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Select item 111593101.

Expression of Pla2g2a prevents carcinogenesis in Muc2‐deficient mice

R. J. A. Fijneman, J. R. Peham, M. A. van de Wiel, G. A. Meijer, I. Matise, A. Velcich, R. T. Cormier

Cancer Sci. 2008 Nov; 99(11): 2113–2119. Published online 2008 Oct 15. doi: 10.1111/j.1349-7006.2008.00924.x

PMCID:: PMC11159310

Abstract Article PDF–195K

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 101358033.

The Roles of sPLA₂s in Skin Homeostasis and Disease

Kei Yamamoto, Haruka Hakoi, Saki Nomura, Makoto Murakami

Biomolecules. 2023 Apr; 13(4): 668. Published online 2023 Apr 12. doi: 10.3390/biom13040668

PMCID:: PMC10135803

Abstract Article PDF–927K

Select item 94370384.

Pla2g2a promotes innate Th2-type immunity lymphocytes to increase B1a cells

Susan A. Shinton, Joni Brill-Dashoff, Kyoko Hayakawa

Sci Rep. 2022; 12: 14899. Published online 2022 Sep 1. doi: 10.1038/s41598-022-18876-4

PMCID:: PMC9437038

Abstract Article PDF–5.5M

Select item 88558355.

Group IIA secreted phospholipase A₂ controls skin carcinogenesis and psoriasis by shaping the gut microbiota

Yoshimi Miki, Yoshitaka Taketomi, Yuh Kidoguchi, Kei Yamamoto, Kazuaki Muramatsu, Yasumasa Nishito, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Tomoyoshi Soga, Eric Boilard, Siddabasave Gowda B. Gowda, Kazutaka Ikeda, Makoto Arita, Makoto Murakami

JCI Insight. 2022 Jan 25; 7(2): e152611. Published online 2022 Jan 25. doi: 10.1172/jci.insight.152611

PMCID:: PMC8855835

Abstract Article PDF–6.9M

Select item 70722566.

Secreted Phospholipase A₂-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation–Fibrosis Link

Ruben Martin, Beatriz Gutierrez, Claudia Cordova, Alberto San Roman, Yolanda Alvarez, Marita Hernandez, Victoria Cachofeiro, Maria L Nieto

Cells. 2020 Feb; 9(2): 396. Published online 2020 Feb 8. doi: 10.3390/cells9020396

PMCID:: PMC7072256

Abstract Article PDF–4.2M

Select item 66747977.

M₁ Muscarinic Receptors Inhibit L-type Ca²⁺ Current and M-Current by Divergent Signal Transduction Cascades

Liwang Liu, Rubing Zhao, Yan Bai, Lee F. Stanish, James E. Evans, Michael J. Sanderson, Joseph V. Bonventre, Ann R. Rittenhouse

J Neurosci. 2006 Nov 8; 26(45): 11588–11598. doi: 10.1523/JNEUROSCI.2102-06.2006

Correction in:: J Neurosci. 2006 Dec 6; 26(49): 12847.

PMCID:: PMC6674797

Abstract Article PDF–3.4M

Select item 65576298.

Synergy between serum amyloid A and secretory phospholipase A₂

Shobini Jayaraman, Marcus Fändrich, Olga Gursky

eLife. 2019; 8: e46630. Published online 2019 May 21. doi: 10.7554/eLife.46630

PMCID:: PMC6557629

Abstract Article PDF–2.5M

Select item 64956409.

Cloning of intestinal phospholipase A2 from intestinal epithelial RNA by differential display PCR

S. Keshav, A. J. McKnight, R. Arora, S. Gordon

Cell Prolif. 1997 Oct; 30(10): 369–383. Published online 2003 Oct 29. doi: 10.1046/j.1365-2184.1997.00100.x

PMCID:: PMC6495640

Summary PDF–1.1M

Select item 600275910.

Diversity in secreted PLA₂-IIA activity among inbred mouse strains that are resistant or susceptible to Apc^Min/+ tumorigenesis

Marina Markova, Revati A Koratkar, Karen A Silverman, Vincent E Sollars, Melina MacPhee-Pellini, Rhonda Walters, Juan P Palazzo, Arthur M Buchberg, Linda D Siracusa, Steven A Farber

Oncogene. Author manuscript; available in PMC 2018 Jun 15.

Published in final edited form as: Oncogene. 2005 Sep 22; 24(42): 6450–6458. doi: 10.1038/sj.onc.1208791

PMCID:: PMC6002759

Abstract Article PDF–3.3M

Select item 564900911.

Cytosolic Phospholipase A₂α Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection

Rudra Bhowmick, Stacie Clark, Joseph V. Bonventre, John M. Leong, Beth A. McCormick

Infect Immun. 2017 Nov; 85(11): e00280-17. Prepublished online 2017 Aug 14. Published online 2017 Oct 18. doi: 10.1128/IAI.00280-17

PMCID:: PMC5649009

Abstract Article PDF–1022K

Select item 474276812.

Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A₂β (iPLA₂β) and Group X Secreted Phospholipase A₂ (sPLA₂)

Roland Abi Nahed, Guillaume Martinez, Jessica Escoffier, Sandra Yassine, Thomas Karaouzène, Jean-Pascal Hograindleur, John Turk, George Kokotos, Pierre F. Ray, Serge Bottari, Gérard Lambeau, Sylviane Hennebicq, Christophe Arnoult

J Biol Chem. 2016 Feb 5; 291(6): 3076–3089. Published online 2015 Dec 11. doi: 10.1074/jbc.M115.677799

PMCID:: PMC4742768

Abstract Article PDF–2.7M

Select item 468773013.

