840029.

Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification

Marianna Dionisi, Federico Alessandro Ruffinatti, Beatrice Riva, Dmitry Lim, Annalisa Canta, Cristina Meregalli, Giulia Fumagalli, Laura Monza, Antonio Ferrer-Montiel, Asia Fernandez-Carvajal, Guido Cavaletti, Armando A. Genazzani, Carla Distasi

Int J Mol Sci. 2020 Oct; 21(19): 7164. Published online 2020 Sep 28. doi: 10.3390/ijms21197164

PMCID:: PMC7584002

Abstract Article PDF–2.0M

Select item 752044610.

TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects

Jérôme Busserolles, Ismail Ben Soussia, Laetitia Pouchol, Nicolas Marie, Mathieu Meleine, Maïly Devilliers, Céline Judon, Julien Schopp, Loïc Clémenceau, Laura Poupon, Eric Chapuy, Serge Richard, Florence Noble, Florian Lesage, Sylvie Ducki, Alain Eschalier, Stéphane Lolignier

Br J Pharmacol. 2020 Oct; 177(20): 4782–4795. Published online 2020 Sep 21. doi: 10.1111/bph.15243

Correction in:: Br J Pharmacol. 2020 Nov; 177(22): 5246.

PMCID:: PMC7520446

Abstract Article PDF–8.3M

Select item 701414611.

PIP₂ Mediated Inhibition of TREK Potassium Currents by Bradykinin in Mouse Sympathetic Neurons

Paula Rivas-Ramírez, Antonio Reboreda, Lola Rueda-Ruzafa, Salvador Herrera-Pérez, J. Antonio Lamas

Int J Mol Sci. 2020 Jan; 21(2): 389. Published online 2020 Jan 8. doi: 10.3390/ijms21020389

PMCID:: PMC7014146

Abstract Article PDF–5.7M

Select item 667106312.

Mtap2 Is a Constituent of the Protein Network That Regulates Twik-Related K⁺ Channel Expression and Trafficking

Guillaume Sandoz, Magalie P. Tardy, Susanne Thümmler, Sylvain Feliciangeli, Michel Lazdunski, Florian Lesage

J Neurosci. 2008 Aug 20; 28(34): 8545–8552. doi: 10.1523/JNEUROSCI.1962-08.2008

PMCID:: PMC6671063

Abstract Article PDF–496K

Select item 666626113.

Glucose Inhibition Persists in Hypothalamic Neurons Lacking Tandem-Pore K⁺ Channels

Alice Guyon, Magalie P. Tardy, Carole Rovère, Jean-Louis Nahon, Jacques Barhanin, Florian Lesage

J Neurosci. 2009 Feb 25; 29(8): 2528–2533. doi: 10.1523/JNEUROSCI.5764-08.2009

PMCID:: PMC6666261

Abstract Article PDF–344K

Select item 658020914.

Elevated expression of TREK-TRAAK K_2P channels in the retina of adult rd1 mice

Xiao-Tong Zhang, Zhen Xu, Kang-Pei Shi, Dian-Lei Guo, Han Li, Lei Wang, Xiao-Bo Zhu

Int J Ophthalmol. 2019; 12(6): 924–929. Published online 2019 Jun 18. doi: 10.18240/ijo.2019.06.07

PMCID:: PMC6580209

Abstract Article PDF–1.3M

Select item 652834815.

Altered detrusor contractility and voiding patterns in mice lacking the mechanosensitive TREK-1 channel

Ricardo H. Pineda, Joseph Hypolite, Sanghee Lee, Alonso Carrasco, Jr, Nao Iguchi, Randall B. Meacham, Anna P. Malykhina

BMC Urol. 2019; 19: 40. Published online 2019 May 21. doi: 10.1186/s12894-019-0475-3

PMCID:: PMC6528348

Abstract Article PDF–4.4M

Select item 650696516.

Deficiency of TREK-1 potassium channel exacerbates blood-brain barrier damage and neuroinflammation after intracerebral hemorrhage in mice

Yongkang Fang, Yeye Tian, Qibao Huang, Yue Wan, Li Xu, Wei Wang, Dengji Pan, Suiqiang Zhu, Minjie Xie

J Neuroinflammation. 2019; 16: 96. Published online 2019 May 9. doi: 10.1186/s12974-019-1485-5

PMCID:: PMC6506965

Abstract Article PDF–8.5M

Select item 620538517.

The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction

Dennis M. Abraham, Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Hong-Gang Wang, Stephan Frangakis, Geoffrey S. Pitt, Svati H. Shah, Matthew J. Wolf, Howard A. Rockman

J Clin Invest. 2018 Nov 1; 128(11): 4843–4855. Published online 2018 Oct 2. doi: 10.1172/JCI95945

PMCID:: PMC6205385

Abstract Article PDF–9.3M

Select item 581470418.

Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins

Andreas Schwingshackl, Benjamin Lopez, Bin Teng, Charlean Luellen, Florian Lesage, John Belperio, Riccardo Olcese, Christopher M. Waters

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1; 313(6): L1030–L1046. Published online 2017 Aug 24. doi: 10.1152/ajplung.00121.2017

PMCID:: PMC5814704

Abstract Article

Select item 577889119.

K_2P2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site

Marco Lolicato, Cristina Arrigoni, Takahiro Mori, Yoko Sekioka, Clifford Bryant, Kimberly A. Clark, Daniel L. Minor, Jr.

Nature. Author manuscript; available in PMC 2018 Jan 23.

Published in final edited form as: Nature. 2017 Jul 20; 547(7663): 364–368. Published online 2017 Jul 10. doi: 10.1038/nature22988

PMCID:: PMC5778891

Abstract Article PDF–2.9M

Select item 491944920.

Formation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits

Miklós Lengyel, Gábor Czirják, Péter Enyedi

J Biol Chem. 2016 Jun 24; 291(26): 13649–13661. Published online 2016 Apr 28. doi: 10.1074/jbc.M116.719039

PMCID:: PMC4919449

Abstract Article PDF–1.6M

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