Thyroid hormone status regulates the expression of secretory phospholipases

Pragya Sharma, Tania Levesque, Eric Boilard, Edwards A. Park

Biochem Biophys Res Commun. Author manuscript; available in PMC 2015 Dec 22.

Published in final edited form as: Biochem Biophys Res Commun. 2014 Jan 31; 444(1): 56–62. Published online 2014 Jan 16. doi: 10.1016/j.bbrc.2014.01.003

PMCID:: PMC4687730

Abstract Article PDF–1.2M

Select item 461905514.

Pla2g2a Attenuates Colon Tumorigenesis in Azoxymethane-Treated C57BL/6 Mice; Expression Studies Reveal Pla2g2a Target Genes and Pathways

Remond J. A. Fijneman, Lindsey K. Bade, Johannes R. Peham, Mark A. van de Wiel, Victor W. M. van Hinsbergh, Gerrit A. Meijer, Michael G. O’Sullivan, Robert T. Cormier

Cell Oncol. 2009; 31(5): 345–356. Published online 2009 Sep 16. doi: 10.3233/CLO-2009-0480

PMCID:: PMC4619055

Abstract PDF–247K

Select item 454894015.

sPLA2 and the epidermal barrier

Dusko Ilic, James M. Bollinger, Michael Gelb, Theodora M. Mauro

Biochim Biophys Acta. Author manuscript; available in PMC 2015 Aug 25.

Published in final edited form as: Biochim Biophys Acta. 2014 Mar; 1841(3): 416–421. Published online 2013 Nov 20. doi: 10.1016/j.bbalip.2013.11.002

PMCID:: PMC4548940

Abstract Article PDF–974K

Select item 450027116.

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A₂-IIA

Anne-Claire Duchez, Luc H. Boudreau, Gajendra S. Naika, James Bollinger, Clémence Belleannée, Nathalie Cloutier, Benoit Laffont, Raifish E. Mendoza-Villarroel, Tania Lévesque, Emmanuelle Rollet-Labelle, Matthieu Rousseau, Isabelle Allaeys, Jacques J. Tremblay, Patrice E. Poubelle, Gérard Lambeau, Marc Pouliot, Patrick Provost, Denis Soulet, Michael H. Gelb, Eric Boilard

Proc Natl Acad Sci U S A. 2015 Jul 7; 112(27): E3564–E3573. Published online 2015 Jun 23. doi: 10.1073/pnas.1507905112

Correction in:: Proc Natl Acad Sci U S A. 2015 Dec 8; 112(49): E6825.

PMCID:: PMC4500271

Abstract Article PDF–1.7M

Select item 426036417.

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A₂ to promote inflammation

Luc H. Boudreau, Anne-Claire Duchez, Nathalie Cloutier, Denis Soulet, Nicolas Martin, James Bollinger, Alexandre Paré, Matthieu Rousseau, Gajendra S. Naika, Tania Lévesque, Cynthia Laflamme, Geneviève Marcoux, Gérard Lambeau, Richard W. Farndale, Marc Pouliot, Hind Hamzeh-Cognasse, Fabrice Cognasse, Olivier Garraud, Peter A. Nigrovic, Helga Guderley, Steve Lacroix, Louis Thibault, John W. Semple, Michael H. Gelb, Eric Boilard

Blood. 2014 Oct 2; 124(14): 2173–2183. Prepublished online 2014 Jul 31. doi: 10.1182/blood-2014-05-573543

Correction in:: Blood. 2015 Jan 29; 125(5): 890.

PMCID:: PMC4260364

Abstract Article

Select item 412540618.

Human Cancer Xenografts in Outbred Nude Mice Can Be Confounded by Polymorphisms in a Modifier of Tumorigenesis

Maged Zeineldin, Derek Jensen, Smita R. Paranjape, Nikhil K. Parelkar, Iman Jokar, George A. Vielhauer, Kristi L. Neufeld

Genetics. 2014 Aug; 197(4): 1365–1376. Published online 2014 Jun 9. doi: 10.1534/genetics.114.166587

PMCID:: PMC4125406

Abstract Article PDF–1.9M

Select item 373354319.

Male Mice That Do Not Express Group VIA Phospholipase A₂ Produce Spermatozoa with Impaired Motility and Have Greatly Reduced Fertility

Shunzhong Bao, David J. Miller, Zhongmin Ma, Mary Wohltmann, Grace Eng, Sasanka Ramanadham, Kelle Moley, John Turk

J Biol Chem. Author manuscript; available in PMC 2013 Aug 5.

Published in final edited form as: J Biol Chem. 2004 Sep 10; 279(37): 38194–38200. Published online 2004 Jul 12. doi: 10.1074/jbc.M406489200

PMCID:: PMC3733543

Abstract Article PDF–1.4M

Select item 340200120.

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice

Olga Ermakova, Lukasz Piszczek, Luisa Luciani, Florence M G Cavalli, Tiago Ferreira, Dominika Farley, Stefania Rizzo, Rosa Chiara Paolicelli, Mumna Al-Banchaabouchi, Claus Nerlov, Richard Moriggl, Nicholas M Luscombe, Cornelius Gross

EMBO Mol Med. 2011 Jan; 3(1): 50–66. doi: 10.1002/emmm.201000112

PMCID:: PMC3402001

Abstract Article PDF–811K

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